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Chemical Research in Chinese Universities 2007年第6期23卷 679-682页

作者： ZHANG Jun-feng GAN Xin ou xue-mei FU Wen-fu College of Chemistry and Chemical Engineering Yunnan Normal University Kunming 650092 P. R. China Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100080 P. R. China

Two novel cyclotriphosphazene derivatives containing 6- （4-hydroxyphenyl）-2,2′-bipyridine （hopbp） side groups, N3 P3 （dobp） 2 （hopbp） 2 （ 1 ） and N3 P3 （dobp）（hopbp） 4 （2）（ dobp = 2,2′-dioxybiphenyl）, were synthesized and characterized. These compounds display strong fluorescent emission both in solution and in solid state. Their absorption and emission spectra are sensitive to proton： the addition of HBF4 to the methanol and dichloromethane solution（9： 1, volume ratio） of compound 1 led to a red-shift from 350 to 460 nm for the emission spectrum, and the process was also characterized by isosbestic points of absorption spectra at 267, 287 and 313 nm.

关键词： Cyelotriphosphazene Bipyridine Proton Spectra

Hot-corrosion mechanism of Ni-Cr coatings at 650℃ under different simulated corrosion conditions

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Journal of China University of Mining and Technology 2008年第3期18卷 444-448页

作者： ou xue-mei SUN Zhi SUN Min Zou Duan-lian School of Material Science and Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

The oxidation and lower temperature hot corrosion (LTHC) processes occurring on the surface of Ni-Cr coatings pro-duced by high velocity arc spray (HVAS) were studied. Several different conditions were studied under simulated boiler conditions at 650 ℃. The protection effect of an Al coating deposited by HVAS onto the Ni-Cr coating was also investigated. Microscope, X-ray diffraction and corrosion rate curves have been used to analyze corrosion mechanisms. The experimental results show that: 1) The oxidation rates are almost superposed in both air (no SO3) and in simulated coal-fired gas (containing SO3) as long as no salt was present on the surface. These rate curves show a logarithmic relationship. 2) When the surface is coated with salt (75%K2SO3 + 25%Na2SO3) the rate curve for LTHC of the Ni-Cr coated surface shows a parabolic shape in the simulated coal-fire flue gas. In air only the oxidation reaction takes place, the second type of LTHC was not seen. And 3) the Al over coating on the Ni-Cr enhances resistance to LTHC because an inter-metallic compound, Al3Ni2, forms at the Al/Ni-Cr interface and because of the increase in coating thickness.

关键词： low-temperature hot-corrosion Ni-Cr coating corrosion product corrosion rate curves

Research on the Anticorrosion Coating Under the Paved Layer for Highway Steel Box Bridge Deck

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Journal of China University of Mining and Technology 2006年第4期16卷 429-432页

作者： SHEN Cheng-jin MING Tu-zhang HU Guang-wei ou xue-mei GEN ou School of Material Science ＆ Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China Jiangsu Provincial Communication Planning and Design Institute Nanjing Jiangsu 210005 China

The corrosion of the anticorrosion coating and the defects of the asphalt concrete paved layer have been investigated on long-span steel box bridge decks. The anticorrosion coating lies in the midclle of two entirely different materials： a highway steel box bridge deck and a paved layer, which is used as anticorrosion and waterproof coating for the steel bridge deck. For our study, electrochemical corrosion and pull strength experiments have been selected for the investigation of the corrosion properties of inorganic zinc rich coating, epoxy zinc rich coating and arc sprayed zinc coating. The adhesive strength between the coatings and the panel, and the effect of the coating corrosion on the shear properties of the paved layers including cast asphalt, thermal asphalt mortar, epoxy asphalt and modified asphalt con- crete have been investigated. The results show that the adhesive strength between the coatings and the bridge panel is controlled by the method of pre-processing rust removal. Coating by sandblasting has stronger adhesive strength than coating by shot peening. The results also reveal that shear strength of the paved layer is affected by the corrosion product of zinc coating. The arc sprayed zinc coating has stronger shear strength than zinc rich coatings.

关键词： steel bridge deck zinc coatings asphalt concrete paved layer

Association of chronic obstructive pulmonary disease with coronary artery disease

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Chinese Medical Journal 2013年第17期126卷 3205-3208页

作者： LIANG Bin-miao XU Zhi-bo YI Qun ou xue-mei FENG Yu-lin Department of Respiratory Medicine West China Hospital of Sichuan University Chengdu Sichuan 610041 China Department of Respiratory Medicine No. 2 People's Hospital of Chengdu Chengdu Sichuan 610017 China

Background The relationship between chronic obstructive pulmonary disease （COPD） and coronary artery disease （CAD） remains largely unknown. This study aimed to explore the association of COPD with CAD, especially with multi- vessel disease （VD）. Methods The data of 354 patients who underwent multi-detector computed tomography （MDCT） for suspected CAD were analyzed. Luminal narrowing was defined as at least one lesion 50% or greater stenosis. The analysis of serum biochemistry profile and spirometrywere performed on all eligible patients, and the diagnosis of COPD was defined as the criteria of Global Initiative for Chronic Obstructive Lung Disease. Results Patients with CAD had a significantly higher complication of COPD than those without CAD （11.8% vs. 3.7%, P 〈0.001）. Comparing with patients without COPD, those with COPD were more likely to have multi-VD, proportion of smoking and high C-reactive protein （CRP）（P 〈0.001）. Multivariate Logistic regression analysis revealed that the multi-VD was significantly correlated with COPD （P=-0.012） and CRP （P=0.015）. Conclusions There was a high complication of COPD in patients with CAD, and COPD may be a critical risk factor for CAD, especially for multi-VD. CAD and COPD were closely associated and the interplay of systemic inflammation might in part explain the relationship between them.

关键词： coronary artery disease multi-detector computed tomography chronic obstructive pulmonary disease

Advanced Chronic Obstructive Pulmonary Disease： Innovative and Integrated Management Approaches

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Chinese Medical Journal 2015年第21期128卷 2952-2959页

作者： Hai-Xia Zhou xue-mei ou Yong-Jiang Tang Lan Wang Yu-Lin Feng Department of Respiratory Medicine West China Hospital Sichuan University Chengdu Sichuan 610041 China

Chronic obstructive pulmonary disease （COPD） is a leading cause of morbidity and mortality worldwide and results in an economic and social burden that is both substantial and increasing. By the year 2020, COPD will be the third leading cause of mortality and the fifth leading cause of disability worldwide, In a population based study conducted at multiple international sites, approximately 10% of participants 40 years of age or older were found to have airflow obstruction of at least moderate severity according to spirometric criteria. In China, the overall prevalence of COPD in individuals 40 years of age or older was 8.2%.m COPD is a slowly progressive respiratory disease, which, although preventable and treatable, is not curable. The final years for patients with advanced COPD are characterized by progressive functional decline, frequent exacerbations, poor quality of life, increasing dependency on informal caregivers and on the health care system. According to the literature, 5-year survival from diagnosis is estimated to be 78% in men and 72% in women with mild disease, but only 30% in men and 24% in women with advanced COPD.

关键词： Advanced Chronic Obstructive Pulmonary Disease End-of-life Care and Hospice Care Management Approaches Opioids Palliative Care Symptom Burden

Increased expression of human calcium-activated chloride channel 1 is correlated with mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease

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Chinese Medical Journal 2007年第12期120卷 1051-1057页

作者： WANG Ke FENG Yu-ling WEN Fu-qiang CHEN xue-rong ou xue-mei XU Dan YANG Jie DENG Zhi-pin Division of Pulmonary Diseases State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine West China Hospital of Sichuan University Chengdu 610041 China

Background Chronic obstructive pulmonary disease （COPD） is usually complicated with mucus overproduction in airway. Recently the increased expression of the human calcium-activated chloride channel 1 （CaCC1） was found to play an important role in mucus overproduction in the asthmatic airways. To investigate the relationship of CaCC1 and mucus overproduction in the airway of Chinese patients with COPD, the expressions of CaCC1, MUC5AC and mucus in bronchial tissues were examined. Methods Bronchial tissues were obtained from fiberoptic bronchoscopy and bronchial biopsy in West China Hospital from April to July in 2004. Twenty-five patients were diagnosed as the patients with COPD overproduction, and other 20 were the control subjects. The expressions of CaCC1, MUC5AC and mucin in bronchial tissues were detected by reverse transcriptase-polymerase chain reaction （RT-PCR）, in situ hybridization with digoxigenin （DIG）-Iabeled RNA probe, immunohistochemical and alcian blue-periodic acid Schiff （AB-PAS） staining, respectively. Results Compared with the control group, the stronger expressions of CaCC1 were further detected throughout the bronchial tissues from patients with COPD （P〈0.01）. Furthermore, the stronger expressions of the CaCC1 mRNA were related to the severity of airflow obstruction. Samples from COPD showed a stronger staining for MUC5AC than those in control subjects （P〈0.01） and AB-PAS staining revealed more mucins in COPD patients＇ submucosal gland comparing with that in control subjects （P〈0.01）. Expression levels of the CaCC1 mRNA were respectively negatively correlated with the patients＇ forced expiratory volume in one second （FEV~） / forced vital capacity （FVC） data, FEV1% predicted data, V50% predicted data, V25% predicted data （r=-0.43, r=-0.43, r=-0.35, r=-0.36, P〈0.01, P〈0.01, P〈0.05, P〈0.05）. While the expression levels of the CaCC1 mRNA were well correlated with the expression levels of the MUC5AC mRNA of airway epithelium and the PAS-AB staine

关键词： calcium-activated chloride channel 1 mucin 5AC mucin mucus overproduction chronic obstructive pulmonary disease

Simvastatin attenuates lipopolysaccharide-induced airway mucus hypersecretion in rats

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Chinese Medical Journal 2008年第17期121卷 1680-1687页

作者： ou xue-mei WANG Bai-ding WEN Fu-qiang FENG Yu-lin HUANG Xiang-yang XIAO Jun Division of Pulmonary Diseases State Key Laboratory of Biotherapy of China and Department of Respiratory Medicine West China Hospital of Sichuan University Chengdu Sichuan 610041 China

Background Mucus hypersecretion in the respiratory tract and goblet cell metaplasia in the airway epithelium contribute to the morbidity and mortality associated with airway inflammatory diseases. This study aimed to examine the effect and mechanisms of simvastatin on airway mucus hypersecretion in rats treated with lipopolysaccharide （LPS）. Methods Mucus hypersecretion in rat airways was induced by intra-tracheal instillation of LPS. Rats treated with or without LPS were administered intra-peritoneally simvastatin （5 and 20 mg/kg） for 4 days. Expression of Muc5ac, RhoA and mitogen-activated protein kinases （MAPK） p38 in lung were detected by real-time polymerase chain reaction （PCR）, immunohistochemistry or Western blotting. Tumor necrosis factor （TNF）-α and IL-8 in bronchoalveolar lavage fluid （BALF） were assayed by an enzyme-linked lectin assay and enzyme linked immunosorbent assay （ELISA）. Results Simvastatin attenuated LPS-induced goblet cell hyperplasia in bronchial epithelium and Muc5ac hypersecretion at both the gene and protein levels in lung （P 〈0.05）. Moreover, simvastatin inhibited neutrophil accumulation and the increased concentration of TNF-α and IL-8 in BALF follows LPS stimulation （P 〈0.05）. The higher dose of simvastatin was associated with a more significant reduction in Muc5ac mRNA expression, neutrophil accumulation and inflammatory cytokine release. Simultaneously, the increased expression of RhoA and p38 MAPK were observed in LPS-treated lung （P 〈0.05）. Simvastatin inhibited the expression of RhoA and p38 phosphorylation in lung following LPS stimulation （P 〈0.05）. However, the increased expression of p38 protein in LPS-treated lung was not affected by simvastatin administration. Conclusions Simvastatin attenuates airway mucus hypersecretion and pulmonary inflammatory damage induced by LPS. The inhibitory effect of simvastatin on airway mucus hypersecretion may be through, at least in part, the suppression of neutrophil accumulation and inflam

关键词： mucus hypersecretion lipopolysaccharide simvastatin RhoA mitogen-activated protein kinases p38

Simvastatin attenuates bleomycin-induced pulmonary fibrosis in mice

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Chinese Medical Journal 2008年第18期121卷 1821-1829页

作者： ou xue-mei FENG Yu-lin WEN Fu-qiang HUANG Xiang-yang XIAO Jun WANG Ke WANG Tao Division of Pulmonary Diseases State Key Laboratory of Biotherapy of China Department of Respiratory Medicine West China Hospital Sichuan University Chengdu Sichuan 610041 China

Background Bleomycin-induced fibrosis is extensively used to model aspects of the pathogenesis of interstitial pulmonary fibrosis. This study aimed to determine the benefic effects and mechanisms of simvastatin on bleomycininduced pulmonary fibrosis in mice. Methods Bleomycin-induced pulmonary fibrosis mice were administered with simvastatin in different doses for 28 days. We measured inflammatory response, fibrogenic cytokines and profibrogenic markers in both bleomycin-stimulated and control lungs, and correlated these parameters with pulmonary fibrosis. Results Simvastatin attenuated the histopathological change of bleomycin-induced pulmonary fibrosis and prevented the increase of lung hydroxyproline content and collagen （Ⅰ and Ⅲ） mRNA expression induced by bleomycin. Moreover, simvastatin down-regulated the increased expression of transforming growth factor-β1 （TGF-β1） and connective tissue growth factor （CTGF） induced by bleomycin at both gene and protein levels. Simultaneously, the accumulation of neutrophils and lymphocytes and the increased production of tumor necrosis factor-a （TNF-α） in bronchial alveolar lavage fluid were inhibited by simvastatin in early inflammatory phase after bleomycin infusion. The higher dose of simvastatin was associated with a more significant reduction in these inflammatory and fibrotic parameters. Furthermore, the inactivation of p38, RhoA and Smad2/3 signaling pathways was observed during simvastatin administration. Conclusions Simvastatin attenuated bleomycin-induced pulmonary fibrosis, as indicated by decreases in Ashcroft score and lung collagen accumulation. The inhibitory effect of simvastatin on the progression of pulmonary fibrosis may be demonstrated by reducing inflammatory response and production of TGF-β1 and CTGR These findings indicate that simvastatin may be used in the treatment of pulmonary fibrosis.

关键词： pulmonary fibrosis simvastatin transforming growth factor-β1 connective tissue growth factor

Relationship between 6-minute walk test and pulmonary function test in stable chronic obstructive pulmonary disease with different severities

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Chinese Medical Journal 2012年第17期125卷 3053-3058页

作者： CHEN Hong LIANG Bin-miao TANG Yong-jiang XU Zhi-bo WANG Ke YI Qun ou xue-mei FENG Yu-lin Department of Respiratory Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Department of Respiratory Medicine Second People's Hospital of ChengduChengduSichuan 610017China

Background The relationship between the 6-minute walk test （6MWT） and pulmonary function test in stable chronic obstructive pulmonary disease （COPD） remains unclear. We evaluate the correlation of 6MWT and spirometric parameters in stable COPD with different severities. 6MWT data assessed included three variables： the 6-minute walk distance （6MWD）, 6-minute walk work （6MWORK）, and pulse oxygen desaturation rate （SPO2%）. Methods 6MWT and pulmonary function test were assessed for 150 stable COPD patients with different severities. Means and standard deviations were calculated for the variables of interest. Analysis of variance was performed to compare means. Correlation coefficients were calculated for 6MWT data with the spirometric parameters and dyspnea Borg scale. Multiple stepwise regression analysis was used to screen pulmonary function-related predictors of 6MWT data. Results The three variables of 6MWT all varied as the severities of the disease. The 6MWD and 6MWORK both correlated with some spirometric parameters （positive or negative correlation; the absolute value of r ranging from 0.34 to 0.67; P 〈0.05） in severe and very severe patients, and the SPO2% correlated with the dyspnea Borg scale in four severities （t= -0.33, -0.34, -0.39, -0.53 respectively; P 〈0.05）. The 6MWD was correlated with the 6MWORK in four severities （r=0.56, 0.57, 0.72, 0.81 respectively, P 〈0.05）, and neither of them correlated with the SPO2%. The percent of predicted forced expiratory volume in 1 second （FEV1% predicted） and residual volume to total lung capacity ratio （RV/TLC） were predictors of the 6MWD, and the maximum voluntary ventilation （MW） was the predictor of the 6MWORK. Conclusions 6MWT correlated with the spirometric parameters in severe and very severe COPD patients. 6MWT may be used to monitor changes of pulmonary function in these patients.

关键词： pulmonary disease, chronic obstructive 6-minute walk test pulmonary function test correlation analysis

苯甲酰胺对高岭石插层的FTIR和XRD研究

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光谱学与光谱分析 2009年第8期29卷 2067-2070页

作者：张生辉强颖怀欧雪梅夏华中国矿业大学材料科学与工程学院江苏徐州221008 中国地质大学材料科学与化学工程学院湖北武汉430074

苯甲酰胺在熔融状态下取代前驱体中的DMSO分子插层高岭石,产物经丙酮洗涤,得到纯净的高岭石/苯甲酰胺插层复合物。XRD结果显示高岭石层间距从0.717nm膨胀到1.437nm。插层作用使高岭石内表面羟基红外伸缩振动峰由3696和3657cm-1移动至370... 详细信息

苯甲酰胺在熔融状态下取代前驱体中的DMSO分子插层高岭石,产物经丙酮洗涤,得到纯净的高岭石/苯甲酰胺插层复合物。XRD结果显示高岭石层间距从0.717nm膨胀到1.437nm。插层作用使高岭石内表面羟基红外伸缩振动峰由3696和3657cm-1移动至3701和3651cm-1处;苯甲酰胺3368和3172cm-1处NH2基伸缩振动峰红移至3474和3184cm-1处,1659cm-1处羰基峰移至1640cm-1处,这些表明原高岭石层间氢键的损失及与苯甲酰胺分子之间氢键的形成。插层反应于30min迅速达到平衡,插层率随反应温度的增加先增加后减小,180℃时有最大插层率;以丙酮作为洗涤剂可以消除表面吸附和残余的苯甲酰胺晶体而不影响复合物的结构。

关键词：高岭石苯甲酰胺插层 XRD FTIR