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万古霉素新旧AUC_(0-24)/MIC计算模型的一致性评价及临床疗效预测价值比较

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中国医院药学杂志 2024年第9期44卷 1038-1047,1055页

作者：郑春茂欧玮宋香清郴州市第一人民医院药学部湖南郴州423000 岳阳市中心医院药剂科湖南岳阳414000 湖南省肿瘤医院药学部湖南长沙410013

目的:比较万古霉素新(新近文献建立)、旧(既往文献建立)两种AUC_(0-24)/MIC(24 h药时曲线下面积与最低抑菌浓度比值)模型计算AUC_(0-24)/MIC值的一致性及对临床疗效的预测价值。方法:回顾性分析42例血流感染患者的临床资料,收集5种共42... 详细信息

目的:比较万古霉素新(新近文献建立)、旧(既往文献建立)两种AUC_(0-24)/MIC(24 h药时曲线下面积与最低抑菌浓度比值)模型计算AUC_(0-24)/MIC值的一致性及对临床疗效的预测价值。方法:回顾性分析42例血流感染患者的临床资料,收集5种共42株耐甲氧西林葡萄球菌,采用配对样本t检验和Bland-Altman图考察所有患者共65种方案基于两模型的65对AUC_(0-24)/MIC值的差异。采用Spearman等级相关分析考察并比较42例患者所有方案共97对基于模型预测的理论疗效分级与实际疗效分级的相关性,以评价两模型的临床疗效预测价值。采用相关系数考察共42对基于两模型的AUC_(0-24)/MIC值与万古霉素用药前后血清肌酐变化情况的相关性,以评价两模型对万古霉素肾毒性的预测价值。结果:两模型AUC_(0-24)/MIC值差异显著,新模型较旧模型平均高28.9,最高62.2。基于新模型的日剂量较旧模型平均高78~1198 mg。基于两模型的理论疗效分级与实际疗效分级均显著相关,但新模型相关性更高(Speaman等级相关系数新模型vs.旧模型为0.826 vs.0.656)。两模型AUC_(0-24)/MIC值与血清肌酐变化均无显著相关。结论:两种AUC_(0-24)/MIC模型不具有一致性,新模型具有更高的临床疗效预测价值,两模型均无法预测万古霉素的肾毒性。

关键词：万古霉素评价模型一致性评价临床疗效预测价值

Progress in the treatment of elderly patients with patent foramen ovale complicated with cryptogenic stroke

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South China Journal of Cardiology 2024年第1期25卷 50-56页

作者：区炜光邓少东陈建英 Department of Structural Heart Disease Affiliated Hospital of Guangdong Medical UniversityZhanjiang 524000China Guangdong Medical University Zhanjiang 524000China.

Background The incidence of cryptogenic stroke(CS)accounts for about 25%of ischemic *** studies have shown that cryptogenic stroke is closely related to patent foramen ovale(PFO).Evaluating the correlation between PFO and CS needs to be combined with multidisciplinary *** clinical studies have shown that drug therapy can reduce the risk of ischemic stroke in elderly PFO patients(>60 years old).However,whether elderly PFO patients(>60 years old)can benefit from PFO closure is still *** article reviewed the research progress of drug therapy and PFO closure therapy for cryptogenic stroke associated with PFO in the elderly.[S Chin J Cardiol 2024;25(1):50-56].

关键词： Patent foramen ovale Cryptogenic stroke Old age Treatment

Amides as surrogates of aldehydes for C–C bond formation:amide-based direct Knoevenagel-type condensation reaction and related reactions

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Science China Chemistry 2020年第1期63卷 11-15页

作者： wei ou Pei-Qiang Huang Department of Chemistry Fujian Provincial Key Laboratory of Chemical Biology College of Chemistry and Chemical Engineering Xiamen University

Aldehydes are perhaps the most versatile compounds that enable many C-C bond forming reactions,which are not amenable for other subclasses of carbonyl *** report the first use of amides as surrogates of aldehydes for C-C bond formation,namely,the direct Knoevenagel-type condensation based on *** one-pot method consists of controlled reduction of an amide with LDBIPA[LiAlH(iBu)2(OiPr)],Lewis acid-mediated release of a reactive iminium ion intermediate,nucleophilic addition,and in situ elimination of *** reaction shows good functional group *** also demonstrated that the Schwartz reagent could be used as an alternative of *** employment of nitromethane and a silyl enol ether as the nucleophiles opens an avenue for the unprecedented amide-based nitro-aldol condensation reaction and aldol condensation reaction,respectively.

关键词： amides Knoevenagel condensation C–C bond formation one-pot reaction amide transformation

Verifying specifications with associated attributes in graph transformation systems

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Frontiers of Computer Science 2015年第3期9卷 364-374页

作者： Yu ZHou Yankai HUANG ou wei Zhiqiu HUANG College of Computer Science and Technology Nanjing University of Aeronautics and Astronautics Nanjing 210016 China State Key Laboratory for Novel Software Technology Nanjing University Nanjing 210093 China

Graph transformation is an important modeling and analysis technique widely applied in software engineer- ing. The attributes can naturally conceptualize the properties of the modeled artifacts. However, the lack of support for the specification of such attribute correspondence by ordi- nary propositional temporal logics hampers its further appli- cation during verification. Different from the theoretical in- vestigations on quantified second order logics, we propose a practical and light-weight approach for the verification of this kind of temporal specifications with associated attributes. Particularly, we apply our approach and extend the general- purpose graph transformation modeling tool： GROOVE. More- over, symmetry reduction techniques are exploited to reduce the number of states. Experiments with performance evalua- tions complement our discussion and demonstrate the feasi- bility and efficiency of our approach.

关键词： graph grammar software design verification

基于残差网络和注意力机制的恩施玉露茶品级分类

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湖北科技学院学报 2024年第1期44卷 143-150页

作者：毛腾跃欧阳德维中南民族大学计算机科学学院湖北武汉430074 湖北省制造企业智能管理工程技术研究中心湖北武汉430074

恩施玉露是湖北省著名的绿茶品牌,茶叶的外形是其品质分级的重要依据。为了解决消费者对于茶叶品质分级存疑的问题,本文在ResNet18的基础上,提出了一种基于空间和通道注意力机制结合深度可分离卷积的茶叶分类网络。首先在残差模块中添... 详细信息

恩施玉露是湖北省著名的绿茶品牌,茶叶的外形是其品质分级的重要依据。为了解决消费者对于茶叶品质分级存疑的问题,本文在ResNet18的基础上,提出了一种基于空间和通道注意力机制结合深度可分离卷积的茶叶分类网络。首先在残差模块中添加注意力模块,让网络去侧重关注茶叶的纹理特征和颜色信息,忽略无关的背景因素,接着在最后两个残差模块中使用深度可分离卷积替换常规卷积,降低模型的参数量,防止网络过拟合。实验结果表明:改进后的ResNet20-CBAM_DW分类模型的准确率可达到95.48%,且模型大小仅为19.32MB。本研究为构建恩施玉露茶的品质分类模型提供了依据,且便于部署在移动端,为消费者对恩施玉露茶的品级分类提供了一种便捷且高效的新方法。

关键词：恩施玉露 ResNet 深度学习茶叶分级

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Recent advances in nature-inspired nanocatalytic reduction of organic molecules with water

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Nano Research 2022年第12期15卷 10292-10315页

作者： Hongli Sun wei ou Like Sun Bo Wang Chenliang Su Institute of Microscale Optoelectronics Shenzhen UniversityInternational Collaboration Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationShenzhen518060China CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen518055China

Nature has provided us the assurance and inspiration for thousands of years in synthesizing value-added chemicals,with the assistance of reactive hydrogen species,and water as the ultimate hydrogen ***,the natural photosynthesis is inefficient due to some intrinsic properties,urging people not only to learn from but also surpass during nature *** this review,we summarized recent progresses on reactive hydrogen species-assisted nanocatalytic reduction of organic molecules towards value-added fine chemicals and pharmaceuticals,with water as the hydrogen source,and especially highlighted how photocatalytically or electrocatalytically evolved reactive hydrogen species synergize with biocatalytic centers and nanocatalytic sites for reduction of organic *** design principles of collaborative semi-artificial systems and nanocatalytic artificial systems,the structure tuning of catalysts for the evolution and utilization of hydrogen species,and the determination of reactive hydrogen species for mechanistic insights were discussed in ***,perspectives were provided for further advancing this emerging area of nanocatalytic reduction of organic molecules from water(or proton)and organics.

关键词： nano-catalysts reactive hydrogen species nature inspiration reduction of organic molecules

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光纤光栅型钢绞线成品拉索的研制

激光与光电子学进展 2024年第15期61卷 82-87页

作者：余文成欧维朱万旭雷芸沈全喜桂林理工大学土木与建筑工程学院广西桂林541004 广西岩土力学与工程重点实验室广西桂林541004

拉索是索类工程结构的主要承载构件,拉索智慧化可为拉索服役状态评估提供数据支撑,对结构的长期安全运营具有重要意义。为提高光纤光栅传感器的存活率和探究内嵌传感器对成品拉索承载性能的影响,提出每根钢绞线中心丝刻槽内嵌5个传感器... 详细信息

拉索是索类工程结构的主要承载构件,拉索智慧化可为拉索服役状态评估提供数据支撑,对结构的长期安全运营具有重要意义。为提高光纤光栅传感器的存活率和探究内嵌传感器对成品拉索承载性能的影响,提出每根钢绞线中心丝刻槽内嵌5个传感器,并通过端堵钻孔引出光纤线束的方案,配制三个光纤光栅型钢绞线成品拉索试件进行静载张拉试验,试验结果表明:张拉过程中传感器存活率达100%,索力监测范围可达破断荷载的80%,拉索锚固效率系数>97%。光纤光栅传感器内嵌封装在中心丝并通过钻孔引出的方法保证了传感器的存活率,实现拉索轴向应力的可靠监测。成品拉索平均承载力为821 kN,钢绞线中心丝刻槽内嵌传感器的成品拉索保持良好的承载性能,满足工程运用要求。

关键词：光纤光栅传感器钢绞线拉索锚固结构静载试验

On the variable timing behavior of PSR B0540-69:an almost excellent example to study the pulsar braking mechanism

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Research in Astronomy and Astrophysics 2016年第5期16卷 81-86页

作者： Fei-Fei Kou Zi-wei ou Hao Tong Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China

PSR B0540-69 has a braking index measurement in its persistent state： n = 2.129± 0.012. Recently, it has been reported to have changes in its spin-down state： a sudden 36% increase in the spin- down rate. Combining the persistent state braking index measurement with different spin-down states, PSR B0540-69 is more powerful than intermittent pulsars in constraining pulsar spin-down models. The pulsar wind model is applied to explain the variable timing behavior of PSR B0540-69. The braking index of PSR B0540-69 in its persistent state results from the combined effect of magnetic dipole radiation and particle wind. The particle density reflects the magnetospheric activity in real-time and may be responsible for the changing spin-down behavior. Corresponding to the 36% increase in the spin-down rate of PSR B0540-69, the relative increase in the particle density is 88% in the vacuum gap model. The braking index calculated with the model in the new state is n = 1.79. Future observations that measure the braking index of PSR B0540-69 in the new spin-down state will be very powerful in distinguishing between different pulsar spin-down models and different particle acceleration models in the wind braking scenario. The variable timing behavior of PSR J 1846-0258 is also understandable in the pulsar wind model.

关键词： pulsars: general -- pulsars: individual (PSR B0540-69 PSR J 1846-0258) -- stars: neutron-- wind

Responses of nematode communities to different land uses in an aquic brown soil

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Frontiers in Biology 2008年第4期3卷 518-524页

作者： Qi LI Wenju LIANG wei ou Institute of Applied Ecology Chinese Academy of SciencesShenyang 110016China Graduate University of Chinese Academy of Sciences Beijing 100049China

An analysis of the seasonal and vertical distribution of soil nematode communities under three contrasting land uses,i.e.,cropland,abandoned cropland and woodland was conducted in an aquic brown *** results showed that different land-use types affected the spatiotemporal distribution of soil nematodes and their dominant genera,and different dominant genera showed different responses to land *** the abandoned cropland and woodland,most dominant genera were present in the 0–20 cm layers and Chiloplacus was mainly distributed in the 5–30 cm layers,while in the cropland,Pratylenchus exhibited an even distribution from the 0–5 cm to the 40–50 cm *** environmental parameters under different land use could influence soil nematodes;soil porosity,total organic C,total N and the C/N ratio could positively influence the abundance of some dominant *** profiles revealed that environmental stability and the homeostasis in the abandoned cropland and woodland lead to higher levels of community structure,and the soil food web tends to succeed to *** faunal analyses are a useful indicator for interpreting the stress and/or nutrient conditions under different land uses.

关键词： soil nematodes dominant genera faunal analysis land use aquic brown soil