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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Effects of daily telephone-based re-education before taking medicine on Helicobacter pylori eradication

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World Journal of Gastroenterology 2016年第15期22卷 4071-4072页

作者： Hakan Demirci Kadir Ozturk omer Kurt Department of Gastroenterology Gulhane Military Medical Academy 06010 Ankara Turkey

We read the article "Effects of daily telephone-based re-education before taking medicine on Helicobacter pylori(H. pylori) eradication: A prospective singlecenter study from china" written by Wang et al with great interest. It is reported in American and European guidelines that there is no sufficient test for the diagnosis of H. pylori except culture and that using at least two different tests for diagnosis of H. pylori is recommended. Patients who used antibiotics or bismuth salts in the previous 2 wk were excluded from study. But patients who used probiotics and antioxidant vitamins such as vitamins c and E were not excluded.

关键词： Helicobacter pylori Erdication rates Telephone based education

Prediction of the Isothermal Sections in the ZrO_(2)- YO_(1.5)-ceO_(2) System

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Journal of Materials Science & Technology 2001年第5期17卷 529-534页

作者： LinLI Shuigen HUANG Luoping XU omer Van Der Biest Jozef Vleugels Dept.of Materials Science and Engineering Shanghai UniversityShanghai 200072China Dept.of Materials and Metallurgy Katholieke Universiteit LeuvenB-3001 HeverleeBelgium

The experimental work on the ZrO2-YO1.5-ceO2 system, its limiting quasi-binaries and previous thermodynamic assessments are reviewed and evaluated. Isothermal sections of ZrO2-YO1.5-ceO2 system in the temperature region between 1450 and 1800 c are estimated according to the substitutional model using the Bonnier equation. The cSS + YSS two-phase region of the calculated isothermal section at 1700 degreesc was found to be in good agreement with the experimentally obtained ternary diagram of Longo and Podda. The phase composition in the ZrO2-rich corner however disagreed significantly.

关键词： Soc cALPHAD ceO2 System Prediction of the Isothermal Sections in the ZrO2-YO

computer simulation of W-c-co-V system diffusion couples

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Rare Metals 2007年第5期26卷 492-497页

作者： HE Yanlin LI Lin HUANG Shuigen Jef Vleugels omer Van der Biest School of Material Science ＆ Engineering Shanghai University Shanghai 200072 China Department of Metallurgy and Materials Engineering Katholieke Universiteit Leuven Kasteelpark Arenberg 44 Heverlee B-3001 Belgium

Diffusion couples,Wc/co-1at.%c,V8c7/co,and Wc/co-0.3wt.%V8c7 were constructed and annealed at temperatures ranging from 1100 to 1300℃. The concentration profile of V and W atoms in these couples were measured by EPMA. Aided by Thermo-calc ＆ DIcTRA software package,the concentration profiles of W and V in established diffusion couples were calculated by the moving boundary model according to revised dynamic parameters and MOB database,respectively. Then the concentration profile of W in co binder during sintering Wc-co cemented carbide was simulated by the cell model. It can provide reference for composition and sintering process design of cemented carbides with high performance. Meanwhile,the validity of revised dynamic parameters of the W-c-co-V system is verified by the comparison of experimental and simulated results.

关键词： material science W-c-co-V system Thermo-calc and DIcTRA software package dynamic parameters

Sintering, thermal stability and mechanical properties of ZrO2-Wc composites obtained by pulsed electric current sintering

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Frontiers of Materials Science 2011年第1期5卷 50-56页

作者： Shuigen HUANG Kim VANMEENSEL omer VAN DER BLEST Jozef VLEUGELS Department of Metallurgy and Materials Engineering Katholieke Universiteit Leuven Kasteelpark Arenberg 44 B-3001 Heverlee Belgium

ZrO2-Wc composites exhibit comparable mechanical properties as traditional Wc-co materials, which provides an opportunity to partially replace Wc-co for some applications. In this study, 2 mol.% Y2O3 stabilized ZrO2 composites with 40 vol.% Wc were consolidated in the 1150℃-1850℃ range under a pressure of 60 MPa by pulsed electric current sintering （PEcS）. The densification behavior, microstructure and phase constitution of the composites were investigated to clarify the role of the sintering temperature on the grain growth, mechanical properties and thermal stability of ZrO2 and Wc components. Analysis results indicated that the composites sintered at 1350℃ and 1450℃ exhibited the highest tetragonal ZrO2 phase transformability, maximum toughness, and hardness and an optimal flexural strength. chemical reaction of ZrO2 and c, originating from the graphite die, was detected in the composite PEcS for 20 min at 1850℃ in vacuum.

关键词： ceramic composite pulsed electric current sintering (PEcS) grain size,mechanical property

characterizing conservative and protective needs of the aridland forests of Sudan

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Journal of Forestry Research 2021年第6期32卷 2365-2373页

作者： Nasradeen A.H.Gadallah Abdelnasir I.A.Hano Eiman Diab Galal omer Dep.of Forest conservation and Protection Faculty of ForestryUniversity of KhartoumKhartoum North 13314Sudan Desrtification and Desert cultivation Studies Institute University of KhartoumKhartoum North 13314Sudan National center for Research Institute of Environment and Natural ResourcesKhartoum 1111Sudan

Forests in the aridlands of Sudan are distinctive in nature and require special attention due to the great role they play as a first and last line of defense against southward ***,to determine their conservative and protective needs based on current conditions in the Wad Al-Bashir Forest(WF),toward ensuring sustainable forest resources in these areas,we used a systematic field survey,existing and available documents review and key informant interviews(KII),to collect data from 08 December 2017 to 15 May 2018.A severe depletion and changes in the forest tree cover and composition were found during the field survey,where species such as Balanitis aegyptiaca is threatened and invasive species(e.g.,Acacia nubica)have started to *** documents have credited illegal cutting and agricultural activities for the changes in the forest status,whereas the KII indicated that past and current forest conservative and protective practices(cPPs),where forest clearance for agricultural,grazing,pests and disease control,were not given a deserved consideration as they relate to tree cutting and reforestation ***,negligence of the needs of those who depend on the forest and inadequate funds have constrained implementation of some ***,on the basis of the results of this study,we recommend that cPPs associated with agriculture,grazing,forest fire,pest and disease control should be a top priority concern of forest *** financial support,which could be enriched by involving governmental and non-governmental organizations,is also needed to boost cPPs in the *** species also need to be cleared and replaced by trees such as *** and *** that are of economic and environmental value.

关键词： Dry forest Forest conservation Protection Desertification