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Testicular prostheses-impact on quality of life and sexual function

Asian Journal of Andrology 2024年第2期26卷 160-164页

作者： ana Sofia Araujo Sara anacleto Ricardo Rodrigues Catarina Tinoco Andreia Cardoso Carlos oliveira Ricardo Leao Department of Urology Braga's HospitalBraga 4710Portugal Faculty of Medicine Coimbra UniversityCoimbra 3000Portugal

Orchiectomy is the recommended treatment for many testicular ***,testicular prosthesis placement is not always performed for different *** this study,we aimed to evaluate patients'opinions and the impact on sexual function and quality of *** retrospective observational single-center study included patients who underwent orchiectomy between January 2014 and December 2020 at the Department of Urology,Braga's Hospital(Braga,Portugal),where testicular implants were always available and the decision to undergo the procedure was made fully independent of *** completed four questionnaires that assessed demographic data,satisfaction,self-esteem,and sexual *** the 96 patients who underwent orchidectomy,59 replied to the questionnaires,and of these patients,86.4%decided to undergo silicone-based testicular prostheses *** remaining 13.6%refused the implant based on concerns about complications(37.5%),because they felt that it was unnecessary(37.5%),or because it was not offered by the doctor(25.0%).Overall,96.1%of these patients were satisfied with the implant;however,25.5%classified it as"too firm".No statistically significant differences were found in sexual function(all P>0.05).However,it can be observed that there are more patients with prostheses presenting normal sexual activity compared to patients without prostheses(74.0%vs 50.0%),and none of them reported severe erectile dysfunction(0 vs 16.7%).Regarding self-esteem,both patients with and without prostheses present very similar average scores with no statistically significant *** present study highlights the highest level of satisfaction among patients who received testicular *** prostheses implantation is a safe procedure that does not hamper sexual function after orchiectomy.

关键词： orchiectomy patient satisfaction quality of life sexual dysfunction sexual health testicular prostheses

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Evaluation of Novel 3D Architectures Based on Knitting Technologies for Engineering Biological Tissues

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Journal of Donghua University(English Edition) 2013年第5期30卷 421-426页

作者： RIBEIRO Viviana Pinto RIBEIRO ana Soares SILVA Carla Joana DURES Nelson Feio BONIFCIO Graa CORRELO Vitor Manuel MARQUES Alexandra Pinto SOUSA Rui Amandi oliveira ana leite REIS Rui Luís 3B's Research G roup-Biomaterials Biodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine ICVS /3B's-PT G overnment Associated Laboratory University of Minho CeNTI Centre for Nanotechnology and Smart MaterialsV. N. CITEVE Technological Centre for Textile and Clothing IndustryV. N. CBQF-School of Biotechnology Portuguese Catholic University

Textile-based technologies are considered as potential routes for the production of 3D porous architectures for tissue engineering( TE) applications. We describe the use of two polymers,namely polybutylene succinate( PBS) and silk fibroin(SF) to produce fiber-based finely tuned porous architectures by weft and warp knittings. The obtained knitted constructs are described in terms of their morphology, mechanical properties,swelling ability,degradation behaviour,and cytotoxicity. Each type of polymer fibers allows for the processing of a very reproducible intra-architectural scaffold geometry,with distinct characteristics in terms of the surface physicochemistry,mechanical performance,and degradation capability,which has an impact on the resulting cell behaviour at the surface of the respective biotextiles. Preliminary cytotoxicity screening shows that both materials can support cell adhesion and proliferation. Furthermore, different surface modifications were performed( acid /alkaline treatment, UV radiation,and plasma) for modulating cell behavior. An increase of cell-material interactions were observed,indicating the important role of materials surface in the first hours of culturing. Human adipose-derived stem cells( hASCs) became an emerging possibility for regenerative medicine and tissue replacement therapies. The potential of the recently developed silk-based biotextile structures to promote hASCs adhesion,proliferation,and differentiation is also evaluated. The obtained results validate the developed constructs as viable matrices for TE applications. Given the processing efficacy and versatility of the knitting technology, and the interesting structural and surface properties of the proposed polymer fibers,it is foreseen that our developed systems can be attractive for the functional engineering of tissues such as bone,skin,ligaments or cartilage and also for develop more complex systems for further industrialization of TE products.

关键词： textile-based technologies silk polybutylene succinate(PBS) surface modifications human adipose-derived stem cells(hASCs) tissue engineering(TE)

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Histological Assessment of Bone Regeneration in the Maxilla with Homologous Bone Graft:A Feasible Option for Maxillary Bone Reconstruction

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Journal of Renewable Materials 2024年第1期12卷 131-148页

作者： Sergio Henrique Gonçalves Motta ana Paula Ramos Soares Juliana Campos Hasse Fernandes Gustavo Vicentis oliveira Fernandes Graduate Center of Faculdade Redentor CLIVORio de JaneiroBrazil Periodontics and Oral Medicine Department University of Michigan School of DentistryAnn ArborMI48109USA Centre for Interdisciplinary Research in Health(CIIS) Universidade Católica PortuguesaViseu3504-505Portugal

Bone biomaterials have been increasingly used to reconstruct maxillary atrophic ***,the aim of this study was to evaluate bone reconstruction in the maxilla using a homologous cortico-cancellous FFB(lyophilized)graft and verify its *** individuals were included from 2014 to *** first surgery was performed to install homologous bone blocks in the *** period of the second intervention varied between 5 months and 15 days to 11 months(≈7.93 months).The biopsies were taken from the central region of the matured graft during the surgery for implant *** patients presented clinical and radiographic conditions for the installation of dental *** was a 100%of survival *** histological assessment showed that the homologous block bone graft was an osteoconductive biomaterial,with connective tissue present,and newly formed bone juxtaposed on its *** were bone trabeculae with osteocytes and active osteoblasts with connective tissue in the mineralization process;the remodeling process can be found through the reverse lines.A limited focus of necrosis with fibrosis was detected,with small resorption and areas of inflammatory infiltrate,but without clinical *** homologous block bone graft can be considered a feasible option to substitute the autogenous bone graft(gold standard),with predictable clinical and favorable histological *** patients had a shorter surgical period,low morbidity,and an unlimited amount of biomaterial available at an accessible cost.

关键词： Regeneration bone graft histology homologous allogenous autogenous

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MicroRNAs in inflammatory bowel disease:What do we know and what can we expect?

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World Journal of Gastroenterology 2024年第16期30卷 2184-2190页

作者： Ellen Cristina Souza de oliveira ana Elisa Valencise Quaglio Thais Gagno Grillo Luiz Claudio Di Stasi Ligia Yukie Sassaki Department of Internal Medicine Medical SchoolSão Paulo State University(Unesp)Botucatu 18618-686São PauloBrazil Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State University(Unesp)Botucatu 18618-689São PauloBrazil

MicroRNAs(miRNAs),small non-coding RNAs composed of 18–24 nucleotides,are potent regulators of gene expression,contributing to the regulation of more than 30%of protein-coding *** that miRNAs are regulators of inflammatory pathways and the differentiation of intestinal epithelial cells,there is an interest in exploring their importance in inflammatory bowel disease(IBD).IBD is a chronic and multifactorial disease of the gastrointestinal tract;the main forms are Crohn's disease and ulcerative *** studies have investigated the dysregulated expression of miRNAs in IBD,demonstrating their important roles as regulators and potential biomarkers of this *** editorial presents what is known and what is expected regarding miRNAs in *** the important regulatory roles of miRNAs in IBD are clearly established,biomarkers for IBD that can be applied in clinical practice are lacking,emphasizing the importance of further *** regarding the influence of miRNAs on the inflammatory process and the exploration of their role in gene regulation are expected to provide a basis for the use of miRNAs not only as potent biomarkers in IBD but also as therapeutic targets for the control of inflammatory processes in personalized medicine.

关键词： MicroRNAs Inflammatory bowel disease Crohn’s disease Ulcerative colitis Biomarker Therapy

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Study of the Conversion of Postconsumer Polystyrene on CeO₂/HZSM-5 Type Materials

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Journal of Materials Science and Chemical Engineering 2024年第4期12卷 29-41页

作者： Mirna oliveira Sant’ana Anne Michelle Garrido Pedrosa Marcelo José Barros de Souza Graduate Program in Chemical Engineering at UFS Federal University of Sergipe (UFS) S&#227o Crist&#243v&#227o Brazil Department of Chemistry Federal University of Sergipe S&#227o Crist&#243v&#227o Brazil

The catalytic conversion of polystyrene (PS) was studied in the presence of the materials type HZSM-5, CeO2, 10% CeO2/HZSM-5 and 20% CeO2/HZSM-5, which were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and nitrogen adsorption at 77K. The catalytic tests were performed via thermogravimetric analysis (TG) at heating rates of 5, 10 and 20˚C min−1 in a temperature range from 30˚C to 900˚C. For the tests, a ratio of 30% by mass of each catalytic material mixed with PS was used and the activation energy of the degradation process was determined by the Vyazovkin method. The obtained results showed that the addition of the catalyst to the PS in general reduced its degradation temperature. The 10% CeO2/HZSM-5 catalyst showed greater efficiency, as it resulted in lower activation energy for PS degradation. Thus, the combination of CeO2 with HZSM-5 resulted in materials with potential for application in the catalytic degradation of polystyrene and the results indicate that the production of a composite material can be a good strategy to generate an increase in catalytic activity and a decrease in energy process activation.

关键词： HZSM-5 Zeolite Cerium Oxide Polystyrene Pyrolysis

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Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Marcel Silva Luz Gabriel Reis Rocha Gabriel Lima Correa Santos Luís Guilherme de oliveira Silva Mariana Santos Calmon Cláudio Lima Souza ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection has been well-established as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged as a leading non-invasive method for detecting *** numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent *** findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of *** *** To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for *** infection in adult patients with *** We conducted an independent search of the PubMed/MEDLINE,EMBASE,and Cochrane Central databases until April *** search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used the QUADAS-2 tool to assess the methodo-logical quality of the *** utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible threshold effect,we conducted Spearman correlation analysis,and we generated summary receiver operating characteristic(SROC)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both as reliable diagnostic tools in clinical *** In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic ***,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

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The interplay between leaf water potential and osmotic adjustment on photosynthetic and growth parameters of tropical dry forest trees

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Journal of Forestry Research 2023年第1期34卷 177-186页

作者： Tiago de Sousa leite Romulo Magno oliveira de Freitas Nildo da Silva Dias Jeferson Luiz Dallabona Dombroski Narjara Walessa Nogueira Federal University of Mato Grosso CuiabáMTBrazil Federal Institute of Education Science and Technology of Rio Grande do NortePau dos FerrosRNBrazil Federal Rural University of the Semi-Arid Region MossoróRNBrazil

Mimosa tenuiflora and Piptadenia stipulacea are commonly accepted as drought-tolerant species but little is known about their response to drought followed by ***,the interplay between leaf water potential and osmotic adjustment on photo synthetic and growth parameters of these species was examined.A greenhouse study was conducted in a split-plot design with two water conditions in the main plots(control;drought followed by rehydration),and eight sampling times in the subplots(1,4and 7 days of drought,and 1,3,6,12,and 17 days of rehydration).Plant water status and biochemical changes were assessed as well as leaf gas exchange and subsequent *** drought stress,both species maintained a low leaf water potential throughout the day by accumulating compatible solutes,thus allowing a rapid and full recovery of water status when *** these plants minimized water loss by closing their stomata,neither showed stomatal limitations to *** inhibition of this process during drought was possibly related to mesophyll limitations as well as to a reversible downregulation of photo systems,along with adjustments of their *** deficits also triggered morphological adaptations at the whole plant level,leading to reduced growth,mainly of the shoots in *** and the roots in ***.

关键词： Drought stress Rehydration Gas exchange Plant biomass

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Spatiotemporal assessment of particulate matter(PM_(10) and PM_(2.5)) and ozone in a Caribbean urban coastal city

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Geoscience Frontiers 2022年第1期13卷 437-445页

作者： ana L.Duarte Ismael L.Schneider Paulo Artaxo Marcos L.S.oliveira Department of Civil and Environmental Universidad de la CostaCalle 58#55-66080002 BarranquillaAtlánticoColombia Instituto de Física Universidade de São PauloSão PauloBrazil Universidad de Lima Avenida Javier Prado Este 4600Santiago de Surco 1503Peru

Air pollution has become a critical issue in urban areas,so a broad understanding of its spatiotemporal characteristics is important to develop public *** study analyzes the spatiotemporal variation of atmospheric particulate matter(PM_(10) and PM_(2.5))and ozone(O_(3))in Barranquilla,Colombia from March 2018 to June 2019 in three monitoring *** average concentrations observed for the Móvil,Policía,and Tres Avemarías stations,respectively,for PM_(10):46.4,51.4,and 39.7μg/m^(3);for PM_(2.5):16.1,18.1,and 15.1μg/m^(3) and for O_(3):35.0,26.6,and 33.6μg/m^(3).The results indicated spatial and temporal variations between the stations and the pollutants *** highest PM concentrations were observed in the southern part of the city,while for ozone,higher concentrations were observed in the *** variations are mainly associated with the influence of local sources in the environment of each site evaluated as well as the meteorological conditions and transport patterns of the study *** study also verified the existence of differences in the concentrations of the studied pollutants between the dry and rainy seasons and the contribution of local sources as biomass burnings from the Isla Salamanca Natural Park and long-range transport of dust particles from the Sahara *** study provides a scientific baseline for understanding air quality in the city,which enables policy makers to adopt efficient measures that jointly prevent and control pollution.

关键词： Particulate matter Ozone Colombian Caribbean Coastal urban area

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3D Printed Gelatin Scaffold with Improved Shape Fidelity and Cytocompatibility by Using Antheraea pernyi Silk Fibroin Nanofibers

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Advanced Fiber Materials 2022年第4期4卷 758-773页

作者： Shengzhi Zou Suna Fan ana L.oliveira Xiang Yao Yaopeng Zhang Huili Shao State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620People’s Republic of China CBQF‑Centro de Biotecnologia e Quimica Fina‑Laboratorio Associado Escola Superior de BiotecnologiaUniversidade Catolica PortuguesaRua Diogo Botelho 13274169‑005 PortoPortugal

Gelatin(G)is a commonly used natural biomaterial owing to its good biocompatibility and easy ***,using pure gelatin as a bioink can barely achieve an ideal shape fidelity in 3D *** this study,Antheraea pernyi silk fibroin nanofibers(ASFNFs)with arginine-glycine-aspartic acid(RGD)peptide and partial natural silk structure are extracted and combined with pure gelatin bioink to simultaneously improve the shape fidelity and cytocompatibility of corresponding 3D printed *** show that the optimum printing temperature is 30℃ for these *** printed filaments using 16G/4ASFNFs bioink(16wt%gelatin and 4wt%ASFNFs)demonstrate better morphology and larger pore size than those printed by pure gelatin bioink(20G,20wt%gelatin),thus successfully improve the shape fidelity and porosity of the 3D printed *** 16G/4ASFNFs scaffold also demonstrate higher swelling ratio and faster degradation rate than the pure gelatin ***,the cell viability and proliferation ability of Schwann cells cultured on the 16G/4ASFNFs scaffold are significantly superior than those cultured on the pure 20G *** ASFNFs enhanced 16G/4ASFNFs scaffold reported here are expected to be a candidate with excellent potential for biomedical applications.

关键词： Antheraea pernyi silk fibroin nanofiber 3D printed scaffold Shape fidelity Cytocompatibility Gelatin

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Development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

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Advances in Molecular Imaging 2024年第2期13卷 7-22页

作者： Maria Renata Valente Brandão Freire Natália Marchesan Bexiga Marco Antonio Stephano João Ezequiel oliveira Carlos Roberto Jorge Soares ana Cláudia Camargo Miranda Anna Carolina de Alcântara Barbosa Marycel Figols de Barboza Laura Fernanda Garcia Luiz Felipe S. Teixeira Maria Helena Marumo Bellini Natanael Gomes da Silva Luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo Centro de Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Tecnologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Centro de Biotecnologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Medicina Nuclear do Hospital Israelita Albert Einstein So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is considered the gold standard in detection of micro and oligometastases in advanced prostate cancer, being used for therapeutic planning, as well as, potentially, for evaluating response to treatment. The development of ready-to-use lyophilized kit of PSMA-11 adds quality and safety to the routine use of this radiopharmaceutical and represents a pharmacotechnical challenge as it must preserve the integrity and specificity of the ligand. Methods: PSMA-11 kit formulation was proposed, considering radiolabeling parameters and the preservation of the peptide during the lyophilization process, using mannitol as an excipient. Critical temperature characterization studies were carried out using DSC equipment and the freeze-drying process was developed. The direct radiolabeling conditions were evaluated and standardized using 68Ge/68Ga generator eluate from two different manufacturers (ITG and Eckert & Ziegler). The radiochemical purity was evaluated by TLC and HPLC. Biological evaluation was carried out with lyophilized PSMA-11 to demonstrate the integrity of the peptide and preservation of biological activity after the lyophilization process. Results: Based on critical temperature characterization studies, the freeze-drying cycle was designed to reach a freezing temperature of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and elegant lyophilized cake was obtained. PSMA-11 lyophilized kit was directly labeled with 68Ga eluate from 68Ge/68Ga GMP generators (ITG and Eckert & Ziegler) resulting in % RP > 95% at pH 4.0 to 4.5. The results obtained from in vitro and in vivo biological competition studies confirmed the preservation of PSMA-11 affinity for the receptor after lyophilization. Conclusion: A lyophilized formulation (Kit) of PSMA-11 was successfully obtained, which preserved the integrity and biological activity of the peptide and guaranteed radiolabeling efficiency.

关键词： 68Ga-PSMA-11 Prostate-Specific Membrane Antigen (PSMA) Ready-to-Use Kit GMP-Grade Generators Metastatic Prostate Cancer PET Imaging

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