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hOGG1 Ser326Cys polymorphism modifies the significance of the environmental risk factor for colon cancer

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World Journal of Gastroenterology 2003年第5期9卷 956-960页

作者： Jae-Il Kim young-Jin Park Ki-Hong Kim Ji-Il Kim Byung-joo Song Meung-Soo Lee Chul-Num Kim Seok-Hyo Chang Department of Surgery Ilsan Paik HospitalInje University College of Medicine.2240Daehwa-dongIlsan-guKoyang shiKyunggido 412-270Korea

AIM:To determine the association of hOGG1 (8-oxoguanine glycosylase I,OGG1) polymorphism of Ser326Cys substitution with colon cancer risk and possible interaction with known environmental risk factors. METHODS:A case-control study with 125 colon cancer cases and 247 controls was conducted, RESULTS:There was no major difference in Ser326Cys genotype distribution between cases and *** meat intake tended to increase the odds ratio for colon cancer with an OR of 1.72 (95 % confidence interval;CI=1.12-2.76). Such tendency was more prominent in Cys/Cys carriers (OR=4.31,95 % CI=1.64-11.48),but meat intake was not a significant risk factor for colon cancer in Ser/Ser or Ser/ Cys *** OR for colon cancer was elevated with marginal significance in smokers who were Cys/Cys carriers (OR=2.75,95 % CI=1.07-7.53) but not in Ser/Ser or Ser/ Cys carriers. CONCLUSION:These results suggest that the hOGG1 Ser326Cys polymorphism is probably not a major contributor to individual colon cancer susceptibility overall,but the Cys/ Cys genotype may alter the impact of some environmental factors on colon cancer development.

关键词： Base Sequence Case-Control Studies Colonic Neoplasms DNA DNA-Formamidopyrimidine Glycosylase Diet Female Genotype Humans Male Meat Middle Aged N-Glycosyl Hydrolases Odds Ratio Polymorphism, Genetic Risk Factors Smoking

Thermal Conductivity Measurement of Zr-ZrO<sub>2</sub>Simulated Inert Matrix Nuclear Fuel Pellet

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World Journal of Nuclear Science and Technology 2013年第2期3卷 46-50页

作者： Dong-joo Kim young Woo Rhee Jong Hun Kim Jang Soo oh Keon Sik Kim Jae Ho Yang LWR Fuel Technology Division Korea Atomic Energy Research Institute Daejeon South Korea

For an evaluation of a thermal conductivity of Zr + 30 vol% ZrO2 simulated inert matrix nuclear fuel pellet, a simulated fuel pellet was fabricated using a hot-pressing method at 800°C in a vacuum and at a 20 MPa load. And several thermophysical properties of the simulated inert matrix fuel pellet were measured and calculated. The thermal diffusivity and linear thermal expansion as a function of temperature of the simulated fuel pellet were measured using a laser flash method and a dilatometry, respectively. Finally, based on the experimental data, the thermal conductivity of the simulated inert matrix fuel pellet was calculated and evaluated.

关键词： Inert Matrix Nuclear Fuel Dispersion Fuel Thermal Conductivity Thermal Expansion Specific Heat

Chemical ablation of the gallbladder using alcohol in cholecystitis after palliative biliary stenting

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World Journal of Gastroenterology 2009年第16期15卷 2041-2043页

作者： Tae Hoon Lee Sang-Heum Park Sang Pil Kim Ji-young Park Chang Kyun Lee Il-Kwun Chung Hong Soo Kim Sun-joo Kim Division of Gastroenterology Department of Internal MedicineSoonchunhyang University College of MedicineCheonan Hospital

Chemical ablation of the gallbladder is effective in patients at high risk of complications after surgery. Percutaneous gallbladder drainage is an effective treatment for cholecystitis; however, when the drain tube cannot be removed because of recurrent symptoms, retaining it can cause problems. An 82-year-old woman presented with cholecystitis and cholangitis caused by biliary stent occlusion and suspected tumor invasion of the cystic duct. We present successful chemical ablation of the gallbladder using pure alcohol, through a percutaneous gallbladder drainage tube, in a patient who developed intractable cholecystitis with obstruction of the cystic duct after receiving a biliary stent. Our results suggest that chemical ablation therapy is an effective alternative to surgical therapy for intractable cholecystitis.

关键词： Percutaneous cholecystostomy Cholecystitis Biliary stenting Alcohol Chemical therapy

Endoscopic diverticulotomy with an isolated-tip needle-knife papillotome (Iso-Tome) and a fitted overtube for the treatment of a Killian-Jamieson diverticulum

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World Journal of Gastroenterology 2008年第42期14卷 6589-6592页

作者： Chang Kyun Lee Il-Kwun Chung Ji-young Park Tae Hoon Lee Suck-Ho Lee Sang-Heum Park Hong-Soo Kim Sun-joo Kim Division of Gastroenterology Department of Internal Medicine Soonchunhyang University College of Medicine Cheonan Hospital Cheonan Choongnam 330-721 South Korea

A Killian-Jamieson diverticulum （KID） is an unfamiliar and rare cervical esophageal diverticulum. This diverticulum originates on the anterolateral wall of the proximal cervical esophagus through a muscular gap （the Killian-Jamieson space） below the cricopharyngeal muscle and lateral to the longitudinal muscle of the esophagus. To date, only surgical treatment has been recommended for a symptomatic KJD due to its close proximity to the recurrent laryngeal nerve and the concern of possible nerve injury. Recently, traditional open surgery for a symptomatic KJD is being challenged by the development of new endoscopic techniques and devices. We present here a case of a symptomatic KID that was successfully treated with the flexible endoscopic diverticulotomy using two new devices. An isolated-tip needle-knife papillotome （Iso-Tome） was used for the dissection of the tissue bridge of the diverticulum. And a flexible overtube with a modified distal end （a fitted overtube） was used for adequate visualization of the tissue bridge of the diverticulum and protection of the surrounding tissue during dissection of the tissue bridge. Our successful experience suggests that the flexible endoscopic diverticulotomy with the use of appropriate endoscopicdevices can be a safe and effective method for the treatment of a symptomatic KJD.

关键词： Esophagus Diverticulum Killian-Jamieson diverticulum Endoscopy Diverticulotomy

Aortoduodenal fistula and aortic aneurysm secondary to biliary stent-induced retroperitoneal perforation

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World Journal of Gastroenterology 2008年第19期14卷 3095-3097页

作者： Tae Hoon Lee Do Hyun Park Ji-young Park Suck-Ho Lee Il-Kwun Chung Hong Soo Kim Sang-Heum Park Sun-joo Kim Division of Gastroenterology Department of Internal MedicineSoonchunhyang University College of Medicine Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of Medicine

Duodenal perforations caused by biliary prostheses are not uncommon, and they are potentially life threatening and require immediate treatment. We describe an unusual case of aortic aneurysm and rupture which occurred after retroperitoneal aortoduodenal fistula formation as a rare complication caused by biliary metallic stent-related duodenal perforation. To our knowledge, this is the first report describing a lethal complication of a bleeding, aortoduodenal fistula and caused by biliary metallic stent-induced perforation.

关键词： Stents Retroperitoneal perforation Aorticaneurysm Fistula

Clinical significance and risk factors of postembolization fever in patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第2期19卷 284-289页

作者： Chung Hwan Jun Ho Seok Ki Hoon Ki Lee Kang Jin Park Seon young Park Sung Bum Cho Chang Hwan Park young Eun joo Hyun Soo Kim Sung Kyu Choi Jong Sun Rew Division of Gastroenterology Department of Internal MedicineChonnam National University Medical SchoolGwangju 501-757South Korea

AIM:To investigate tumor response and survival in patients with postembolization fever(PEF) and to determine the risk factors for ***:Four hundred forty-three hepatocellular carcinoma(HCC) patients who underwent the first session of transcatheter arterial chemoembolization(TACE) between January 2005 and December 2009 were analyzed *** was defined as a body temperature greater than 38.0 ℃ that developed within 3 d of TACE without evidence of *** tumor progression-free interval was defined as the interval from the first TACE to the second TACE based on mRECIST *** staging was based on the American Joint Committee on Cancer tumor,node,metastases(TNM) classification of malignant *** patients were admitted before their 1 st TACE treatment,and blood samples were obtained from all patients before and after *** variables and host-related variables were compared between two groups:patients with PEF vs patients without ***,variables related to 20-mo mortality and tumor progression-free survival were ***:The study population comprised 370(85.4%) men and 73(14.6%) women with a mean age of 62.29 ± 10.35 years.A total of 1836 TACE sessions were conducted in 443 patients,and each patient received between 1 and 27(mean:4.14 ± 3.57) TACE *** mean follow-up duration was 22.23 ± 19.6 mo(range:0-81 mo).PEF developed in 117 patients(26.41%) at the time of the first TACE *** was not associated with 20-mo survival(P = 0.524) or computed tomography(CT) response(P = 0.413) in a univariate analysis.A univariate analysis further indicated that diffuse-type HCC(P = 0.021),large tumor size(≥ 5 cm)(P = 0.046),lipiodol dose(≥ 7 mL,P = 0.001),poor blood glucose control(P = 0.034),alanine aminotransferase(ALT) value after TACE(P = 0.004) and C-reactive protein(CRP) value after TACE(P = 0.036) served as possible risk factors correlated with *** ALT value after TACE(P = 0.02

关键词： Chemoembolization Therapeutic Fever Carcinoma Hepatocellular Prognosis Progression-free survival

Long-term follow-ups of revascularized immature necrotic teeth:three case reports

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International Journal of Oral Science 2012年第2期4卷 109-113页

作者： Duck-Su Kim Hae-Jin Park Je-Ha Yeom Ji-Sung Seo Gil-joo Ryu Ki-Ho Park Seung-Il Shin Sun-young Kim Department of Conservative Dentistry School of DentistryKyung Hee UniversitySeoulKorea Good Will Dental Hospital BusanKorea Department of Orthodontics School of DentistryKyung Hee UniversitySeoulKorea Department of Periodontology School of DentistryKyung Hee UniversitySeoulKorea

Revascularization of immature necrotic teeth is a reliable treatment alternative to conventional apexogenesis or apexification. In case 1, a 12-year-old boy had his necrotic, immature mandibular left second premolar treated with a revascularization technique. At a 24-month follow-up, periapical radiolucency had disappeared and thickening of the root wall was observed. In cases 2 and 3, a lO-year-old boy had his necrotic, immature, bilateral mandibular second premolars treated with the same modality. At 48-month （in case 2） and 42-month （in case 3） follow-ups, loss of periapical radiolucencies and increases in the root wall thickness were also observed.

关键词： revascularization pulp necrosis mineral trioxide aggregate antibiotic mixture immature tooth

The first observation of Ni nanoparticle exsolution from YSZ and its application for dry reforming of methane

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Materials Reports(Energy) 2021年第2期1卷 70-76页

作者： Sangwook joo Chaehyun Lim ohhun Kwon Linjuan Zhang Jing Zhou Jian-Qiang Wang Hu young Jeong Yong-wook Sin Sihyuk Choi Guntae Kim Department of Energy Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan698-798Republic of Korea Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai201800PR China UNIST Central Research Facilities and School of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan44919Republic of Korea Materials&Devices Advanced Research Institute LG ElectronicsSeoulRepublic of Korea Department of Mechanical Engineering Kumoh National Institute of TechnologyGyeongbuk39177Republic of Korea

Ni nanocatalysts produced through exsolution have shown strong resistance to particle sintering and carbon coking in a beneficial dry reforming of methane(DRM)reaction utilizing greenhouse gases such as CH_(4)and CO_(2).However,most of the existing oxide supports for exsolution have been limited to perovskite oxide,while studies on fluorite support have been rarely conducted due to the limited solubility despite its excellent redox *** we demonstrate that 3 mol%Ni can be successfully dissolved into the yttria-stabilized zirconia(YSZ)lattice and be further exsolved to the surface in a reducing *** YSZ decorated with exsolved Ni nanoparticles shows enhanced catalytic activity for DRM reaction compared to the conventional cermet type of bulk ***,the catalytic activity is extremely stable for about 300 h without significant *** results suggest that the YSZ-based fluorite structure can be utilized as one of the support oxides for exsolution.

关键词： Dry forming of methane Exsolution Yttria-stabilized zirconia(YSZ) Ni nanoparticle

Contrast-enhanced ultrasonography for the evaluation of liver fibrosis after biliary obstruction

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World Journal of Gastroenterology 2015年第9期21卷 2614-2621页

作者： Hyun joo Shin Eun young Chang Hye Sun Lee Jung Hwa Hong Gyuri Park Hyun Gi Kim Myung-joon Kim Mi-Jung Lee Department of Radiology and Research Institute of Radiological Science Severance Children’s HospitalYonsei University College of MedicineSeoul 120-752South Korea Department of Pediatric Surgery Severance Children’s HospitalYonsei University College of MedicineSeoul 120-752South Korea Biostatistics Collaboration Unit Yonsei University College of MedicineSeoul 120-752South Korea Department of Laboratory Animal Resources Avison Bio Medical Research CenterYonsei University College of MedicineSeoul 120-752South Korea

AIM:To investigate perfusion change in contrastenhanced ultrasonography(CEUS) to evaluate liver fibrosis based on biliary obstruction using an animal ***:New Zealand white rabbits(3-4 kg) underwent bile duct ligation to form a biliary obstruction *** performed liver CEUS and laboratory tests on the day before the operation(day 0) and every 7 postoperative days until the rabbits were *** CEUS,signal intensity of liver parenchyma with a time-intensity curve was *** parameters were automatically calculated from regionof-interests,including peak signal intensity,mean transit time,area under the curve and time to *** grades of liver fibrosis were assessed according to the Metavir score system immediately after *** estimating equations were used to analyze the association between liver fibrosis grades and perfusion parameters for statistical *** perfusion parameters were measured on the last day and the difference between day 0 and the last day were ***:From the nine rabbits,histological grades of liver fibrosis were grade 1 in one rabbit,grade 2 and 3 in three rabbits each,and grade 4 in two *** the four CEUS parameters,only the peak signal intensity measured on the last day demonstrated a significant association with liver fibrosis grades(OR =1.392,95%CI:1.114-1.741,P =0.004).The difference in peak signal intensity between day 0 and the last dayalso demonstrated an association with liver fibrosis(OR =1.191,95%CI:0.999-1.419,P =0.051).The other parameters tested,including mean transit time,area under the curve,and time to peak,showed no significant correlation with liver fibrosis ***:This animal study demonstrates that CEUS can be used to evaluate liver fibrosis from biliary obstruction using peak signal intensity as a parameter.

关键词： Ultrasonography Contrast enhanced ultrasound Liver