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Cdc42 regulates the cellular localization of Cdc42ep1 in controlling neural crest cell migration

Journal of Molecular Cell Biology 2018年第5期10卷 376-387页

作者： Shlomi cohen Daniel T. Kovari Wenbin Wei Rebecca Keate Jennifer E. Curtis Shuyi Nie School of Biological Sciences Georgia institute of Technology Atlanta GA 30332 USA School of Physics Georgia Institute of Technology Atlanta GA 30332 USA Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology Atlanta GA 30332 USA Department of Physics Emory University Atlanta GA 30322 USA Wallace H. Coulter Department of Biomedical Engineering Georgia institute of Technology Atlanta GA 30332 USA

The member of Rho family of small GTPases Cdc42 plays important and conserved roles in cell polarity and motility. The Cdc42ep family proteins have been identified to bind to Cdc42, yet how they interact with Cdc42 to regulate cell migration remains to be elucidated. In this study, we focus on Cdc42epl, which is expressed predominantly in the highly migratory neural crest ceils in frog embryos. Through morpholino-mediated knockdown, we show that Cdc42epl is required for the migration of cranial neural crest cells. Loss of Cdc42epl leads to rounder cell shapes and the formation of membrane blebs, consistent with the observed disruption in actin organization and focal adhesion alignment. As a result, Cdc42ep1 is critical for neural crest cells to apply traction forces at the correct place to migrate efficiently. We further show that Cdc42ep1 is localized to two areas in neural crest celts： in membrane protrusions together with Cdc42 and in perinuciear patches where Cdc42 is absent. Cdc42 directly interacts with Cdc42epl （through the CRIB domain） and changes in Cdc42 level shift the distribution of Cdc42epl between these two subcellular locations, controlling the formation of membrane protrusions and directionality of migration as a consequence. These results suggest that Cdc42ep1 elaborates Cdc42 activity in neural crest cells to promote their efficient migration.

关键词： actin cytoskeleton neural crest Rho GTPases Cdc42 effector protein 1 cell migration

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A New Modeling and Implementation Technique for Agent-Based Discrete Industrial Automation

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通讯和计算机（中英文版） 2011年第1期8卷 1-7页

作者： Yuval cohen Department of Industrial Engineering The Open University of Israel Raanana 43107 Israel Department of Industrial Engineering Tel-Aviv （Afeka） College of Engineering Tel-Aviv 69988 Israel

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"Climate Change" and the Rupture of Cultural Critique

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Comparative Literature:East & West 2011年第2期 13-48页

作者： cohen,Tom University at Albany SUNY

世界各地频频发生的极端气候现象已成为不容忽视的问题。然而二十世纪主要的思想家们并没有解决二十一世纪这十年间所凸显的生态灾难逻辑学问题。本文通过对二十世纪主要思想流派与理论家的梳理,指出环境危机对政治、经济与文学文化理... 详细信息

世界各地频频发生的极端气候现象已成为不容忽视的问题。然而二十世纪主要的思想家们并没有解决二十一世纪这十年间所凸显的生态灾难逻辑学问题。本文通过对二十世纪主要思想流派与理论家的梳理,指出环境危机对政治、经济与文学文化理论的现有思维模式而言具有解构的意味。气候变化时代的难点与理论蓬勃发展的二十世纪大为不同,而由二十世纪承传而来的批评传统中则缺乏环境主义的参与。文化批评理论应如何转变、修正,并适应气候变化时代完全不同的议题,在文化研究中如何建立气候变化话语或气候变化理论是本文着重探讨的核心。

关键词：二十世纪气候变化理论家气候现象环境危机思维模式生态灾难逻辑学文化理论时代

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System-level Pareto frontiers for on-chip thermoelectric coolers

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Frontiers in Energy 2018年第1期12卷 109-120页

作者： Sevket U. YURUKER Michael C. FISH Zhi YANG Nicholas BALDASARo Philip BARLETTA Avram BAR-cohen Bao YANG Department of Mechanical Engineering University of MarylandCollege Park MD 20742 USA Research Triangle Institute Research Triangle Park NC 27709 USA Micross Components Research Triangle Park NC 27709 USA

The continuous rise in heat dissipation of integrated circuits necessitates advanced thermal solutions to ensure system reliability and efficiency. Thermoelectric coolers are among the most promising techniques for dealing with localized on-chip hot spots. This study focuses on establishing a holistic optimization methodol- ogy for such thermoelectric coolers, in which a thermo- electric element＇s thickness and the electrical current are optimized to minimize source temperature with respect to ambient, when the thermal and electrical parasitic effects are considered. It is found that when element thickness and electrical current are optimized for a given system architecture, a ＂heat flux vs. temperature difference＂ Pareto frontier curve is obtained, indicating that there is an optimum thickness and a corresponding optimum current that maximize the achievable temperature reduc- tion while removing a particular heat flux. This methodol- ogy also provides the possible system level AT＇s that can be achieved for a range of heat fluxes, defining the upper limits of thermoelectric cooling for that architecture. In this study, use was made of an extensive analytical model, which was verified using commercially available finite element analysis software. Through the optimization process, 3 pairs of master curves were generated, which were then used to compose the Pareto frontier for any given system architecture. Finally, a case study wasperformed to provide an in-depth demonstration of the optimization procedure for an example application.

关键词： thermoelectric cooling thermal management,optimization high flux electronics

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Generalized laws of refraction and reflection at interfaces between different photonic artificial gauge fields

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Light(Science & Applications) 2020年第1期9卷 45-55页

作者： Moshe-Ishay cohen Christina Jörg Yaakov Lumer Yonatan Plotnik Erik H.Waller Julian Schulz Georg von Freymann Mordechai Segev Physics Department Technion-Israel Institute of TechnologyHaifa 32000Israel Solid State Institute Technion-Israel Institute of TechnologyHaifa 32000Israel Physics Department and Research Center oPTIMAS TU Kaiserslautern67663 KaiserslauternGermany Department of Physics The Pennsylvania State UniversityState CollegePA 16802USA Fraunhofer Institute for Industrial Mathematics ITWM 67663 KaiserslauternGermany

Artificial gauge fields the control over the dynamics of uncharged particles by engineering the potential landscape such that the particles behave as if effective external fields are acting on *** years have witnessed a growing interest in artificial gauge fields generated either by the geometry or by time-dependent modulation,as they have been enablers of topological phenomena and synthetic dimensions in many physical settings,e.g.,photonics,cold atoms,and acoustic ***,we formulate and experimentally demonstrate the generalized laws of refraction and reflection at an interface between two regions with different artificial gauge *** use the symmetries in the system to obtain the generalized Snell law for such a gauge interface and solve for reflection and *** identify total internal reflection(TIR)and complete transmission and demonstrate the concept in *** addition,we calculate the artificial magnetic flux at the interface of two regions with different artificial gauge fields and present a method to concatenate several gauge *** an example,we propose a scheme to make a gauge imaging system-a device that can reconstruct(image)the shape of an arbitrary wavepacket launched from a certain position to a predesigned location.

关键词： gauge refraction interface

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Mechanical Properties, Metallurgical Characteristics and Anisotropy of Additive Manufacturing of 316L

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Journal of Minerals and Materials Characterization and Engineering 2022年第2期10卷 209-223页

作者： D. Moreno Y. Nahmana o. Nafman o. Kam B. Wolfman A. Y. cohen M. Shapira Bet Shemesh Engines LTD FAA & EASA Bet Shemesh Israel

Additive manufacturing (AM), while enabling the production of parts with complex geometries, presents new challenges. In particular, the achievement of the basic mechanical properties of the alloy must be ensured. In general, the strength-ductility properties of metals depend strongly on their microstructure, and controlling these properties requires paying attention to the alloy composition, processing technique and heat treatments. Austenite 316L stainless steel parts produced by AM demonstrate good ductility and high yield strength—higher than that obtained with annealed 316L. Some preferred orientation of the mechanical properties was found as a function of the laser path, namely, the Young’s modulus varied with respect to the angle between the build direction and the normal to the build direction. In the present study, samples of AM 316L in three orientations relative to the print direction (0˚, 45˚and 90˚) are compared to a forged sample. Mechanical properties, scanning electron microscopy-SEM fractography, energy dispersive X-ray spectroscope-EDS analysis of the fracture and optical cross section images of the samples along the stress tension after the failure are presented.

关键词： SS316L Additive Manufacturing (AM) Preferred orientation Mechanical Properties Young’s Modulus

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Youku ***：The Same old Back and Forth

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China International Business 2009年第11期 48-49页

作者： SEBASTIAN cohen

Legal wrangling between companies gets press attention for one main reason - they are often juicy and sordid tales. Yet while lawsuits are often the sign of a changing situation on the ground, this is not always the c... 详细信息

关键词：往复式法律纠纷新闻界诉讼

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Journal of Geographical Sciences 2022年第4期32卷 589-604页

作者： FENG Huihui DING Ying ZoU Bin cohen Jason Blake YE Shuchao YANG Zhuolin QIN Kai LIU Lei GU Xiaodong School of Geosciences and Info-Physics Central South UniversityChangsha 410083China Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring of Chinese Ministry of Education Changsha 410083China School of Atmospheric Sciences Sun Yat-sen UniversityGuangzhou 510275China School of Environment Science and Spatial Informatics China University of Mining and TechnologyXuzhou 221116JiangsuChina College of Earth and Environmental Sciences Lanzhou UniversityLanzhou 730000China Guangzhou Center for Rule of Green Development Law Studies Guangdong University of Foreign StudiesGuangzhou 510420China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou 511458China

Vegetation plays an important role in the dry deposition of particles with significant spatial variability,but the magnitude remains unclear at the global *** the aid of satellite products,this study estimated the vegetation-related dry deposition of fine particulate matter(PM_(2.5)).Methodologically,dry deposition was first calculated using an empirical ***,deposition on the leaf surface was estimated to evaluate the influence of *** results showed that the mean deposition velocity(V_(d))of global PM_(2.5)was 0.91×10^(-3)μg·m^(-2)·s^(-1),with high velocities observed in sparsely vegetated regions because of the high friction *** the combined effect of the PM_(2.5)mass concentration and deposition velocity,the global mean dry deposition reached 0.47 g·m-^(2)·yr^(-1).Global vegetation absorbed 0.26 g·m-^(2)·yr^(-1)from PM_(2.5)pollution sources,contributing 54.98%of the total dry ***,vegetation-related dry deposition was high in the Amazon,Central Africa and East China due to dense vegetation coverage or serious ***,the increasing trends were mainly in Central Africa and India because of worsening air *** results of this study helped to clarify the impact of vegetation on air pollution,which supported related land management and planning for air quality improvement.

关键词： air pollution PM_(2.5) dry deposition vegetation change globe satellite

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A Hundred Flowers Bloom in the Mobile Marketplace

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China International Business 2009年第10期 32-34页

作者： SEBASTIAN cohen

Having a phone that makes and receives calls and text messages is just not enough these days. Mobile apps -- games and add-ons -- are becoming increasingly popular, and Apple＇s success in creating a mobile application market with its iPhone and Apple stores has inspired just about every company with a stake in the mobile space to launch their own offerings.

关键词：手机市场移动应用 iPhone 苹果公司

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Prior abdominal surgery as a potential risk factor for colonic diverticulosis or diverticulitis

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World Journal of Clinical Cases 2023年第35期11卷 8320-8329页

作者： Eran Ariam Vered Richter Anton Bermont Yael Sandler Daniel L cohen Haim Shirin Department of Gastroenterology Kaplan Medical CenterRehovot 76100Israel The Gonczarowski Family Institute of Gastroenterology and Liver Diseases Shamir Medical CenterZerifin 70300Israel and the Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Surgery Division Shamir Medical CenterZerifin 70300Israel

BACKGRoUND Abnormal colonic pressure profiles have been associated with an increased risk of colonic diverticulosis.A surgical history is a known risk factor for abdominal adhesions and these may lead to increased intraluminal colonic *** To assess whether previous abdominal surgery is associated with colonic divertic-ulosis or *** We analyzed data from a study of patients undergoing colonoscopy for different indications from 2020 through *** completed a structured question-naire concerning previous abdominal surgeries,dietary and lifestyle exposures including smoking,alcohol use and *** Three hundred and fifty-nine patients were included in the *** mean age was 67.6 and 46%were *** mellitus,hypertension,ischemic heart disease,chronic obstructive pulmonary disease,chronic renal failure,and body mass index were similar in the diverticulosis and control *** overall prevalence of colonic diverticulosis was 25%(91/359)and 48%of the patients had previous abdominal *** expected,the prevalence of diverticulosis increased with *** was no difference in the rate of previous abdominal surgery between patients with or without diverticulosis(49%vs 47%,P=0.78).In regards to specific surgeries,inguinal hernia repair was significantly associated with diverticulosis(52%vs 20%,P=0.001),but not *** contrast,appendectomy was not associated with diverticulosis(6%vs 14%,P=0.048).CoNCLUSIoN These findings suggest that post-operative abdominal adhesions inducing high colonic intraluminal pressures do not appear to be the mechanism for diverticula ***,inguinal hernia and diverticulosis may share similar connective tissue pathologies with no causative relationship between them.

关键词： Diverticulosis Diverticulitis General surgery Adhesions Risk factors Abdomen

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