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小潮气量机械通气和人免疫球蛋白联合治疗儿童重症肺炎疗效观察

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新乡医学院学报 2024年第10期41卷 930-934页

作者：王春雨李亚王家豪驻马店市中心医院急诊儿科河南驻马店463000

目的探讨小潮气量机械通气联合人免疫球蛋白治疗儿童重症肺炎的临床疗效及对患儿肺功能、体液免疫功能的影响。方法选择2019年1月至2020年12月驻马店市中心医院收治的126例重症肺炎患儿为研究对象。根据治疗方法将患儿分为对照组(n=65)... 详细信息

目的探讨小潮气量机械通气联合人免疫球蛋白治疗儿童重症肺炎的临床疗效及对患儿肺功能、体液免疫功能的影响。方法选择2019年1月至2020年12月驻马店市中心医院收治的126例重症肺炎患儿为研究对象。根据治疗方法将患儿分为对照组(n=65)和观察组(n=61)。2组患儿均给予常规治疗,在此基础上,对照组患儿给予小潮气量机械通气治疗,观察组患儿给予小潮气量机械通气联合人免疫球蛋白治疗,2组患儿均连续治疗1周。比较2组患儿的临床疗效、治疗前后肺功能指标[第1秒用力呼气量(FEV_(1))、用力肺活量(FVC)、呼气流量峰值(PEF)]、血气分析指标[动脉血氧分压(Pao_(2))、动脉血二氧化碳分压(PaCo_(2))、氧合指数(Pao_(2)/Fio_(2))]、体液免疫功能指标[免疫球蛋白(Ig)A、IgG、IgM]及不良反应发生情况。结果对照组和观察组患儿治疗总有效率分别为73.85%(48/65)、88.52%(54/61),观察组患儿总有效率显著高于对照组(P0.05);2组患儿治疗后FEV_(1)、FVC、PEF均显著高于治疗前(Po_(2)、PaCo_(2)、Pao_(2)/Fio_(2)比较差异无统计学意义(P>0.05);2组患儿治疗后Pao_(2)、Pao_(2)/Fio_(2)显著高于治疗前,PaCo_(2)显著低于治疗前(Po_(2)、Pao_(2)/Fio_(2)显著高于对照组,PaCo_(2)显著低于对照组(P0.05);2组患儿治疗后IgA、IgG、IgM水平显著低于治疗前(P0.05)。结论相较于小潮气量机械通气治疗,小潮气量机械通气联合人免疫球蛋白治疗儿童重症肺炎临床疗效更显著,能有效改善患儿肺功能、血气分析指标及体液免疫功能,且不会明显增加不良反应。

关键词：重症肺炎小潮气量机械通气人免疫球蛋白肺功能体液免疫儿童

乡村幼儿园师幼关系现状和影响因素研究——以黑山县四所幼儿园为例

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当代教研论丛 2024年第8期10卷 117-121页

作者：马雅莉王京玉金芳沈阳师范大学学前与初等教育学院辽宁沈阳110034

幼儿园师幼关系是幼儿教育中的一个核心要素,对幼儿的全面发展具有深远的影响。为了解乡村幼儿园师幼关系,文章采用了整群抽样的方法,对黑山县四所幼儿园的134名教师进行了问卷调查,采用SPSS26.0对收集到的数据进行分析。结果发现:乡村... 详细信息

幼儿园师幼关系是幼儿教育中的一个核心要素,对幼儿的全面发展具有深远的影响。为了解乡村幼儿园师幼关系,文章采用了整群抽样的方法,对黑山县四所幼儿园的134名教师进行了问卷调查,采用SPSS26.0对收集到的数据进行分析。结果发现:乡村幼儿园师幼关系整体状况良好,且亲密性高,依赖性和冲突性低。教师的编制、年龄、教龄和学历层次与师幼关系的好坏密切相关。并据此提出建议:保障利益,解决乡村教师“生存之困”;加强培训,提供教师主体“发展之源”;自我塑造,激发师幼关系“内生之力”。

关键词：乡村幼儿园师幼关系现状影响因素

Inhibition of α-glucosidase activity by N-deoxynojirimycin analogs in several insect phloem sap feeders

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Insect Science 2016年第1期23卷 59-67页

作者： Marina Katzman ya'kobovitz Terry D. Butters Ephraim Cohen Department of Entomology Robert H. Smith Faculty of Agriculture Food and Environment The Hebrew University of Jerusalem RehovotIsrael Department of Biochemistry University of Oxford Oxford OX1 3QU UK

Secondary metabolites and synthetic iminosugars that structurally resemble monosaccharides are potent inhibitors of a-glucosidase activity. The enzyme is core in cleaving sucrose in phloem feeding insects and it also plays a crucial role of reducing osmotic stress via the formation of oligosaccharides. Inhibition of hydrolysis by iminosug- ars should result in nutritional deficiencies and/or disruption of normal osmoregulation. Deoxynojirimycin （DNJ） and 2 N-alkylated analogs [N-butyl DNJ （NB-DNJ） and N-nonyl DNJ （NN-DNJ）] were the major iminosugars used throughout the study. The extensive experiments conducted with a-glucosidase of the whitefly Bemisia tabaci indicated the competitive nature of inhibition and that the hydrophilic DNJ is a potent inhibitor in com- parison to the more hydrophobic NB-DNJ and NN-DNJ compounds. The same inhibitory pattern was observed with the psyllid Cacopsylla bidens a-glucosidase. In contrast to the above pattern, enzymes of the aphids, Myzus persicae and Aphis gossypii were more sen- sitive to the hydrophobic iminosugars as compared to DNJ. In vivo experiments in which adult B. tabaci were fed dietary iminosugars, show that the hydrophilic DNJ was far less toxic than the lipophilic NB-DNJ and NN-DNJ. It is proposed that this pattern is attributed to the better accessibility of the hydrophobic NN-DNJ to the a-glucosidase membrane- bound compartment in the midgut. Based on the inhibitory effects of certain polyhydroxy N-alkylated iminosugars, a-glucosidase of phloem feeding hemipterans could serve as an attractive target site for developing novel pest control agents.

关键词： a-glucosidase inhibition Bemisia tabaci Cacopsylla bidens iminosugars Myzuspersicae osmoregulation phloem sap feeders

NoX2参与适应性免疫反应及其与慢性肉芽肿病伴随性自身免疫病的联系

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现代免疫学 2024年第2期44卷 165-169页

作者：苏晓亚洪莉陈同辛上海交通大学医学院附属上海儿童医学中心风湿免疫科上海200127 上海交通大学医学院附属上海儿童医学中心儿科转化医学研究所上海200127 上海交通大学医学院附属上海儿童医学中心临床营养科上海200127

吞噬细胞还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶又称NoX2,是一种多组分酶复合物,在宿主免疫防御和免疫调节中发挥重要作用。NoX2组分功能缺陷会导致慢性肉芽肿病(chronic granulomatous disease,CGD)。NoX2缺陷引起的固有免疫反应改变是... 详细信息

吞噬细胞还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶又称NoX2,是一种多组分酶复合物,在宿主免疫防御和免疫调节中发挥重要作用。NoX2组分功能缺陷会导致慢性肉芽肿病(chronic granulomatous disease,CGD)。NoX2缺陷引起的固有免疫反应改变是CGD感染性疾病发生的主要原因。随着对CGD发病机制的深入研究,发现NoX2缺陷能够影响T、 B细胞介导的免疫应答,进而影响CGD患者自身免疫病的发生、发展。该文将对NoX2缺陷引起的适应性免疫的改变及其与CGD患者伴随性自身免疫病的关系进行综述。

关键词：吞噬细胞还原型烟酰胺腺嘌呤二核苷酸磷酸氧化酶慢性肉芽肿病适应性免疫自身免疫病

旧古建筑墙型钢组合单面支模施工技术的研究与应用

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建筑技术开发 2024年第3期51卷 26-28页

作者：周岳衡李亚欣陈伟中建二局第三建筑工程有限公司北京100070

研究主要介绍古旧建筑墙新做现浇混凝土结构加固单面支模的相关施工技术,通过工程实例的应用提出了一种创新的型钢组合单面支模施工技术,成功解决了工程中的保留古旧砖墙新增现浇结构加固单面支模的施工技术难题,最大程度地保留墙体原... 详细信息

研究主要介绍古旧建筑墙新做现浇混凝土结构加固单面支模的相关施工技术,通过工程实例的应用提出了一种创新的型钢组合单面支模施工技术,成功解决了工程中的保留古旧砖墙新增现浇结构加固单面支模的施工技术难题,最大程度地保留墙体原始建筑风貌及特点,符合工程形象提升要求。

关键词：古建筑墙体型钢支撑桁架单面支模侧墙模板

Microstructure and corrosion resistance of Fe/Mo composite amorphous coatings prepared by air plasma spraying

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International Journal of Minerals,Metallurgy and Materials 2012年第7期19卷 657-662页

作者： Chao-ping Jiang ya-zhe Xing Feng-ying Zhang Jian-min Hao Engineering Research Center of Transportation Materials (Ministry of Education) School of Materials Science and Engineering Chang'an University Xi'an 710064China

Fe/Mo composite coatings were prepared by air plasma spraying （APS） using Fe-based and Mo-based amorphous and nanocrys- talline mixed powders. Microstructural studies show that the composite coatings present a layered structure with low porosity due to adding the self-bonded Mo-based alloy. Corrosion behaviors of the composite coatings, the Fe-based coatings and the Mo-based coatings were in- vestigated by electrochemical measurements and salt spray tests. Electrochemical results show that the composite coatings exhibit a lower polarization current density and higher corrosion potentials than the Fe-based coating when tested in 3.5wt% NaC1 solutions, indicating supe- rior corrosion resistance compared with the Fe-based coating. Also with the increase in addition of the Mo-based alloy, a raised corrosion re- sistance, inferred by an increase in corrosion potential and a decrease in polarization current density, can be found. The results of salt spray tests again show that the corrosion resistance is enhanced by adding the Mo-based alloy, which helps to reduce the porosity of the composite coatings and enhance the stability of the passive films.

关键词： composite coatings plasma spraying amorphous corrosion resistance microstructure

Nondoped-type White organic Light-Emitting Diode Using Star-Shaped Hexafluorenylbenzene as an Energy Transfer Layer

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Chinese Journal of Chemical Physics 2008年第5期21卷 500-504页

作者： Jun-sheng Yu Tao Ma Shuang-ling Lou ya-dong Jiang Qing Zhang State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Information University of Electronic Science and Technology of China Chengdu 510054 China Department of Polymer Science School of Chemistry and Chemical Technology Shanghai Jiao Tong University Shanghai 200240 China

White organic light-emitting diodes （WoLEDs） with a structure of indium-tin-oxide （ITo）/N,N＇-bis- （1-naphthyl）-N,N＇-diphenyl- （1, 1＇-biphenyl）-4,4＇-diamine （NPB）/1,2,3,4,5,6-hexakis（9,9-diethyl-9H-fluoren-2- yl）benzene （HKEthFLYPh）/5,6,11,12-tetraphenylnaphtacene （rubrene）/tris（8-hydroxyquinoline） aluminum （Alq3）/Mg：Ag were fabricated by vacuum deposition method, in which a novel star-shaped hexafluorenyl- benzene HKEthFLYPh was used as an energy transfer layer, and an ultrathin layer of rubrene was inserted between HKEthFLYPh and Alq3 layers as a yellow light-emitting layer instead of using a time-consuming doping process. A fairly pure WoLED with Commissions Internationale De L＇Eclairage （CIE） coordinates of （0.32, 0.33） was obtained when the thickness of rubrene was 0.3 nm, and the spectrum was insensitive to the applied voltage. The device yielded a maximum luminance of 4816 cd/m2 at 18 V.

关键词： White organic light-emitting diode diethyl-9H-fluoren-2-yl)benzene Energy transfer Star-shaped hexafluorenylbenzene 1 2 3 4 5 6-hexakis(9 9- Ultrathin layer

Bismuth Mediated organic Reaction: A Convenient Method for the Synthesis of Allylic (Benzylic) Selenides and α-organylselenocarbonyl Compounds in Aqueous Media

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Chinese Chemical Letters 2000年第12期11卷 1037-1040页

作者： Pei Pei SUN ya Ping XIAo Bao Chuan SHI Department of Chemistry Nanjing Normal UniversityNanjing 210097

In the presence of BiCl3/Al or BiCl3/Fe, in THF-H2o, allylic (benzylic) bromides or α-bromoketones react with diorganyl diselenides to give allylic (benzylic) selenides orα-organylselenocarbonyl compounds respective... 详细信息

关键词： Bismuth allylic ( benzylic) selenides,α-organylselenocarbonyl compounds synthesis.

Energy dependence on modes of electric activities of neuron driven by different external mixed signals under electromagnetic induction

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Science China(Technological Sciences) 2019年第3期62卷 427-440页

作者： LU LuLu JIA ya XU Ying GE Mengyan yaNG LiJian ZHAN Xuan Institute of Biophysics and Department of Physics Central China Normal University

Energy supply and release play an important role in individual neuron and neural network. In this paper, the electrical activities and Hamilton energy of neuron are investigated when external mixed signals(i.e., the periodic stimulus current and the periodic electromagnetic field) are imposed on the neuron under the electromagnetic induction. As a result, the Hamilton energy is much dependent on the mode transition, the multiple electric activity modes and the numerical analysis of Hamilton energy are more complicated under various parameters. When the periodic high-low frequency electromagnetic radiation is imposed in neuron, it is found that the electrical activities are more complex, and the changing of energy is obvious. In addition, the response of electrical activity and Hamilton energy is much dependent on the changing of amplitude A, B when the external high-low frequency signal is imposed on the neuron, meanwhile, the energy of bursting state is lower than the one of spiking state. It can be used for investigation about the energy coding in the neuron even the neuron networks.

关键词： Hamilton energy electromagnetic induction electric activity multiple growing modes