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A Hybrid optimization Approach of Single point Incremental Sheet Forming of AISI 316L Stainless Steel Using Grey Relation Analysis Coupled with principal Component Analysiss

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Journal of Wuhan University of Technology(Materials Science) 2024年第1期39卷 160-166页

作者： A Visagan p Ganesh Department of production Technology Madras Institute of TechnologyChennai-600044India

We investigated the parametric optimization on incremental sheet forming of stainless steel using Grey Relational Analysis(GRA) coupled with principal Component Analysis(pCA). AISI 316L stainless steel sheets were used to develop double wall angle pyramid with aid of tungsten carbide tool. GRA coupled with pCA was used to plan the experiment conditions. Control factors such as Tool Diameter(TD), Step Depth(SD), Bottom Wall Angle(BWA), Feed Rate(FR) and Spindle Speed(SS) on Top Wall Angle(TWA) and Top Wall Angle Surface Roughness(TWASR) have been studied. Wall angle increases with increasing tool diameter due to large contact area between tool and workpiece. As the step depth, feed rate and spindle speed increase,TWASR decreases with increasing tool diameter. As the step depth increasing, the hydrostatic stress is raised causing severe cracks in the deformed surface. Hence it was concluded that the proposed hybrid method was suitable for optimizing the factors and response.

关键词： single point incremental forming AISI 316L taguchi grey relation analysis principal component analysis surface roughness scanning electron microscopy

Rotating effects on the photoionization cross-section of a 2D quantum ring

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Communications in Theoretical physics 2024年第10期76卷 153-159页

作者： Carlos Magno o pereira Frankbelson dos S Azevedo Luís Fernando C pereira edilberto o Silva Departamento de Física Universidade Federal do Maranh?o

In this article, we investigate the nonrelativistic quantum motion of a charged particle within a rotating frame, taking into account the Aharonov–Bohm(AB) effect and a uniform magnetic field. our analysis entails the derivation of the equation of motion and the corresponding radial equation to describe the system. Solving the resulting radial equation enables us to determine the eigenvalues and eigenfunctions, providing a clear expression for the energy levels. Furthermore,our numerical analysis highlights the substantial influence of rotation on both energy levels and optical properties. Specifically, we evaluate the photoionization cross-section with and without the effects of rotation. To elucidate the impact of rotation on the photoionization process of the system, we present graphics that offer an appealing visualization of the intrinsic nature of the physics involved.

关键词： Aharonov-Bohm effect photoionization cross-section quantum ring rotating effect

engineering nanomedicines for immunogenic eradication of cancer cells:Recent trends and synergistic approaches

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Acta pharmaceutica Sinica B 2024年第6期14卷 2475-2504页

作者： Ahmed o.elzoghby omar Samir Hagar e.emam Ahmed Soliman Riham M.Abdelgalil Yomna M.elmorshedy Kadria A.elkhodairy Mahmoud L.Nasr Division of engineering in Medicine and Division of Renal Medicine Department of MedicineBrigham and Women's HospitalHarvard Medical SchoolBoston 02115MAUSA Cancer Nanotechnology Research Laboratory(CNRL) Faculty of PharmacyAlexandria UniversityAlexandria 21521Egypt

Resistance to cancer immunotherapy is mainly attributed to poor tumor immunogenicity as well as the immunosuppressive tumor microenvironment(TMe)leading to failure of immune *** therapeutic strategies including chemotherapy,radiotherapy,photodynamic,photothermal,magnetic,chemodynamic,sonodynamic and oncolytic therapy,have been developed to induce immunogenic cell death(ICD)of cancer cells and thereby elicit immunogenicity and boost the antitumor immune ***,many challenges hamper the clinical application of ICD inducers resulting in modest immunogenic ***,we outline the current state of using nanomedicines for boosting ICD of cancer ***,synergistic approaches used in combination with ICD inducing nanomedicines for remodeling the TMe via targeting immune checkpoints,phagocytosis,macrophage polarization,tumor hypoxia,autophagy and stromal modulation to enhance immunogenicity of dying cancer cells were *** further highlight the emerging trends of using nanomaterials for triggering amplified ICD-mediated antitumor immune *** reticulum localized ICD,focused ultrasound hyperthermia,cell membrane camouflaged nanomedicines,amplified reactive oxygen species(RoS)generation,metallo-immunotherapy,ion modulators and engineered bacteria are among the most innovative *** challenges,merits and demerits of ICD inducer nanomedicines were also discussed with shedding light on the future role of this technology in improving the outcomes of cancer immunotherapy.

关键词： Immunogenic cell death Immunogenic eradication Nanomedicines Drug delivery Cancer immunotherapy Antitumor immunity T cells Tumor associated antigens Synergistic immune response

Harnessing the power of pericytes and hypoxia-inducible factor-1 to modulate stroke outcome

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Neural Regeneration Research 2024年第3期19卷 473-474页

作者： omolara o.ogunshola Chih-Chieh Tsao Institute of Veterinary physiology Vetsuisse FacultyUniversity of ZurichZurichSwitzerland

The human brain has exceedingly high metabolic *** cerebral vasculature has the critical task of providing sufficient blood supply to meet this *** sudden interruption of blood flow to the brain,as observed during ischemic stroke,results in acute neurological injury with devastating consequences-a high rate of adult disability and *** stroke is thus a vascular disorder with a dramatic neurological *** is an urgent need for more effective disease management to combat stroke as current treatment paradigms,focusing on vascular recanalization and neuroprotection,have only limited clinical *** accumulating data suggests successful long-term neuroprotection is unlikely to be achievable without a functional microvascular network,strategies that reduce endothelial dysfunction could be ***,very recent evidence highlighted herein suggests protecting the humble pericyte may be a new approach to reaching this goal.

关键词： consequences exceeding herein

Groupoid Approach to ergodic Dynamical System of Commutative von Neumann Algebra

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Advances in pure Mathematics 2024年第3期14卷 167-184页

作者： Nicholas o. okeke Murphy e. egwe physical and Mathematical Sciences Dominican University Ibadan Nigeria Department of Mathematics University of Ibadan Ibadan Nigeria

Given a compact and regular Hausdorff measure space (X, μ), with μ a Radon measure, it is known that the generalised space M(X) of all the positive Radon measures on X is isomorphic to the space of essentially bounded functions Lp>∞p>(X, μ) on X. We confirm that the commutative von Neumann algebras M⊂B(H), with H=Lp>2p>(X, μ), are unitary equivariant to the maximal ideals of the commutative algebra C(X). Subsequenly, we use the measure groupoid to formulate the algebraic and topological structures of the commutative algebra C(X) following its action on M(X) and define its representation and ergodic dynamical system on the commutative von Neumann algebras of M of B(H) .

关键词： Measure Groupoid Groupoid equivalence ergodic Action Convolution Algebra von Neumann Algebra Generalized Space

particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+T cell activation,macrophage uptake,and the protein corona

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Nano Research 2024年第10期17卷 9052-9064页

作者： Savannah e.est-Witte Sydney R.Shannon Dennis H.Gong Kaitlyn G.Calabresi Jawaun J.Harris Kaitlyn Storm edwin J.Yoo Ariel Isser Vivek p.Jani Natalie K.Livingston Mary o.omotoso Kelly Rhodes elana Ben-Akiva Randall A.Meyer Zoe T.Hsieh Simone Sidoli Stephany Y.Tzeng Jonathan p.Schneck Jordan J.Green Translational Tissue engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACT,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aApCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aApCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+T cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aApCs for in vivo T-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aApC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific T cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo T cell activation and investigate possible mechanisms including the effects of aApC elasticity on T cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

Mutations of voltage-gated sodium channel contribute to pyrethroid resistance in panonychus citri

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Insect Science 2024年第3期31卷 803-816页

作者： Deng pan Qiu-Juan Luo Andrias o.o'Reilly Guo-Rui Yuan Jin-Jun Wang Wei Dou Key Laboratory of entomology and pest Control engineering College of Plant ProtectionAcademy of Agricultural SciencesSouthwest UniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green production of Upper Yangtze River(Ministry of education) Academy of Agricultural SciencesSouthwest UniversityChongqingChina School of Biological and environmental Sciences Liverpool John Moores UniversityLiverpoolUK

Insecticide resistance in panonychus citri is a major obstacle to mite control in citrus *** insecticides are continually used to control mites in China,although resistance to pyrethroids has evolved in some ***,the resistance to the pyrethroid fenpropathrin was investigated and 7 out of 8 field-collected populations of p citri exhibited a high level of resistance,ranging from 171-fold to 15391-fold higher than the susceptible(SS)comparison *** voltage-gated sodium channel(VGSC)mutations were identified in the tested populations:L1031V,F1747L,and *** sequencing was used to evaluate the frequency of these mutations in the 19 field populations.L1031V and F1751I were present in all populations at frequencies of 11.6%-82.1%and 0.5%-31.8%,respectively,whereas the F1747L mutation was only present in 12 populations from Chongqing,Sichuan,Guangxi,and Yunnan *** of these mutations singly or in combination into transgenic flies significantly increased their resistance to fenpropathrin and these flies also exhibited reduced mortality after exposure to the pyrethroids permethrin andβ-*** citri VGSC homology modeling and ligand docking indicate that F1747 and F1751 form direct binding contacts with pyrethroids,which are lost with mutation,whereas L1031 mutation may diminish pyrethroid effects through an allosteric ***,the results provide molecular markers for monitoring pest resistance to pyrethroids and offer new insights into the basis of pyrethroid actions on sodium channels.

关键词： amplicon sequencing kdr mutation molecular docking panonychus citri pyrethroid resistance transgenic flies

Green hydrogen energy production: current status and potential

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CLeAN eNeRGY 2024年第2期8卷 1-7页

作者： Maka, Ali o. M. Mehmood, Mubbashar Libyan Ctr Res & Dev Saharian Communities Murzuq Libya Heriot Watt Univ Sch Engn & Phys Sci Edinburgh EH14 4AS Scotland

The technique of producing hydrogen by utilizing green and renewable energy sources is called green hydrogen production. Therefore, by implementing this technique, hydrogen will become a sustainable and clean energy source by lowering greenhouse gas emissions and reducing our reliance on fossil fuels. The key benefit of producing green hydrogen by utilizing green energy is that no harmful pollutants or greenhouse gases are directly released throughout the process. Hence, to guarantee all of the environmental advantages, it is crucial to consider the entire hydrogen supply chain, involving storage, transportation and end users. Hydrogen is a promising clean energy source and targets plan pathways towards decarbonization and net-zero emissions by 2050. This paper has highlighted the techniques for generating green hydrogen that are needed for a clean environment and sustainable energy solutions. Moreover, it summarizes an overview, outlook and energy transient of green hydrogen production. Consequently, its perspective provides new insights and research directions in order to accelerate the development and identify the potential of green hydrogen production. Hydrogen is a promising clean energy source and a pathway towards decarbonization and net-zero emissions by 2050. This article provides perspective on techniques for generating green hydrogen that are needed for a clean environment and sustainable energy solutions. Graphical Abstract

关键词： green hydrogen energy hydrogen production energy transition clean energy perspective of green hydrogen TeCHNoLoGIeS RoADMAp

Congenital Mesoblastic Nephroma: A Case Report

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open Journal of pediatrics 2024年第5期14卷 834-840页

作者： e. A. Alinnor o. C. Ugwa I. o. Nnamani Department of paediatrics University of Port Harcourt Teaching Hospital Port Harcourt Nigeria Department of Anatomical pathology University of Port Harcourt Teaching Hospital Port Harcourt Nigeria

Background: Congenital Mesoblastic Nephroma (CMN) is a mesenchymal renal tumour of early life. With a median diagnosis of two months and over 90% of cases occurring within the first year of life, it is the most prevalent non-Wilms’ renal tumour. even though imaging can be used as a diagnosing tool, it is frequently identified in the neonatal period when the baby has an abdominal mass. There are three different histologic types: mixed, cellular, and classic. Radical nephrectomy is the usual mode of treatment, though adjuvant chemotherapy may be necessary for the cellular type, which may be aggressive. Case presentation: We report on a case of a 2-day-old term male neonate born to a 27-year-old mother through spontaneous vertex delivery (SVD). He presented with a right-sided abdominal mass from birth. An abdominal ultrasound scan revealed a huge, well-circumscribed heterogeneous soft tissue mass in the right hemi-abdomen extending to the left side, measuring 10.2 cm by 8.0 cm. He underwent a right radical nephrectomy with a tumour weight of 450 g and a size of 18 cm × 15 cm × 6 cm. Histopathological diagnosis was Congenital Mesoblastic Nephroma (cellular type) Stage 1. Conclusion: Any infant with a renal tumour should be evaluated for congenital mesoblastic nephroma. Detailed investigation and complete resection are fundamental for ensuring an excellent outcome.

关键词： Congenital Mesoblastic Nephroma Nephrectomy Neonate