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3.0T磁共振快速应变编码(SENC)成像对心内膜下和透壁性心肌梗死的诊断和进一步的鉴别

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国际医学放射学杂志 2012年第1期 93-94页

作者： N.oyama-manabe N.Ishimori H.Sugimori M.Van Cauteren K.Kudo o.manabe 张继 Department of Diagnostic and Interventional Radiology Hokkaido University HospitalKita15Nishi 7kita-kuSapporoJapan

目的探索快速应变编码(SENC)测量的环形和纵向峰值应变能否诊断心内膜下和透壁性心肌梗死并进一步鉴别。方法 19例缺血性心脏病病人行3T快速SENC和晚期

关键词： MRI 心肌梗死钆肾性系统性纤维化诊断

循环旋转弯曲变形中65Cu-35Zn黄铜管显微组织和力学性能的演变

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Transactions of Nonferrous Metals Society of China 2022年第11期32卷 3610-3622页

作者：张自成 Tsuyoshi FURUSHIMA Ken-ichi manabe 东北大学机械工程与自动化学院沈阳110819 Department of Mechanical and Biofunctional Systems Institute of Industrial ScienceThe University of TokyoKomaba 4-6-1MeguroTokyo 153-8505Japan Department of Mechanical Engineering Tokyo Metropolitan University1-1 Minami-OsawaHachioji-shiTokyo 192-0397Japan

为了细化65Cu−35Zn黄铜管的晶粒尺寸,并改善其力学性能,进行不同变形条件下的循环旋转弯曲(CRB)实验。利用光学显微镜、EBSD和常温拉伸实验,对变形后管材的显微组织和轴向力学性能进行研究。为了获得变形过程中黄铜管的累计有效塑性应变... 详细信息

为了细化65Cu−35Zn黄铜管的晶粒尺寸,并改善其力学性能,进行不同变形条件下的循环旋转弯曲(CRB)实验。利用光学显微镜、EBSD和常温拉伸实验,对变形后管材的显微组织和轴向力学性能进行研究。为了获得变形过程中黄铜管的累计有效塑性应变,对黄铜管不同变形条件下的CRB进行有限元模拟。结果表明,常温变形条件下,黄铜管的平均晶粒尺寸随旋转时间的增加而减小;在200℃变形条件下,其平均晶粒尺寸随弯曲角度的减小而减小。随着累计有效塑性应变的增加,变形后黄铜管平均晶粒尺寸减小率呈现增大趋势,其抗拉强度呈现波状增加,而伸长率呈现先增加后迅速减小的趋势。

关键词：黄铜管循环旋转弯曲工艺剧烈塑性变形显微组织力学性能

Chain-Length-Dependent Hydrogen-Bonded Self-Assembly of Terminally Functionalized Discrete Polyketones

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Precision Chemistry 2023年第1期1卷 34-39页

作者： Kilingaru I.Shivakumar Yumehiro.manabe Tomoki Yoneda Yuki Ide Yasuhide Inokuma Institute for Chemical Reaction Design and Discovery(WPI-ICReDD) Hokkaido UniversitySapporoHokkaido 001-0021Japan Division of Applied Chemistry Faculty of EngineeringHokkaido UniversitySapporoHokkaido 060-8628Japan

Here,we report the synthesis and the chain-lengthdependent self-assembling behaviors of discrete di-,tetra-,and hexaketones terminally functionalized with hydrogen-bonding carboxyl(C1,C2,and C3)and 3-acylaminopyridine groups(P1,P2,and P3).These polyketones were prepared by the coupling reactions of silylated analogues of 3,3-dimethylpentane-2,4-dione and t-butyl 2,2-dimethyl-3-oxobutanoate and the subsequent hydrolysis or amidation with ***-crystal Xray diffraction analysis revealed that C1 and C2 form helical assemblies in which the components are connected by the dimerization of terminal carboxyl groups,whereas the longer C3 showed infinite hydrogen-bonded chains mediated by 1,4-dioxane used as a crystallization ***-terminated P1 exhibited a three-dimensional hydrogen-bonded network owing to multiple NH…N(pyridine)hydrogen bonds in the solid state.P2 generated a double-helix-like fiber structure in the crystalline *** the pyridine-terminated polyketones P1−P3,only P2 showed gelation behavior in chloroform(100 mM concentration)at 25℃.The scanning electron microscopy measurement of xerogel P2 revealed the formation of rod-like structures with a thickness of approximately 0.5−3.5μ*** results demonstrate that the precise control of the polyketone chain length can significantly alter hydrogen-bonded self-assembly in the solid state and in solution even with the same terminal structures.

关键词： polyketone hydrogen bond helix self-assembly gel

Influence of Heat Treatment on Hydroformability of TRIP Seamless Steel Tube

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Journal of Iron and Steel Research(International) 2014年第7期21卷 695-701页

作者： Zi-cheng ZHANG Ken-ichi manabe School of Mechanical Engineering and Automation Northeastern University Department of Mechanical Engineering Tokyo Metropolitan University

A low-carbon TRIP seamless steel tube, which is expected to be used in the hydroforming process, was successfully fabricated using piercing, cold-drawing and two-stage heat treatment process. The two-stage heat treatment is one crucial step because it significantly affects the microstructure and mechanical properties of TRIP seam less steel tube. In order to obtain the TRIP seamless steel tube with high hydroformability, several different heat treatment processes were conducted. The effects of heat treatment conditions （intercritical annealing （IA） and isothermal bainite treatment （IBT）） on the TRIP seamless steel tube hydroformability which was determined by free hydraulic bulge test were analyzed. Two different internal pressure boosting velocities of 0.2 and 0.5 MPa/s of free hydraulic bulge tests were adopted to determine the effective stress vs. effective strain curve of TRIP seamless steel tube. The results showed that for the predetermined IA condition, the maximum bulge height increased, but the maximum burst internal pressure decreased, with the increase of IBT holding time from 4 to 6 rain. For the predetermined IBT condition, the maximum bulge height decreased, but the maximum burst internal pressure increased, with the increase of IA holding time from 5 to 10 rain. By analyzing the free hydraulic bulge test results, it was found that the maximum bulge heights of TRIP seamless steel tubes with the internal pressure boosting velocity of 0.5 MPa/s were higher than those when the internal pressure boosting velocity was 0.2 MPa/s. This means that an appropriate deformation rate should be chosen to obtain the optimal hydroformability of TRIP seamless steel tube. In addition, the effective stress vs. effective strain curves of TRIP seamless steel tubes were ohtained with free hydraulic bulge test.

关键词： TRIP steel heat treatment hydroformability seamless tube hydraulic bulge test

Study and evaluation of a plant form modeling system based on the Lindenmayer system

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第3期9卷 107-114页

作者： Taiyo Maeda Yasuhiko.manabe Shigeo Kawata Department of System Engineering Graduate School of Engineering Saitama Institute of Technology 1690 Fusaiji FukayaSaitama 369-0293Japan Department of Electrical and Electronics Engineering National Institute of Technology Numazu CollegeJapan Department of Electrical and Electronic Engineering Graduate School of Engineering Utsunomiya UniversityJapan

In order to evaluate and recognize plant growth automatically based on photos of plants in plant science and engineering,we propose a diagnostic system for plant growth in which simulated plant growth is used as a reference for real growing *** our diagnostic system,we employ the Lindenmayer system[Lecture Notes in Computer Science,15,53–68,1974]to model healthy growing *** the Lindenmayer system plant growth is expressed by string expressions designed as a numerical model for the *** proposal system provides users the string expressions by using image *** users compare with two strings such as DNA sequence genetic code,users obtain developmental change of plat *** results show that our automatic plant diagnostic system is effective in checking actual healthy plant growth,and suggest that the diagnostic system should be useful in large-scale plant factories.

关键词： Plant growth Lindenmayer system string expression for plant modeling

Degradation of differently processed Mg-based implants leads to distinct foreign body reactions(FBRs)through dissimilar signaling pathways

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镁合金学报(英文) 2023年第6期11卷 2106-2124页

作者： Xiaosong Liu Guoqiang Chen Xiongxiong Zhong Tianfang Wang Xiaohong He Weipeng Yuan Pingping Zhang Ying Liu Dongming Cao Shu Chen Ken-ichi manabe Zhengyi Jiang Tsuyoshi Furushima Damon Kent Yang Chen Guoying Ni Mingyong Gao Hejie Li Cancer Research Institute First People’s Hospital of FoshanFoshanGuangdong 528000China Department of Rheumatology First People’s Hospital of FoshanFoshanGuangdong 528000China The Second Clinical Medical College of Jinan University Shenzhen People’s HospitalShenzhenGuangdong 510632China Genecology Research Centre University of the Sunshine CoastMaroochydore BCQLD 4558Australia Department of Medical Imaging First People’s Hospital of FoshanFoshanGuangdong 528000China Department of Surgery First People’s Hospital of FoshanFoshanGuangdong 528000China Department of Mechanical Engineering Graduate School of Science and EngineeringTokyo Metropolitan University1-1 Minami-osawaHachiojiTokyo 192-0397Japan School of Mechanical MaterialsMechatronic and Biomedical EngineeringFaculty of Engineering and Information SciencesUniversity of WollongongNorthfields AveWollongong NSW 2522Australia Institute of Industrial Science Department of Mechanical and Biofunctional Systemsthe University of Tokyo4-6-1KomabaMeguroTokyo 153-8505Japan School of Science Technology and EngineeringUniversity of the Sunshine CoastMaroochydore BCQLD 4558Australia

Mg alloys have mechanical properties compatible with human ***,their rapid degradation and associated foreign body reactions in vivo significantly limit their application for human *** this study,three differently processed Mg alloys,pure Mg(PM),cold extruded Mg alloy AZ31(CE AZ31),and fully annealed AZ31 Mg alloy(FA AZ31)were comparatively investigated for their potential as implants using a rat *** three implanted Mg alloys do not show any impact on hepato-and renal function,nor any signs of observable changes to vital *** analysis of tissues directly contacting the implants 2.5 months post implantation revealed that FA AZ31 activates very few inflammation and immune associated signaling pathways;while the CE AZ31 and PM produce more significant inflammatory responses as confirmed by cytokine array ***,FA AZ31 activated pathways for cell organization and development that may improve the recovery of injured ***,EBSD analysis reveals that the FA AZ31 alloy has a higher ratio of first-order pyramidal orientated(10–11){10–1–2}grain texture with a value of 0.25,while PM and CE AZ31 alloys have lower ratios of first-order pyramidal orientated texture with the values of 0.16 and 0.17,*** is associated with recovery and recrystallisation during annealing which promotes grain texture which exhibits enhanced degradation behaviours and induces a more limited immune response in *** conclusion,the FA AZ31 demonstrated better biocompatibility and corrosion resistance and is a promising candidate for metal-based degradable implants which warrants further investigation.

关键词： Toxicity test Proteomics analysis Signaling pathway Biocompatibility and corrosion resistance First-order pyramidal slip system Recovery and recrystallization Foreign body reactions(FBRs)

Endoscopic submucosal dissection as excisional biopsy for anorectal malignant melanoma:A case report

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World Journal of Clinical Cases 2019年第13期7卷 1652-1659页

作者： Shigeo.manabe Yoshio Boku Michiyo Takeda Fumitaka Usui Ikuhiro Hirata Shuji Takahashi Department of Gastroenterology Kouseikai Takeda Hospital Kyoto 600-8558 Japan Fujita Clinic 67 Gokiya-cho Oomiya-dori Shichijo-kudaru Shimogyo-ku Kyoto 600-8267 Japan

BACKGRoUND Anorectal malignant melanoma (AMM) is a rare disorder with an extremely poor prognosis. Although there is currently no consensus on the treatment methods for AMM, surgical procedures have been the most common treatment methods used until now. We recently encountered a case of AMM that we diagnosed using endoscopic submucosal dissection (ESD). To our knowledge, this is the first case of ESD for AMM, suggesting that ESD can potentially be a diagnostic and treatment method for AMM. CASE SUMMARY A 77-year-old woman visited our hospital with a chief complaint of anal bleeding and a palpable rectal mass. Colonoscopy revealed a 20-mm protruded lesion in the lower rectum. After obtaining biopsy specimens from the lesion, although a malignant rectal tumor was suspected, a definitive diagnosis was not made. Endoscopic ultrasonography revealed tumor invasion into the submucosal layer but not the muscular layer. Therefore, we performed an excisional biopsy using ESD. Immunohistochemical examination of the ESD-resected specimen revealed tumor cells positive for Human Melanin Black-45, Melan-A, and S-100. Moreover, the tumor cells lacked melanin pigment;thus, a diagnosis of amelanotic AMM was made. Although the AMM had massively invaded the submucosal layer and both lymphatic and venous invasion were present, we closely monitored the patient without any additional therapy on the basis of her request. Six months after ESD, local recurrence was detected, and the patient consented to wide local excision. CoNCLUSIoN It is suggested that ESD is a potential diagnostic and treatment method for AMM.

关键词： Endoscopic submucosal dissection Anorectal malignant melanoma Endoscopic mucosal resection Case report

Effect of Cooling Method on Microstructure and Mechanical Properties of Hot-Rolled C-Si-Mn TRIP Steel

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Journal of Iron and Steel Research(International) 2012年第1期19卷 41-46页

作者： LIU Ji-yuan ZHANG Zi-cheng ZHU Fu-xian LI Yan-mei manabe Ken-ichi State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110004LiaoningChina Department of Mechanical Engineering Tokyo Metropolitan UniversityTokyo 192-0397Japan

The controlled cooling technology following hot rolling process is a vital factor that affects the final micro- structure and mechanical properties of the hot-rolled transformation induced plasticity （TRIP） steels. In the present study, low alloy C-Si-Mn TRIP steel was successfully fabricated by hot rolling process with a 4450 hot roiling mill. To maximize the volume fraction and stability of retained austenite of the steel, two different cooling methods （aircooling and ultra-fast cooling ＂AC-UFC＂ and ultrmfast cooling, air cooling and ultra-fast cooling ＂UFC-AC-UFC＂） were conducted. The effects of the cooling method on the microstructure of hot-rolled TRIP steel were investigated via optical microscope, transmission electron microscope and conversion electron Mossbauer spectroscope. The mechanical properties of the steel were also evaluated by conventional tensile test. The results indicated that ferrite and bainite in the microstructure were refined with the cooling method of UFC-AC-UFC. The morphology of retained austenite was also changed from small islands distributing in bainite district （obtained with AC-UFC） to granular shape locating at the triple junction of the ferrite grain boundaries （obtained with UFC-AC-UFC）. As a result, the TRIP steel with a content of retained austenite of 11. 52%, total elongation of 32% and product of tensile strength and total elongation of 27 552 MPa·% was obtained.

关键词： hot-rolled TRIP steel retained austenite TRIP effect Mossbauer spectra mechanical property

Gastric adenocarcinoma of fundic gland type spreading to heterotopic gastric glands

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World Journal of Gastroenterology 2017年第38期23卷 7047-7053页

作者： Shigeo.manabe Ken-ichi Mukaisho Takayuki Yasuoka Fumitaka Usui Tatsuzo Matsuyama Ikuhiro Hirata Yoshio Boku Shuji Takahashi Department of Gastroenterology Kouseikai Takeda Hospital Department of Pathology Shiga University of Medical Science Fujita Clinic

Herein, we present a case of gastric adenocarcinoma of fundic gland type(GA-FG) spreading to heterotopic gastric glands(HGG) in the submucosa. A 58-year-old man with epigastric pain was referred to our hospital and underwent an esophagogastroduodenoscopy. A Borrmann type II gastric cancer at the antrum and a 10 mm submucosal tumor-like lesion in the lesser curvature of the upper third of the stomach were detected. Histological examination of the biopsy specimens obtained from the submucosal tumorlike lesion suggested a GA-FG. Therefore, endoscopic submucosal dissection was performed as excisional biopsy, and histopathological examination of the resected specimen confirmed a GA-FG and HGG proximal to the GA-FG. Although the GA-FG invaded the submucosal layer slightly, the submucosal lesion of the GA-FG had a poor stromal reaction and was located just above the HGG in the submucosa. Therefore, wefinally diagnosed the lesion as a GA-FG invading the submucosal layer by spreading to HGG.

关键词： fundic 腺类型的胃的腺癌 Heterotopic 胃的腺内视镜的 submucosal 解剖 Paracancerous 损害 Pepsinogen -- 我 H/K-ATPase