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化学通报 1983年第7期 11-12+22页

作者： o.j.simpson 卞有生北京市环境保护科学研究所

(1)所谓同位素,是A.电子数相同的不同元素的原子B.中子数相同的不同元素的原子C.中子数不同的同种元素的原子

关键词：答案

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《化学选择题习题集》例解

化学教学 1980年第1期 34-36页

作者： o.j.simpson ,王一川

《化学选择题习题集》是供英国高中化学复习和考查化学成绩用的,内容分选择题、分类题、多种组合题、分析和计算题以及实验操作题五部分,共编有一千多道题。这些习题包括有关化学事实材料的、推理的、分析问题的以及实验操作知识和技能... 详细信息

《化学选择题习题集》是供英国高中化学复习和考查化学成绩用的,内容分选择题、分类题、多种组合题、分析和计算题以及实验操作题五部分,共编有一千多道题。这些习题包括有关化学事实材料的、推理的、分析问题的以及实验操作知识和技能的内容。这些习题可以考查学生掌握化学基本概念、基础理论、基本知识和基本技能的理解程度和熟练技巧,也可以培养学生分析问题和解决问题的能力。因此,这些习题可用作检查学生知识质量的试题,也可用作高中化学复习时的练习题。《化学选择题习题集》从1969年发行以来,近十年里被英美等国广泛采用,1977年经过更新修订,再版发行,深受高中化学教师和大学化学基础课教师的欢迎和赞许。有鉴于此,特选译各部的示范例题和解答,供教师们参考、借鉴。

关键词：选择题氢氧化钠高锰酸钾溶液氯化物组合题

Two Crimes, Two Punishments

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大学英语 1995年第12期 32-32页

作者： o.j.simpson Susan Smith RICK BRAGG

on different sides of the country, in different worlds of power and influence, Susan V. Smith and o.j. simpson are accused of murder by unspeakable means. The difference is in the price the criminal-justice system wil... 详细信息

关键词： In Two Crimes Two Punishments

A marathon,not a sprint:Increasing population physical activity as a legacy of sports mega-events

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journal of Sport and Health Science 2024年第6期13卷 732-735页

作者： Fiona C.Bull Paul j.simpson Physical Activity Unit Department of Health PromotionWorld Health OrganizationGeneva CH-1211Switzerland The BMj London WC1H 9JPUK

*** matters The withdrawal of Australia as hosts for the Commonwealth Games in 2026 demonstrates that large international sporting events are more than just sporting mastery,medals,and *** also matters.1 The cost of hosting a major international tournament is eye-wateringly *** governments need to show that the billions of dollars of investment deliver a return beyond sporting glory to justify the resources that are spent.

关键词： return dollar sport

CoVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history

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journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith Tiffany M.Zúñiga Forrest L.Baker Helena Batatinha Charles R.Pedlar Shane C.Burgess Michael P.Gustafson Emmanuel Katsanis Richard j.simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA Laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(CoVID-19).We sought to determine if CoVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a CoVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb ***:CoVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral CoVID-19 Exercise immunology SARS-CoV-2 T-Cells Vaccine

Distinct vibrational signatures and complex phase behavior in metallic oxygen

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Matter and Radiation at Extremes 2024年第2期9卷 4-11页

作者： Philip Dalladay-simpson Bartomeu Monserrat Li Zhang Federico Gorelli Center for High Pressure Science Technology Advanced Research 1690 Cailun RoadShanghai 201203China Department of Materials Science and Metallurgy University of Cambridge27 Charles Babbage RoadCambridge CB3 OFSUnited Kingdom Cavendish Laboratory University of CambridgeJ.J.Thomson AvenueCambridge CB3 OHEUnited Kingdom Istituto Nazionale di ottica Consiglio Nazionale delle Ricerche(CNR-INO)50125 FlorenceItaly Shanghai Advanced Research in Physical Sciences(SHARPS) ShanghaiChina

Evidence for metallization in dense oxygen has been reported for over 30 years[Desgreniers et al.,***.94,1117(1990)]at a now routinely accessible 95 GPa[Shimizu et al.,Nature 393,767(1998)].However,despite the longevity of this result and the technological advances since,the nature of the metallic phase remains poorly constrained[Akahama et al.,***.74,4690(1995);Goncharov et al.,***.B 68,224108(2003);Ma,***.B 76,064101(2007);and Weck et al.,***.102,255503(2009)].In this work,through Raman spectroscopy,we report the distinct vibrational characteristics of metallicζ-o_(2) from 85 to 225 *** comparison with numerical simulations,weﬁnd reasonable agreement with the candidate structure up to about 150 *** higher pressures,the C2/mstructure is found to be unstable and incompatible with experimental *** candidate structures,and Ci,with C2/m C2/conly two molecules in the primitive unit cell,are found to be stable and more compatible with measurements above 175 GPa,indicative of the dissociation of(o_(2))4 ***,we report and discuss a strong hysteresis and metastability with the precursory phaseϵ-o_(2).Theseﬁndings will reinvigorate experimental and theoretical work into the dense oxygen system,which will have importance for oxygen-bearing chemistry,prevalent in the deep Earth,as well as fundamental physics.

关键词： metallic phase vibrational

Modern Corrosion Mapping of Storage Tank Bottoms--Notable Advancements in Critical Zone Coverage,Inspection Efficiency and Data Integrity

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journal of Civil Engineering and Architecture 2024年第3期18卷 148-153页

作者： Andrew j.simpson Matthew A.Boat Eddyfi Technologies-Eddyfi UK Ltd Clos Llyn CwmSwansea Enterprise ParkSwanseaSA68QYUK

Every day,an NDT(Non-Destructive Testing)report will govern key decisions and inform inspection strategies that could affect the flow of millions of dollars which ultimately affects local environments and potential risk to *** is a direct correlation between report quality and equipment *** more able the equipment is-in terms of efficient data gathering,signal to noise ratio,positioning,and coverage-the more actionable the report *** results in optimal maintenance and repair strategies providing the report is clear and well ***,when considering tank floor storage inspection it is essential that asset owners have total confidence in inspection findings and the ensuing *** floor inspection equipment must not only be efficient and highly capable,but data sets should be traceable and integrity maintained *** mapping of large surface areas such as storage tank bottoms is an inherently arduous and time-consuming ***(magnetic flux leakage)based tank bottom scanners present a well-established and highly rated method for *** are many benefits of using modern MFL technology to generate actionable *** among these includes efficiency of coverage while gaining valuable information regarding defect location,severity,surface origin and the extent of *** recent advancements in modern MFL tank bottom scanners afford the ability to scan and record data sets at areas of the tank bottom which were previously classed as dead zones or areas not scanned due to physical *** example of this includes scanning the CZ(critical zone)which is the area close to the annular to shell junction *** of these additional dead zones increases overall inspection coverage,quality and *** of the CZ areas allows engineers to quickly determine the integrity of arguably the most important area of the tank *** we discuss notable developments in CZ coverage

关键词： Storage tank tank bottom CZ MFL stars corrosion corrosion-mapping efficiency coverage paperless reporting data traceability

Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster

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journal of Genetics and Genomics 2017年第10期44卷 493-501页

作者： Dwayne j.Byrne Mark j.Harmon jeremy C.simpson Craig Blackstone Niamh C. o'Sullivan UCD School of Biomolecular and Biomedical Science UCD Conway Institute University College Dublin Dublin 4 Ireland UCD School of Biology and Environmental Science UCD Conway Institute of Biomolecular and Biomedical Research University College Dublin Dublin 4Ireland Cell Biology Section Neurogenetics Branch National Institute of Neurological Disorders and Stroke National Institutes of Health Bethesda MD 20892 USA

The VCP-Ufd1-Npl4 complex regulates proteasomal processing within cells by delivering ubiquitinated proteins to the proteasome for *** in VCP are associated with two neurodegenerative diseases,amyotrophic lateral sclerosis（ALS） and inclusion body myopathy with Paget＇s disease of the bone and frontotemporal dementia（IBMPFD）,and extensive study has revealed crucial functions of VCP within *** contrast,little is known about the functions of Npl4 or Ufd1 in *** neuronalspecific knockdown of Npl4 or Ufd1 in Drosophila melanogaster,we infer that Npl4 contributes to microtubule organization within developing motor ***,Npl4 RNAi flies present with neurodegenerative phenotypes including progressive locomotor deficits,reduced lifespan and increased accumulation of TAR DNA-binding protein-43 homolog（TBPH）.Knockdown,but not overexpression,of TBPH also exacerbates Npl4 RNAi-associated adult-onset neurodegenerative *** contrast,we find that neuronal knockdown of Ufd1 has little effect on neuromuscular junction（NMj） organization,TBPH accumulation or adult *** findings suggest the differing neuronal functions of Npl4 and Ufd1 in vivo.

关键词： Proteasome TDP-43 accumulation Neurodegeneration Drosophila

The overview of antimicrobial peptide-coated implants against oral bacterial infections

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聚集体(英文)

聚集体(英文) 2023年第3期4卷 3-18页

作者： Zhe Sun Li Ma Xiaodong Sun Alastair j.Sloan Neil M.o’Brien-simpson Wenyi Li Department of Stomatology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinanShandongChina Department of Endodontics Gaoxin branch of Jinan Stomatological HospitalJinanShandongChina Melbourne Dental School Division of Basic and Clinical Oral SciencesThe University of MelbourneCarltonVictoriaAustralia ACTV Research Group Melbourne Dental SchoolDivision of Basic and Clinical Oral SciencesThe Bio21 Institute of Molecular Science and BiotechnologyThe University of MelbourneCarltonVictoriaAustralia

Dental implants are the most common therapeutic approach for resolving tooth loss and *** technical advances in treatment,implant failure rates can be as high as 23%with the major cause of peri-implantitis:a multi-species bacterial *** an annual growth rate in implant placements of 8.78%per annum,implant failure caused by bacterial infection is a significant oral and general health *** rise in antibiotic resistance in oral bacteria further adds pressure to implant failure;thus,there is a need for adjunctive therapy to improve implant *** to the broad spectrum of activity and a low risk of inducing bacterial resistance,peptide antibiotics are emerging as a promising implant coating material to reduce/prevent peri-implantitis and improve dental implant success *** this review,we summarised the current strategies of coating antimicrobial peptides(AMPs)onto dental implant material surfaces with multi-functional properties to enhance osteoblast growth and prevent bacterial *** review compared the recent reported literature on dental implant coating with AMPs,which will provide an overview of the current dental implant coating strategies using AMPs and insights for future clinical applications.

关键词： antimicrobial coating antimicrobial peptides dental implants implant-associated infection peptide release peri-implant disease

A Note on the Relationship Between Temperature and Water Vapor over oceans, Including Sea Surface Temperature Effects

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Advances in Atmospheric Sciences 2006年第1期23卷 141-148页

作者： C.-L. SHIE W.-K. TAo j. simpson Goddard Earth Sciences and Technology Center University of MarylandBaltimore CountyBaltimoreMaryland 21250USA Laboratory for AtmospheresNASA Goddard Space Flight CenterGreenbeltMaryland 20771USA Laboratory for Atmospheres NASA Goddard Space Flight CenterGreenbeltMaryland 20771USA

An ideal and simple formulation is successfully derived that well represents a quasi-linear relationship found between the domain-averaged water vapor, Q （ram）, and temperature, T （K）, fields for the three tropical oceans （i.e., the Pacific, Atlantic and Indian oceans） based on eleven GEoS-3 [Goddard Earth observing System （EoS） Version-3] global re-analysis monthly products. A Q - T distribution analysis is also performed for the tropical and extra-tropical regions based on in-situ sounding data and numerical simulations [GEoS-3 and the Goddard Cumulus Ensemble （GCE） model]. A similar positively correlated Q - T distribution is found over the entire oceanic and tropical regions; however, Q increases faster with T for the former region. It is suspected that the tropical oceans may possess a moister boundary layer than the Tropics. The oceanic regime falls within the lower bound of the tropical regime embedded in a global, curvilinear Q - T relationship. A positive correlation is also found between T and sea surface temperature （SST）; however, for one degree of increase in T, SST is found to increase 1.1 degrees for a warmer ocean, which is slightly less than an increase of 1.25 degrees for a colder ocean. This seemingly indicates that more （less） heat is needed for an open ocean to maintain an air mass above it with a same degree of temperature rise during a colder （warmer） season [or in a colder （warmer） region]. Q and SST are also found to be positively correlated. Relative humidity （RH） exhibits similar behaviors for oceanic and tropical regions. RH increases with increasing SST and T over oceans, while it increases with increasing T in the Tropics. RH, however, decreases with increasing temperature in the extratropics. It is suspected that the tropical and oceanic regions may possess a moister local boundary layer than the extratropics so that a faster moisture increase than a saturated moisture increase is favored for the former regions. T, Q, saturated water v

关键词： moisture temperature relationship quasi-equilibrium states Tropics oceans