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Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o’Dowd Antoinette o’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

Neuroinflammation revisited through the microglial lens

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Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João B.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell Biology(IBMC) University of PortoPortoPortugal Department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

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Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teodoro Mafalda Ribeiro Ramos Lara Carvalho iNoVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.o’Connell Matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Coarse to Fine: The Role of Severe Plastic Deformation in Advancing Titanium-Based Medical Implants - A Comprehensive Review

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 295-306页

作者： Dragana R Mihajlović Bojan I Međo Ivana Lj Cvijović-Alagić Veljko R Djokić Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča Institute of Nuclear Sci-ences-National Institute of the Republic of Serbia University of Belgrade11001BeogradSerbia Innovation Centre of the Faculty of Technology and Metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic deformation(SPD)procedures,which are utilized to form an ultrafine-grained structure in metallic *** the SPD process,a solid material sample is subjected to very high loads without a significant change in sample *** the present work,the high-pressure torsion(HPT)process,as one of the SPD techniques,which achieves a high degree of deformation and ensures refinement of the microstructure,will be discussed in more *** that grain size control is accepted as a method to obtain materials with desired characteristics,an overview of the properties of ultrafine-grained titanium-based biomaterials to be used in medicine is ***,particular attention is dedicated to the influences of HPT process parameters,primarily hydrostatic pressure,and number of revolutions during torsion,on the grain size and physical and mechanical characteristics(modulus of elasticity,microhardness,and tensile properties),corrosion resistance,and biocompatibility of the titanium-based biomaterials.A review of the literature indicates that titanium-based materials obtained by the SPD process show improved mechanical and physical properties without losing biocompatibility and corrosion resistance,which suggests that these methods of obtaining implants are something that should be further developed in the future.

关键词： high-pressure torsion process ultrafine-grained titanium-based materials electrochemical anodization physical properties mechanical properties

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： H.HoSSEINI o.BALILASHAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词： Stress concentration

Injector of the Turkish light source facility TURKAY

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Nuclear Science and Techniques 2017年第11期28卷 210-216页

作者： Zafer Nergiz Avni aksoy Department of Physics Faculty of Arts and Sciences Omer Halisdemir University 51200 Nigde Turkey Institute of Accelerator Technologies Ankara University06830 Golbasi Ankara Turkey

A synchrotron radiation source called TURKAY is proposed as a sub-project of the Turkish Accelerator Center Project. The storage ring of TURKAY is a low emittance synchrotron and the radiation ranges between 0.01 and 60 keV can be generated from the insertion devices and bending magnets placed on it. The injector system of the facility will mainly consist of a 150 MeV linac and full energy booster. In this study, we present design considerations and beam dynamics studies of the pre-injector linac and booster ring for TURKAY.

关键词： Booster ring Pre-injector linac Beam dynamics

RELIABILITY oF LINEAR (n,f,k) SYSTEMS WITH WEIGHTED CoMPoNENTS

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Journal of Systems Science and Systems Engineering 2010年第3期19卷 277-284页

作者： Serkan ERYILMAZ Timur aksoy Department of Mathematics Izmir University of Economics Faculty of Computer Science and Engineering Sabanci University

The （n,f, k）： F（G） system consists ofn components and the system fails （works） if and only if there are at least flailed （working） components or at least k consecutive failed （working） components. These system models can be used in electronic equipment, automatic payment systems in banks, and furnace systems. In this paper we introduce and study the （n, f, k）：F and （n, f, k）： G systems consisting of weighted components. Recursive equations are presented for reliability evaluation of these new models. We also provide some conditions on the weights to represent weighted-（n,f, k） systems as usual （n,f, k） systems.

关键词： Consecutive-weighted-k-out-of-n systems system reliability weighted-k-out-of-n systems weighted-(n,f k) systems

RULES-IT： incremental transfer learning with RULES family

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Frontiers of Computer Science 2014年第4期8卷 537-562页

作者： Hebah ELGIBREEN Mehmet Sabih aksoy Information Technology Department College of Computer and Information Sciences King Saud University Riyadh 11415 Saudi Arabia Information Sysytem Department College of Computer and Information Sciences King Saud University Riyadh 11543 Saudi Arabia

In today＇s world of excessive development in technologies, sustainability and adaptability of computer applications is a challenge, and future prediction became significant. Therefore, strong artificial intelligence （AI） became important and, thus, statistical machine learning （ML） methods were applied to serve it. These methods are very difficult to understand, and they predict the future without showing how. However, understanding of how machines make their decision is also important, especially in information system domain. Consequently, incremental covering algorithms （CA） can be used to produce simple rules to make difficult decisions. Nevertheless, even though using simple CA as the base of strong AI agent would be a novel idea but doing so with the methods available in CA is not possible. It was found that having to accurately update the discovered rules based on new information in CA is a challenge and needs extra attention. In specific, incomplete data with missing classes is inappropriately considered, whereby the speed and data size was also a concern, and future none existing classes were neglected. Consequently, this paper will introduce a novel algorithm called RULES-IT, in order to solve the problems of incremental CA and introduce it into strong AI. This algorithm is the first incremental algorithm in its family, and CA as a whole, that transfer rules of different domains to improve the performance, generalize the induction, take advantage of past experience in different domain, and make the learner more intelligent. It is also the first to introduce intelligent aspectsinto incremental CA, including consciousness, subjective emotions, awareness, and adjustment. Furthermore, all decisions made can be understood due to the simple representation of repository as rules. Finally, RULES-IT performance will be benchmarked with six different methods and compared with its predecessors to see the effect of transferring rules in the learning process, and to pro

关键词： incremental learning transfer learning covering algorithms RULES family inductive learning