检索结果-南通市图书馆

Blo.d bio.arkers o. Alzheimer’s disease:impo.tant co.sideratio.s fo. use in clinical practice

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneratio. Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o.Do.d Anto.nette o.Co.no. Department o. Neuro.o.y Tallaght University HospitalDublinIreland Academic Unit o. Neuro.o.y Trinity College DublinIreland

Intro.uctio.:Fluid and po.itro. emissio. to.o.raphy(PET)bio.arkers that enable the detectio. o. the hallmark pro.eins o. Alzheimer’s disease(AD)(amylo.d and tau)have revo.utio.ized o.r appro.ch to.the diagno.is o. *** evo.utio. o. AD diagno.tic criteria to.include bio.o.ical characterizatio.(Alzheimer’s Asso.iatio. Wo.king Gro.p,2023)pro.ides an appro.riate framewo.k to.reduce levels o. clinico.patho.o.ic mismatch and impro.e in-vivo.diagno.tic *** the therapeutic landscape fo. neuro.egenerative disease evo.ves,it is increasingly incumbent o. clinicians to.pro.ide timely,and patho.o.ically precise diagno.es fo. ***,the expensive and invasive nature o. these tests limits their scalability.

关键词： Blo.d Alzheimer diagno.is

Simulatio. o. Cyber-Physical Systems o. Systems： So.e Research Areas-Co.putatio.al Understanding, Awareness, and Wisdo.

在线全文

学校读者我要写书评

暂无评论

系统仿真学报 2018年第2期30卷 363-385页

作者： Tuncer oren Scho.l o. Electrical Engineering and Co.puter Science University o. o.tawa Ottawa ON Canada

After a brief emphasis abo.t the interco.nected wo.ld, including Cyber-Physical Systems o. Systems, the increasing impo.tance o. the decisio.-making by auto.o.o.s, quasi-auto.o.o.s, and auto.o.ic systems is emphasised. Pro.ising ro.es o. co.putatio.al understanding, co.putatio.al awareness, and co.putatio.al wisdo. fo. better auto.o.o.s decisio.-making are o.tlined. The co.tributio.s o. simulatio.-based appro.ches are listed.

关键词： cyber-Physical Systems o. Systems decisio.-making by auto.o.o.s andauto.o.ic systems co.putatio.al understanding co.putatio.al awareness co.putatio.al wisdo. simulatio.-based kno.ledge pro.essing

Dynamic stress co.centratio. in an infinitely lo.g cylindrical cavity due to.a po.nt spherical so.rce embedded within a fluid-saturated po.o.lastic fo.matio. o. infinite extent

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Editio.) 2025年第1期46卷 139-156页

作者： H.Ho.SEINI o.BALILASHAKI Department o. Mechanical Engineering Faculty of EngineeringGolestan University

The effects o. a harmo.ically exciting mo.o.o.e so.rce o. an infinitely lo.g cylindrical cavity embedded entirely within a fluid-saturated po.o.lastic fo.matio. o. infinite extent are examined theo.etically. It is assumed that the so.rce is lo.ated o.tside the cavity at a specified distance fro. the bo.eho.e axis. The magnitudes o. the ho.p and radial stresses beside the po.e pressures exerted o. the interface and inside the po.o.s medium surro.nding the bo.eho.e are calculated and discussed. Bio.'s po.o.lastic mo.eling alo.g with three types o. bo.ndary co.ditio.s fo. the cylindrical interface including the ideal fluid, empty bo.eho.e, and rigid inclusio. with a hard bo.ndary is emplo.ed fo. the analysis. Utilizing a pro.er translatio.al additio. theo.em fo. expressing the incident spherical wave in terms o. cylindrical wave expansio.s, the pro.o.ed bo.ndary co.ditio.s at the interface are satisfied. Stresses are fo.mulated by means o. wave po.ential functio.s in a three-dimensio.al(3D) manner. The effects o. the frequency and the radial distance between the so.rce and bo.eho.e o. the induced stresses are examined fo. the first cylindrical mo.es o.er frequency spectra. Two.permeability co.ditio.s fo. the interface and three types o. so.ls fo. the po.o.s fo.matio. are co.sidered thro.gho.t the analysis. To.give an o.erall o.tline o. the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has co.siderable effects o. the induced stress values. In additio., the interface permeability co.ditio. and so.l characteristics play an impo.tant ro.e in determining the dynamic respo.se o. the bo.eho.e. Finally,the o.tained results are co.pared with the relevant analyses existing in the literature fo. so.e limit cases, and go.d agreement is achieved.

关键词：

Predictio. o. selected bio.iesel fuel pro.erties using artificial neural netwo.k

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Fro.tiers in Energy 2015年第4期9卷 433-445页

作者： So.o.o. o. GIWA Sunday o. ADEKo.AYA Kayo.e o. ADAMA Mo.uf o. MUKAILA Department o. Agricultural and Mechanical Engineering College of Engineering and Environmental Studies Olabisi Onabanjo University lbogun Campus Ifo Ogun State Nigeria

Bio.iesel is an alternative fuel to.replace fo.sil- based diesel fuel. It has fuel pro.erties similar to.diesel which are generally determined experimentally. The experimental determinatio. o. vario.s pro.erties o. bio.iesel is co.tly, time co.suming and a tedio.s pro.ess. To.so.ve these pro.lems, artificial neural netwo.k （ANN） has been co.sidered as a vital to.l fo. estimating the fuel pro.erties o. bio.iesel, especially fro. its fatty acid （FA） co.po.itio.. In this study, fo.r ANNs have been designed and trained to.predict the cetane number （CN）, flash po.nt （FP）, kinematic visco.ity （KV） and density o. bio.iesel using ANN with lo.sig and purelin transfer functio.s in the hidden layer o. all the netwo.ks. The five mo.t prevalent FAs fro. 55 feedsto.ks fo.nd in the literature utilized as the input parameters fo. the mo.el are palmitic, stearic, o.eic, lino.eic and lino.enie acids except fo. density netwo.k with a sixth parameter （temperature）. o.her FAs that are present in the bio.iesels have been co.sidered based o. the number o. carbo. ato. chains and the level o. saturatio.. Fro. this study, the predictio. accuracy and the average abso.ute deviatio. o. the netwo.ks are CN （96.69%; 1.637%）, KV （95.80%; 1.638%）, FP （99.07%; 0.997%） and density （99.40%; 0.101%）. These values are reaso.ably better co.pared to.previo.s studies o. empirical co.relatio.s and ANN predictio.s o. these fuel pro.erties fo.nd in literature. Hence, the present study demo.strates the ability o. ANN mo.el to.predict fuel pro.erties o. bio.iesel with high accuracy.

关键词： bio.iesel fuel pro.erties artificial neuralnetwo.k fatty acid predictio.

Neuro.nflammatio. revisited thro.gh the micro.lial lens

在线全文

学校读者我要写书评

暂无评论

Neural Regeneratio. Research 2025年第7期20卷 1989-1990页

作者： Renato.So.o.ato.Jo.̃o.B.Relvas Institute o. Research and Inno.atio. in Health(i3S)and Institute fo. Mo.ecular and Cell Bio.o.y(IBMC) University of PortoPortoPortugal Department o. Bio.edicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuro.mmuno.o.y is emerging as a pivo.al field,shedding light o. the intricate dialo.ues between the central nervo.s system(CNS)and the immune *** explo.atio. is particularly significant in understanding micro.lia,the CNS’s innate immune cells,beyo.d the co.ventio.al co.flatio. o.“neuro.nflammatio.”and“micro.lial activatio..”This co.flatio. has clo.ded the true co.plexity o. these pro.esses,po.entially stalling scientific pro.ress and the develo.ment o. new *** challenge the lo.g-standing perspectives that have o.ersimplified these interactio.s,advo.ating fo. a deeper explo.atio. o. the dynamic relatio.ship between neuro.nflammatio. and micro.lial *** dissecting specific mo.ecular pathways,we aim to.illuminate their elabo.ate ro.es in neuro.nflammato.y respo.ses,especially in the co.text o. Alzheimer’s disease(AD).Here,neuro.nflammatio. is no. merely a passive o.server o. a direct antago.ist but a co.plex agent in the disease’s *** article calls fo. a significant paradigm shift to.ards an integrative,multi-o.ics appro.ch to.*** such a co.prehensive framewo.k is crucial fo. advancing o.r understanding o. neuro.nflammato.y co.ditio.s and paving the way fo. targeted therapeutic strategies fo. brain diseases.

关键词： inflammatio. simplified activatio.

Breakage o. dro.s and bubbles in a stirred tank： A review o.experimental studies

在线全文

学校读者我要写书评

暂无评论

Chinese Jo.rnal o. Chemical Engineering 2017年第6期25卷 698-711页

作者： Basim o. Hasan Department o. Chemical Engineering Technical University of Berlin 6ermany Department o. Chemical Engineering AI-Nahrain University lraq

The rate o. breakage o. dro.s and bubbles(fluid particles) in stirred systems is o. great co.sequence o. mass,heat, and mo.entum transpo.t pheno.ena. Therefo.e, o.er the years, the to.ic has gained a co.siderable attentio. fro. the researchers to.study and characterize this pheno.eno.. In present wo.k, the experimental studies o. breakage pheno.eno. in a stirred tank in the last fo.r decades were reviewed. The review highlighted the investigated experimental co.ditio.s and the majo. findings co.cerning the breakage mechanism and the effect o. o.erating co.ditio.s. The discrepancy and co.tradictio.s o. the o.tco.es o. tho.e studies were specified and discussed. Experimental o.servatio.s and co.clusio.s co.cerning the breakage characterizatio. parameters,such as defo.matio., breakage pro.ability, breakage time, and breakage lo.atio. were presented and co.mented o.. Po.sible future refinements and pro.pective were reco.mended. The review indicated that there are clear discrepancies and co.tradictio.s between previo.s studies regarding the effect o. so.e o.erating parameters and the values o. breakage time, breakage pro.ability, number o. daughter particles, and breakage lo.atio. relative to.the impeller. In additio., there are still many scientific gaps that need to.be studied and characterized in future by o.erco.ing specific experimental difficulties and uncertainties.

关键词： Dro. Bubble Breakage Stirred tank Review Breakage rate

Co.tributio. o. mechanical fo.ces to.structural synaptic plasticity:insights fro. 3D cellular mo.ility mechanisms

在线全文

学校读者我要写书评

暂无评论

Neural Regeneratio. Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teo.o.o.Mafalda Ribeiro.Ramo. Lara Carvalho iNo.A4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and o.gans are co.stantly subjected to.the actio. o. mechanical fo.ces fro. the extracellular enviro.ment-and the nervo.s system is no.***-intrinsic pro.erties such as membrane lipid co.po.itio.,abundance o. mechano.enso.s,and cyto.keletal dynamics make cells mo.e o. less likely to.sense these *** and extrinsic cues are integrated by cells and this co.bined info.matio. determines the rate and dynamics o. membrane pro.rusio. gro.th o. retractio.(Yamada and Sixt,2019).Cell pro.rusio.s are extensio.s o. the plasma membrane that play crucial ro.es in diverse co.texts such as cell migratio. and neuro.al synapse *** the nervo.s system,neuro.s are highly dynamic cells that can change the size and number o. their pre-and po.tsynaptic elements(called synaptic bo.to.s and dendritic spines,respectively),in respo.se to.changes in the levels o. synaptic activity thro.gh a pro.ess called *** plasticity is a hallmark o. the nervo.s system and is present thro.gho.t o.r lives,being required fo. functio.s like memo.y fo.matio. o. the learning o. new mo.o. skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

Limno.o.ical instrumentatio. in the middle o. the 19^(th) century:the first temperature and density pro.iles measured in the Dead Sea

在线全文

学校读者我要写书评

暂无评论

Chinese Jo.rnal o. o.eano.o.y and Limno.o.y 2015年第6期33卷 1496-1504页

作者： Aharo. oren Department o. Plant and Enviro.mental Sciences Alexander Silberman Institute of Life SciencesHebrew University of Jerusalem

The first mo.em survey o. the Dead Sea was perfo.med by the Geo.o.ical Survey o. Israel in 1959-1960, and the repo.t published remains the baseline study fo. o.r understanding o. the physical and chemical pro.erties o. the lake. At the time the Dead Sea was a mero.ictic lake with a stro.g salinity gradient separating the deep waters （〉40 m depth） fro. the less saline surface waters. A few results o. analyses o. deeper water samples co.lected in the 1930s were repo.ted, but o.erall we have very little info.matio. abo.t the structure o. the lake＇s water co.umn befo.e the 1959-1960 survey. Ho.ever, it is little kno.n that data o. the physical and the chemical structure o. the Dead Sea water co.umn were o.tained already in the middle o. the 19~ century, and the info.matio. co.lected then is highly relevant fo. the reco.structio. o. the limno.o.ical pro.erties o. the lake in earlier times. The expeditio. o. Lieutenant William Lynch （U.S. Navy） in 1848 repo.ted the presence o. a temperature minimum at a depth o.-18 m, and also.retrieved a water sample co.lected clo.e to.the bo.to. fo. chemical analysis. In 1864, the French Dead Sea explo.atio. by the Duc de Luynes and his crew yielded detailed density and salinity pro.iles fo. a number o. sampling statio.s. The results o. these pio.eering studies are discussed here, as well as the sampling equipment and measuring instruments used by the 1848 and the 1864 expeditio.s.

关键词： Dead Sea stratificatio. research histo.y sampling equipment self-registering thermo.eter

p53:no. just a tumo. suppresso.

在线全文

学校读者我要写书评

暂无评论

Jo.rnal o. Mo.ecular Cell Bio.o.y 2019年第7期11卷 539-543页

作者： Mo.he oren Department o. Mo.ecular Cell Bio.o.y Weizmann Institute of ScienceRehovot 76100Israel

No.adays,p53 is like a Dreamliner airplane,riding the high skies o. cancer research with dignity and *** do.no. have to.be a card-bearing p53 researcher to.kno. abo.t p53,care abo.t it,and respect ***,this was no. always *** a matter o. fact,in the first years o. p53 research,fro. its disco.ery in the late 1970's to.abo.t the end o. the 1980's,p53 was mo.e like a kite:o.e mo.ent high up in the air,the next mo.ent being dragged o. the gro.nd.

关键词： Dreamliner dignity gro.nd