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Chemo.mechanical co.plings in co.pacted argillite submitted to.high-pH enviro.ment

Jo.rnal o. Ro.k Mechanics and Geo.echnical Engineering 2010年第4期2卷 314-320页

作者： o. cuisinier F. Masro.ri LAEGo Nancy Université

In the French co.cept o. deep nuclear wastes repo.ito.y, the galleries sho.ld be backfilled with excavated argillite after the site explo.tatio. perio.. After several tho.sands o. years, the degradatio. o. the co.crete lining o. the galleries will generate alkaline fluid (pH > 12) that will diffuse thro.gh the backfill. The o.jective o. the paper is to.describe the influence o. such so.ute diffusio. o. the micro.tructure and the mechanical behavio. o. co.pacted argillite. Saturated-po.tlandite water was circulated thro.gh co.pacted samples fo. 3, 6 and 12 mo.ths at 20 °C o. 60 °C, respectively. The micro.tructures befo.e and after fluid circulatio. were determined with mercury intrusio. po.o.imetry. Since it was planned to.intro.uce additives (bento.ite o. lime) in the remo.lded argillite to.backfill the deep galleries, such mixtures were also.studied. The results sho. that the influence o. the alkaline fluid o. the pro.erties o. the argillite is a functio. o. the nature o. the additive. The pure argillite undergo.s slight mo.ificatio.s that can be related to.a limited disso.utio. o. its clayey particles. Co.versely, intense alteratio. o. the bento.ite-argillite mixture was o.served. Lime additio. impro.es the mechanical characteristics o. the argillite thro.gh the precipitatio. o. cementitio.s co.po.nds.

关键词： chemo.mechanical co.plings alkaline plume argillite micro.tructure shear strength

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Dental stem cell-co.ditio.ed medium fo. tissue regeneratio.: o.timizatio. o. pro.uctio. and sto.age

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Wo.ld Jo.rnal o. Stem Cells 2022年第4期14卷 287-302页

作者： Bato.l Cho.aib Frédéric cuisinier Pierre-Yves Co.lart-Dutilleul Labo.ato.y Bio.ngineering and Nano.ciences UR_UM104 University of MontpellierMontpellier 34000France

BACKGRo.ND Mesenchymal stem cells(MSC)effects o. tissue regeneratio. are mainly mediated by their secreted substances(secreto.e),inducing their paracrine *** Co.ditio.ed medium(CM),including so.uble facto.s(pro.eins,nucleic acids,lipids)and extracellular vesicles is emerging as a po.ential alternative to.cell ***,the manufacturing o. CM suffers fro. variable pro.edures and pro.o.o.s leading to.varying results between ***,there is no.welldefined o.timized pro.edure targeting specific applicatio.s in regenerative *** To.fo.us o. co.ditio.ed medium pro.uced fro. dental MSC(DMSC-CM),we reviewed the current parameters and manufacturing pro.o.o.s,in o.der to.pro.o.e a standardizatio. and o.timizatio. o. these manufacturing *** We have selected all publicatio.s investigating the effects o. dental MSC secreto.e in in vitro.and in vivo.mo.els o. tissue regeneratio.,in acco.dance with the PRISMA *** A to.al o. 351 results were *** based o. the inclusio. criteria described abo.e,118 unique articles were included in the systematic ***-CM pro.uctio. was co.sidered at three stages:befo.e CM reco.ery(cell so.rces fo. CM),during CM pro.uctio.(culture co.ditio.s)and after pro.uctio.(CM treatment).Co.CLUSIo. No.clear co.sensus co.ld be reco.ered as evidence-based metho.s,but we were able to.describe the mo.t co.mo.ly used pro.o.o.s:do.o.s under 30 years o. age,dental pulp stem cells and exfo.iated deciduo.s to.th stem cells with cell passage between 1 and 5,at a co.fluence o. 70%to.80%.CM were o.ten co.lected during 48 h,and sto.ed at-80°*** is impo.tant to.po.nt o.t that the preco.ditio.ing enviro.ment had a significant impact o. DMSCCM co.tent and efficiency.

关键词： Tissue engineering Mesenchymal stem cells Dental Co.ditio.ed medium Secreto.e Regeneratio.

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Micro.tructural evo.utio. and physico.chemical behavio. o. co.pacted clayey so.l submitted to.an alkaline plume

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Jo.rnal o. Ro.k Mechanics and Geo.echnical Engineering 2010年第2期2卷 169-177页

作者： D.Deneele o.cuisinier V.Hallaire F.Masro.ri Labo.ato.re Central des Po.ts et Chaussées Nancy Université UMR INRA/Agro.ampus

In the French co.cept o. deep nuclear waste repo.ito.ies,the galleries sho.ld be backfilled with excavated argillite after the site has been *** additives like lime co.ld be used to.impro.e the mechanical characteristics o. the *** tho.sands o. years,the degradatio. o. the co.crete lining o. the galleries will generate an alkaline so.utio.（pH value 12） that will diffuse thro.gh the *** study presents the effect o. a saturated Ca（o.）_2 so.utio. circulatio. thro.gh lime-treated sample at 60 ℃ fo. 3,6 and 12 mo.ths,*** effect o. such circulatio. o. the lime-treated Mano.s argillite（MA） was assessed by petro.raphical examinatio. co.pled to.image analysis and scanning electro. micro.co.y（SEM） equipped with energy dispersive X-ray（EDX） analyser o. so.l *** o.jective o. this study is to.make the link amo.g the mineralo.ical transfo.matio.s,the textural and mechanical changes pro.uced in the co.pacted clayey so.l as a co.sequence o. the alkaline so.utio. circulatio..

关键词： argillite lime treatment petro.raphical examinatio. scanning electro. micro.co.y(SEM) image analysis micro.tructure

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Insulin Effect o. Gene Expressio. o. Dental Pulp Cell during o.teo.ifferentiatio.

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Jo.rnal o. Bio.ciences and Medicines 2022年第1期10卷 99-107页

作者： Fidan Huseyno.a Alamdar Mammado. Irada Huseyno.a Frédéric cuisinier Véro.ique Barragan-Mo.tero LBN University Montpellier Montpellier France Institute Mo.ecular Bio.o.y and Bio.echno.o.y o. ANAS Baku Azerbaijan

Insulin, an o.d but still actual mo.ecule, has many ro.es in vario.s cellular pro.esses including bo.e fo.matio. and also.angio.enesis. Insulin effects o. different cell types were investigated, and we intended to.check its effect o. dental pulp cells (DPC) during o.teo.last differentiatio.. First, bo.e differentiatio. ability o. iso.ated dental pulp cells was assessed by alizarin red (AR) staining. Insulin increased dental pulp cell pro.iferatio. after 25 ho.rs o. culture. It increased mRNA expressio. o. o.teo.enic markers such as Co.1, RunX2, ALP, o.c, Mef2C and expressio. o. genes invo.ved in TGF b pathway such as Smad3, TSP1, VEGF at different time po.nts.

关键词： Dental Pulp Cells Gene Expressio. o.teo.ifferentiatio. Insulin

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Allo.enic banking o. dental pulp stem cells fo. inno.ative therapeutics

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Wo.ld Jo.rnal o. Stem Cells 2015年第7期7卷 1010-1021页

作者： Pierre-Yves Co.lart-Dutilleul Franck Chaubro. Jo.n De Vo. Frederic J cuisinier Bio.Nano.Labo.ato.y EA 4203 Montpellier 1 University Institut Clinident Bio.Pharma Biopole Clermont-Limagne INSERM U1040 Genetic Instability of Human Pluripotent Stem Cells CHRU Mo.tpellier Hospital Saint-EloiInstitut de Recherche en Biothérapie

Medical research in regenerative medicine and cellbased therapy has bro.ght enco.raging perspectives fo. the use o. stem cells in clinical trials. Multiple types o. stem cells, fro. pro.enito.s to.pluripo.ent stem cells, have been investigated. Amo.g these, dental pulp stem cells(DPSCs) are mesenchymal multipo.ent cells co.ing fro. the dental pulp, which is the so.t tissue within teeth. They represent an interesting adult stem cell so.rce because they are reco.ered in large amo.nt in dental pulps with no.-invasive techniques co.pared to.o.her adult stem cell so.rces. DPSCs can be o.tained fro. discarded teeth, especially wisdo. teeth extracted fo. o.tho.o.tic reaso.s. To.shift fro. pro.ising preclinical results to.therapeutic applicatio.s to.human, DPSCs must be prepared in clinical grade lo.s and transfo.med into.advanced therapy medicinal pro.ucts(ATMP). As the pro.uctio. o. patient-specific stem cells is co.tly and time-co.suming, allo.enic bio.anking o. clinical grade human leuko.yte antigen(HLA)-typed DPSC lines pro.ides efficient inno.ative therapeutic pro.ucts. DPSC bio.anks represent industrial and therapeutic inno.atio.s by using discarded bio.o.ical tissues(dental pulps) as a so.rce o. mesenchymal stem cells to.pro.uce and sto.e, in go.d manufacturing practice(GMP) co.ditio.s, DPSC therapeutic batches. In this review, we discuss abo.t the challenges to.transfer bio.o.ical samples fro. a do.o. to.HLA-typed DPSC therapeutic lo.s, fo.lo.ing regulatio.s, GMP guidelines and ethical principles. We also.present so.e clinical applicatio.s, fo. which there is no.efficient therapeutics so.far, but that DPSCs-based ATMP co.ld po.entially treat.

关键词： Adult stem cells Multipo.ent stem cells Cell-based therapy Cell tissue bank

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摘要《ANKYLo.~号种植体周围软组织的组织学分析的动物实验研究》

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口腔生物医学 2012年第4期 226-226页

作者： Henri Tenenbaum Jean-Frano.s Schaaf Frédéric J.G cuisinier 斯特拉斯堡路易斯巴斯德大学牙科学院牙周病系斯特拉斯堡路易斯巴斯德大学牙科学院特拉斯堡路易斯巴斯德大学牙科学院生物材料系

Purpo.e&Aim:The impo.tance o. the so.t tissue-implant interface is enhanced by the presence o. a micro.gap between the implant and the abutment,which represents a co.taminatio. site fo. *** aim o. this study was to.investigate the interface between the ANKYLo. gap-free implant system and the surro.nding so.t tissues in a do. mo.el.原因与目的:种植体与修复基台的连接处存在着微隙,构成细菌的污染区域,这一特点使得软组织一种植体界面的重要性更加被重视

关键词：周围种植体 ANKYLo.

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