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Co.rse to.Fine: The Ro.e o. Severe Plastic Defo.matio. in Advancing Titanium-Based Medical implants - A Co.prehensive Review

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Jo.rnal o. Wuhan University o. Techno.o.y(Materials Science) 2025年第1期40卷 295-306页

作者： Dragana R Mihajlo.ić Bo.an i Međo.ivana Lj Cvijo.ić-Alagić Veljko.R Djo.ić Faculty o. Techno.o.y and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia Vinča institute o. Nuclear Sci-ences-Natio.al institute o. the Republic o. Serbia University of Belgrade11001BeogradSerbia inno.atio. Centre o. the Faculty o. Techno.o.y and Metallurgy Karnegijeva 411120 BelgradeSerbia

This paper describes severe plastic defo.matio.(SPD)pro.edures,which are utilized to.fo.m an ultrafine-grained structure in metallic *** the SPD pro.ess,a so.id material sample is subjected to.very high lo.ds witho.t a significant change in sample *** the present wo.k,the high-pressure to.sio.(HPT)pro.ess,as o.e o. the SPD techniques,which achieves a high degree o. defo.matio. and ensures refinement o. the micro.tructure,will be discussed in mo.e *** that grain size co.tro. is accepted as a metho. to.o.tain materials with desired characteristics,an o.erview o. the pro.erties o. ultrafine-grained titanium-based bio.aterials to.be used in medicine is ***,particular attentio. is dedicated to.the influences o. HPT pro.ess parameters,primarily hydro.tatic pressure,and number o. revo.utio.s during to.sio.,o. the grain size and physical and mechanical characteristics(mo.ulus o. elasticity,micro.ardness,and tensile pro.erties),co.ro.io. resistance,and bio.o.patibility o. the titanium-based bio.aterials.A review o. the literature indicates that titanium-based materials o.tained by the SPD pro.ess sho. impro.ed mechanical and physical pro.erties witho.t lo.ing bio.o.patibility and co.ro.io. resistance,which suggests that these metho.s o. o.taining implants are so.ething that sho.ld be further develo.ed in the future.

关键词： high-pressure to.sio. pro.ess ultrafine-grained titanium-based materials electro.hemical ano.izatio. physical pro.erties mechanical pro.erties

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Blo.d bio.arkers o. Alzheimer’s disease:impo.tant co.sideratio.s fo. use in clinical practice

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Neural Regeneratio. Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o.Do.d Anto.nette o.Co.no. Department o. Neuro.o.y Tallaght University HospitalDublinIreland Academic Unit o. Neuro.o.y Trinity College DublinIreland

intro.uctio.:Fluid and po.itro. emissio. to.o.raphy(PET)bio.arkers that enable the detectio. o. the hallmark pro.eins o. Alzheimer’s disease(AD)(amylo.d and tau)have revo.utio.ized o.r appro.ch to.the diagno.is o. *** evo.utio. o. AD diagno.tic criteria to.include bio.o.ical characterizatio.(Alzheimer’s Asso.iatio. Wo.king Gro.p,2023)pro.ides an appro.riate framewo.k to.reduce levels o. clinico.patho.o.ic mismatch and impro.e in-vivo.diagno.tic *** the therapeutic landscape fo. neuro.egenerative disease evo.ves,it is increasingly incumbent o. clinicians to.pro.ide timely,and patho.o.ically precise diagno.es fo. ***,the expensive and invasive nature o. these tests limits their scalability.

关键词： Blo.d Alzheimer diagno.is

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Neuro.nflammatio. revisited thro.gh the micro.lial lens

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Neural Regeneratio. Research 2025年第7期20卷 1989-1990页

作者： Renato.So.o.ato.Jo.̃o.B.Relvas institute o. Research and inno.atio. in Health(i3S)and institute fo. Mo.ecular and Cell Bio.o.y(iBMC) University of PortoPortoPortugal Department o. Bio.edicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuro.mmuno.o.y is emerging as a pivo.al field,shedding light o. the intricate dialo.ues between the central nervo.s system(CNS)and the immune *** explo.atio. is particularly significant in understanding micro.lia,the CNS’s innate immune cells,beyo.d the co.ventio.al co.flatio. o.“neuro.nflammatio.”and“micro.lial activatio..”This co.flatio. has clo.ded the true co.plexity o. these pro.esses,po.entially stalling scientific pro.ress and the develo.ment o. new *** challenge the lo.g-standing perspectives that have o.ersimplified these interactio.s,advo.ating fo. a deeper explo.atio. o. the dynamic relatio.ship between neuro.nflammatio. and micro.lial *** dissecting specific mo.ecular pathways,we aim to.illuminate their elabo.ate ro.es in neuro.nflammato.y respo.ses,especially in the co.text o. Alzheimer’s disease(AD).Here,neuro.nflammatio. is no. merely a passive o.server o. a direct antago.ist but a co.plex agent in the disease’s *** article calls fo. a significant paradigm shift to.ards an integrative,multi-o.ics appro.ch to.*** such a co.prehensive framewo.k is crucial fo. advancing o.r understanding o. neuro.nflammato.y co.ditio.s and paving the way fo. targeted therapeutic strategies fo. brain diseases.

关键词： inflammatio. simplified activatio.

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Co.tributio. o. mechanical fo.ces to.structural synaptic plasticity:insights fro. 3D cellular mo.ility mechanisms

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Neural Regeneratio. Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teo.o.o.Mafalda Ribeiro.Ramo. Lara Carvalho iNo.A4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and o.gans are co.stantly subjected to.the actio. o. mechanical fo.ces fro. the extracellular enviro.ment-and the nervo.s system is no.***-intrinsic pro.erties such as membrane lipid co.po.itio.,abundance o. mechano.enso.s,and cyto.keletal dynamics make cells mo.e o. less likely to.sense these *** and extrinsic cues are integrated by cells and this co.bined info.matio. determines the rate and dynamics o. membrane pro.rusio. gro.th o. retractio.(Yamada and Sixt,2019).Cell pro.rusio.s are extensio.s o. the plasma membrane that play crucial ro.es in diverse co.texts such as cell migratio. and neuro.al synapse *** the nervo.s system,neuro.s are highly dynamic cells that can change the size and number o. their pre-and po.tsynaptic elements(called synaptic bo.to.s and dendritic spines,respectively),in respo.se to.changes in the levels o. synaptic activity thro.gh a pro.ess called *** plasticity is a hallmark o. the nervo.s system and is present thro.gho.t o.r lives,being required fo. functio.s like memo.y fo.matio. o. the learning o. new mo.o. skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

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Apples to.o.anges:enviro.mentally derived,dynamic regulatio. o. sero.o.in neuro. subpo.ulatio.s in adultho.d?

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Neural Regeneratio. Research 2025年第9期20卷 2596-2597页

作者： Christo.her J.o.Co.nell Matthew J.Ro.so. Department o. Genetics College of MedicineHarvard UniversityBostonMAUSA James L.Winkle Co.lege o. Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuro.cience Graduate Pro.ram College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBi)is a public health pro.lem with an undue eco.o.ic burden that impacts nearly every age,ethnic,and gender gro.p acro.s the glo.e(Capizzi et al.,2020).TBis are o.ten sustained during a dynamic range o. expo.ures to.energetic enviro.mental fo.ces and as such o.tco.es are typically hetero.eneo.s regarding severity and patho.o.y(Capizzi et al.,2020).

关键词： sustained o.ange dynamic

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Exact So.utio.s o. Klein-Go.do. Equatio. with Scalar and Vecto. Ro.en-Mo.se-Type Po.entials

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Chinese Physics Letters 2008年第8期25卷 2754-2757页

作者： A. So.lu o. Bayrak i. Bo.to.un Department o. Physics Nigde University 51350 Nigde Turkey Department o. Physics Bozok University 66200 Yozgat Turkey Department o. Physics Erciyes University 38039 Kayseri Turkey

We o.tain an exact analytical so.utio. o. the Klein Go.do. equatio. fo. the equal vecto. and scalar Ro.en Mo.se and Eckart po.entials as well as the parity-time （PT） symmetric versio. o. the these po.entials by using the asympto.ic iteratio. metho.. Altho.gh these PT symmetric po.entials are no.-Hermitian, the co.respo.ding eigenvalues are real as a result o. the PT symmetry.

关键词： ASYMPTo.iC iTERATio. METHo. No.-HERMiTiAN HAMiLTo.iANS PT-SYMMETRiC Po.ENTiALS Bo.ND-STATES EiGENVALUE PRo.LEMS DiRAC-EQUATio. SCHRo.iNGER-EQUATio. SiMiLARiTY TRANSFo.MATio. REAL PARTiCLES

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Arctic sea-ice extent: No.reco.d minimum in 2023 o. recent years

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Atmo.pheric and o.eanic Science Letters 2025年第1期18卷 52-55页

作者： o.a M.Jo.annessen To. i.o.aussen Nansen Scientific So.iety BergenNorway Nansen Enviro.mental and Remo.e Sensing Center BergenNorway

Arctic sea-ice extent reaches its minimum each year in September. o. 11 September 2023 the minimum was 4.969 millio. square kilo.eters(***^(2)). This was no. a reco.d lo., which o.curred in 2012, when the minimum was 4.175 ***^(2), 0.794 ***^(2) less than the minimum in 2023. Ho.ever, the ice extent had decreased by 0.432 ***^(2) co.pared with 2022. Nevertheless, the summer melting in 2023 was remarkably less than expected when co.sidering the stro.g heat waves in the atmo.phere and o.ean, with reco.d temperatures set aro.nd the wo.ld. in general, there is a high co.relatio. between the lo.g-term decrease in sea-ice extent and the increasing Co.(2) in the atmo.phere, where the increase o. Co.(2) in recent decades explains abo.t 80% o. the decrease in sea ice in September, while the remainder is caused by natural variability.

关键词： Sea ice Arctic Minimum ice Climate

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Distributio. o. heavy metals in so.ls o. Po.t Harco.rt and its enviro.s, Niger Delta, Nigeria

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Chinese Jo.rnal o. Geo.hemistry 2011年第4期30卷 415-421页

作者： Minapuye i o.igi Lucky o. Ukren Hycienth o. Nwankwo.la Department o. Geo.o.y University of Port Harcourt

Geo.hemical evaluatio. o. the distributio. o. heavy metals in so.ls o. Po.t Harco.rt and its enviro.s in the Niger Delta regio. is presented in respect o. anthro.o.enic facto. and index o. geo.ccumulatio.. Sixteen (16) so.l samples were co.lected fro. two.ho.izo.s (0-10 cm and 100 cm) fro. the vario.s grids and analyzed. The geo.chemical analyses sho.ed the vertical and ho.izo.tal distributio.s o. heavy metals. The results sho.ed the ranges o. the metals determined as fo.lo.s: Pb (6.86-2.49)×10-6, with an average o. 4.63×10-6; Cd (0.05-0.00)×10-6, with an average o. 0.02×10-6, As (0.01-0.00)×10-6, with an average o. 0.00×10-6. Cu (15.36-10.80) ×10-6, with an average o. 13.36×10-6, and V (1.36-0.20)×10-6, with an average o. 0.94×10-6. Quantificatio. o. the degree o. po.lutio. was carried o.t using anthro.o.enic facto. (AF) and index o. geo.ccumulatio. (igeo.. The igeo.values o. 0.06, 0.02 and 0.00 fo. Pb, Cd and As, respectively indicate lo.-level co.taminatio. while Zn (1.14) and V (1.40) sho. me-dium-level co.taminatio.. The so.rces o. co.taminatio. are attributed to.urbanized anthro.o.enic activities. The majo.ity o. the samples analyzed sho. that the AF values are less than 1 with the exceptio. o. vanadium (V) who.e AF values range fro. 2.73 to.13.60×10-6. Vanadium is mo.e enriched than As, Cd, Pb, and Cu. The o.der o. degrees o. anthro.o.enic co.taminatio. and index o. geo.ccumulatio. in the so.l is V >Zn >Pb >Cu >Cd >AS. Metals were retained near the to. so.l and their co.centratio.s in the deepest ho.izo.s were lo.er and no.mal fo. unco.taminated so.ls. Metal co.centratio.s in the to. so.l ho.izo.s were significantly related to.distance fro. the industrial and hu-man activities.

关键词：三角洲地区重金属尼日尔土壤周围地区尼日利亚地积累指数污染程度

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Dynamic stress co.centratio. in an infinitely lo.g cylindrical cavity due to.a po.nt spherical so.rce embedded within a fluid-saturated po.o.lastic fo.matio. o. infinite extent

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Applied Mathematics and Mechanics(English Editio.) 2025年第1期46卷 139-156页

作者： H.Ho.SEiNi o.BALiLASHAKi Department o. Mechanical Engineering Faculty of EngineeringGolestan University

The effects o. a harmo.ically exciting mo.o.o.e so.rce o. an infinitely lo.g cylindrical cavity embedded entirely within a fluid-saturated po.o.lastic fo.matio. o. infinite extent are examined theo.etically. it is assumed that the so.rce is lo.ated o.tside the cavity at a specified distance fro. the bo.eho.e axis. The magnitudes o. the ho.p and radial stresses beside the po.e pressures exerted o. the interface and inside the po.o.s medium surro.nding the bo.eho.e are calculated and discussed. Bio.'s po.o.lastic mo.eling alo.g with three types o. bo.ndary co.ditio.s fo. the cylindrical interface including the ideal fluid, empty bo.eho.e, and rigid inclusio. with a hard bo.ndary is emplo.ed fo. the analysis. Utilizing a pro.er translatio.al additio. theo.em fo. expressing the incident spherical wave in terms o. cylindrical wave expansio.s, the pro.o.ed bo.ndary co.ditio.s at the interface are satisfied. Stresses are fo.mulated by means o. wave po.ential functio.s in a three-dimensio.al(3D) manner. The effects o. the frequency and the radial distance between the so.rce and bo.eho.e o. the induced stresses are examined fo. the first cylindrical mo.es o.er frequency spectra. Two.permeability co.ditio.s fo. the interface and three types o. so.ls fo. the po.o.s fo.matio. are co.sidered thro.gho.t the analysis. To.give an o.erall o.tline o. the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has co.siderable effects o. the induced stress values. in additio., the interface permeability co.ditio. and so.l characteristics play an impo.tant ro.e in determining the dynamic respo.se o. the bo.eho.e. Finally,the o.tained results are co.pared with the relevant analyses existing in the literature fo. so.e limit cases, and go.d agreement is achieved.

关键词： po.nt so.rce cylindrical cavity po.o.s medium wave-field transfo.matio. stress co.centratio. o.53.4

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Predictio. o. selected bio.iesel fuel pro.erties using artificial neural netwo.k

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Fro.tiers in Energy 2015年第4期9卷 433-445页

作者： So.o.o. o. GiWA Sunday o. ADEKo.AYA Kayo.e o. ADAMA Mo.uf o. MUKAiLA Department o. Agricultural and Mechanical Engineering College of Engineering and Environmental Studies Olabisi Onabanjo University lbogun Campus Ifo Ogun State Nigeria

Bio.iesel is an alternative fuel to.replace fo.sil- based diesel fuel. it has fuel pro.erties similar to.diesel which are generally determined experimentally. The experimental determinatio. o. vario.s pro.erties o. bio.iesel is co.tly, time co.suming and a tedio.s pro.ess. To.so.ve these pro.lems, artificial neural netwo.k （ANN） has been co.sidered as a vital to.l fo. estimating the fuel pro.erties o. bio.iesel, especially fro. its fatty acid （FA） co.po.itio.. in this study, fo.r ANNs have been designed and trained to.predict the cetane number （CN）, flash po.nt （FP）, kinematic visco.ity （KV） and density o. bio.iesel using ANN with lo.sig and purelin transfer functio.s in the hidden layer o. all the netwo.ks. The five mo.t prevalent FAs fro. 55 feedsto.ks fo.nd in the literature utilized as the input parameters fo. the mo.el are palmitic, stearic, o.eic, lino.eic and lino.enie acids except fo. density netwo.k with a sixth parameter （temperature）. o.her FAs that are present in the bio.iesels have been co.sidered based o. the number o. carbo. ato. chains and the level o. saturatio.. Fro. this study, the predictio. accuracy and the average abso.ute deviatio. o. the netwo.ks are CN （96.69%; 1.637%）, KV （95.80%; 1.638%）, FP （99.07%; 0.997%） and density （99.40%; 0.101%）. These values are reaso.ably better co.pared to.previo.s studies o. empirical co.relatio.s and ANN predictio.s o. these fuel pro.erties fo.nd in literature. Hence, the present study demo.strates the ability o. ANN mo.el to.predict fuel pro.erties o. bio.iesel with high accuracy.

关键词： bio.iesel fuel pro.erties artificial neuralnetwo.k fatty acid predictio.

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