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Cisplatin-induced activatio. o. TGF-βsignaling co.tributes to.drug resistance

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o.co.o.y Research 2024年第1期32卷 139-150页

作者： SAYAKA IMATSUJI YUKIKo.UJIE HIRo.UKI o.AKE MASAYA imoto SUSUMU ITo. ETSU TASHIRo Department o. Bio.ciences and Info.matics Faculty of Science and TechnologyKeio UniversityYokohama223-8522Japan Department o. Neuro.o.y Juntendo University Graduate School of MedicineTokyo113-8421Japan Labo.ato.y o. Bio.hemistry Showa Pharmaceutical UniversityTokyo194-8543Japan

Gro.ing evidence suggests an asso.iatio. between epithelial-mesenchymal transitio.(EMT),a hallmark o. tumo. malignancy,and chemo.esistance to.a number o. anti-cancer ***,the mechanism o. EMT inductio. in the pro.ess o. acquiring anti-cancer drug resistance remains *** address this issue,we o.tained a number o. cisplatin-resistant clo.es fro. Lo.o.cells and fo.nd that almo.t all o. them lo.t cell-cell *** these clo.es,the epithelial marker E-cadherin was do.nregulated,whereas the mesenchymal marker N-cadherin was ***,the expressio. o. EMT-related transcriptio. facto.s,including Slug,was *** the o.her hand,the upregulatio. o. o.her mesenchymal marker Vimentin was weak,suggesting that the mesenchymal-like pheno.ypic changes o.curred in these cisplatin-resistant *** mesenchymal-like features o. cisplatin-resistant clo.es were partially reversed to.parental epithelial-like features by treatment with transfo.ming gro.th facto.-β(TGF-β)recepto. kinase inhibito.s,indicating that TGF-βsignaling is invo.ved in cisplatin-induced the mesenchymallike pheno.ypic ***,cisplatin was o.served to.enhance the secretio. o. TGF-βinto.the culture media witho.t influencing TGF-βgene *** results suggest that cisplatin may induce the mesenchymal-like pheno.ypic changes by enhancing TGF-βsecretio.,ultimately resulting in drug resistance.

关键词： Cisplatin EMT Chemo.resistance TGF-β

A Review: Manufacturing, and Pro.erties o. the D-Fructo.e Epimer D-Allulo.e (D-Psico.e)

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Advances in Bio.cience and Bio.echno.o.y 2024年第9期15卷 522-542页

作者： o.ama o. Ibrahim Bio.nno.atio. LLC Gurnee IL USA

D-allulo.e, also.kno.n by the name D-psico.e o. just allulo.e, is a rare keto.sugar epimer o. D-fructo.e in the third carbo. (C3), and naturally o.curs in small quantity in fruits such as grapes and figs. It is lo. calo.ie sweetener pro.uced enzymatically fro. D-fructo.e by enzymes D-keto.e 3-epimerase (DKEase) family. D-allulo.e has a similar taste, texture and functio.ality as sweetener co.paring to.high calo.ie sweetener sugar table sucro.e. D-allulo.e is po.rly metabo.ized in the bo.y with minimal impact o. blo.d sugar levels making it a natural lo.-calo.ie sweetener. This pro.erty makes D-allulo.e an attractive sweetener fo. diabetes and fo. bo.y weight management. Labo.ato.y studies o. D-allulo.e intake demo.strated its safety with no.significant adverse effects. United States Fo.d and Drug Administratio. (FDA) has granted D-allulo.e the status o. Generally Reco.nized as Safe (GRAS). Plus, it is co.sidered safe fo. human co.sumptio. by regulato.y o.ganizatio.s in o.her co.ntries except in Euro.ean Unio. due to.their request fo. further labo.ato.y testing. Maximum acceptable daily intake o. D-allulo.e is 0.9 grams per kilo.ram bo.y weight. Excessive intake fo. mo.e than the reco.mended daily intake co.ld lead to.so.e side effects such as gastro.ntestinal disco.fo.t o. laxative effects. In general, D-allulo.e is co.sidered o.e o. the preferred natural lo. calo.ies sweeteners fo. tho.e seeking an alternative to.table sugar sucro.e.

关键词： D-Allulo.e D-Keto.e 3-Epimerase (DKEase) D-Tagato.e 3-Epimerase (DTEase) D-Allulo.e 3-Epimerase (DAEase) D-Psico.e 3-Epimerase (DPEase)

Develo.ment and Evaluatio. o. 3D Delivery Animatio. So.tware Designed to.Impro.e the Mo.her’s and Spo.se’s Satisfactio. with Delivery

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Health 2024年第5期16卷 439-458页

作者： Ayako.Sasaki Sachi Chikazawa No.ima Kumiko.To.ita Takako.Hatakeyama Keiko.imoto Yasufumi imoto No.utane Faculty o. Nursing Osaka Medical and Pharmaceutical University Takatsuki Japan imoto Ladies Clinic Echizen Japan

Purpo.e: To.clarify the effectiveness o. 3-D delivery animatio. so.tware fo. the mo.her’s and husband’s satisfactio. with delivery. Subjects and Metho.: We independently develo.ed a so.tware applicatio. used to.display the pelvic regio. and explain the labo. pro.ess. The study invo.ved a co.labo.atio. with ho.pital staff who.recruited 18 primiparo.s and 18 multiparo.s mo.hers who.were ho.pitalized fo. delivery at Facility A. The midwife explained the pro.ess o. delivery using the “Delivery Animatio. So.tware”. A self-administered, ano.ymo.s questio.naire was distributed and analyzed separately fo. primiparo.s and multiparo.s mo.hers and their husbands. Results: 1) Fo. bo.h primiparo.s and multiparo.s co.ples, bo.h mo.hers and their husbands gained a significantly higher level o. understanding after delivery than during pregnancy. 2) The Self-Evaluatio. Scale fo. Experience o. Delivery results were as fo.lo.s: “I did my best fo. the baby even if it was painful” was selected mo.e o.ten fo. “birth co.ing skills”;“reliable medical staff” was selected mo.e o.ten fo. “physio.o.ical birth pro.ess”;“the birth pro.ressed as I expected” was selected frequently by primiparo.s mo.hers;and “the birth pro.ressed smo.thly” was selected o.ten by multiparo.s mo.hers. 3) In terms o. husbands’ satisfactio. with the delivery, “I was satisfied with the delivery”, “I was given an easy-to.understand explanatio.”, and “They explained the pro.ess to.me” was selected o. primiparo.s and multiparo.s fathers. 4) All primiparo.s and multiparo.s mo.hers po.itively evaluated whether the delivery animatio. was helpful in understanding the pro.ess o. delivery. Co.clusio.: The delivery animatio. was effective in impro.ing the understanding and satisfactio. o. bo.h the mo.hers and their husbands.

关键词： Mo.her Spo.se Satisfactio. 3D Delivery Animatio. So.tware

Co.genital Meso.lastic Nephro.a: A Case Repo.t

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o.en Jo.rnal o. Pediatrics 2024年第5期14卷 834-840页

作者： E. A. Alinno. o. C. Ugwa I. o. Nnamani Department o. Paediatrics University of Port Harcourt Teaching Hospital Port Harcourt Nigeria Department o. Anato.ical Patho.o.y University of Port Harcourt Teaching Hospital Port Harcourt Nigeria

Backgro.nd: Co.genital Meso.lastic Nephro.a (CMN) is a mesenchymal renal tumo.r o. early life. With a median diagno.is o. two.mo.ths and o.er 90% o. cases o.curring within the first year o. life, it is the mo.t prevalent no.-Wilms’ renal tumo.r. Even tho.gh imaging can be used as a diagno.ing to.l, it is frequently identified in the neo.atal perio. when the baby has an abdo.inal mass. There are three different histo.o.ic types: mixed, cellular, and classic. Radical nephrecto.y is the usual mo.e o. treatment, tho.gh adjuvant chemo.herapy may be necessary fo. the cellular type, which may be aggressive. Case presentatio.: We repo.t o. a case o. a 2-day-o.d term male neo.ate bo.n to.a 27-year-o.d mo.her thro.gh spo.taneo.s vertex delivery (SVD). He presented with a right-sided abdo.inal mass fro. birth. An abdo.inal ultraso.nd scan revealed a huge, well-circumscribed hetero.eneo.s so.t tissue mass in the right hemi-abdo.en extending to.the left side, measuring 10.2 cm by 8.0 cm. He underwent a right radical nephrecto.y with a tumo.r weight o. 450 g and a size o. 18 cm × 15 cm × 6 cm. Histo.atho.o.ical diagno.is was Co.genital Meso.lastic Nephro.a (cellular type) Stage 1. Co.clusio.: Any infant with a renal tumo.r sho.ld be evaluated fo. co.genital meso.lastic nephro.a. Detailed investigatio. and co.plete resectio. are fundamental fo. ensuring an excellent o.tco.e.

关键词： Co.genital Meso.lastic Nephro.a Nephrecto.y Neo.ate

Abso.ute Wall Thickness Measurement o. Co.ducting Plates Using Pulsed Eddy Currents

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Jo.rnal o. Electro.agnetic Analysis and Applicatio.s 2024年第3期16卷 25-41页

作者： Victo.-o. de Haan Riccardo.Sco.tini Bo.Physics Research and Investigatio.s BV Puttershoek Netherlands

The metho. using pulsed eddy currents to.determine the thickness o. a co.ductio. plate is extended to.enable the simultaneo.s measurement o. the plate thickness and material pro.erties. Fo. o.timal perfo.mance, a pro.e must be designed depending o. the thickness range that sho.ld be accessible. The need fo. a calibratio. o. the material pro.erties o. a co.ducting plate to.enable the measurement o. its thickness has been remo.ed. All that is needed is a pro.e with kno.n dimensio.s and suitable hardware to.create a current pulse and measure a transient magnetic inductio..

关键词： Pulsed Eddy Currents Wall Thickness Abso.ute and Relative Measurements

Numerical So.utio.s o. the Classical and Mo.ified Buckley-Leverett Equatio.s Applied to.Two.Phase Fluid Flo.

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o.en Jo.rnal o. Fluid Dynamics 2024年第3期14卷 184-204页

作者： Raphael de o. Garcia Graciele P. Silveira Department o. Actuarial Science Federal University of So Paulo Osasco Brazil Department o. Physics Chemistry and Mathematics Federal University of So Carlos Sorocaba Brazil

Climate change is a reality. The burning o. fo.sil fuels fro. o.l, natural gas and co.l is respo.sible fo. much o. the po.lutio. and the increase in the planet’s average temperature, which has raised discussio.s o. the subject, given the emergencies related to.climate. An energy transitio. to.clean and renewable so.rces is necessary and urgent, but it will no. be quick. In this sense, increasing the efficiency o. o.l extractio. fro. existing so.rces is crucial, to.avo.d waste and the drilling o. new wells. The purpo.e o. this wo.k was to.add diffusive and dispersive terms to.the Buckley-Leverett equatio. in o.der to.inco.po.ate extra pheno.ena in the tempo.al evo.utio. between the water-o.l and o.l-water transitio.s in the pipeline. Fo. this, the mo.ified Buckley-Leverett equatio. was discretized via essentially weighted no.-o.cillato.y schemes, co.pled with a three-stage Runge-Kutta and a fo.rth-o.der centered finite difference metho.s. Then, co.putatio.al simulatio.s were perfo.med and the results sho.ed that new features emerge in the transitio.s, when co.pared to.classical simulatio.s. Fo. instance, the dispersive term inhibits the diffusive term, adding o.cillatio.s, which indicates that the abso.ptio. o. the fluid by the po.o.s medium o.curs in a no.-ho.o.eneo.s manner. Therefo.e, based o. research such as this, decisio.s can be made regarding the replacement o. the po.o.s medium o. the insertio. o. new co.po.ents to.delay the replacement.

关键词： Co.putatio.al Fluid Dynamics Buckley-Leverett Equatio. Numerical Metho.s Two.phase Fluid Flo.

Determinants and o.tco.es o. Pregnancies amo.g Bo.ked versus Unbo.ked Patients in a Tertiary Ho.pital So.th East, Nigeria

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o.en Jo.rnal o. o.stetrics and Gyneco.o.y 2024年第1期14卷 144-161页

作者： Chijio.e S. Anyigo.-o.ah Jo.n o. Egede Chijio.e o. o.eh Chika C. Agunanne Alpho.us I. o.io.o.Chinyere C. Duru Department o. Family Medicine Alex Ekwueme Federal University Teaching Hospital Abakaliki Ebonyi State Nigeria Department o. o.stetrics and Gynaeco.o.y Alex Ekwueme Federal University Teaching Hospital Abakaliki Ebonyi State Nigeria Department o. Paediatrics Alex Ekwueme Federal University Teaching Hospital Abakaliki Ebonyi State Nigeria

Backgro.nd: Inadequate antenatal care, bo.h in co.erage and standard, has been linked with po.r pregnancy o.tco.es. In a reso.rce po.r setting, ho.e delivery is co.sidered very cheap, but the po.sible o.tco.e o. such pregnancies has been a subject o. interest. This study evaluated the asso.iatio. o. bo.king status with pregnancy o.tco.es. o.jectives: To.examine the facto.s that influence bo.king and impact o. the bo.king status o. pregnancy o.tco.es. Metho.s: This was a ho.pital-based pro.pective co.o.t study o. 240 (120 bo.ked and 120 un-bo.ked) pregnant mo.hers selected thro.gh systematic rando. sampling. The study was carried o.t at the Department o. o.stetrics and Gynaeco.o.y, Alex Ekwueme Federal University Teaching Ho.pital Abakaliki, Nigeria. Chi-square test, t-test and lo.istic regressio. were used fo. analysis. Results: The mean age o. the participants was 30.39 ± 5.05 years and 29.05 ± 6.36 years respectively fo. the bo.ked and unbo.ked. Marital status (o. = 6.35, 95% CI = 1.24 - 32.59), educatio.al status (o. = 36.40, 95% CI = 5.26-152.83), place o. residence (o. = 0.15, 95% CI = 0.06 - 0.41), partner’s suppo.t (o. = 0.05, 95% CI = 0.01 - 0.37), family suppo.t (o. = 0.03, 95% CI = 0.01 - 0.13), mo.e o. delivery (o. = 0.23, 95% CI = 0.12 - 0.46), APGAR sco.e in first minute (o. = 6.02, 95% CI = 2.45 - 14.83) and NBICU admissio. (o. = 3.75, 95% CI = 1.67 - 8.43) were asso.iated with bo.ked status. Ho.ever, being unmarried, nulliparity/grandmultiparity, lo. level o. educatio., blue co.ar jo.s, lo. inco.e, rural dwelling and po.r partner and po.r family suppo.t were asso.iated with the unbo.ked. The bo.ked parturients had a better perinatal o.tco.e co.pared the unbo.ked. Co.clusio./Reco.mendatio.: There was high prevalence o. o.erative deliveries, perinatal mo.bidity and mo.tality amo.g the unbo.ked mo.hers. Girl child educatio., emplo.ment and po.erty alleviatio. wo.ld impro.e antenatal care utilizatio..

关键词： So.io.Demo.raphic Characteristics Bo.king Status Antenatal Delivery

The Timing o. Primary Neuro.urgical Repair and Wo.nd-Site Infectio. in Children with Myelo.eningo.ele

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o.en Jo.rnal o. Mo.ern Neuro.urgery 2024年第2期14卷 137-148页

作者： Jo.eph o. o.ande Paul T. Bitrus Elizabeth I. o.ande Divisio. o. Neuro.urgery Department of Surgery University of Abuja Teaching Hospital Abuja Nigeria Po.t-Basic Scho.l o. Critical Care Nursing University of Abuja Teaching Hospital Abuja Nigeria

Backgro.nd: The o.timal time to.clo.ure o. a newbo.n with a myelo.eningo.ele has been the fo.us o. a number o. evaluatio.s. The Timing o. primary surgery has received significant attentio. due to.its relatio.ship to.repair-site infectio. that can lead to.increased mo.bidity and pro.o.ged ho.pital stays. It is o. this basis that reco.mendatio.s have utilized 48 - 72 ho.rs po.t birth as ideal time o. clo.ure. This is no. o.ly prevent infectio. at the site but also.prevent ventriculitis and neural structure damage. We therefo.e, hypo.hesized an increase in wo.nd infectio. rates in tho.e patients with delays in myelo.eningo.ele repair. Metho.s: We retro.pectively reviewed the reco.ds o. 103 children with myelo.eningo.ele treated between 2016 and 2023. At discharge the patients were fo.lo.ed up at the po.t-o.erative clinic visit 2 weeks later. Children were assigned to.1 o. 2 gro.ps, tho.e who.underwent primary neuro.urgical repair within 72 ho.rs o. delivery (Gro.p 1) and tho.e undergo.ng repair after 72 ho.rs (Gro.p 2). We co.pared the infectio. rates. Results: 103 children who.underwent myelo.eningo.ele repair were identified, with a median time fro. birth to.treatment o. 1 day. Eight (7.8 %) patients were no.ed to.have po.t-repair surgical site co.plicatio.s. There was no.significant difference in rates o. infectio. between Gro.p 1 and Gro.p 2 repair times. The presence o. infectio. was asso.iated increased length o. stay when co.pared to.neo.ates witho.t infectio.. Co.clusio.: In children with myelo.eningo.ele, the timing o. primary neuro.urgical repair appears no. to.have a significant impact o. surgical site infectio.. Clo.ure o. the spinal lesio. within the first 72 ho.rs o. life may be mo.e favo.able fo. neural damage preventio.. These results suggest that early myelo.eningo.ele repair may no. impart significantly o. the rate o. wo.nd-site infectio..

关键词： Spina Bifida Surgical Timing Excisio. and Repair Surgical Site Infectio. Myelo.eningo.ele

Mathematical Mo.eling o. the Co.Infectio. Dynamics o. HIV and Tuberculo.is Inco.po.ating Inco.sistency in HIV Treatment

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Jo.rnal o. Applied Mathematics and Physics 2024年第5期12卷 1744-1768页

作者： Sr Mary Nyambura Mwangi Virginia M. Kitetu Isaac o. o.wany Department o. Mathematics and Actuarial Science Catholic University of Eastern Africa Nairobi Kenya

A no.-linear HIV-TB co.infectio. has been fo.mulated and analyzed. The po.itivity and invariant regio. has been established. The disease free equilibrium and its stability has been determined. The lo.al stability was determined and fo.nd to.be stable under given co.ditio.s. The basic repro.uctio. number was o.tained and acco.ding to.findings, co.infectio. diminishes when this number is less than unity, and persists when the number is greater than unity. The glo.al stability o. the endemic equilibrium was calculated. The impact o. HIV o. TB was established as well as the impact o. TB o. HIV. Numerical so.utio. was also.do.e and the findings indicate that when the rate o. HIV treatment increases the latent TB increases while the co.infected po.ulatio. decreases. When the rate o. HIV treatment decreases the latent TB po.ulatio. decreases and the co.infected po.ulatio. increases. Enco.raging co.munities to.prio.itize the co.sistent treatment o. HIV infected individuals must be emphasized in o.der to.reduce the sco.rge o. HIV-TB co.infectio..

关键词： Co.Infectio. Mo.eling HIV-TB Co.Infectio. Mathematical Mo.eling Repro.uctio. Number Inco.sistent Treatment