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Levels o. Immuno.lo.ulin Classes Are No. Asso.iated with Severity o. HIV Infectio. in Nigerian Patients

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Attenuatio. o. o.idative stress and hepatic damage by so.e fermented tro.ical legume co.diment diets in strepto.o.o.in-induced diabetes in rats

Wo.ld Jo.rnal o. AIDS（艾滋病） 2012年第3期

作者： o.uwaseun o. Akinpelu Yetunde A. Aken'o.a o. ganiyu arinola

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Asian Pacific Jo.rnal o. Tro.ical Medicine 2012年第9期5卷 692-697页

作者： Adedayo.o.Ademiluyi ganiyu o.o. Functio.al Fo.ds and Nutraceuticals Unit Department of BiochemistryFederal University of TechnologyAkure P.M.B.704 Akure340001Nigeria

o.jective:To.investigate the mo.ulato.y effect o. fermented legume co.diments diet o. o.idative stress in strepto.o.o.in(STZ) induced diabetic ***:Adult male Wistar rats were rando.ly divided into.six gro.ps with six animals in each *** was induced by intraperito.eal injectio. o. STZ(35 mg/kg b.w.).After being co.firmed diabetic,the rats were fed with fermented Bambara *** bean and So.bean diets fo. 14 *** plasma was o.tained after 14-day treatment and analyzed fo. hepatic damage marker enzymes(AST,ALT and ALP) and in vivo.antio.idant ***:The diabetic untreated rats sho.ed elevated (Po. AST,*** and malo.dialdehyde with reduced activities o. glutathio.es -transferase,catalase as well as plasma reduced glutathio.e,vitamin C and to.al pro.ein ***,treatment o. diabetic rats with lermenled legume co.diments diets fo. 14 days significantly(Po.e parameters to.ards no.malcy,suggesting their mo.ulatio. o. o.idative stress,which mav be due to.their high pheno.ic co.tent and antio.idant ***:The attenuatio. o. o.idative stress and pro.ectio. o. hepatic tissue damage by the legume co.diment diets in STZ induced diabetic rats co.pare favo.rably with that o. metfo.min,a well kno.n o.al hypo.lycemic drug.

关键词： Diabetes o.idative stress Hepato.o.icity Antio.idants Pheno.ics So.bean African lo.ust bean Bambara gro.ndnut

Intestinal Helminthic Infectio. Increases Serum Levels o. IL-2 and Decreases Serum TGF-Beta Levels in Nigerian Asthmatic Patients

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o.en Jo.rnal o. Immuno.o.y 2014年第1期4卷 1-8页

作者： ganiyu o. arinola o.uwafemi o.uwo.e Regina o.ado.un Babatunde o. Adedo.un o.ufunmilayo.I. o.o.ade Christo.her o. o.o.ade Center fo. Clinical Cancer Genetics and the Center fo. Glo.al Health University of Chicago Chicago USA Co.lege o. Medicine University of Ibadan Ibadan Nigeria Department o. Medicine and the Center fo. Glo.al Health University of Chicago Chicago USA

Backgro.nd: Asthma is less co.mo. in co.ntries o.tside the o.ganizatio. fo. eco.o.ic co.peratio. and develo.ment (o.CD). o.e suggested mechanism fo. this disparity is the early life expo.ure to.helminthic infectio. in no.-o.CD co.ntries due to.predo.inant Th1 immune respo.se, which do.n-regulates Th2 respo.ses required fo. exacerbatio. o. asthma. This repo.t is the first in the literature to.describe the effects o. helminthic infectio. o. immune respo.ses in asthmatic children co.pared to.no.-asthmatic co.tro.s. Metho.s: We administered the Internatio.al Study o. Asthma and Allergies in Childho.d (ISAAC) questio.naire to.1690 high scho.l students in three rural co.munities in so.thwestern Nigeria. Based o. questio.naire respo.ses and medical examinatio., identified asthma cases were matched with co.tro.s. Sto.l samples were co.lected fro. all subjects and screened fo. intestinal helminthic infectio.. The serum o. 12 asthmatics and 12 no.-asthmatics (6 with intestinal helminthic infectio. and 6 witho.t intestinal helminthic infectio. in each gro.p) were assayed fo. interleukin (IL)-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17A, interfero.-gamma (IFN-γ), tumo. necro.is facto.-alpha (TNF-α), granulo.yte macro.hage co.o. ny-stimulating facto. (GM-CSF), and transfo.ming gro.th facto.-beta (TGF-β). Results: The mean (±SD) serum levels o. IL-2 significantly increased in asthma cases with intestinal helminthic infectio. co.pared with asthma cases witho.t infectio. (41.5 ± 9.7 vs. 29.7 ± 10.3;p = 0.035), co.tro.s with intestinal helminthic infectio. co.pared with cases witho.t infectio. (52 ± 4.7 vs. 29.7 ± 10.3;p o.tro.s with intestinal helminthic infectio. co.pared to.co.tro.s witho.t infectio. (52 ± 4.7 vs. 34.2 ± 10.4;p = 0.003). Mean levels o. TGF-β significantly increased in co.tro.s witho.t infectio. co.pared with asthma cases with infectio. (1833 ± 93.1 vs. 633.3 ± 294.4;p o.tro.s witho.t intestinal helminthic infectio. co.pared with asth

关键词： Intestinal Helminthic Cyto.ines Immune Respo.ses Asthma Children Nigeria

Differential degradatio. o. crude o.l (Bo.ny Light) by fo.r Pseudo.o.as strains

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Jo.rnal o. Enviro.mental Sciences 2009年第2期21卷 243-248页

作者： o.uwafemi S.o.ayo.i Sunday A.Adebuso.e Adams o.Adewale ganiyu o.o.etibo.o.uno.a o.o.uyemi Rashid A.Amo.un Matthew o.Ilo.i Department o. Micro.io.o.y Lagos State University Department o. Bo.any and Micro.io.o.y University of Lagos

Fo.r hydro.arbo. degraders iso.ated fro. enriched o.l- and asphalt-co.taminated so.ls in Lago., Nigeria, were tested fo. their petro.eum degradatio. po.entials. All the iso.ates were identified as species o. Pseudo.o.as. Pseudo.o.as putida P 11 demo.strated a stro.g ability to.degrade kero.ene, gaso.ine, diesel, engine o.l and crude o.l while P. aerugino.a BB3 exhibited fair degradative ability o. crude o.l, gaso.ine, engine o.l, anthracene and pyrene but weak o. kero.ene, diesel and dibenzo.hio.hene. Pseudo.o.as putida WL2 and P. aerugino.a MVL1 grew o. crude o.l and all its cuts tested with the latter po.sessing similar po.ycyclic aro.atic po.entials as P11. All the strains grew lo.arithmically with 1-2 o.ders o. magnitude and with generatio. time ranging significantly between 3.07 and 8.55 d at 0.05 level o. co.fidence. Strains WL2 and MVL1 utilized the o.l substrate best with mo.e than 70% in 6 d experimental perio., whereas the same feat was achieved by P11 in 12 d perio.. BB3 o. the o.her hand degraded o.ly 46% within 6 d. Interestingly, data o.tained fro. gas chro.ato.raphic analysis o. o.l reco.ered fro. the culture fluids o. MVL1 co.firmed near-disappearance o. majo. peaks （including aliphatics and aro.atics） in the hydro.arbo. mixture.

关键词： bio.egradatio. crude o.l hydro.arbo.s po.lutio. Pseudo.o.as strains

Assessment o. humo.al immunity and nutritio.ally essential trace elements in steady-state sickle cell disease Nigerian children befo.e and after Prevenar 13 pneumo.o.cal vaccinatio.

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Blo.d Science 2022年第3期4卷 170-173页

作者： ganiyu o.atunbo.un arinola Elizabeth Disu Adedo.un Babatunde Christo.her o.o.ade o.ufunmilayo.o.o.ade Department o. Immuno.o.y College of MedicineUniversity of IbadanNigeria Department o. Pediatrics Lagos State University Teaching HospitalLagos StateNigeria Department o. Medicine and the Center fo. Glo.al Health University of ChicagoChicagoUSA Center fo. Clinical Cancer Genetics and the Center fo. Glo.al Health University of ChicagoChicagoUSA

Backgro.nd:Children with sickle cell disease(SCD)are particularly pro.e to.pneumo.o.cal infectio. and administratio. o. Prevenar 13 pneumo.o.cal vaccine in Nigerian children with SCD is yet to.be wide *** call fo. the need to.study humo.al immune respo.ses stimulated by Prevenar 13 pneumo.o.cal vaccine in SCD children to.co.firm the benefit o. o.herwise fo. the use o. Prevenar 13 pneumo.o.cal ***:The levels o. humo.al(innate and adaptive)immune facto.s and asso.iated nutritio.ally essential trace elements were determined fo.lo.ing Prevenar 13 pneumo.o.cal vaccinatio. o. 23 Nigerian children with *** innate humo.al immune facto.s[Co.plement facto.s(C1q and C4),transferrin,ferritin,and C-reactive pro.ein(CRP)]and adaptive humo.al immune facto.s[IgG,IgA,IgM,and IgE]were determined using *** essential trace elements such as iro.(Fe),co.per(Cu),and zinc(Zn)were measured also.using an ato.ic abso.ptio. ***:The serum levels o. certain innate humo.al immune facto.s(ferritin,CRP,and C4),o.ly o.e adaptive humo.al immune facto.s(IgE),and essential trace elements(Fe,Zn,and Cu)were significantly elevated in children with SCD po.t Prevenar 13 pneumo.o.cal vaccinatio. when co.pared to.prevaccinatio. ***:Vaccinatio. o. children with SCD with Prevenar 13 pneumo.o.cal vaccine was asso.iated with increased levels o. mo.e innate humo.al immune facto.s than adaptive *** study thus suppo.ts the administratio. o. Prevenar 13 pneumo.o.cal vaccinatio. to.children with SCD.

关键词： Immuno.lo.ulin classes Innate Immunity Prevenar 13 pneumo.o.cal vaccine Sickle cell disease

Mo.ulato.y effects o. dietary inclusio. o. garlic(Allium sativum) o. gentamycin-induced hepato.o.icity and o.idative stress in rats

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Asian Pacific Jo.rnal o. Tro.ical Bio.edicine 2013年第6期3卷 470-475页

作者： Adedayo.o.Ademiluyi ganiyu o.o. To.in R o.o.o.e o.uwaseun J Agbebi Functio.al Fo.ds Nutraceuticals and Phytomedicine UnitDepartment of BiochemistryFederal University of Technology

o.jective:To.investigate die amelio.ative effect o. dietary inclusio. o. garlic(Allium sativum)o. gentamycin-induced hepato.o.icity in ***:Adult male rats were rando.ly divided into.fo.r gro.ps with sis animals in each *** 1 and 2 were fed basal diet while Gro.ps 3 and 4 were fed diets co.taining 2%and 4%garlic respeetively fo. 27 d prio. to.gentamycin *** was induced by the intraperito.eal administratio. at gentamycin(100 mg/kg bo.y weight)fo. 3 *** liver and plasma were studied fo. hepato.o.icity and antio.idant ***:Gentamycin induces hepatic damage as revealed by significant(Po. o. liver damage marker enzymes(aspartate transaminase and alanine amino.ransferase)and reductio. in plasma albumin *** also.eaused a significant(Po. in plasma and liver enzymatic(catalase,glutathio.e and super o.ygen dehydro.enises)and no.-enzymatic(glutathio.e and vitamin C)antio.idant indices with co.co.itant increase in the malo.dialdehyde co.tent;ho.ever,there was a significant(Po.atio. o. the antio.idant status co.pled with significant(Po.dialdehyde co.tent,fo.lo.ing co.sumptio. o. diets co.taining ***:These results suggest that dietary inclusio. o. garlic po.der co.ld pro.ect against gentamycin-induced hepato.o.icity,impro.e antio.idant status and mo.ulate o.idative stress;a functio. attributed to.their pheno.ic co.stituents.

关键词： Gentamycin Hepato.o.icity o.idative stress Garlic(Allium sativum) Phyto.hemicals

In vitro.inhibitio. activity o. po.ypheno.-rich extracts fro. Syzygium aro.aticum(L.)Merr.& Perry(Clo.e)buds against carbo.ydrate hydro.yzing enzymes linked to.type 2 diabetes and Fe^(2+)-induced lipid pero.idatio. in rat pancreas

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Asian Pacific Jo.rnal o. Tro.ical Bio.edicine 2012年第10期2卷 774-781页

作者： Stephen Adeniyi Adefegha ganiyu o.o. Department o. Bio.hemistry Federal University of TechnologyAkure

To.investigate and co.pare the inhibito.y pro.erties o. free and bo.nd pheno.ic extracts o. clo.e bud against carbo.ydrate hydro.yzing enzymes (alpha-amylase & alpha-gluco.idase) and Fe2+-induced lipid pero.idatio. in rat pancreas in vitro. Metho.s: The free pheno.ics were extracted with 80% (v/v) aceto.e, while bo.nd pheno.ics were extracted fro. the alkaline and acid hydro.yzed residue with ethyl acetate. Then, the interactio. o. the extracts with alpha-amylase and alpha-gluco.idase was subsequently assessed. Thereafter, the to.al pheno.ic co.tents and antio.idant activities o. the extracts were determined. Results: The result revealed that bo.h extracts inhibited alpha-amylase and alpha-gluco.idase in a do.e-dependent manner. Ho.ever, the alpha-gluco.idase inhibito.y activity o. the extracts were significantly (Po.y activity. The free pheno.ics (31.67 mg/g) and flavo.o.d (17.28 mg/g) co.tents were significantly (Po.nd pheno.ic (23.52 mg/g) and flavo.o.d (13.70 mg/g) co.tents. Bo.h extracts also.exhibited high antio.idant activities as typified by their high reducing po.er, 1,1 diphenyl-2- picrylhydrazyl (DPPH) and 2, 2-azino.is-3-ethylbenzo.thiazo.ine-6-sulfo.ate (ABTS) radical scavenging abilities, as well as inhibitio. o. Fe2+-induced lipid pero.idatio. in rat pancreas in vitro. Co.clusio.s: This study pro.ides a bio.hemical ratio.ale by which clo.e elicits therapeutic effect o. type 2 diabetes.

关键词： Alpha-amylase Alpha-gluco.idase Fe^(2+)-induced lipid pero.idatio. Pancrea Pheno. Antio.idant

Mechanisms o. medicinal plants in the treatment o. diabetic wo.nd

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Asian Pacific Jo.rnal o. Tro.ical Bio.edicine 2023年第6期13卷 233-241页

作者： o.uwakemi V.Adeleke Stephen A.Adefegha ganiyu o.o. Functio.al Fo.ds Nutraceuticals and Phytomedicine LaboratoryDepartment of BiochemistryFederal University of Technology AkureAkureNigeria Department o. Science Labo.ato.y Techno.o.y Ekiti State UniversityAdo EkitiNigeria

Wo.nd repair is no.iceably pro.o.ged in a diabetic state due to.a faulty inflammato.y pro.ess and an underlying *** medicinal plants and their pro.ucts have been o. prime impo.tance fo. the management o. wo.nds o.er the *** mechanisms whereby medicinal plants elicit their actio. in wo.nd repair are revealed and so.e plants are pro.en to.be experimentally effective in enhancing wo.nd clo.ure and achieving *** mechanisms identified include hyperglycemic co.tro.,alleviatio. o. physio.o.ical inflammatio.,co.tro.led o.idative stress,infectio. co.tro.,and influence o. gene *** in this review was so.rced fro. research and review articles in electro.ic databases such as Web o. Science,Sco.us,PubMed,and Go.gle Scho.ar.

关键词： Diabetes Infectio. Inflammatio. Medicinal plants Wo.nd healing o.idative stress

Antio.idant pro.erties o. aqueo.s extracts o. unripe Musa Paradisiaca o. so.ium nitro.russide induced lipid pero.idatio. in rat pancreas in vitro

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Asian Pacific Jo.rnal o. Tro.ical Bio.edicine 2013年第6期3卷 449-457页

作者： Sidiqat Adamso. Sho.ehinde ganiyu o.o. Department o. Bio.hemistry Adekunle Ajasin University Functio.al Fo.ds and Nutraceuticals Unit Department of BiochemistryFederal University of Technology

o.jective:To.evaluate and co.pare antio.idant activities o. the aqueo.s extracts o. unripe plantain(Musa paradisiaca),assess their inhibito.y actio. o. so.ium nitro.russide induced lipid pero.idatio. in rat pancreas in vitro.and to.cliaracterize the main pheno.ic co.stituents o. the plantain pro.ucts using gas chro.ato.raphy ***:Aqueo.s extracts o. plantain pro.ucts(raw,elastic pastry,ro.sted and bo.led)(lo.r o. 0.1 g/mL(each)were used to.determine their to.al pheno.,to.al flavo.o.d,1,1 diphenyl-2 picrylhydrazyl(DPPH)and hydro.yl(o.)radical scavenging *** inhibito.y effect o. the extracts o. so.ium nitro.msside induced lipid pero.idatio. was also.***:The results revealed that all the aqueo.s extracts sho.ed antio.idant *** bo.led Ho.r had highest DPPH and o. radical scavenging ability while raw Ho.r had the highest Fe^(2+)chelating ability,so.ium nilro.russide inhibito.)effect and vitamin C *** antio.idant results sho.ed that elastic pastry had the highest to.al pheno. and to.al flavo.o.d *** o. the unripe plantain pro.ucts fo. po.ypheno. co.tents using gas chro.ato.raphy sho.ed varied quantity o. apigenin,***,capsaicin,*** acid,kampfero.,quercetin,p-hydro.ybenzo.c acid,sho.ao.,glycitein and gingero. per pro.uct o. the ***:Co.sidering the antio.idant activities and ability to.inhibit lipid pero.idatio. o. unripe plantain,this co.ld justify their traditio.al use in the management/preventio. o. diseases related to.stress.

关键词： Po.ypheno.s Antio.idants Musa paradisiaca So.ium nitro.russide Lipid pero.idatio.