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o. the functio.s o. astro.yte-mediated neuro.al slo. inward currents

Neural Regeneratio. Research 2024年第12期19卷 2602-2612页

作者： balázs Pál Department o. Physio.o.y Faculty of MedicineUniversity of DebrecenDebrecenHungary

Slo. inward currents are kno.n as neuro.al excitato.y currents mediated by glutamate release and activatio. o. neuro.al extra synaptic N-met hyl-D-aspartate recepto.s with the co.tributio. o. *** events are significantly slo.er than the excitato.y po.tsynaptic *** o. slo. inward currents are determined by seve ral facto.s including the mechanisms o. astro.ytic activatio. and glutamate release,as well as the diffusio. pathways fro. the release site to.ards the extra synaptic recepto.*** are stimulated by neuro.al netwo.k activity,which in turn excite neuro.s,fo.ming an astro.yte-neuro. feedback *** as a co.sequence o. brain edema,astro.ytic swelling can also.induce slo. inward currents under patho.o.ical *** is a gro.ing bo.y o. evidence o. the ro.es o. slo. inward currents o. a single neuro. o. lo.al netwo.k *** events o.ten o.cur in synchro.ny o. neuro.s lo.ated in the same astro.ytic *** synchro.izatio. o. neuro.al excitability,slo. inward currents also.set synaptic strength via eliciting timing-dependent synaptic *** additio.,slo. inward currents are also.subject to.no.-synaptic plasticity triggered by lo.g-la sting stimulatio. o. the excitato.y *** no.e,there might be impo.tant regio.specific differences in the ro.es and actio.s triggering slo. inward *** greater netwo.ks,the patho.hysio.o.ical ro.es o. slo. inward currents can be better understo.d than physio.o.ical *** inward currents are identified in the patho.hysio.o.ical backgro.nd o. autism,as slo. inward currents drive early hypersynchro.y o. the neural *** inward currents are significant co.tributo.s to.paro.ysmal depo.arizatio.al shifts/interictal *** events are related to.epilepsy,but also.fo.nd in Alzheimer's disease,Parkinso.'s disease,and stro.e,leading to.the decline o. co.nitive *** with features o.erlapping with slo. inward currents(excitato.y,N-methyl-Dasp

关键词： astro.yte co.tical spreading depo.arizatio. glio.ransmissio. glutamate neural synchro.izatio. NMDA recepto. paro.ysmal depo.arizatio.al shift slo. inward current

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Integrated analysis o. public datasets fo. the disco.ery and validatio. o. survival-asso.iated genes in so.id tumo.s

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The Inno.atio. 2024年第3期5卷 129-137页

作者： balázs Gyo.ffy Department o. Bio.hysics Medical SchoolUniversity of Pecs7624 PecsHungary Department o. Bio.nfo.matics Semmelweis University1094 BudapestHungary Cancer Bio.arker Research Gro.p Institute of Molecular Life SciencesHUN-REN Research Centre for Natural Sciences1117 BudapestHungary

Identifying genes with pro.no.tic significance that can act as bio.arkers in so.id tumo.s can help stratify patients and unco.er no.el therapy ***,o.r go.l was to.expand o.r previo.s ranking analysis o. survival-asso.iated genes in vario.s so.id tumo.s to.include co.o. cancer specimens with available transcripto.ic and clinical data.A Gene Expressio. o.nibus search was perfo.med to.identify available datasets with clinical data and raw gene expressio. measurements.A co.bined database was set up and integrated into.o.r Kaplan-Meier plo.ter,making it po.sible to.identify genes with expressio. changes linked to.altered *** a demo.stratio. o. the utility o. the platfo.m,the mo.t po.erful genes linked to.o.erall survival in co.o. cancer were identified using uni-and multivariate Co. regressio. *** co.bined co.o. cancer database includes 2,137 tumo. samples fro. 17 independent *** mo.t significant genes asso.iated with relapse-free survival with a false disco.ery rate belo. 1%in co.o. cancer carcino.a were RBPMS(hazard rate[HR]=2.52),TIMP1(HR=2.44),and Co.4A2(HR=2.36).The three stro.gest genes asso.iated with sho.ter survival in stage II co.o. cancer include CSF1R(HR=2.86),FLNA(HR=2.88),and TPBG(HR=2.65).In summary,a new integrated database fo. co.o. cancer is presented.A co.o. cancer analysis subsystem was integrated into.o.r Kaplan-Meier plo.ter that can be used to.mine the entire database(https://***).The po.tal has the po.ential to.be emplo.ed fo. the identificatio. and prio.itizatio. o. pro.ising bio.arkers and therapeutic target candidates in multiple so.id tumo.s including,amo.g o.hers,breast,lung,o.arian,gastric,pancreatic,and co.o. cancers.

关键词： co.o. tumo.s analysis

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Green hydro.en energy pro.uctio.: current status and po.ential

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CLEAN ENERGY 2024年第2期8卷 1-7页

作者： Maka, Ali o. M. Mehmo.d, Mubbashar Libyan Ctr Res & Dev Saharian Co.munities Murzuq Libya Herio. Watt Univ Sch Engn & Phys Sci Edinburgh EH14 4AS Scotland

The technique o. pro.ucing hydro.en by utilizing green and renewable energy so.rces is called green hydro.en pro.uctio.. Therefo.e, by implementing this technique, hydro.en will beco.e a sustainable and clean energy so.rce by lo.ering greenho.se gas emissio.s and reducing o.r reliance o. fo.sil fuels. The key benefit o. pro.ucing green hydro.en by utilizing green energy is that no.harmful po.lutants o. greenho.se gases are directly released thro.gho.t the pro.ess. Hence, to.guarantee all o. the enviro.mental advantages, it is crucial to.co.sider the entire hydro.en supply chain, invo.ving sto.age, transpo.tatio. and end users. Hydro.en is a pro.ising clean energy so.rce and targets plan pathways to.ards decarbo.izatio. and net-zero.emissio.s by 2050. This paper has highlighted the techniques fo. generating green hydro.en that are needed fo. a clean enviro.ment and sustainable energy so.utio.s. Mo.eo.er, it summarizes an o.erview, o.tlo.k and energy transient o. green hydro.en pro.uctio.. Co.sequently, its perspective pro.ides new insights and research directio.s in o.der to.accelerate the develo.ment and identify the po.ential o. green hydro.en pro.uctio.. Hydro.en is a pro.ising clean energy so.rce and a pathway to.ards decarbo.izatio. and net-zero.emissio.s by 2050. This article pro.ides perspective o. techniques fo. generating green hydro.en that are needed fo. a clean enviro.ment and sustainable energy so.utio.s. Graphical Abstract

关键词： green hydro.en energy hydro.en pro.uctio. energy transitio. clean energy perspective o. green hydro.en TECHNo.o.IES Ro.DMAP

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A hybrid so.ar-bio.as system fo. po.t-Co.ID-19 rural energy access

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CLEAN ENERGY 2024年第1期8卷 84-99页

作者： o.eren, o.huko.K. o.ileke, Kechrist Meyer, Edso. L. Makaka, Go.den Apeh, o.iver o. Univ Ft Hare Ft Hare Inst Technol Private Bag X1314 ZA-5700 Alice South Africa Univ Ft Hare Renewable Energy Res Ctr Dept Phys Private Bag X1314 ZA-5700 Alice South Africa Univ Jo.annesburg Fac Engn & Build Environm Dept Elect & Elect Engn Sci ZA-2006 Auckland Pk South Africa

So.ar ho.e systems fo. rural electrificatio. are o.ten designed with a limited energy supply, which presents a drawback fo. the techno.o.y. Furthermo.e, unco.tro.led livesto.k faeces in rural co.munities co.stitute enviro.mental sanitatio. and health risks. Livesto.k excrement can be used thro.gh a bio.as digester to.supplement so.ar energy to.pro.ide adequate and sustainable electricity access to.underserved rural co.munities while achieving waste management. Therefo.e, this study presents a hybrid so.ar-bio.as system fo. a mo.e dynamic energy supply and waste management fo. po.t-Co.id reco.ery plans in rural co.munities. A parametric research appro.ch that invo.ves the use o. the Integrated Enviro.ment So.utio. Virtual Enviro.ment so.tware applicatio. and mathematical mo.els to.design the desired ho.seho.d lo.d and the hybrid system sizing is used in the study. The findings sho. that the daily ho.seho.d energy co.sumptio. was 6.6 kWh, equivalent to.206.40 kWh/mo.th. A 1.2-kWp and 1.2-m3 hybrid so.ar-bio.as system was fo.nd to.adequately po.er the ho.se. Financially, the to.al initial investment co.t o. the system was $5777.20 with a net present value o. $6566.78, net pro.it o. $4443.6, a payback perio. o. 14 years and 8 mo.ths, and a levelized co.t o. energy o. $0.21/kWh; these include a 60% initial investment and maintenance co.ts subsidy. Energy perfo.mance co.tracting and energy-as-a-service were reco.mended to.effectively run and o.erate the system. The study successfully revealed the design, specificatio.s and upscaling mechanism o. the pro.o.ed hybrid so.ar-bio.as system. Mo.e research is required to.unveil the efficacy o. the system, the perfo.mance gap and the perceptio. o. the techno.o.y by the beneficiaries. A hybrid so.ar-bio.as system is designed fo. a mo.e dynamic energy supply and waste management fo. po.t-Co.id reco.ery plans in rural co.munities. A parametric research appro.ch is used to.specify the desired ho.seho.d lo.d and the hybrid system sizi

关键词： energy access sustainable rural develo.ment clean energy waste management po.t-Co.ID-19 reco.ery plan So.TH-AFRICA ELECTRIFICATIo. BATCH

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Temperature Trends and Accumulatio. o. Chill Ho.rs, Chill Units, and Chill Po.tio.s in So.th Caro.ina

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Atmo.pheric and Climate Sciences 2024年第2期14卷 173-190页

作者： Jo.é o. Payero Edisto.Research and Educatio. Center Clemson University Blackville SC USA Department o. Agricultural Sciences Clemson University Clemson SC USA

There is co.siderable co.cern abo.t the po.ential impact o. climate change o. agriculture, such as the accumulatio. o. chilling ho.rs needed to.break the do.mancy o. many perennial plants, like fruit trees. Therefo.e, this study aimed to.determine if there had been a significant change in air temperatures and chill ho.rs, chill units, and chill po.tio. accumulatio. in So.th Caro.ina o.er the last two.decades. Two.decades o. daily maximum (Tmax) and minimum (Tmin) air temperature reco.ds were o.tained fro. weather statio.s in thirty-o.e co.nties in So.th Caro.ina. Ho.rly temperature data, reco.structed fro. the daily data, were used to.calculate the daily and annual chill ho.rs, chill units, and chill po.tio.s accumulatio. using fo.r different chill mo.els fo. each lo.atio. and year. The chill mo.els included the T(t) °C mo.el, the 0°C °C mo.el, the Utah mo.el, and the Dynamic mo.el. Fo. each co.nty, regressio. analyses were co.ducted to.evaluate the histo.ical trends. Despite year-to.year variability, the tendency was a statistically significant (α = 0.05) increase in air temperature, averaging 0.089°C per year fo. 20 o.t o. 31 co.nties in So.th Caro.ina. The o.her 11 co.nties had no.significant change in temperature. The average temperature increase in the 31 co.nties was 0.072°C per year. The temperature increase resulted in a decrease in annual chill accumulatio. during the fall to.spring, averaging 17.7 chill ho.rs, 8.6 chill ho.rs, 17.0 chill units, and 0.40 chill po.tio.s per year calculated with the T(t) °C, 0°C °C, Utah, and Dynamic mo.els, respectively. Ho.ever, whether this decrease in chill values was statistically significant o. no. depended o. the chill mo.el used. This study did no. investigate the cause o. the o.served histo.ical trends in temperature and chill accumulatio.. Still, if the trends co.tinue, they could significantly impact the future o. the temperate fruit tree industry in the state.

关键词： Chill Ho.rs Chill Units Chill Po.tio.s Temperature Fruit Trees Climate Change Do.mancy

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A Review: Manufacturing, and Pro.erties o. the D-Fructo.e Epimer D-Allulo.e (D-Psico.e)

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Advances in Bio.cience and Bio.echno.o.y 2024年第9期15卷 522-542页

作者： o.ama o. Ibrahim Bio.nno.atio. LLC Gurnee IL USA

D-allulo.e, also.kno.n by the name D-psico.e o. just allulo.e, is a rare keto.sugar epimer o. D-fructo.e in the third carbo. (C3), and naturally o.curs in small quantity in fruits such as grapes and figs. It is lo. calo.ie sweetener pro.uced enzymatically fro. D-fructo.e by enzymes D-keto.e 3-epimerase (DKEase) family. D-allulo.e has a similar taste, texture and functio.ality as sweetener co.paring to.high calo.ie sweetener sugar table sucro.e. D-allulo.e is po.rly metabo.ized in the bo.y with minimal impact o. blo.d sugar levels making it a natural lo.-calo.ie sweetener. This pro.erty makes D-allulo.e an attractive sweetener fo. diabetes and fo. bo.y weight management. Labo.ato.y studies o. D-allulo.e intake demo.strated its safety with no.significant adverse effects. United States Fo.d and Drug Administratio. (FDA) has granted D-allulo.e the status o. Generally Reco.nized as Safe (GRAS). Plus, it is co.sidered safe fo. human co.sumptio. by regulato.y o.ganizatio.s in o.her co.ntries except in Euro.ean Unio. due to.their request fo. further labo.ato.y testing. Maximum acceptable daily intake o. D-allulo.e is 0.9 grams per kilo.ram bo.y weight. Excessive intake fo. mo.e than the reco.mended daily intake could lead to.so.e side effects such as gastro.ntestinal disco.fo.t o. laxative effects. In general, D-allulo.e is co.sidered o.e o. the preferred natural lo. calo.ies sweeteners fo. tho.e seeking an alternative to.table sugar sucro.e.

关键词： D-Allulo.e D-Keto.e 3-Epimerase (DKEase) D-Tagato.e 3-Epimerase (DTEase) D-Allulo.e 3-Epimerase (DAEase) D-Psico.e 3-Epimerase (DPEase)

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A Pro.edure fo. Trisecting an Acute Angle (Metho. 2)

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Advances in Pure Mathematics 2024年第4期14卷 204-213页

作者： Lyndo. o. Barto. Department o. Math and Physics Delaware State University Dover USA

This paper presents an alternate graphical pro.edure (Metho. 2), to.that presented in earlier publicatio.s entitled, “A Pro.edure fo. Trisecting an Acute Angle” and “A Key to.So.ving the Angle Trisectio. Pro.lem”. The pro.edure, when applied to.the 30˚ and 60˚ angles that have been “pro.en” to.be no.trisectable and the 45˚ benchmark angle that is kno.n to.be trisectable, in each case pro.uced a co.structio. having an identical angular relatio.ship with Archimedes’ Co.structio., as in Sectio. 2 o. THEo.Y o. this paper, where the required trisectio. angle was fo.nd to.be o.e-third o. its respective angle (i.e. DE’MA = 1/3 DE’CG). Fo. example, the trisectio. angle fo. the 30˚, 45˚ and 60˚ angles were 10.00000˚, 15.00000˚, and 20.00000˚, respectively, and Sectio. 5 o. PRo.F in this paper. Therefo.e, based o. this identical angular relatio.ship and the numerical results (i.e. to.five decimal places), which represent the highest degree o. accuracy and precisio. attainable by The Geo.eter’s Sketch Pad so.tware, o.e can o.ly co.clude that no. o.ly the geo.etric requirements fo. arriving at an exact trisectio. o. the 30˚ and 60˚ angle (which have been “pro.en” to.be no.-trisectable) have been met, but also. the co.structio. is valid fo. any arbitrary acute angle, despite theo.etical pro.fs to.the co.trary by Wantzel, Dudley, and o.hers.

关键词： Archimedes’ Co.structio. Co.lege Geo.etry Co.lege Mathematics Angle Trisectio. Famo.s Pro.lems in Mathematics Mechanism Analysis Geo.eter’s Sketch Pad

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Climate Trends and Their Impact o. So.ghum Pro.uctio. in Marigat, Baringo.Co.nty: A Histo.ical Analysis

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o.en Jo.rnal o. Mo.ern Hydro.o.y 2024年第2期14卷 106-129页

作者： Kennedy o. o.uku Japheth o. o.yando.Ro.ulus o. o.wany Clement K. Kiptum Department o. Agricultural Engineering Egerton University Nakuru Kenya Scho.l o. Engineering University of Eldoret Eldoret Kenya

Climate is subject to.fluctuatio.s in the majo.ity o. the wo.ld, mainly caused by rainfall as well as temperature variatio.s. Climate fluctuatio.s in Kenya have resulted in the spread o. desert-like co.ditio.s in the ASALs regio., such as Marigat in Baringo.Co.nty. As a co.nty, Baringo.experiences great variatio.s in climate annually, as well as uncertainty in expected rains, thereby negatively impacting the pro.uctio. o. cro.s such as so.ghum. This study applied the rainfall ano.aly index (RAI), standardised precipitatio. evapo.ranspiratio. index (SPEI), standard precipitatio. index (SPI), and Mann-Kendall (MK) statistical test fo. trends o. histo.ical climatic data in analysing bo.h temperature and precipitatio. data o.er the perio. 1990 to.2022 to.determine their trend, patterns and ho. they affect the pro.uctio. o. so.ghum cro.s. The machine learning metho. (R studio. with inputs was used to.calculate the SPI, SPEI, RAI and MK trend test. The rainfall varied fro. belo. average to.abo.e average during the study perio. with no.clear pattern in the RAI, SPEI and SPI values. The years 2020 and 2000 sto.d o.t as they had higher and lo.er rainfall than usual, respectively. The Marigat area generally experienced mo.e rainfall during the high/lo.g rainfall seaso. (AMJJ). The MK trend test o. average mo.thly rainfall, So.D, AMJJ, and annual precipitatio. co.firmed a po.itive trend in precipitatio.. Ho.ever, the sho.t rainy seaso. (So.D) was fo.nd to.be the mo.t variable perio. fo. rainfall, and there was a slight increase in daily average temperatures during this seaso..

关键词： Trends Precipitatio. Temperature RAI SPI SPEI and MK

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Cardio.ascular risk burden and disability:findings fro. the Internatio.al Mo.ility in Aging Study(IMIAS)

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Jo.rnal o. Geriatric Cardio.o.y 2024年第3期21卷 331-339页

作者： Juan-David Martinez-Aristizábal Carmen-Lucia Curcio.Juliana Fernandes Afshin Vafael Cristiano.do. Santo. Go.es Fernando.Go.ez Internal Medicine Critical Care DepartmentPablo Tobón Uribe HospitalMedellínColombia Research Gro.p in Geriatrics and Gero.to.o.y Faculty of Health SciencesUniversidad de CaldasManizalesColombia Labo.ato.y o. Physical Therapy and Co.lective Health Physical Therapy DepartmentFederal University of PernambucoJornalista Aníbal Fernandes Avenue RecifeBrazil Department o. Public Health Sciences Queen’s UniversityKingstonONCanada Department o. Physio.herapy University of PernambucoBR 203KmBrazil

BACKGRo.ND The asso.iatio. o. cardio.ascular risk burden with disability is *** examined the asso.iatio. between trajecto.ies o. the Framingham general cardio.ascular disease risk sco.e(FGCRS)with the trajecto.ies o. limitatio.s o. physical functio. in o.der *** A to.al o. 1219 participants with no.disabilities fro. the Internatio.al Mo.ility in Aging Study(IMIAS)study who.had up to.three repeated measures o. FGCRS between 2012–2016 and witho.t a histo.y o. stro.e o. co.o.ary heart disease at baseline and fo.lo.-up were *** at baseline was assessed and catego.ized into.*** functio. was evaluated with the Sho.t Physical Perfo.mance Battery(SPPB).The data were analyzed using linear mixed-effects *** At baseline,FGCRS ranged between 3–94(mean sco.e:24±15.8),participants were 32(2.6%),502(41.2%)and 685(56.2%)in lo.est,middle,and highest tertiles,*** the trajecto.ies o. limitatio.s o. physical functio.,the lo.est FGCRS had no.differences,while the middle and highest had a decrease in physical perfo.mance between 2012–2014(P=0.0001).Age,being female,living in Andes Mo.ntains,having middle and highest FGCRS,higher alco.o. co.sumptio.,being o.ese,lack o. exercise and co.nitive impairment increase the pro.ability o. disability(Po.e develo.ed regio.s and having a higher educatio.al level reduced the pro.ability o. disability during the fo.lo.-up time(Po.CLUSIo.S Higher cardio.ascular risk burden is asso.iated with decreased physical perfo.mance,especially in *** suggest SPPB may pro.ide a measure o. cardio.ascular health in o.der adults.

关键词： finding Battery burden

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Accuracy o. tree mapping based o. hand-held laser scanning co.paring leaf-o. and leaf-o.f co.ditio.s in mixed fo.ests

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Jo.rnal o. Fo.estry Research 2024年第5期35卷 14-25页

作者： Frederico.Tupinambá-Simões Adrián Pascual Juan Guerra-Hernández Cristóbal o.dóñez Tiago.de Co.to.Felipe Bravo iuFo. Sustainable Forest Management Research InstituteUniversity of Valladolid&INIAValladolidSpain Department o. Geo.raphical Sciences University of MarylandCollege ParkMD 20742USA Fo.est Research Centre School of AgricultureUniversity of LisbonTapada da Ajuda1349‑017 LisbonPortugal

The use o. mo.ile laser scanning to.survey fo.est eco.ystems is a pro.ising,scalable techno.o.y to.describe fo.est 3D structures at high *** co.firm the co.-sistency in the retrieval o. fo.est structural parameters using hand-held laser scanning(HLS),befo.e o.eratio.alizing the metho.,co.firming the data is *** analyzed the per-fo.mance o. tree-level mapping based o. HLS under differ-ent pheno.o.y co.ditio.s o. a mixed fo.est in western Spain co.prising Pinus pinaster and two.deciduo.s species,Alnus glutino.a and Quercus *** area was surveyed twice during the gro.ing seaso.(July 2022)and o.ce in the deciduo.s seaso.(February 2022)using several scan-ning *** reference data(418 trees,15 snags)was used to.calibrate the HLS data and to.assess the influence o. pheno.o.y when co.verting 3D data into.tree-level attrib-utes(DBH,height and vo.ume).The HLS-based wo.kflo. was ro.ust at iso.ating tree po.itio.s and reco.nizing stems despite changes in ***-six percent o. all pairs matched belo. 65 *** DBH,pheno.o.y barely altered *** o.served a stro.g agreement when co.paring HLS-based tree height *** values exceeded 2 m when co.paring height measurements,co.firming height data sho.ld be carefully used as reference in remo.e sensing-based invento.ies,especially fo. deciduo.s *** vo.ume was mo.e precise fo. pines(r=0.95,and rela-tive RMSE=21.3–23.8%)co.pared to.deciduo.s species(r=0.91–0.96,and relative RMSE=27.3–30.5%).HLS data and the fo.est structural co.plexity to.l perfo.med remark-ably,especially in tree po.itio.ing co.sidering mixed fo.ests and mixed pheno.o.y co.ditio.s.

关键词： Precisio. fo.estry Fo.est mo.ito.ing Mo.ile laser scanning Fo.est invento.y

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