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Chinese Medical Jo.rnal 2011年第3期124卷 364-368页

作者： TANG Bi-xia Yo. Xin ZHAo.Li-dan LI Yang ZHANG Xuan TANG Fu-lin ba De-nian HE Wei Department o. Rheumato.o.y Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100032 China Department o. Immuno.o.y School of Basic Medicine Peking Union Medical College and Institute of Basic Medical SciencesChinese Academy of Medical Sciences Beijing 100005 China

backgro.nd p53 is a tumo. suppresso. and plays a key ro.e in regulating cell hyperplasia, repairing DNA and inducing apo.to.is. This study was to.investigate p53 expressio. in fibro.last-like syno.io.ytes （FLS） and its effect o. CD4＋ T lympho.ytes fro. patients with active rheumato.d arthritis （ra）.Metho.s Human FLS were transfected with p53 siRNA and co.ultured with CD4＋ T lympho.ytes fro. patients with active ra. The expressio.s o. o.teo.ro.egerin and interleukin （IL）-6 were detected in p53 siRNA and scramble siRNA-transfected FLS. In additio., pro.ein levels o. interfero. （IFN）-γ, IL-17, IL-4 and CD25 as well as mRNAs o. IFN-γ,retino.c acid-related o.phan recepto. （Ro.）-γt, IL-17 and Fo.p3 in co.ultured CD4＋ T lyrmpho.ytes were also.*** IL-6 decreased in p53-kno.kdo.n FLS while o.teo.ro.egerin expressio. was no. altered. FLS with p53 deletio. significantly increased the pro.uctio. o. IL-17 and IFN-γ by CD4＋ T cells and upregulated Fo.p3 mRNA expressio. witho.t effects o. the pro.o.tio. o. CD4＋CD25high T *** p53 in FLS might regulate Th1 and Th17 functio.s in patients with ra and participate in the patho.enesis o. ra.

关键词： rheumato.d arthritis p53 helper T-cells

Meningio.a o. the o.tical Nerves in a Case at the Ho.pitalier Center o. Saint Denis in Ile de France

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o.en Jo.rnal o. o.hthalmo.o.y 2023年第1期13卷 23-29页

作者： Adama Dembele Mo.o.Sidibe Ibrahim Co.aré Mamado. Ko.é Sidibé Larcheveque Flo.ence Sero. Julien Abdo.laye Napo.Dao.da Go.ta o.mar Diallo.Djo.ny Jo.as Dembele Mamado. Adama To.o.Kadiato. ba Ko.ta Abdo.laye No.ho.m Co.libaly Cheick Fantamady To.nkara No.ho.m To.ré Abdo.laye Ko.até Jeannette Trao.e Sano.ssi bamani Lamine Trao.é Japhet Po.ano. Théra Regio.al Ho.pital o. Sikasso Sikasso Mali Alliance fo. the Develo.ment o. Co.munity o.hthalmo.o.y (ADo.) Bamako Mali African Tro.ical o.hthalmo.o.y Institute Bamako Mali Ho.pital Center Saint Denis France

Summary: o.tic nerve tumo.s are rare tumo.s, representing 3% - 5% o. intracranial tumo.s develo.ing mainly alo.g the o.tic nerve and/o. the chiasm. o.tic nerve meningio.as are histo.o.ically benign tumo.s who.e severity is linked to.diagno.tic and especially therapeutic difficulties. The o.tic nerve meningio.a is the seco.d leading cause o. o.tic nerve tumo. after glio.a. o.servatio.: We repo.t the case o. a 49-year-o.d wo.an fro. So.th Asia, who.co.sults an o.hthalmo.o.y department fo. pro.ressive visual lo.s in her right eye fo. abo.t a year with her glasses and wo.ld like to.renew her o.tical co.rectio.. Having no.particular medical histo.y apart fro. left unilateral blindness is kno.n fo. appro.imately 15 years. Magnetic Reso.ance Imaging (IRM) cerebral fo.nd a tissue mass with a clear o.tline and po.ylo.ules o. the left tempo.o.peduncular. Thro.gh this case, we describe the circumstances o. disco.ery o. the disease, the clinical characteristics, as well as o.r diagno.tic appro.ch. Co.clusio.: In the majo.ity o. cases, these are benign tumo.rs, the circumstances o. which are disco.ered in multiple ways. A mo.tly unilateral and no.-impro.able lo.s o. visual acuity must attract o.r attentio.. Renewing glasses may be the reaso. fo. disco.ering the disease. To.ay Magnetic Reso.ance Imaging (IRM) remains an impo.tant and capital examinatio. fo. the diagno.is and mo.ito.ing o. this patho.o.y.

关键词： Meningio.a o.tic Nerve Decreased Visual Acuity IRM

Facto.s Affecting the Ho.seho.ds’ Willingness-to.Pay fo. Wastewater Treatment in Agro.Fo.d Pro.essing Craft Villages, Nhue-Day River basin, Vietnam

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Jo.rnal o. Enviro.mental Pro.ectio. 2019年第9期10卷 1119-1130页

作者： Tran Thi Thu Trang Ro.erto.F. rañ o.a Jr. Nguyen Van So.g Department o. Natural Reso.rces and Enviro.mental Eco.o.ics Faculty of Economics and Rural Development Vietnam National University of Agriculture Hanoi Vietnam Department o. Agricultural and Applied Eco.o.ics College of Economics and Management University of the Philippines Los Ba&ntilde o. Los Ba&ntilde o. Philippines

Industrializatio. is a majo. strategy o. Vietnam fo. the develo.ment o. the co.ntryside. o.e such pro.ram is the pro.o.io. o. craft villages that have been successful in increasing inco.e levels that are 5 times mo.e than tho.e villages mainly engaged in agricultural pro.uctio.. Ho.ever, while such pro.rams have bro.ght pro.perity to.these villages, they have igno.ed the adverse effects o. the enviro.ment bro.ght abo.t by the wastewaters fro. the pro.essing plants. Wo.ld these ho.seho.ds invo.ved in agro.fo.d pro.essing be willing to.pay fo. the establishment o. a wastewater plant to.address the enviro.mental pro.lems? What facto.s wo.ld influence their willingness to.pay? The results o. the study amo.g the selected ho.seho.ds in Nhue-Day River basin, Vietnam invo.ved in agro.pro.essing sho.ed that the majo. facto.s affecting their willingness to.pay fo. the establishment o. a wastewater treatment plant are their level o. educatio., quantity o. ho.seho.ds’ untreated wastewater, presence o. yo.ng children who.are mo.e vulnerable to.the adverse effects o. po.lutio., experience o. family members getting sick, ho.seho.ds’ awareness o. benefits fro. treated wastewater, capacity to.pay, access to.credit and membership in craft village’s Asso.iatio.. The study reco.mended that decisio.s o. addressing enviro.mental issues sho.ld be participato.y to.be able to.take into.co.sideratio. the so.io.eco.o.ic co.ditio.s o. the stakeho.ders.

关键词： Wastewater Treatment Willingness-to.Pay Craft Villages o.dered Lo.it Mo.el

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粉煤灰早强硅酸盐水泥的性能

哈尔滨建筑工程学院学报 1988年第S1期 1-15页

作者：巴恒静哈尔滨建筑工程学院粉煤灰综合利用研究室

在采用复合矿化剂的前提下,利用粉煤灰全部代替粘土配制水泥生料,在干法中空转窑内1300～1400℃烧制成水泥熟料,再以粉煤灰为混合材生产粉煤灰硅酸监水泥。熟料中A含量占70%左右,水泥具有早强性能。以粉煤灰作混合材掺量为30～35%时,水... 详细信息

在采用复合矿化剂的前提下,利用粉煤灰全部代替粘土配制水泥生料,在干法中空转窑内1300～1400℃烧制成水泥熟料,再以粉煤灰为混合材生产粉煤灰硅酸监水泥。熟料中A含量占70%左右,水泥具有早强性能。以粉煤灰作混合材掺量为30～35%时,水泥28天标号在425以上。1t水泥总用灰量为50%左右,3天强度相当于ra425以上。该水泥具有良好的耐久性,其各项技术指标均达到设计、施工、工程的要求。

关键词：粉煤灰水泥早强

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钻杆加厚过渡带漏磁检测方法研究

华中科技大学学报（自然科学版） 2014年第5期42卷 12-15页

作者：冯搏巴鲁军孙燕华康宜华华中科技大学数字制造装备与技术国家重点实验室湖北武汉430074 胜利油田渤海钻井管具公司山东东营257200

通过磁折射理论及相应的有限元模型分析了加厚过渡区的磁场分布特性,主要包括由于内外径变化产生的空间磁场和由于壁厚变化产生的磁感应强度的非均匀性;找到并确认了变径产生的空间磁场是造成漏磁检测信号基线漂移的主要原因,并通过差... 详细信息

通过磁折射理论及相应的有限元模型分析了加厚过渡区的磁场分布特性,主要包括由于内外径变化产生的空间磁场和由于壁厚变化产生的磁感应强度的非均匀性;找到并确认了变径产生的空间磁场是造成漏磁检测信号基线漂移的主要原因,并通过差分法进行了消除;同时,也发现了变壁厚区磁化的非均匀性会导致同当量缺陷的漏磁场信号不一致,通过分析壁厚及磁化强度对漏磁场的影响,提出深度饱和磁化方法.结果表明:该方法能有效消除钻杆过渡带区域的背景磁场干扰并保证信号一致性,使漏磁法能适用于钻杆加厚过渡带的检测.

关键词：无损检测漏磁钻杆加厚过渡带深度饱和磁化

鱼腥草乙酸乙酯萃取部位的化学成分及抗植物病原菌活性研究

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天然产物研究与开发 2024年第4期36卷 616-621页

作者：张丽孙建鹏巴其斌兰州城市学院化学工程学院兰州730070

采用硅胶、大孔树脂、葡聚糖凝胶、MCI树脂、薄层色谱以及高效液相色谱等色谱分离方法,从鱼腥草(Ho.ttuynia co.data)地上部分95%乙醇提取物的乙酸乙酯萃取部位分离得到10个化合物。运用质谱、核磁共振等波谱技术和文献对比法鉴定了其结... 详细信息

采用硅胶、大孔树脂、葡聚糖凝胶、MCI树脂、薄层色谱以及高效液相色谱等色谱分离方法,从鱼腥草(Ho.ttuynia co.data)地上部分95%乙醇提取物的乙酸乙酯萃取部位分离得到10个化合物。运用质谱、核磁共振等波谱技术和文献对比法鉴定了其结构,分别鉴定为去氢催吐萝芙木醇(1)、5,6-环氧-3-羟基-β-紫罗兰酮(2)、黑麦草内酯(3)、pubinerno.d A(4)、槲皮苷(5)、槲皮素(6)、阿福豆苷(7)、4-甲氧基苯-1,2-二醇(8)、4-羟基苯甲醛(9)、苯甲酸(10)。化合物1~4为首次从鱼腥草中分离得到的降碳倍半萜。对所有化合物进行了抗植物病原菌活性筛选,结果显示:在40 mg/mL浓度下,化合物5~7对禾谷镰刀菌、褐枝孢菌、番茄灰霉病菌、瓜类球腔菌和棉花枯萎病菌抑菌率介于38%~50%之间。

关键词：鱼腥草分离鉴定降碳倍半萜抗植物病原菌活性

Effo.t and Reco.ery in Nello.e o.en during Vaquejada Assessed with o.ular and Tail Infrared Thermo.raphy Superficial Temperature

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o.en Jo.rnal o. Veterinary Medicine 2021年第7期11卷 258-271页

作者： raíssa Karo.liny Salgueiro.Cruz Cesar Fabiano.Vilela Diego.barbo.a de Freitas Calena Co.ta Paixão.Caro.ina Jo.es Ferreira Lima da Silva Keity Laiane Go.es Trindade Juliette Go.çalves da Silva Helena Emília Cavalcanti da Co.ta Co.deiro.Manso.Helio.Co.deiro.Manso.Filho Veterinary Medicine Scho.l Cesmac University Center (CESMAC) Maceió Brazil Equine Research Center Federal Rural University of Pernambuco Recife PE Brazil Private Veterinarian Americana SP Brazil Private Veterinarian Colorado PR Brazil Private Veterinarian Feira de Santana BA Brazil

Infrared thermo.raphy (IRT) has emerged fo. evaluatio. o. animal welfare. To.test the hypo.hesis that cattle subjected to.vaquejada increased temperature in the eye (CLo. and tail due to.physical effo.t, a research was develo.ed that aimed to.measure maximum surface temperature in the CLo.and base o. tail using IRT. Eighty Nello.e cattle were used, which were subjected to.physical effo.t in three perio.s (mo.ning, afterno.n and night). IRT was perfo.med at CLo.and base o. tail, in rest pen/co.ral (co.tro.) and during the vaquejada (pre- and po.t-run). Tails’ analysis was divided in 3 po.nts (E1, E2 and E3). ANo.A and Tukey’s test (p o. analysis. Temperatures were higher in mo.ning and afterno.n and different fro. tho.e at night o. co.tro. (p o.e run, CLo.was higher in pre-run, fo.lo.ed by a slight reductio. in po.t-run (p ratures variatio.s at tail, higher temperatures were o.served in the mo.ning, fo.lo.ed by the evening and night (p o.t differences within the pre- and po.t-run perio.s. Temperatures at tail’s po.nts were higher in mo.ning perio. in cattle with two.runs (p o.cluded that there were no.increases in CLo.o. at tail’s po.nts after vaquejada races. The IRT metho. was efficient in determining surface temperatures in CLo.and tail po.nts in cattle under the same co.ditio.s and may be a go.d no.invasive metho. fo. clinical and welfare assessments.

关键词： Thermo.ram Bo.ine Welfare Diagno.is Exercise

Identificatio. o. IL11ra and MELK amplificatio. in gastric cancer by co.prehensive geno.ic pro.iling o. gastric cancer cell lines

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Wo.ld Jo.rnal o. Gastro.ntero.o.y 2016年第43期22卷 9506-9514页

作者： Danielle Queiro. Calcagno.Sylvia Santo.i Takeno.Caro.ina o.iveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Elizabeth Suchi Chen Taíssa Maíra Tho.az Araújo.Eleo.idas Mo.ra Lima Maria Isabel Melaragno.Samia Demachki Paulo.Pimentel Assumpcao.Ro.mel Ro.riguez Burbano.Marília Cardo.o.Smith Disciplina de Genética Departamento de Morfologia e GenéticaUniversidade Federal de Sao Paulo Núcleo.de Pesquisas em o.co.o.ia Hospital Universitário Joao de Barros Barreto Departamento.de Bio.o.ia Mo.ecular Universidade Federal da Paraíba Disciplina de Gastro.ntero.o.ia Cirúrgica Universidade Federal de Sao Paulo Departamento.de o.to.edia e Traumato.o.ia Universidade Federal de Sao Paulo

AIM To.identify co.mo. co.y number alteratio.s o. gastric cancer cell *** Fo.r gastric cancer cell lines(ACP02, ACP03, AGP01 and PG100) underwent chro.o.o.al co.parative geno.e hybridizatio. and array co.parative geno.e hybridizatio.. We also.co.firmed the results by fluo.escence in situ hybridizatio. analysis using the bacterial artificial chro.o.o.e clo.e and quantitative real time PCR *** The amplificatio. o. 9p13.3 was detected in all cell lines by bo.h metho.o.o.ies. An increase in the co.y number o. 9p13.3 was also.co.firmed by fluo.escence in situ hybridizatio. analysis. Mo.eo.er, the interleukin 11 recepto. alpha(IL11ra) and maternal embryo.ic leucine zipper kinase(MELK) genes, which are present in the 9p13.3 amplico., revealed gains o. the MELK gene in all the cell lines studied. Additio.ally, a gain in the co.y number o. IL11 ra and MELK was o.served in 19.1%(13/68) and 55.9%(38/68) o. primary gastric adeno.arcino.a samples, respectively. Co.CLUSIo. The characterizatio. o. a small gain regio. at 9p13.3 in gastric cancer cell lines and primary gastric adeno.arcino.a samples has revealed MELK as a candidate target gene that is po.sibly related to.the develo.ment o. gastric cancer.

关键词： IL11ra Gastric cancer Geno.ic pro.iling MELK 9p13.3

Expressio. o. 26S pro.easo.e in differentiatio. o. human bo.e marro. stro.al cells into.neural-like cells

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Expression of 26S proteasome in differentiation of human bon...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Li LU,Wei-Guo.ZHANG,Gui-Jiao.YANG~*,ba-Yi YAN Department o. anato.y,Shanxi Medical University.Taiyuan 030001.China

＜正＞o.jective To.investigate the pro.ess o. Human Bo.e Marro. Stro.al Cells（hBMSCs） differentiatio. into.neural-like cells and the expressio. o. 26S pro.easo.e in neuro.al *** Purified hBMSCs were treated withβ-mercapto.thano.（β-ME） fo. 1 day and retino.c acid（ra） fo. 3 days,fo.lo.ed by gro.th facto.（GF;10 ng/ml bFGF, 20 ng/ml NGF） fo. ano.her 3 *** was perfo.med to.detect the expressio. o. nestin（a neural precurso. cells marker）,Tuj 1（a premature neuro.al marker）,and neuro.ilament（NF,a mature neuro.al marker） at all stages o. induced *** and RT-PCR were used to.analyze the expressio. o. 26S pro.easo.e during neuro.al differentiatio. o. *** Quantificatio. results sho.ed that the untreated cells were almo.t never po.itive fo. nestin,Tuj 1 and *** treatment withβ-ME/ra,the number o. nestin-po.itive cells（34.41±1.27）%and Tujl -po.itive cells（27.79±1.27）%was ***,the number o. NF-po.itive cells was significantly increased to.56.72±2.4）% after inductio. with P-ME/ra/*** analysis sho.ed that undifferentiated hBMSCs were weakly stained by antibo.y against 26S pro.easo.e,but the number o. cells with high-intensity 26S pro.easo.e was increased after treatment withβ-ME/ra and mo.e significantly so.after treatment withβ-ME/ra/*** RT-PCR result o. 26S pro.easo.e further co.firmed that the mRNA level o. cells differentiated byβ-ME/ra（1.33）,as well as by P-ME/ra/GF （1.77）,was significantly increased,co.pared to.the undifferentiated *** After inductio. with P-ME/ra/GF, hBMSCs co.ld be differentiated into.neural-like cells and express neuro.al *** the expressio. o. 26S pro.easo.e is increasing during inductio.,suggesting that 26S pro.easo.e may be invo.ved in neuro.al differentiatio. o. hBMSCs.

关键词： human bo.e marro. stro.al cells 26S pro.easo.e neural-like cells differentiatio.

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乌头汤治疗类风湿关节炎的研究进展

医药导报 2023年第2期42卷 173-177页

作者：巴鑫陈哲涂胜豪华中科技大学同济医学院附属同济医院中西医结合科武汉430030

乌头汤作为治疗痹证的经典方剂,治疗类风湿关节炎(ra)已有千年历史。一系列临床研究证实,乌头汤在改善ra关节炎症、肿胀、疼痛等方面有较好的疗效。同时作为一种补充替代疗法,乌头汤与西药联合应用可以减少西药的用量,减轻西药副作用,... 详细信息

乌头汤作为治疗痹证的经典方剂,治疗类风湿关节炎(ra)已有千年历史。一系列临床研究证实,乌头汤在改善ra关节炎症、肿胀、疼痛等方面有较好的疗效。同时作为一种补充替代疗法,乌头汤与西药联合应用可以减少西药的用量,减轻西药副作用,提高现有ra治疗方案的安全性和有效性。随着对ra病理机制研究及乌头汤的药理学研究的深入,乌头汤在治疗ra方面的研究取得许多进展,尤其在抗炎、镇痛、免疫调节以及抑制血管生成等方面。该文从临床研究和实验研究两个方面对乌头汤治疗ra相关进展进行系统性综述。

关键词：乌头汤类风湿关节炎炎症免疫调节镇痛血管生成