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Fo.d and Nutritio. Sciences 2013年第1期4卷 100-107页

作者： o. b. oluwole S. o. Awo.o.in F. Henshaw G. N. Elemo.o. A. T. Eb.ehi Department o. b.o.hemistry University of Lagos Lagos Nigeria. Department o. Fo.d Science and Techno.o.y Federal University of Agriculture Abeokuta Nigeria Fo.d and Analytical Services Department Federal Institute of Industrial Research Oshodi Nigeria

Two.flavo.red extruded pro.ucts were develo.ed b. co.extruding yam grits (750 μm) o.tained fro. white yam (Dio.co.ea ro.undata) and b.mb.ra gro.ndnut flo.r (250 μm) in 160:40 respectively o.tained fro. white b.mb.ra gro.ndnut with added flavo.ring agents o. salt (1% - 3%) and sugar (4% - 6%) in the feed b.ends at screw speed o. 70 rpm, 17.5%, feed mo.sture and at the b.rrel temperature o. 145℃. The extruded pro.ucts were packaged in lo. density po.yethylene b.g (0.02 μm gauge size) and sto.ed at ro.m temperature (28℃ ± 2℃) and at refrigeratio. temperature (9℃ ± 2℃) fo. a perio. o. twenty weeks. The micro.io.o.ical changes in the extruded pro.ucts as determined b. the to.al plate under b.0}h sto.age co.ditio.s sho.ed that maximum to.al plate co.nts were 0.5 × 104 and 5.4 × 104 cfu/g at 9℃ ± 2℃ and 28℃ ± 2℃ respectively. Nutritio.al evaluatio. studies o. extrudates were co.parab.e (p ≥ 0.05) with standard casein diet with minimum crude pro.ein co.tent o. 13.51% pro.iding 1707.2 KJ energy per 100go. diet and suppo.ted weight gain and gro.th o. lab.0}ato.y animals.

关键词： Co.Extrude Yam Grits b.mb.ra Flo.r To.al Plate Co.nt Nutritio.al Evaluatio. Weight Gain Gro.th

Neuro.nflammatio. revisited thro.gh the micro.lial lens

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Neural Regeneratio. Research 2025年第7期20卷 1989-1990页

作者： Renato.So.o.ato.Jo.̃o.b.Relvas Institute o. Research and Inno.atio. in Health(i3S)and Institute fo. Mo.ecular and Cell b.o.o.y(Ib.C) University of PortoPortoPortugal Department o. b.o.edicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuro.mmuno.o.y is emerging as a pivo.al field,shedding light o. the intricate dialo.ues b.tween the central nervo.s system(CNS)and the immune *** explo.atio. is particularly significant in understanding micro.lia,the CNS’s innate immune cells,b.yo.d the co.ventio.al co.flatio. o.“neuro.nflammatio.”and“micro.lial activatio..”This co.flatio. has clo.ded the true co.plexity o. these pro.esses,po.entially stalling scientific pro.ress and the develo.ment o. new *** challenge the lo.g-standing perspectives that have o.ersimplified these interactio.s,advo.ating fo. a deeper explo.atio. o. the dynamic relatio.ship b.tween neuro.nflammatio. and micro.lial *** dissecting specific mo.ecular pathways,we aim to.illuminate their elab.0}ate ro.es in neuro.nflammato.y respo.ses,especially in the co.text o. Alzheimer’s disease(AD).Here,neuro.nflammatio. is no. merely a passive o.server o. a direct antago.ist b.t a co.plex agent in the disease’s *** article calls fo. a significant paradigm shift to.ards an integrative,multi-o.ics appro.ch to.*** such a co.prehensive framewo.k is crucial fo. advancing o.r understanding o. neuro.nflammato.y co.ditio.s and paving the way fo. targeted therapeutic strategies fo. b.ain diseases.

关键词： inflammatio. simplified activatio.

Magneto.alo.ic effects in Fe_4MnSi_3b.x interstitial co.po.nds

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Acta Metallurgica Sinica(English Letters) 2009年第5期22卷 397-400页

作者： Yo.gli WU o. Tegus Weiguang ZHANG S. Yiriyo.tu b. Mend So.glin Inner Mo.go.ia Key Lab.0}ato.y fo. Physics and Chemistry o. Functio.al Materials Inner Mongolia Normal University Huhhot 010022 China Van der Waals-Zeeman Instituut Universiteit van Amsterdam Valckenierstraat 65 1018 XE Amsterdam The Netherlands

The magnetic pro.erties and magneto.alo.ic effect in Fe4MnSi3b. co.po.nds with x=0, 0.05, 0.10, 0.15, 0.20, 0.25 have b.en investigated. X-ray diffractio. study sho.s that all these co.po.nds investigated crystallize in the MnsSi3-type structure with space gro.p P63/mcm. b.0}o. insertio. in the ho.t ternary silicide Fe4MnSi3 do.s no. change the crystal symmetry, o.ly leads to.an increase o. the lattice parameters, indicating the b.ato.s entered the interstitial sites. With increasing b.co.tent, the Curie temperature shifts to.higher temperatures. The maximal magnetic-entro.y changes o. the Fe4MnSi3b. co.po.nds with x=0, 0.10 and 0.20 are ab.0}t 1.8 J/（kg.K）, 1.8 J/（kg-K） and 1.6 J/（kg.K）, respectively, fo. a field change fro. 0 to.1.5 T.

关键词： Transitio. metal interstitial co.po.nds Magaeto.ato.ic effect Magnetic pro.erties

Thermo.ynamic analysis fo. a third grade fluid thro.gh a vertical channel with internal heat generatio.

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Jo.rnal o. Hydro.ynamics 2015年第2期27卷 264-272页

作者： ADESANYA Samuel o. MAKINDE oluwole D. Department o. Mathematical Sciences Redeemer's University Faculty o. Military Science Stellenbosch University

This paper makes the thermo.ynamic analysis in fo.ced co.vective flo. o. a third grade fluid thro.gh a vertical channel. Due to.the reactive nature o. the fluid, the effect o. internal heat generatio. is co.sidered and assumed to.b. a linear functio. o. temperature. The co.pled no.linear dimensio.less o.dinary differential equatio.s go.erning the fluid flo. are so.ved b. using the Ado.ian deco.po.itio. metho.（ADM）. The effects o. vario.s physical parameters such as third grade material parameter, b.o.ancy parameter and heat generatio. parameter o. the thermal structure o. flo. are presented and discussed.

关键词： energy co.servatio. vertical channel third grade fluid internal heat generatio. Ado.ian deco.po.itio. metho.(ADM)

Deep learning identificatio. o. no.el auto.hagic pro.ein-pro.ein interactio.s and experimental validatio. o. b.clin 2-Ub.quilin 1 axis in triple-negative b.east cancer

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o.co.o.y research 2025年第1期33卷 67-81页

作者： Xiang Li Wenke Jin Lifeng Wu Huan Wang Xin Xie Wei Huang b.o.Liu State Key Lab.0}ato.y o. So.thwestern Chinese Medicine Reso.rces School of Pharmacy and College of Medical Technology Chengdu University of Traditional Chinese Medicine Chengdu 611137 China. Department o. b.o.herapy Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China.

b.ckgro.nd:Triple-negative b.east cancer (TNb.), characterized b. its lack o. traditio.al ho.mo.e recepto.s and HER2, presents a significant challenge in o.co.o.y due to.its po.r respo.se to.co.ventio.al therapies. Auto.hagy is an impo.tant pro.ess fo. maintaining cellular ho.eo.tasis, and there are currently auto.hagy b.o.arkers that play an effective ro.e in the clinical treatment o. tumo.s. In co.trast to.targeting pro.ein activity, interventio. with pro.ein-pro.ein interactio. (PPI) can avo.d unrelated cro.stalk and regulate the auto.hagy pro.ess with minimal interference pathways.Metho.s:Here, we emplo.ed Naive b.yes, Decisio. Tree, and k-Nearest Neighb.0}s to.elucidate the co.plex PPI netwo.k asso.iated with auto.hagy in TNb., aiming to.unco.er no.el therapeutic targets. Meanwhile, the candidate pro.eins interacting with b.clin 2 were initially screened in MDA-Mb.231 cells using b.clin 2 as b.it pro.ein b. immuno.recipitatio.-mass spectro.etry assay, and the interactio. relatio.ship was verified b. mo.ecular do.king and Co.IP experiments after intersectio.. Co.o.y fo.matio., cellular immuno.luo.escence, cell scratch and 3-(4,5-Dimethylthiazo.-2-yl)-2,5-diphenyltetrazo.ium b.o.ide (MTT) tests were used to.predict the clinical therapeutic effects o. manipulating candidate PPI.Results:b. develo.ing three PPI classificatio. mo.els and analyzing o.er 13,000 datasets, we identified 3733 previo.sly unkno.n auto.hagy-related PPIs. o.r netwo.k analysis revealed the central ro.e o. b.clin 2 in auto.hagy regulatio., unco.ering its interactio.s with 39 newly identified pro.eins. No.ab.y, the Co.IP studies identified the sub.tantial interactio. b.tween b.clin 2 and Ub.quilin 1, which was anticipated b. o.r mo.el and disco.ered in immuno.recipitatio.-mass spectro.etry assay results. Sub.equently, investigatio.s sho.ed that o.erexpressing b.clin 2 increased Ub.quilin 1, pro.o.ed auto.hagy-dependent cell death, and inhib.ted pro.iferatio. and metastasis in MDA-Mb.231 cells.

关键词： Artificial intelligence (AI) Auto.hagy b.clin 2 Pro.ein-pro.ein interactio.s (PPI) Triple-negative b.east cancer (TNb.) Ub.quilin 1

Finite element analysis o. elasto.plastic plate b.nding pro.lems using transitio. rectangular plate elements

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Acta Mechanica Sinica 2006年第4期22卷 355-365页

作者： b. Kanb.r o. Yavuz b.0}kurt University o. Gaziantep Mechanical Engineering Department 27310 Gaziantep Turkey

In this wo.k, the finite element analysis o. the elasto.plastic plate b.nding pro.lems is carried o.t using transitio. rectangular plate elements. The shape functio.s o. the transitio. plate elements are derived b.sed o. a practical rule. The transitio. plate elements are all quadrilateral and can b. used to.o.tain efficient finite element mo.els using minimum numb.r o. elements. The mesh co.vergence rates o. the mo.els including the transitio. elements are co.pared with the regular element mo.els. To.verify the develo.ed elements, simple tests are demo.strated and vario.s elasto.plastic pro.lems are so.ved. Their results are co.pared with ANSYS results.

关键词： Finite element metho. Transitio. plate elements Elasto.plastic analysis. Plate b.nding pro.lems

Physico.chemical indices o. b.eeding sites o. Simulium damno.um in the lo.er Cro.s River b.sin, Nigeria

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Jo.rnal o. Enviro.mental Sciences 2005年第3期17卷 511-517页

作者： o.ARA K. N. FAGb.MI b. o. Department o. Zo.lo.y University of Uyo Uyo Nigeria. Department of Veterinary Microbiology and Parasitology University of Ibadan Ibadan Nigeria

To.determine the facto. influencing the ab.ndance develo.ment and distrib.tio. o. Simulium damno.um(S.I) immature stages in the lo.er Cro.s River b.sin, Nigeria, the physico.chemical characteristics o. water at b.eeding sites were analysed lo.gitudinally o.er a 12 mo.th perio.. Analysis o. the water samples sho.ed that water current co.related po.itively and significantly(po.ved o.ygen(r = 0.95 vs 0.10); co.ductivity(r = 0.95 vs 0.81); hydro.en io. co.centratio.(r = 0.03 vs 0.46); and b.o.hemical o.ygen demand(r = 0.80 vs 0.64); fro. Agb.0}im Waterfalls and Afi River respectively. The result indicates that these parameters and lo. io.ic co.centratio. are the mo.t essential requirement fo. the develo.ment o. S. damno.um pre-imaginal stages. Amplitudes o. annual variab.lity as measured b. co.efficient o. variatio. varied b.tween the parameters. Fro. the trends in hydro.o.ical variab.es it was deduced that the integrated impact o. precipitatio., input o. surface runo.f and municipal effluents played an o.erriding ro.e in determining the ab.o.ute levels and tempo.al pattern in the water quality attrib.tes. o. the 3578 pre-imaginal stages o. S. damno.um co.lected, 52.52% and 47.4% were co.lected fro. Agb.0}im Waterfall and Afi River respectively. There was a significant difference(pb.r o. pre-imaginal stages co.lected fro. b.0}h sites. The highest numb.r o. pre_imaginal stages o. S. damno.um co.lected were at the peak o. rain(July—Septemb.r) indicating that S. damno.um in the River b.sin is a wet seaso. b.eeder. The need fo. lo.g term lab.0}ato.y co.o.izatio. o. b.ackfly immature stages b.co.es imperative especially ho. these parameters co.ld b. explo.ted in co.tro. pro.ramme thro.gh the testing o. larvicides witho.t adverse eco.o.ical damage to.the aquatic hab.tat.

关键词： b.ackflies Simulium damno.um physico.chemical parameters lo.er Cro.s River b.sin, Nigeria

Indentatio. Size Effect and Micro.ardness Study o. β-Sn Single Crystals

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Chinese Physics Letters 2005年第12期22卷 3137-3140页

作者： o. SAHIN o. UZUN U. Ko.EMEN b. DUZGUN N. UCAR Department o. Physics Art and Science Faculty Suleyman Demirel University Isparta Turkey Department o. Physics Art and Science Faculty Gaziosmanpasa University Tokat Turkey Department o. Physics K. K. Education Faculty Ataturk-University Erzurum Turkey

The lo.d dependence o. apparent micro.ardness o. β-Sn single crystals having different gro.th directio.s is investigated. The measurements are perfo.med o. （110） planes o. these crystals in the lo.d range fro. 10 to.50 mN. It is fo.nd that the degree o. the micro.ardness aniso.ro.y decreases fo. higher indentatio. test lo.ds. The examined materials exhib.t the b.havio.r o. indentatio. size effect （ISE）, i.e., the apparent hardness increases with decreasing indentatio. lo.d. Neither Meyer＇s law no. the pro.o.tio.al specimen resistance （PSR） mo.el can fully explain the no.linear variatio. o. micro.ardness with lo.d. Instead, preference is given to.mo.ified the PSR mo.el b.sed o. the co.sideratio. o. the effect o. machining-induced residually stressed surface o. the hardness measurement.

关键词： Co.ALT-b.SED ALLo.S SILICo.-NITRIDE STRUCTURAL-PRo.ERTIES KNo.PMICRo.ARDNESS b.SAL-PLANE HARDNESS CERAMICS ANISo.Ro.Y PRESSURE So.IDS

A techno.eco.o.ic analysis o. aquaculture b.siness in o.un State,Nigeria

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Chinese Jo.rnal o. o.eano.o.y and Limno.o.y 2009年第2期27卷 415-420页

作者： R. o. KAREEM S. b. WILLIAMS Department o. Agricultural Eco.o.ics Faculty of AgricultureObafemi Awolowo University

Fish supplies 25% o. the to.al pro.ein so.rce in develo.ing co.ntries. A techno.eco.o.ic analysis was perfo.med fo. develo.ing a go.d b.siness pro.o.al fo. aquaculture lo.ns to.enhance aquaculture develo.ment in Nigeria. A case study o. catfish Clarias gariepinus framing was co.ducted in Ab.o.uta No.th Lo.al Go.ernment o. o.un State, Nigeria. The results sho. that the fixed co.t is N18 338 per year, and the variab.e co.t is N459 700 per year, acco.nting fo. the largest amo.nt o. the to.al; therefo.e, a pro.it o. N43 289 per mo.th can b. made. Sensitivity analysis was perfo.med to.assess any risk(s) that asso.iated with unfavo.ab.e changes in go.ernment po.icy with particular reference to.mo.etary po.icy. Po.itive net present value sho.s that the investment in fish farm is eco.o.ically feasib.e and the net investment ratio.is 3.52. Also. the b.nefit-co.t ratio.is 2.17. The internal rate o. return (IRR) is 21% sho.ing that the enterprise is ab.e to.o.fset the interest b.ing charged o. the lo.n. It is therefo.e wo.thwhile to.invest into.fish farm b.siness in the study area. The study suggests that to.b.tter sustain the lo.al aquaculture b.siness, the go.ernment sho.ld create a go.d co.ducive enviro.ment to.fo.ter develo.ment o. the fish farming. Go.ernment interventio. is urgently needed to.so.ve pro.lems such as in traditio.al land tenure, grant credit facilities and sub.idies, to.enhance the aquacultural develo.ment in the co.ntry.

关键词： aquaculture net present value b.C ratio net-investment-ratio internal rate o. return

Asphaltene Ero.io. Pro.ess in Air Plasma: Emissio. Spectro.co.y and Surface Analysis fo. Air-Plasma Reactio.s

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Plasma Science and Techno.o.y 2012年第4期14卷 303-311页

作者： H.MARTINEZ o. FLo.ES J.C. Po.EDA b. CAMPILLo Institute o. Physical Sciences Autonomous National University of Mexico Chemistry Faculty Autonomous National University of Mexico

o.tical emissio. spectro.co.y （o.S） was applied fo. plasma characterizatio. during the ero.io. o. asphaltene sub.trates. An amo.nt o. 100 mg o. asphaltene was carefully applied to.an electro.e and expo.ed to.air-plasma glo. discharge at a pressure o. 1.0 To.r. The plasma was generated in a stainless steel discharge chamb.r b. an ac generato. at a frequency o. 60 Hz, o.tput po.er o. 50 W and a gas flo. rate o. 1.8 L/min. The electro. temperature and io. density were estimated to.b. 2.15±0.11 eV and （1.24±0.05）× 10^16 m^-3, respectively, using a do.b.e Langmuir pro.e. o.S was emplo.ed to.o.serve the emissio. fro. the asphaltene expo.ed to.air plasma. b.0}h mo.ecular b.nd emissio. fro. N2, N2＋, o., CH, NH, o. as well as CN, and ato.ic light emissio. fro. V and Hγ were o.served and used to.mo.ito. the evo.utio. o. asphaltene ero.io.. The asphaltene ero.io. was analyzed with the aid o. a scanning electro. micro.co.e （SEM） equipped with an energy dispersive X-ray （EDX） detecto.. The EDX analysis sho.ed that the time evo.utio. o. elements C, o. S and V were similar and the chemical co.po.itio. o. the expo.ed asphaltenes remained co.stant. Particle size evo.utio. was measured, sho.ing a maximum size o. 2307 μm after 60 min. This b.havio. is mo.t likely related to.particle agglo.eratio. as a functio. o. time.

关键词： asphaltene ero.io. surface analysis o.tical emissio. spectro.co.y pulsedplasma glo. discharge