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中国设备管理 2000年第1期 53-55页

作者： Kenneth o'reilly 娄冰冰星阁

用MEMS加速度计作为拾音器完美再现乐器音效

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今日电子 2009年第9期 41-44页

作者： Rob o’reilly Alex Khenkin Kieran Harney ADI公司

MEMS（微机电系统）传感器在汽车、手机、个人电脑、相机等各种应用中屡见不鲜，但是直到现在，这类传感器还未用于吉他领域。本文作者将探究以下问题的答案：如何采用MEMS加速度计作为声学传感器。

关键词： MEMS 加速度计拾音器声学传感器音效乐器微机电系统个人电脑

Immiscible metallic melts in the deep Earth: clues from moissanite(SiC)in volcanic rocks

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Science Bulletin 2020年第17期65卷 1479-1488,M0004页

作者： Jin-Xiang Huang Qing Xiong Sarah E.M.Gain William L.Griffin Timothy D.Murphy Andrei A.Shiryaev Liwu Li Vered Toledo Mikhail D.Tomshin Suzanne Y.o’reilly ARC Centre of Excellence for Core to Crust Fluid Systems and GEMoC Department of Earth and Planetary SciencesMacquarie UniversityNorth RydeNSW 2109Australia State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430074China Frumkin Institute of Physical Chemistry and Electrochemistry RAS Moscow 119071Russia Key Laboratory of Gas Geochemistry Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Shefa Gems Ltd. Netanya 42106Israel Diamond and Precious Metal Geology Institute SB RASYakutsk 677007Russia Center for Microscopy Characterisation and Analysisthe University of Western AustraliaPerth 6009Australia

The occurrence of moissanite(SiC), as xenocrysts in mantle-derived basaltic and kimberlitic rocks sheds light on the interplay between carbon, hydrogen and oxygen in the lithospheric and sublithospheric mantle. SiC is stable only at fo2ospheric mantle and related melts commonly are considered to be much more oxidized. SiC grains from both basaltic volcanoclastic rocks and kimberlites contain metallic inclusions whose shapes suggest they were entrapped as melts. The inclusions consist of Si^0+ Fe3Si7± FeSi2 Ti ± CaSi2Al2± FeSi2Al3± CaSi2, and some of the phases show euhedral shapes toward Si^0. Crystallographically-oriented cavities are common in SiC, suggesting the former presence of volatile phase(s), and the volatiles extracted from crushed SiC grains contain H2+ CH4± Co2± *** observations suggest that SiC crystalized from metallic melts(Si-Fe-Ti-C ± Al ± Ca), with dissolved H2+ CH4± Co2± Co derived from the sublithospheric mantle and concentrated around interfaces such as the lithosphere-asthenosphere and crust-mantle boundaries. When mafic/ultramafic magmas are continuously fluxed with H2+ CH4 they can be progressively reduced, to a point where silicide melts become immiscible, and crystallize phases such as SiC. The occurrence of SiC in explosive volcanic rocks from different tectonic settings indicates that the delivery of H2+ CH4 from depth may commonly accompany explosive volcanism and modify the redox condition of some lithospheric mantle volumes. The heterogeneity of redox states further influences geochemical reactions such as melting and geophysical properties such as seismic velocity and the viscosity of mantle rocks.

关键词： Moissanite Reduced gas Alloy inclusion Mantle

Chimeric antigen receptor therapy of human TCR-like antibodies to intracellular WT1 oncoprotein

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Chimeric antigen receptor therapy of human TCR-like antibodi...

透辉石的激光探针ICP质谱分析及其深部地质意义

第九届全国免疫学学术大会

作者： Qi Zhao Mahiuddin Ahmed Dimiter V.Tassev Aisha Hasan Richard J.o'reilly Nai-Kong V.Cheung Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Department of Pediatrics Memorial Sloan-Kettering Cancer CenterNew YorkUSA Pediatric Stem Cell Transplant Service Memorial Sloan-Kettering Cancer CenterNew YorkUSA

Background:WT1(RMFPNAPYL)is a human leukocyte antigen-A2(HLA-A2)restricted peptide derived from Wilms tumor protein(WT1),which is widely expressed in a broad spectrum of leukemias,lymphomas and solid ***:A novel T-cell-receptor(TCR)-like fully-human antibody specific for the T cell epitope consisting of the WT1/HLA-A2 complex was isolated from a human antibody *** antibody selectively bound and killed WT1(+)and HLA-A2(+)leukemia and solid tumor cell ***:The TCR-like antibody was affinity-matured by mutagenesis combined with yeast display,and structurallyanalyzed using a homology ***-maturated antibodies as native proteins or chimeric antigen receptor(CAR)were evaluated in vitro ADCC assays,and leukemia therapeutic ***:This monovalent scFv showed a 100-fold affinity improvement(KD=3nM).Bivalent scFv-huIgGl-Fc fusion protein demonstrated an even higher avidity(K=2pM)binding to the T cell epitope and was capable of mediating ADCC or tumor lysis by CAR-expressing human T or NK *** antibody demonstrated potent cytotoxicity in vivo towards WT1(+)and HLA-A2(+)leukemia ***:In summary,we provide a strategy for developing high affinity human TCR-like antibodies targeting intracellular oncogenic proteins for potential clinical therapy.

关键词： TCR-like antibodies HLA-A2 WT1 chimeric antigen receptors yeast display

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科学通报 1997年第16期42卷 1707-1711页

作者：陈绍海周新华张国辉 S.Y.o’reilly W.L.Griffin M.Zhang 中国科学院地质研究所岩石圈开放实验室北京100029 GEMoCSchoolofEarthSciences MacquarieUniversitySydney2109Australia GEMoCSchoolofEarthSciences MacquarieUniversitySydney2109

第三纪汉诺坝玄武岩中含有大量的橄榄岩类捕虏体,通过激光探针ICP质谱对其组成矿物透辉石的分析,揭示了华北克拉通北缘岩石圈地幔的总体亏损特征和不均一性,指出岩石的部分熔融程度对透辉石的稀土元素组成特征的影响,提出复合捕虏体形... 详细信息

第三纪汉诺坝玄武岩中含有大量的橄榄岩类捕虏体,通过激光探针ICP质谱对其组成矿物透辉石的分析,揭示了华北克拉通北缘岩石圈地幔的总体亏损特征和不均一性,指出岩石的部分熔融程度对透辉石的稀土元素组成特征的影响,提出复合捕虏体形成于上地幔内部的应力作用,而非后期地幔流体的交代作用。

关键词：橄榄岩类捕虏体激光探针透辉石 ICP质谱

华夏地块古老物质的发现和前寒武纪地壳的形成

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科学通报 2007年第1期52卷 11-18页

作者：于津海 Y.S.o’reilly 王丽娟 W.L.Griffin 蒋少涌王汝成徐夕生壳幔演化与成矿作用研究国家重点实验室南京大学地球科学系南京210093 GEMoC National Key Centre Department of Earth and Planetary SciencesMacquarie UniversitySydneyNSW 2109Australia.

对粤北南雄地区一个副片麻岩中56个碎屑锆石的年代学研究显示,华夏腹地晚新元古代沉积岩主要由新太古代(～2.5 Ga)和Grenville期(0.9～1.1 Ga)的碎屑物质组成,其中还包含了一定数量的中元古代和少量中太古代(3.0～3.2 Ga)和古太古代(3.7... 详细信息

对粤北南雄地区一个副片麻岩中56个碎屑锆石的年代学研究显示,华夏腹地晚新元古代沉积岩主要由新太古代(～2.5 Ga)和Grenville期(0.9～1.1 Ga)的碎屑物质组成,其中还包含了一定数量的中元古代和少量中太古代(3.0～3.2 Ga)和古太古代(3.76 Ga)的碎屑物质.这些发现表明华夏地块存在非常古老的物质.37颗锆石的Hf同位素组成显示这些碎屑物质具有不同的成因,少量结晶于有较多新生地壳组分熔融产生的岩浆,而大多数结晶于古老地壳组分部分熔融产生的岩浆.锆石U-Pb年龄和Hf同位素综合研究指出华夏地块新生地壳物质主要是在2.5～2.6 Ga形成,中太古代(3.0～3.3 Ga)、古元古代晚期(～1.8 Ga)和古太古代(～3.7 Ga)也是重要的地壳生长期.中元古代-新元古代的岩浆活动非常强烈,但主要表现为古老物质的再循环,只有很少有新生地壳增生.～2.1 Ga模式年龄峰值的存在和同时代锆石的缺失表明许多锆石的古元古代模式年龄很可能是源区中新太古代和古元古代晚期物质混合的结果.

关键词：锆石U-Pb定年锆石Hf同位素太古代物质华夏地块地壳的形成

华夏南部可能存在Grenville期造山作用:来自基底变质岩中锆石U-Pb定年及Lu-Hf同位素信息

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科学通报 2008年第14期53卷 1680-1692页

作者：王丽娟于津海 o’reilly S.Y. Griffin W.L. 孙涛魏震洋舒良树蒋少涌内生矿床成矿机制研究国家重点实验室南京大学地球科学系 GEMoC National Key Centre Department of Earthand Planetary ScienceMacquarie UniversitySydneyNSW2109Australia

对华夏地块南部粤中增城和赣南鹤仔3个基底变质岩的地球化学和碎屑锆石年代学研究表明,它们的原岩都是形成于晚新元古代的沉积岩.3个变质沉积岩都主要由新元古代早期(1.0～0.9Ga)的碎屑物质组成,并混有少量中元古代和新元古代中晚期(0.8... 详细信息

对华夏地块南部粤中增城和赣南鹤仔3个基底变质岩的地球化学和碎屑锆石年代学研究表明,它们的原岩都是形成于晚新元古代的沉积岩.3个变质沉积岩都主要由新元古代早期(1.0～0.9Ga)的碎屑物质组成,并混有少量中元古代和新元古代中晚期(0.8～0.6Ga)的碎屑物,说明沉积物主要来源于一个遭受过Gondwana大陆聚合事件影响的Grenville期造山带.碎屑锆石的Hf同位素成分显示这些Grenville期锆石可能是造山旋回早期形成的弧与古老大陆碰撞产生的岩浆结晶的.结合华夏地块其他地区～1.0Ga年龄锆石的分布及形态学特征,本文认为华夏地块的南缘很可能曾经存在或者极其靠近一个Grenville期的造山带.而这期造山作用的时代与东印度以及东南极的Grenville造山带一致,且同样受到Gondwana大陆聚合事件的影响.因此,从Rodinia超大陆裂解到Gondwana超大陆聚合期间,华南地块很可能位于澳大利亚西部而与东印度和东南极相邻.

关键词：华夏地块 Grenville造山带锆石U-Pb定年 Hf同位素新元古代Rodinia超大陆

Transition-Zone Mineral Assemblages in Peridotite Massifs, Tibet: Implications for Collision-zone Dynamics and orogenic Peridotites

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Acta Geologica Sinica(English Edition) 2015年第A2期89卷 90-91页

作者： W. L. GRIFFIN N.M. MCGoWAN J. M. GoNZALEZ-JIMENEZ E. A. BELoUSoVA D. HoWELL J. C. AFoNSo YANG J.S SHI R Suzanne Y. o'reilly N. J. PEARSoN CCFS/GEMoC Earth and Planetary Sciences Macquarie University NSW 2109 Australia State Key Laboratory for Continental Tectonics and Dynamics CAGS Beijing 100037 China Institute for Tibetan Plateau Research CAS Beijing 100085 China

Diamonds have been reported from Tibetan ＂ophiolites＂ for 〉30 years, but have been widely dismissed as contaminants, because their unusual morphology and light C （δ13C=-18 to -27） are unlike those of kimberlitic diamonds. However, the diamonds have now been found in situ in both the chromitites and the peridotites of ＂ophiolites＂ along the Yarlung-Zangbo suture （Tibet） and the Polar Urals （Yang et al., 2014）.

关键词： MINERALS PERIDoTITE DIAMoNDS IGNEoUS rocks CRUST of the earth

Toxicity of a seafood toxin， domoic acid， in the retina via modulation of the NRF2 and NF-κB pathways

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Food Science and Human Wellness 2024年

作者： Gabriel Mbuta Tchivelekete Yanqun Cao Mohammad Almarhoun Xinzhi Zhou Agostinho Francisco Cachapa Sebasti?o Tumitangua James reilly Patricia E.Martin Xinhua Shu Department of Biological and Biomedical Sciences， Glasgow Caledonian University Department of Marine Biology， Faculty of Natural Science， University of Namibe Puai Medical School， Shaoyang University Department of Vision Science， Glasgow Caledonian University

Domoic acid (DA)， a biotoxin， is produced by several species of marine dinoflagellate and diatom during harmful algal bloom events. DA is a neurotoxin， in humans and non-human primates， oral exposure to DA results in gastrointestinal effects， while DA at higher doses leads to neurological symptoms， seizures and memory deficiency. Exposure of humans to DA occurs mainly through consumption of contaminated seafoods containing an accumulation of the toxin. Previously， it was unclear if DA can have toxic effects on the retina. We assessed the toxicity of DA in human retinal cells (ARPE-19) and in zebrafish embryos. DA significantly lowered ARPE-19 cell viability dose-dependently， and decreased anti-oxidative capacity， increased inflammation， and promoted cell death， possibly through modulating the NRF2 and NF-κB signalling pathways. Zebrafish embryos exposed to DA for four days from one day post fertilization (dpf) had an increase in mortality and a decrease in both hatching and heartbeat rate and exhibited morphological abnormalities. DA treatment also significantly downregulated expression of antioxidant genes and upregulated expression of inflammation mediators， as well as causing photoreceptor death in zebrafish embryos. The results demonstrate that consuming seafood containing DA will have potential toxic effects in human retinas.

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对急性胰腺炎预防性应用抗生素有争议

中国处方药 2005年第3期4卷 90-91页

作者： Derek A o’reilly Andrew N Kingsnorth 乔建军

急性胰腺炎是一种常见的外科急症.据报道,英国每年发病率高达38/10万,且呈上升趋势.

关键词：急性胰腺炎预防用药抗生素环丙沙星甲硝唑