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ANALYSIS MoDEL To SIMULATE THE CRACKED PIPE BURIED IN SoIL

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Acta Mechanica Sinica 1998年第2期14卷 147-156页

作者：庄茁 P.E.o’donoghue Department of Engineering Mechanics Tsinghua University Beijing China 100084 Department of Civil Engineering University College Dublin Earlsfort Terrace Dublin 2 Ireland

The finite element method was used to simulate the crack propagation in a pipeline in the presence of soil backfill. Since typical values for soil modulus are known, a spring element can be used to simulate the effects of backfilled soil on crack propagation. This consists of the relationship between the soil property and the stiffness of the spring element, and the effect of backfill depth on the crack propagation in the pipes. By equating crack driving force, G, in the presence of soil, to the dynamic fracture toughness of the pipeline material, a theoretical predictive capability was obtained for the gas transmission and distribution pipelines. Numerical calculations had also been carried out for the cracked pipe with backfill and without backfill. (Edited author abstract) 9 Refs.

关键词： fracture mechanics finite element simulation pipeline soil

Highly Fluorescent Dye-Doped Silica Nanoparticles Increase Flow Cytometry Sensitivity for Cancer Cell Monitoring

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Nano Research 2009年第6期2卷 448-461页

作者： M.-Carmen Estévez Meghan B.oʼdonoghue Xiaolan Chen Weihong Tan Center for Research at the Bio/Nano Interface Departments of Chemistry and Department of Physiology and Functional GenomicsShands Cancer Center and UF Genetics InstituteMcKnight Brain InstituteUniversity of FloridaGainesvilleFlorida 32611-7200USA

Early and accurate diagnosis and treatment of cancer depend on rapid,sensitive,and selective detection of tumor *** diagnosis of cancers,especially leukemia,relies on histology and fl ow cytometry using single dye-labeled ***,this combination may not lead to high signal output,which can hinder detection,especially when the probes have relatively weak affi nities or when the receptor is expressed in a low concentration on the target cell *** solve these problems,we have developed a novel method for sensitive and rapid detection of cancer cells using dye-doped silica nanoparticles(NPs)which increases detection sensitivity in fl ow cytometry analyses between 10-and 100-fold compared to standard *** NPs are~60 nm in size and can encapsulate thousands of individual dye molecules within their *** have extensively investigated surface modifi cation strategies in order to make the NPs suitable for selective detection of cancer cells using fl ow *** NPs are functionalized with polyethylene glycol(PEG)to prevent nonspecifi c interactions and with neutravidin to allow universal binding with biotinylated *** virtue of their reliable and selective detection of target cancer cells,these NPs have demonstrated their promising usefulness in conventional fl ow ***,they have shown low background signal,high signal enhancement,and effi cient functionalization,either with antibody-or aptamer-targeting moieties.

关键词： Silica nanoparticle flow cytometry aptamer cell detection polyethylene glycol fl uorophore

Comparative eye-tracking evaluation of scatterplots and parallel coordinates

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Visual Informatics 2017年第2期1卷 118-131页

作者： Rudolf Netzel Jenny Vuong Ulrich Engelke Seán o’donoghue Daniel Weiskopf Julian Heinrich Visualization Research Center(VISUS) University of StuttgartStuttgartGermany Commonwealth Scientific and Industrial Research organisation(CSIRo)(Sydney Hobart)Australia University of Tübingen TübingenGermany

We investigate task performance and reading characteristics for scatterplots(Cartesian coordinates)and parallel *** a controlled eye-tracking study,we asked 24 participants to assess the relative distance of points in multidimensional space,depending on the diagram type(parallel coordinates or a horizontal collection of scatterplots),the number of data dimensions(2,4,6,or 8),and the relative distance between points(15%,20%,or 25%).For a given reference point and two target points,we instructed participants to choose the target point that was closer to the reference point in multidimensional *** present a visual scanning model that describes different strategies to solve this retrieval task for both diagram types,and propose corresponding hypotheses that we test using task completion time,accuracy,and gaze positions as dependent *** results show that scatterplots outperform parallel coordinates significantly in 2 dimensions,however,the task was solved more quickly and more accurately with parallel coordinates in 8 *** eye-tracking data further shows significant differences between Cartesian and parallel coordinates,as well as between different numbers of *** parallel coordinates,there is a clear trend toward shorter fixations and longer saccades with increasing number of *** an area-of-interest(AoI)based approach,we identify different reading strategies for each diagram type:For parallel coordinates,the participants’gaze frequently jumped back and forth between pairs of axes,while axes were rarely focused on when viewing Cartesian *** further found that participants’attention is biased:toward the center of the whole plot for parallel coordinates and skewed to the center/left side for Cartesian *** anticipate that these results may support the design of more effective visualizations for multidimensional data.

关键词： Parallel coordinates Scatterplots Cartesian coordinates Eye tracking Controlled laboratory user study

Modelling Financially optimal Afforestation and Forest Management Scenarios Using a Bio-Economic Model

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open Journal of Forestry 2016年第1期6卷 19-38页

作者： Mary Ryan Cathal o’donoghue Henry Phillips Rural Economy and Development Programme Teagasc Athenry Ireland

The expansion of non-industrial private forests (NIPF) in Ireland is unique in the European context in which the almost doubling of forest cover within the last thirty years has taken place largely on farmland. This is not surprising as Ireland has some of the highest growth rates for conifers in Europe and also has a large proportion of land which is marginal for agriculture but highly productive under forests. However, in recent years, afforestation in Ireland as in many European countries has fallen well short of policy targets. As the farm afforestation decision essentially involves an inter-temporal land use change, farmers need comprehensive information on forest market returns under different environmental conditions and forest management regimes. This paper describes the systematic development of a cohort forest bio-economic model which examines financially optimal afforestation and management choices. Simulating a range of productivity and harvesting scenarios for Sitka spruce, we find that different objectives result in different outcomes. We see substantial differences between the biologically optimal rotation, the reduced rotation in common usage and the financially optimal rotation which maximises net present value and find that the results are particularly sensitive to the choice of management and methodological assumptions. Specifically, we find that better site productivity and thin versus no-thin options result in shorter rotations across all optimisations, reinforcing the usefulness of this type of financial modelling approach. This information is critical for future policy design to further incentivise afforestation of agricultural land.

关键词： Forestry Bio-Economic Modelling Afforestation optimisation

Versus—A tool for evaluating visualizations and image quality using a 2AFC methodology

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Visual Informatics 2018年第4期2卷 225-234页

作者： Jenny Vuong Sandeep Kaur Julian Heinrich Bosco K.Ho Christopher J.Hammang Benedetta F.Baldi Seán I.o’donoghue CSIRo Data61Australia Garvan Institute of Medical Research Australia University of New South Wales Australia University of Tübingen Germany University of Sydney Australia

Novel visualization methods and strategies are necessary to cope with the deluge of datasets present in any scientific field to make discoveries and find answers to previously unanswered *** methods and strategies should not only present scientific findings as images in a concise way but also need to be effective and expressive,which often remain ***,we present Versus,a tool to enable easy image quality assessment and image ranking,utilizing a two-alternative forced choice methodology(2AFC)and an efficient ranking algorithm based on a binary *** tool provides a systematic way of setting up evaluation experiments via the web without the necessity to install any additional software or require any programming ***,Versus can easily interface with crowdsourcing platforms,such as Amazon’s Mechanical Turk,or can be used as a stand-alone system to carry out evaluations with *** demonstrate the use of Versus by means of an image evaluation study,aiming to determine if hue,saturation,brightness,and texture are good indicators of uncertainty in three-dimensional protein *** from the power of crowdsourcing,we argue that there is demand and also great potential for this tool to become a standard for simple and fast image evaluations,with the aim to test the effectiveness and expressiveness of scientific visualizations.

关键词： Evaluation Visualization Visual analytics Image comparison Crowdsourcing Evaluation methods 2AFC Image evaluation Tool Visualization evaluation

Analysis of HIV mutation dynamics for a linear mutation tree

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Analysis of HIV mutation dynamics for a linear mutation tree

Joint 48th IEEE Conference on Decision and Control and 28th Chinese Control Conference

作者： Jorge Ferreira Yoann o’donoghue Rick Middleton Hamilton Institute National University of Ireland-Maynooth

This work is focused on modelling HIV mutation and drug *** develop a technique to study viral dynamics in a system of m viral strains including mutation between the different *** analysis of the nonlinear dynamics involving the free virus and its host cell is *** the class of model considered,with "low" mutation rate,we analytically determine all possible equilibria,their local stability and positivity *** results show that the model describes the ability of HIV to mutate into drugresistant variants resulting from its replication process.

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来源： cnki会议评论

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桥小脑角内窥镜解剖

国际耳鼻咽喉头颈外科杂志 1994年第2期18卷 125-126页

作者： o'donoghue-GM 蔡莉筠朱家赛

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聋儿伴发眼病的循征医学研究

中华耳科学杂志 2007年第3期5卷 307-325页

作者： Nikolopoulos TP Lioumi D Stamataki S o＇donoghue GM 房高丽（译）马芙蓉（审校）希腊雅典大学医学院（Department of otorhinolaryngology Athens UniversityIppokration HospitalAthens）耳鼻喉科医学博士不详北京大学第三医院耳鼻咽喉科北京100083

背景为培养交流技巧,更好的认识自己周围的世界,聋儿需要更多的倚重于视觉功能的正常存在。因此,任何眼部疾病都会对这个过程产生负面的影响,尤其是没能在发病早期发现,影响更大。一些能够纠正和治疗的疾病,如近视和白内障,早期确认将... 详细信息

背景为培养交流技巧,更好的认识自己周围的世界,聋儿需要更多的倚重于视觉功能的正常存在。因此,任何眼部疾病都会对这个过程产生负面的影响,尤其是没能在发病早期发现,影响更大。一些能够纠正和治疗的疾病,如近视和白内障,早期确认将有助于完善语言的发育和培养社会认知能力;还有一些无法纠正和治疗的疾病,如Usher综合征的视网膜色素变性,就需要多方面的适应环境,给予适当的照顾和康复治疗。目的回顾长久以来累积形成的聋儿眼病的科学知识,并评价这些文献的质量,从而更好的诊断和治疗疾病。材料和方法本研究审阅了超过1000篇的文章,其中191篇文章符合本研究的目的,因而被本文引用。总结这些研究,其中95%为描述性研究或个案报道(Ⅲ型或Ⅳ型证据),只有3%是Ⅱ型证据,2%为Ⅰ型证据。结果和结论本研究主要的结论包括以下几点:a)关于聋儿伴发眼病的研究及文献报道总体上循证医学证据的质量不高;b)聋儿眼病的发生率非常高(大约40%～60%),尽管这些疾病可能严重影响儿童交流技能的培养,但往往很多年不被发现;c)聋儿眼病筛查应得到鼓励,一旦耳聋的诊断成立,无论年龄大小,应立即展开专业的眼科检查,而且可能需要在以后的随访中经常复查;d)患儿家属应该通过与相关的专业医师讨论,被告知筛查过程的实质,并通过不同形式、不同语言给予正确的信息指导;e)进行检查的专业医师应该熟悉患眼病的聋儿的需要,并且要敏感地觉察到儿童交流的需要,尤其是进行行为测听检查需要患儿配合时;f)尽管视轴纠正师能够开展绝大多数心理物理学检测(视力和立体视觉检查,眼球运动检查等等),全面的眼科检查仍然需要开展,包括:裂隙灯显微镜检查,带状视网膜检影法,直接和间接检眼镜检查,眼内压测定等等。视网膜电流描记也经常被用来确认Usher综合征的存在;g)对于双重感觉缺陷的儿童,需要进行连续的听力检测以监测听力阈值,完善助听器的使用,对有需要的患儿进行人工耳蜗植入。

关键词：眼病筛查聋儿医学研究伴发 Usher综合征循证医学证据裂隙灯显微镜检查视网膜色素变性

社会工作督导研究回顾及展望(1970～2010)

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中国社会工作研究 2017年第2期 190-208页

作者： Kieran o’donoghue 徐明心史天琪(译) 梅西大学(新西兰)健康与社会服务学院社会工作与社会政策系香港明爱专上学院社会科学院厦门大学公共事务学院社会学与社会工作系

本文对过去四十年间（1970~2010）发表在社会工作同行评审期刊上的社会工作实务督导研究进行了一个广泛回顾。我们对筛选出的86篇文章的发表年代、地域分布、研究设计、研究参与者和研究焦点及发现进行了分析,在此基础上讨论了社会工作... 详细信息

本文对过去四十年间（1970~2010）发表在社会工作同行评审期刊上的社会工作实务督导研究进行了一个广泛回顾。我们对筛选出的86篇文章的发表年代、地域分布、研究设计、研究参与者和研究焦点及发现进行了分析,在此基础上讨论了社会工作督导理论与实践知识的发展现状。我们建议,未来的研究需要关注三个方面：以经验为本的督导模式发展、督导对服务对象改变的影响评估与不同国家督导实践的比较。

关键词：社会工作督导职业督导督导研究