检索结果-南通市图书馆

Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents

Signal Transduction and Targeted Therapy 2023年第1期8卷 266-275页

作者： Xiaofeng Mu Carolyn A.Cohen Daniel Leung Jaime S.Rosa Duque Samuel M.S.Cheng Yuet chung Howard H.W.Wong Amos M.T.Lee Wing Yan Li Issan Y.S.Tam Jennifer H.Y.Lam Derek H.L.Lee Sau Man Chan Leo C.H.Tsang Karl C.K.Chan John K.C.Li Leo L.H.Luk Sara Chaothai Kelvin K.H.Kwan nym coco chu Masashi Mori Trushar Jeevan Ahmed Kandeil Richard JWebby Wenwei Tu Sophie A.Valkenburg Malik Peiris Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina HKU-Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Infectious Diseases St Jude Children’s Research HospitalMemphisTNUSA Department of Microbiology and Immunology Peter Doherty Institute for Infection and ImmunityUniversity of MelbourneMelbourneVICAustralia Centre for Immunology&Infection C2i Hong KongChina

The high effectiveness of the third dose of BNT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies,but immune responses conferring this protection are not yet *** this analysis,our study(NCT04800133)aims to evaluate the humoral and cellular responses against wild-type and Omicron(BA.1,BA.2 and/or BA.5)SARS-CoV-2 before and after a third dose of BNT162b2 in healthy *** 5 months after 2 doses,S IgG,S IgG Fc receptor-binding,and neutralising antibody responses waned significantly,yet neutralising antibodies remained detectable in all tested adolescents and S IgG avidity increased from 1 month after 2 *** antibody responses and S-specific IFN-γ^(+)and IL-2^(+)CD8^(+)T cell responses were significantly boosted in healthy adolescents after a homologous third dose of *** to adults,humoral responses for the third dose were non-inferior or superior in *** S-specific IFN-γ^(+)and IL-2^(+)CD4^(+)and CD8^(+)T cell responses in adolescents and adults were comparable or ***,after 3 doses,adolescents had preserved S IgG,S IgG avidity,S IgG FcγRIIIa-binding,against Omicron BA.2,as well as preserved cellular responses against BA.1 S and moderate neutralisation levels against BA.1,BA.2 and *** from 100 and 96%of adolescents tested at 1 and 5 months after two doses could also neutralise *** study found high antibody and T cell responses,including potent cross-variant reactivity,after three doses of BNT162b2 vaccine in adolescents in its current formulation,suggesting that current vaccines can be protective against symptomatic Omicron disease.

关键词： doses neutral protective

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification of a new isoform of the murine Sh2d1a gene and its functional implications

引用

Science China(Life Sciences) 2014年第1期57卷 81-87页

作者： WU LongYan LU PeiWen MA WeiWei chu coco XU HePing QI Hai Tsinghua-Peking Center for Life Sciences Laboratory of Dynamic Immunobiology School of Medicine School of Life SciencesTsinghua University

Signaling lymphocytic activation molecule （SLAM）-associated protein （SAP） is a Src homology （SH） domain 2-containing in- tracellular adaptor protein that is predominantly expressed in the hematopoietic system by T lymphocytes and NK cells. SAP protein is encoded by the SH2DIA gene located on the X chromosome. Loss-of-function mutations in SAP cause the X-linked lymphoproliferative disease （XLP）, a severe immunodeficiency characterized by heightened susceptibility to Epstein-Barr vi- rus and impaired humoral immunity. Normal individuals express several functional and non-functional isoforms of SAP as a result of alternative splicing. In this study, we identify a cryptic exon in the murine Sh2dla gene. At the mRNA level, the new isoform of SAP （SAP-2） that includes this new exon is widely expressed in lymphoid tissues by C57BL/6 and 129 strains of inbred mice. SAP-2 accounts for approximately 1%-3% of total SAP transcripts, and it is dynamically regulated during lym- phocyte activation. At the protein level, the SAP-2 isoform is a 144 amino-acid protein. Compared to the dominant 126 ami- no-acid SAP-I isoform, the additional 18 amino acids are inserted into a structural region that is critical for phosphotyrosine binding. Our functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability. Thus, both human and mouse have multiple SAP splice isoforms that may or may not function. Modulation of relative propor- tions of these isoforms is potentially a mechanism whereby cells can regulate SAP-mediated biological activities.

关键词： Sh2dla SAP X-linked lymphoproliferative disease (XLP) isoform

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

To be or not to be direct:The role of neuromedin U in neuro-eosinophil crosstalk

引用

Science Bulletin 2024年第2期69卷 148-150页

作者： Ruichao Liu Wenhao Shao Jun Xu coco chu SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine Taiyuan 030001China Insttute for Immunogy Department of Basic Medical SciencesSchool of Medicinesinghua UnierstyBejing 100084China Tsinghua-Peking Center for Life Sciences Tsinghua UniversityBeijing 100084China Shanxi Medical University Taiyuan 030012China Department of Surgery First Hospital of Shanxi Medical UniversityShanxi Provincial Key Laboratory for Digestive Diseases and Organ TransplantationTaiyuan 030001China Beijing Key Laboratory for Immunological Research on Chronic Diseases Tsinghua UniversityBejing 100084China

With the development of new experimental techniques(e.g.,single-cell RNA sequencing(scRNA-seq),light sheet microscopy,and clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9),emerging studies have begun to uncover the interactions between the nervous system and the immune system,both in health and *** example,in mucosal tissues such as the lung and the intestine,neurotransmitters including acetylcholine[1]and adrenaline[2]can directly regulate the immune cell functions thus affect the results of allergy,asthma,and anti-pathogen host defense[3].

关键词： intestine lung asthma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reduction mechanism of high-chromium vanadium–titanium magnetite pellets by H_2–CO–CO_2 gas mixtures

引用

International Journal of Minerals,Metallurgy and Materials 2015年第6期22卷 562-572页

作者： Jue Tang Man-sheng chu Feng Li Ya-ting Tang Zheng-gen Liu Xiang-xin Xue School of Material and Metallurgy Northeastern University

The reduction of high-chromium vanadium–titanium magnetite as a typical titanomagnetite containing 0.95wt% V2O5 and 0.61wt% Cr2O3 by H2–CO–CO2 gas mixtures was investigated from 1223 to 1373 K. Both the reduction degree and reduction rate increase with increasing temperature and increasing hydrogen content. At a temperature of 1373 K, an H2/CO ratio of 5/2 by volume, and a reduction time of 40 min, the degree of reduction reaches 95%. The phase transformation during reduction is hypothesized to proceed as follows： Fe2O3 → Fe3O4 → FeO → Fe; Fe9 TiO 15 ＋ Fe2Ti3O9 → Fe2.75Ti0.25O4 → FeT iO 3 → TiO 2;（Cr0.15V0.85）2O3 → Fe2VO4; and Cr1.3Fe0.7O3 → FeC r2O4. The reduction is controlled by the mixed internal diffusion and interfacial reaction at the initial stage; however, the interfacial reaction is dominant. As the reduction proceeds, the internal diffusion becomes the controlling step.

关键词： magnetite ore reduction phase transformation reaction mechanism kinetics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development of transplanting manipulator for hydroponic leafy vegetables

引用

International Journal of Agricultural and Biological Engineering 2019年第6期12卷 38-44页

作者： Bo Li Song Gu Qi chu Yanli Yang Zhongjian Xie Kaijun Fan Xiaogeng Liu College of Engineering South China Agricultural UniversityGuangzhou 510642China Key Laboratory of Key Technology on Agricultural Machine and Equipment Ministry of EducationSouth China Agricultural UniversityGuangzhou 510642China Guangzhou Sky Mechanical&Electrical Technology Co. LtdGuangzhou 510642China

The production of hydroponic leafy vegetable plug-seedlings uses coco-peat as culture substrate in South ***-peat has lowered density than peat-moss,and the friction between substrate block and pickup tool is ***,it is hard to pick up in mechanism *** order to increase the friction,the existing transplanting manipulator had relatively complex *** simplify the structure of transplanting manipulator and improve the stability of picking up substrate block,four stainless steel fingers with rectangular cross-section were used in this research.A vertical driving was used to realize the coupling effect that could insert and shrink at the same time,by applying different combination of constraints to the steel *** could increase friction between the steel fingers and the substrate block,and then enhance the stability of the substrate *** combinations of constraints were applied to the rectangular stainless steel fingers(3 mm×0.8 mm).The working videos of steel fingers were taken by high-speed ***-speed motioned analysis software was used to acquire and analyze traces of steel fingers *** the length which top end of the steel fingers moved outward(M)is equal to 1.5 mm,the length which guiding part widened(N)is equal to 1 mm,the shrinking distance of steel fingers is 4.2 *** this research,16-day hydroponic leafy vegetable plug-seedlings were used for performance,which cultivated with coco-peat substrate with the moisture in the substrate at 81%.The transplanting manipulator was attached to a Denso robotic arm to conduct transplanting performance *** the shrinking distance of steel fingers increased from 0 mm to 3.2 mm and the inserting angle decreased from 80°to 77°,the lifting force of substrate block increased by 118%from 1.45 N to 3.16 ***,excessive shrinkage stirred the substrate block,which would reduce the friction between the substrate block and pickup parts and lowered the l

关键词： transplanting robot transplant manipulator steel fingers hydroponic leafy vegetable plug-seedlings high-speed photography guidance constraints shrinkage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

引入级联通道注意力的轻量化人体姿态估计

引用

计算机工程与应用 2024年第13期60卷 219-227页

作者：林远强郜辉王鹏吕志刚李晓艳王储西安工业大学电子信息工程学院西安710021 西安工业大学发展规划处西安710021

针对当前人体姿态估计模型在轻量化过程中精度损失严重的问题,以高分辨率网络(HRNet)为基线提出一种引入级联通道注意力的轻量化人体姿态估计模型。构建一种保持内部高分辨率特征的级联通道注意力,学习输入特征各通道的重要性来提高模... 详细信息

针对当前人体姿态估计模型在轻量化过程中精度损失严重的问题,以高分辨率网络(HRNet)为基线提出一种引入级联通道注意力的轻量化人体姿态估计模型。构建一种保持内部高分辨率特征的级联通道注意力,学习输入特征各通道的重要性来提高模型表征能力;通过设计一种基于MetaFormer结构的轻量级深度卷积变换模块来替换HRNet阶段2、3、4中运算复杂度较高的残差模块;设计一种多尺度特征融合方法减少HRNet原融合方法中的多维特征语义信息损失;采用无偏数据处理来消除关键点热力图编码过程中导致的偏移误差。coco2017验证集的实验结果表明,所提出的模型同基准模型相比,在AP降低2个百分点的情况下,模型参数量和浮点运算量分别减少了90.2%和83.1%,并且以AP为71.4%的表现在轻量化模型中达到精度最优。

关键词：人体姿态估计轻量化通道注意力 MetaFormer结构多尺度特征融合

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

蚕茧收烘经营管理体制的探讨

引用

苏州丝绸工学院学报 1985年第2期 77-84页

作者：朱世彬杨霞影车怀明

本文系根据江苏吴江县所采取的方法,对供销社代收代烘和乡、村自营收烘作了对比分析.说明乡、村自营收烘有较多的优越性,这点也为实践所证实,最后提出了较为名理,完善的收烘经营管理体制.

关键词：蚕茧利润自营茧价财政管理经营管理体制上茧率干茧茧层率茧站

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

椰糠培育叶菜种苗移植机械手设计与试验

引用

农业工程学报 2017年第14期33卷 18-24页

作者：黎波辜松初麒吕亚军胡俊生谢忠坚杨艳丽江海宇华南农业大学工程学院广州510642 华南农业大学南方农业机械与装备关键技术教育部重点实验室广州510642 广州实凯机电科技有限公司广州510642 广州市绿翔机电安装工程有限公司广州511400

针对椰糠与泥炭相比容重小、孔隙度大、颗粒间黏附性弱,现有移植机械手对椰糠培育种苗移植适应性不佳的问题,该文以椰糠培育芥蓝种苗为移植对象,设计了一种4伸缩针式移植机械手,伸缩针直径2.5 mm、入土角76°。在移植机械手移植过程中,... 详细信息

针对椰糠与泥炭相比容重小、孔隙度大、颗粒间黏附性弱,现有移植机械手对椰糠培育种苗移植适应性不佳的问题,该文以椰糠培育芥蓝种苗为移植对象,设计了一种4伸缩针式移植机械手,伸缩针直径2.5 mm、入土角76°。在移植机械手移植过程中,仅依靠基质块的基质散落质量百分比难以说明移植部件对种苗根系的影响,该文提出了一种基质散落质量百分比结合基质散落区域评分的综合评价法。针对50穴盘椰糠培育芥蓝种苗,通过伸缩针拾取试验,在保证椰糠基质块移植过程中保持完整条件下,确定了移植机械手伸缩针间距为36 mm;通过移植作业性能试验表明,叶菜种苗根系状态对移植成功率影响最大,机械手作业移动加速度也有一定影响,对最优组合分析后补做试验,试验结果表明对于正常长势椰糠培育芥蓝种苗根系状态,在根系分布率大于80%、垂直加速度0.3 m/s^2、水平加速度1.5 m/s^2和基质含水率81.01%条件下,芥蓝种苗移植成功率可达100%。该研究可为移植椰糠培育种苗的移植机开发提供技术参考。

关键词：农业机械设计试验水培叶菜种苗移植机械手椰糠基质

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

松辽盆地松科2井早白垩世沙河子组天文年代标尺

引用

第四纪研究 2023年第6期43卷 1573-1583页

作者：麻晓娟李山褚润健房强时美楠吴怀春中国地质大学(北京)生物地质与环境地质国家重点实验室北京100083 中国地质大学(北京)海洋学院北京100083 中国地质大学(北京)深时数字地球前沿科学中心北京100083

对松辽盆地白垩纪国际大陆科学钻探工程——松科2井的沙河子组自然伽马测井数据(GR)开展了详细的旋回地层学研究。频谱分析结果揭示,沙河子组上段(3336~4727 m)具有142~188 m、44~57 m、14 m和7~9 m的沉积旋回;下段(4727~5960 m)具有170... 详细信息

对松辽盆地白垩纪国际大陆科学钻探工程——松科2井的沙河子组自然伽马测井数据(GR)开展了详细的旋回地层学研究。频谱分析结果揭示,沙河子组上段(3336~4727 m)具有142~188 m、44~57 m、14 m和7~9 m的沉积旋回;下段(4727~5960 m)具有170~205 m、44~61 m、16~18 m和7.5~11.5 m的沉积旋回。这些沉积旋回的周期之比近似早白垩世天文轨道周期之比20:5:2:1,将这些沉积旋回依次解释为405 ka长偏心率、约100 ka短偏心率、约37 ka斜率和约20 ka岁差旋回。相关系数法(coco)通过统计检验获得上、下段地层沉积速率约为40 cm/ka和56 cm/ka,支持了该天文周期的解释。对405 ka长偏心率沉积旋回信号进行带通滤波,并以松科2井3961 m处凝灰岩样品的锆石U-Pb二次离子探针年龄(U-Pb SIMS)113.9±0.9 Ma为锚点,建立了松科2井沙河子组(112.3~118.2)±0.4 Ma的"浮动"天文年代标尺,其持续时间约为5.92±0.4 Ma。本研究为确定早白垩世升温过程中松辽盆地重大环境和地质事件的年代提供了新的年代学约束,为该时期全球海、陆相地质事件对比提供了年代学基础。

关键词：松科2井沙河子组旋回地层年代标尺

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于未知类别少样本学习的开放世界目标定位

引用

南昌航空大学学报（自然科学版） 2024年第3期38卷 33-44,71页

作者：王三泉王璐储珺黄斌南昌航空大学软件学院南昌330063

开放世界目标识别中未知类别样本难以获取,这些样本无法有效参与训练,针对这个问题,提出基于未知类别少样本学习的开放世界目标定位方法。首先,利用伪标签生成模型,将背景区域中高目标性得分的目标区域标记为伪标签,为模型学习未知类提... 详细信息

开放世界目标识别中未知类别样本难以获取,这些样本无法有效参与训练,针对这个问题,提出基于未知类别少样本学习的开放世界目标定位方法。首先,利用伪标签生成模型,将背景区域中高目标性得分的目标区域标记为伪标签,为模型学习未知类提供少量样本,增强模型对未知类别的泛化能力;其次,设计两个分支共同学习目标特征,其一为目标性分支,其二为定位质量分支。前者专注于确定目标框内是否存在目标,后者则集中于评估目标框的质量,从目标存在性和目标定位质量两个维度提取和理解目标特征。同时,目标性分支联合训练真实标签与伪标签样本增强对未知类别的识别能力,定位质量分支通过学习高质量的真实标签样本并排除伪标签样本,以减少噪声干扰。最后在coco数据集上对该方法进行有效性评估,结果显示,与其他方法相比,所提方法具有较为出色的检测性能。

关键词：开放世界目标检测目标定位伪标签定位质量

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：