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Nutraceutical with Anti-Inflammatory Activity for the Management of Airway Remodeling in Bronchial Asthma: <i>Kalanchoe integra</i>Var. Crenata (Andr.) Cuf Leaf Extract

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Pharmacology & Pharmacy 2014年第3期5卷 250-261页

作者： Asiedu-Gyekye Isaac Julius Awortwe Charles nyamekye effah samuel Antwi Daniel Ansong Seidu Mahmood Adjei samuel Banga N’guessan Benoit Kwame Amoateng Patrick Nkansah Edwin Department of Animal Experimentation Noguchi Memorial Institute for Medical Research College of Health Sciences Legon Ghana Department of Chemical Pathology School of Allied Health Sciences College of Health Sciences Korle-Bu Ghana Department of Pharmacology and Toxicology University of Ghana School of Pharmacy College of Health Sciences Legon Ghana Department of Physiology University of Ghana Medical School Col-lege of Health Sciences Korle-Bu Ghana Division of Pharmacology Faculty of Health Sciences University of Stellenbosch Cape Town South Africa

Background: Kalanchoe integra is widely used in folklore medicine as an antiasthmatic agent. Previous studies have shown the ameliorating effect of Kalanchoe integra leaf extract [KILE] on bronchial hyperesponsiveness and inflammation. Further, the stabilizing effect of Kalanchoe sp on mast cell degranulation, suggests that Kalanchoe species are suitable candidates for allergic asthma therapy. This study is designed to investigate the anti-asthmatic potential of KILE and monitor the accompanying histopathological and immunobiochemical changes that occur in an animal model of bronchial asthma using ovalbumin sensitized guinea pigs. Method: Thirty male guinea pigs were divided into five groups of six animals each. Bronchial asthma was simulated in guinea pigs using ovalbumin. Both low dose (300 mg/kg) and high dose extract (900 mg/kg) were administered daily for 42 days. Prednisolone (2.5 mg/kg) was the standard drug used. Results: Guinea pigs in all KILE treated groups maintained the integrity of their airway structures: bronchial folds and walls, alveoli, alveolar ducts and sacs. KILE and prednisolone caused a reduction in immune parameters (p 0.001), extent of bronchoconstriction, bronchial wall thickness and goblet cell accumulation in the sensitized guinea pigs. Conclusion: This study demonstrates the anti-asthmatic potential of KILE during prolonged administration by the oral route.

关键词： Kalanchoe Integra Asthma Bronchoconstriction Goblet Cells Perivascular Oedema

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Using Geospatial Information Component to Monitor the Watersheds along the Densu Basin in Ghana

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Journal of Geographic Information System 2016年第5期8卷 618-632页

作者： Clement nyamekye Faruk Kwansah Nyame samuel Anim Ofosu Department of Civil Engineering Koforidua Polytechnic Koforidua Ghana COCOBOD Cartography and Survey Division Accra Ghana

The Densu basin is a coastal river catchment in southern Ghana and a typical rural community like all other rural settlements in Ghana. It is the only basin amongst 43 other basins of the country that supplies water to two regional capitals of Ghana, namely, the capital city of Ghana, Accra and Eastern regional capital, Koforidua. The qualities of these water resources vary naturally and widely depending on climate, season, and the geology of the bedrock, as well as anthropogenic activities. The primary aim of this research is to determine data requirements for efficient and cost-effective development of a Geographic Information System (GIS) to map and detect the extent of the sources of the watersheds and how to protect the environment for continuous supply of water. Among the Nine catchment areas, only one catchment WSA_05 (Koforidua Township) was determined to have a very high risk of being vulnerable and therefore required urgency to protect environment for continuous supply of water. Four catchment areas WSA_02 (Weija Dam), WSA_03 (Apedwa-Asafo), WSA_06 (Suhum) and WSA_09 (New Tafo) were determined to have a high risk of being affected and therefore there was the need to protect the environment for continuous supply of water. Ghana as a country will have to take a responsible step in protecting its water body and its environment to enable continuous and sustainable supply of water to its citizens. This study therefore reveals the state of the water users and how urgent it environment needs to be protected.

关键词： Watershed Geographical Information System (GIS) Densu Basin Water Service Areas (WSA) Land Use Land Cover (LULC)

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Evaluating the Stability of Indigenous Akwadum Soil with Cassava Peel Ash and Quarry Dust

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Journal of Geoscience and Environment Protection 2016年第12期4卷 48-55页

作者： Clement nyamekye samuel Anim Ofosu Alexander Fordjour Theophilus Ayitey-Adjin Department of Civil Engineering Koforidua Technical University Koforidua Ghana

Cassava peels are produced as a waste from cassava, which are disposed into landfills. These become an environmental problem;therefore the use of cassava peel ash (CPA) as a soil stabilizer must be encouraged. This study investigates the effects of CPA and quarry dust (QD) on the engineering properties of Akwadum soil behavior, using compaction test, Atterberg limit, and California bearing ratio (CBR). These properties were compared with those of unstabilized soil (original) and soil stabilized with CPA and QD. The natural soil was obtained from a borrowed pit at Akwadum near Koforidua at an average depth of 0.8 m which is meant for road works. This soil sample was stabilized with CPA and QD at 5%, 10% and 20% respectively. The compaction, California bearing ratio and Atterberg limit test were performed on the stabilized soils to thoroughly evaluate them. The results indicate that increasing the percentage of CPA to the natural soil decreases the maximum dry density at increasing optimum water content. The addition of QD at higher percentage increases the maximum dry density at decreasing optimum water content. The results reveal that both QD and CPA improve the engineering properties of the soil with QD providing better results.

关键词： Cassava Peel Ash (CPA) Stabilization Quarry Dust (QD) CBR Atterberg Limit

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