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Association of Vitamin D Deficiency with Diabetic Retinopathy in Young People with Type 1 Diabetes Mellitus

Open Journal of Ophthalmology 2023年第1期13卷 48-63页

作者： Abir Bin Sajj Bedowra Zabeen Mohammad Zafar Khaled nuzhat choudhury Tohura Sharmin Vision Eye Hospital Dhaka Bangladesh Department of Paediatric Endocrinology CDIC Bangladesh Institute of Research and Rehabilitation in Diabetes Endocrine and Metabolic Disorder (BIRDEM) Dhaka Bangladesh Department of Ophthalmology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Community Medicine Ad-Din Women’s Medical College Dhaka Bangladesh

Background: Diabetic retinopathy is among the most common diabetic complications, and is one of the leading causes of blindness in the world. Recent studies have linked vitamin D to the pathogenesis of diabetes and there is growing evidence that vitamin D can interfere with the mechanisms involved in diabetes and its complications. Despite improvements in treatment, diabetic retinopathy remains a significant complication of type 1 diabetes mellitus. Identification of early treatable predictors of diabetic retinopathy such as vitamin D deficiency, may allow more aggressive management of those at high risk. Purpose: To assess the association of vitamin D deficiency with diabetic retinopathy in young people with type 1 diabetes mellitus. Design: Observational study with case control design. Method: 60 young people with type 1 diabetes aged between 11 to 24 years were included in this study. Among them, 30-young people have diabetic retinopathy and 30-young people do not have diabetic retinopathy. Purposive sampling technique was applied as per inclusion criteria. Statistical analysis of the results was done by using computer-based software, SPSS version 26. P value of less than 0.05 was considered as statistically significant. Results: Vitamin D deficiency was present in 83% of the young people with diabetic retinopathy and in 53% without diabetic retinopathy. The mean vitamin D level in young people with and without diabetic retinopathy was 17.38 ± 3.77 ng/ml and 20.15 ± 5.06 ng/ml respectively and the difference was statistically significant (p = 0.019). Vitamin D deficiency was increased with the severity of diabetic retinopathy. Univariate and multivariate logistic regression showed vitamin D deficiency was independently associated with diabetic retinopathy with a crude odds ratio of 5.69 with a p value of 0.008 and adjusted odds ratio of 16.08 with a p value of 0.002 respectively. Conclusion: Result of the study revealed that vitamin D deficiency was strongly asso

关键词： Vitamin D Deficiency Type 1 Diabetes Mellitus Diabetic Retinopathy Young People

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