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中国药理学与毒理学杂志 2015年第S1期29卷 13-13页

作者： KornkanokINGKANINAN NanteetipLIMPEANCHOB SakchaiWITTAYA-AREEKUL KrongkarnCHOOTIP PornnarinTAEPAWARAPRUK nuwattaepawarapruk JintanapornWATTANATHORN SeewaboonSIREERATAWONG WarapornPUTALUN WatooPHROMPITTAYARAT HiroyukiTANAKA Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry Naresuan University Phitsanulok 65000 Thailand Faculty of Medical Sciences Naresuan University Phitsanulok 65000 Thailand Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand Faculty of Medicine Chiang Mai University Chiang Mai 50200 Thailand Faculty of Pharmaceutical Sciences Khon Kaen University Khon Kaen 40002 Thailand Faculty of Public Health Naresuan University Phitsanulok 65000 Thailand Graduate School of Pharmaceutical Sciences Kyushu University Fukuoka 812-8582 Japan

OBJECTIVE Brahmi(Bacopa monnieri Wettst.,Schrophulariaceae)has been used in Ayuravedic medicine as a memory *** aimed at research and development of Brahmi for clinical use as the food supplement for memory *** The standardized extract of Brahmi has been *** neuroprotective effect of the extract was tested using in vitro and in vivo assay.A double-blinded randomized control trial of brahmi tablet was conducted in 60 middle-aged elderly *** The in vivo studies indicated that the standardized extract had neuroprotective effect at the doses of 40 and 80mg·*** escape latency time of rats in Morris water maze test was ***,the reduction of neurons and cholinergic neuron densities were *** also tested its protection effect against the beta-amyloid protein and glutamate-induced neurotoxicity in primary cortical cultured *** result demonstrated that Brahmi extract protected neurons from beta-amyloid-induced cell death,but not glutamate-induced *** standardized extract of Brahmi is formulated as a film-coated *** effect of Brahmi extract on learning and memory was studied in the middle aged and elderly *** results showed that Brahmi extract(300and 600mg·d-1)could improve quality of life in the elderly by improving the physical fitness via the increase in efficiency of postural *** also improved the psychological fitness by increasing alertness and attention resulted in the improvement of learning and *** addition,Brahmi extract could decrease depression-like *** dosage used in this study did not produce toxic and side *** The in vitro and in vivo studies suggested that brahmi is a potential medicinal plant for memory *** clinical study showed that brahmi tablet could improve physical fitness and enhance memory in healthy volunteers.

关键词： Bacopa monnieri clinical study memory neuroprotect

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