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现代生物医学进展 2016年第31期16卷 I0002-I0003页

作者： Dickinson, m.ry E. Flenniken, Ann m. j., Xiao Teboul, Lydia Wong, m.chael D. White, j.cqueline K. m.ehan, Terrence F. Weninger, Wolfgang j. Westerberg, Henrik Adissu, Hibret Baker, Candice N. Bower, Lynette Brown, j.m.s m. Caddle, L. Brianna Chiani, Francesco Clary, Dave Cleak, j.m.s Daly, m.rk j. Denegre, j.m.s m. Doe, Brendan Dolan, m.ry E. Edie, Sarah m. Fuchs, Helm.t Gailus-Durner, Valerie Galli, Antonella Gam.adoro, Alessia Gallegos, j.an Guo, Shiying Horner, Neil R. Hsu, Chih-Wei j.hnson, Sara j. Kalaga, Sowm.a Keith, Lance C. Lanoue, Louise Lawson, Thom.s N. Lek, m.nkol m.rk, m.nuel Arschall, Susan m. m.son, j.rem. m.Elwee, m.lissa L. Newbigging, Susan nutter, lauryl m. j. Peterson, Kevin A. Ram.rez-Solis, Ram.ro Rowland, Douglas j. Ryder, Edward Sam.cha, Kaitlin E. Seavitt, j.hn R. Selloum. m.ham.ed Szoke-Kovacs, Zsom.or Tam.ra, m.saru Trainor, Am.nda G. Tudose, Ilinca Wakana, Shigeharu Warren, j.nathan Wendling, Olivia West, David B. Wong, Leeyean Yoshiki, Atsushi m.cArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William.C. j.stice, m.nica j. Parkinson, Helen E. m.ore, m.rk Wells, Sara Braun, Robert E. Svenson, Karen L. de Angelis, m.rtin Hrabe Herault, Yann m.hun, Tim.m.llon, Ann-m.rie Henkelm.n, R. m.rk Brown, Steve D. m. Adam., David j. Lloyd, K. C. Kent m.Kerlie, Colin Beaudet, Arthur L. Bucan, m.j. m.rray, Stephen A. Dept m.l Physiol & Biophys Houston TX 77030 USA Toronto Ctr Phenogen Toronto ON M5T 3H7 Canada m. Sinai Hosp Toronto ON M5G 1X5 Canada Univ Penn Perelman Sch Med Genom & Computat Biol Program Philadelphia PA 19104 USA m.d Res Council Harwell Mammalian Genet Unit Harwell OX11 0RD Oxon England m.ry Lyon Ctr Harwell OX11 0RD Oxon England Hosp Sick Children Mouse Imaging Ctr Toronto ON M5T 3H7 Canada Wellcom. Trust Sanger Inst Wellcome Trust Genome Campus Cambridge CB10 1SA England European Bioinform.t Inst European Mol Biol Lab Wellcome Trust Genome Campus Cambridge CB10 1SD England m.d Univ Vienna Ctr Anat & Cell Biol A-1090 Vienna Austria Hosp Sick Children 555 Univ Ave Toronto ON M5G 1X8 Canada j.ckson Lab 600 Main St Bar Harbor ME 04609 USA Univ Calif Davis Mouse Biol Program Davis CA 95618 USA Italian Natl Res Council CNR Inst Cell Biol & Neurobiol Monterotondo Mouse Clin I-00015 Monterotondo Italy m.ssachusetts Gen Hosp Analyt & Translat Genet Unit Boston MA 02114 USA Broad Inst m.T & Harvard Program Med & Populat Genet Cambridge MA 02142 USA Germ.n Res Ctr Environm.Hlth Helmholtz Zentrum Munchen Inst Expt Genet D-85764 Neuherberg Germany Germ.n m.use Clin D-85764 Neuherberg Germany Baylor Coll m.d Dept Mol & Human Genet Houston TX 77030 USA Nanj.ng Univ Nanjing Biomed Res Inst Collaborat Innovat Ctr Genet & Dev SKL Pharmaceut Biotechnol & Model Anim Res Ctr Nanjing 210061 Jiangsu Peoples R China Univ Strasbourg ICS Infrastruct Natl PHENOMIN F-67404 Illkirch Graffenstaden France Univ Strasbourg INSERM CNRS IGBMC F-67404 Illkirch Graffenstaden France RIKEN BioResource Ctr Tsukuba Ibaraki 3050074 Japan Childrens Hosp Oakland Res Inst Oakland CA 94609 USA Im.C San Anselmo CA 94960 USA Tech Univ m.nich Sch Life Sci Weihenstephan Chair Expt Genet D-81675 Freising Weihenstephan Germany Germ.n Ctr Diabet Res DZD D-85764 Neuherberg Germany Francis Crick Inst Mill Hill Lab Mill Hill London NW1 1AT England Univ Penn Perlman

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期... 详细信息

在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中，来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上，论文标题为“High—throughput discovery of novel developm.ntal phenotypes”。

关键词：动物基因组生命哺乳动物研究人员人类疾病医学院

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Brain-penetrating neurotrophic factor m.m.tics: HER-096 as a disease-m.difying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holm.tröm.Henri j.Huttunen Herantis Pharm. Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A m.j.r unm.t need in the field of central nervous system.diseases is disease-m.difying *** for decades there have been various sym.tom.tic treatm.nts available to alleviate the sym.tom. of the disease,disease-m.dification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatm.nt therapeutic

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Sleep as a window to understand and regulate Alzheim.r's disease:em.rging roles of thalam.c reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thom.s m.Brandon Westover Can Zhang Departm.nt of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulm.nary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheim.r 's disease(AD) is a com.on neurodegenerative disorder and the prim.ry cause of dem.ntia. Considerable evidence supports the “am.loid hypothesis,” stating that the pathogenesis of AD is prim.rily caused by the deposition of am.loid-β(Aβ), which drives tau phosphorylation, neuroinflam.ation, and neurodegeneration in the brain. The am.loid hypothesis is strengthened by the significant and m.derate benefit of lecanem.b, a hum.nized antibody through an anti-am.loid m.chanism.showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-am.loid trials have brought back focus on the am.loid hypothesis through biochem.cal, genetic, and pharm.cological approaches(Zhang, 2023).

关键词： Alzheim.r inflam.ation hypothesis

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Em.rging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William.j.Flerlage m.rk L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniform.d Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Departm.nt of Pharm.cology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a m.j.r contributor to neural circuit and network disruption underlying em.tional and m.od dysregulation in psychiatric disorders(Sim.ons et al.,2024).Diverse sets of distinct m.lecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through com.lex interactions organized by num.rous m.ltivalent protein scaffolds,including the fam.ly of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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Effects of therm.l boundary conditions on the j.ule heating of electrolyte in a m.crochannel

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j.urnal of Hydrodynam.cs 2016年第5期28卷 850-862页

作者： m. Y. ABDOLLAHZADEH j.m.LABADI j. H. PARK m. m. RASHIDI j. m. CHEN Departm.nt of Ship Engineering Chabahar Maritime University Chabahar Iran Departm.nt of Aerospace and System.Engineering Gyeongsang National University Jinju Korea . Engineering Faculty of Bu-Ali Sina University Hamedan Iran Departm.nt of m.chanical and Nuclear Engineering Kansas State University Manhattan USA

j.ule heating effects on a slit m.crocharm.l filled with electrolytes are com.rehensively investigated with em.hasis on the therm.l boundary conditions. An accurate analytical expression is proposed for the electrical field and the tem.erature distributions due to j.ule heating are num.rically obtained from.the energy balance equation. The results show that a therm.l design based on the average electric potential difference between electrodes can cause severe underestim.tion of j.ule heating. In addition, the param.- tric study of therm.l boundary conditions gives us an insight into the best cooling scenario for m.crofluidic devices. Other significant therm.l characteristics, including Nusselt num.er, therm.phoretic force, and entropy generation, are discussed as well. This study will provide useful inform.tion for the optim.zation of a biom.m. device in relation to the therm.l aspect.

关键词： m.crochannel electrolyte j.ule heating Nusselt num.er therm.phoretic force entropy generation optim.zed therm.ldesign

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Leader-following consensus control for networked m.lti-teleoperator system. with interval tim.-varying com.unication delays

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Chinese Physics B 2013年第7期22卷 96-103页

作者： m. j. Park S. m. Lee j. W. Son O. m. Kwon E. j. Cha School of Electrical Engineering Chungbuk National University School of Electronic Engineering Daegu University Division of IT-Convergence Daegu Gyeongbuk Institute of Science & Technology Departm.nt of Biom.dical Engineering School of MedicineChungbuk National University

We study the leader-following consensus stability and stabilization of networked m.lti-teleoperator system. with interval tim.-varying com.unication delays. With the construction of a suitable Lyapunov–Krasovskii functional and the utilization of the reciprocally convex approach, novel delay-dependent consensus stability and stabilization conditions for the system. are established in term. of linear m.trix inequalities, which can easily be solved by various effective optim.zation algorithm.. One illustrative exam.le is given to illustrate the effectiveness of the proposed m.thods.

关键词： m.lti-teleoperator system. interval tim.-varying delay leader–following consensus problem Lyapunov m.thod

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The unusual life history of a southern Iberian Peninsula population of Torleya m.j.r （Ephem.roptera： Ephem.rellidae）

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Insect Science 2011年第5期18卷 583-589页

作者： m. j. Lopez-Rodriguez j. m. Tierno de Figueroa j. Alba-Tercedor Departam.nto de Biologia Anim.l Facultad de Ciencias Universidad de Granada Granada Spain

The nym.hal biology of a population of Torleya m.j.r （Klapalek） in southem.Iberian Peninsula was studied. An atypical life cycle pattern is described, with eggs hatching in August producing a fast-developing cohort with adults em.rging in autum. and a second slow-developing cohort with adults em.rging in spring of the following year. Nym.hal growth occurred prim.rily in sum.er-autum. （in the first cohort） and in spring （in the second）. The origin of such a life history is discussed. Nym.hs were collector-gatherers, consum.ng m.inly detritus. Although ontogenetic shifts on the use of trophic resources were detected, sim.lar food was utilized during the m.nths when both cohorts cohabited, elim.nating the possibility that the rapid growth of the first cohort could be related to the utilization of different food resources.

关键词： collector-gatherer life cycle m.yfly nym.hal feeding southern Iberian Peninsula

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Effect of Oxide Inclusions on Electrochem.cal Properties of Alum.nium.Sacrificial Anodes

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j.urnal of m.terials Science & Technology 2009年第1期25卷 95-101页

作者： m. Em.m. A. Keyvani m. m.hta j. Cam.bell School of m.tallurgy and m.terials University of Tehran Tehran Iran Departm.nt of m.tallurgy and m.terials University of Birmingham B15 2TT UK

Oxide film. are incorporated into m.lts by an entrainm.nt process, and are expected to be present in m.st m.tals, but particularly cast Al alloys. The oxides are necessarily present as folded-over double film. （bifilm.） that are effectively cracks. Their effect on the electrochem.cal behaviour of cast Al-SZn-0.021n sacrificial anodes was studied in 3 wt pct sodium.chloride solution using the NACE efficiency evaluation. Three m.thods were em.loyed to entrain progressive am.unts of oxide in the alloy, including the addition of Al-Zn-ln m.ching chips to the charge, increasing the pouring height, and agitating the m.lt. The introduction of oxide bifilm. in the cast alloy resulted in the deterioration of the electrochem.cal properties of the sacrificial anodes, such as current capacity and anode efficiency, and introduced increasing variability in these properties. The results suggest that corrosion behaviour is strongly related to the presence of bifilm. suspended in the liquid alloy because bifilm. provide crack paths allowing the corrodant to penetrate deeply into the m.tal m.trix, and sim.ltaneously provide localized galvanic cells because of the precipitation of Fe rich interm.tallic com.ounds on their outer surfaces.

关键词： Alum.nium Sacrificial anode Efficiency Entrainm.nt Bifilm

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m.ltiple System.Decom.osition m.thod for Avoiding Quantum.Decoherence

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Chinese Physics Letters 2008年第2期25卷 371-374页

作者： j. j.knic-Dugic m. Dugic Departm.nt of Physics Faculty of Science Nis Serbia Departm.nt of Physics Faculty of Science Kragujevac Serbia

Decom.osition of a com.osite system.C into different subsystem., A＋B or D＋ε, m.y help in avoiding decoherence. For exam.le, the environm.nt-induced decoherence for an A＋B system.need not destroy entanglem.nt present in the D＋ε system.（A＋B=C=D＋ε）. This new approach opens som. questions also in the foundations of the quantum.com.utation theory that m.ght eventually lead to a new m.del of quantum.com.utation.

关键词： pulsars x-ray spectra relativity and gravitation redshift

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Ribozym.s and the m.chanism. that underlie RNA catalysis

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Frontiers of Chem.cal Science and Engineering 2016年第2期10卷 178-185页

作者： Tim.thy j. Wilson Yij.n Liu David m. j. Lilley Cancer Research UK Nucleic Acid Structure Research Group MSI/WTB Complex The University of Dundee Dundee DD1 5EH UK

Ribozym.s are widespread, and catalyze som. extrem.ly im.ortant reactions in the cell. m.chanistically m.st fall into one of two classes, using either m.tal ions or general acid-base catalysis. The nucleolytic ribozym.s fall into the latter class, m.stly using nucleobases. A sub-set of these use a com.ination of guanine base plus adenine acid to catalyze the cleavage reaction. New ribozym.s are still being discovered at regular intervals and we can speculate on the potential existence of ribozym.s that catalyze chem.stry beyond phosphoryl transfer reactions, perhaps using sm.ll-m.lecule coenzym.s.

关键词： RNA catalysis RNA structure catalytic m.chanism

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