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Toxicity effects of water extracts of Holothuria atra Jaeger in mice

Asian Pacific Journal of Tropical Biomedicine 2014年第8期4卷 614-617页

作者： Ridzwan Bin Hashim nurul alia azizan Zaitunnatakin Zamli Farah Hanis Zulkipli Nurzafirah Mazlan Osama Yousef Althunibat Department of Biomedical Science Faculty of Allied Health SciencesInternational Islamic University Malaysia Kuantan CampusJalan Sultan Ahmad ShahBandar Indera Mahkota 1025200 KuantanPahangMalaysia Faculty of Pharmacy Alzaytoonah University of JordanAmmanJordan

Objective:To determine lethal median dose(LD_(50)) and histopalhological toxicity of water extract of Hololhuria atra(H,atra) in ***:The behavioral changes,mortality and histopathology examination on liver were assessed in mice 14 d after the administration(i.p.) of *** water *** doses 110,20,30,50.100.150 and 200 mg/kg) of *** were *** control group was treated with normal saline,Results:In the acute study in mice,the water extracts of H,atra caused dose-dependent general behavior adverse affects and *** main behavioral sign of toxicity was hypoactivity,noticed immediately after administration of the extract which was more obvious at the higher doses and persisted until *** increased with increasing doses,the calculated LD_(50)was 41 mg/kg in *** liver toxicity was confirmed by histopalhological examination,which indicated the presence of abnormal hepatocytes with a distorted shape and undefined cell lining as well as enlarged nuclei in low doses *** doses groups indicated a more prominent distortion of the polyhedral hepatocytes with undefined cell lining,massive cytoplasm,*** and karyolytie nuclei(necrosis of hepatocytes).Control group showed polyhedral hepatocytes with defined cell lining arranged in cords and normal round nuclei,with granular ***:Because of the relatively low LD_(50) value in the acute study in mice,it may be concluded that the *** water extract is toxic.

关键词： Holothuria atra Water extract Lethal median dose Animal toxicity

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Isolation of Kytococcus schroeteri from the brown rat Rattus norvegicus

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Asian Pacific Journal of Tropical Medicine 2021年第4期14卷 191-192页

作者： Shih Keng Loong nurul Asma Anati Che-Mat-Seri Kim-Kee Tan Noor-Syahida azizan Siti Noraisah Ahmad-Nasrah Siti Nursheena Mohd-Zain Sazaly AbuBakar Tropical Infectious Diseases Research&Education Centre High Impact Research BuildingUniversity of Malaya50603 Kuala LumpurMalaysia Department of Medical Microbiology Faculty of MedicineUniversity of Malaya50603 Kuala LumpurMalaysia Institute of Biological Sciences Faculty of ScienceUniversity of Malaya50603 Kuala LumpurMalaysia

Rodents such as Rattus rattus and Rattus norvegicus have adapted to living close to human settlements[1].This presents a public health challenge as these rodents are considered as pests that can transmit a number of zoonotic diseases to humans[1,2].A rodent surveillance programme was initiated between the years 2014 and 2015,focusing on rodents captured at wet markets where there is abundant food and considerable human *** present study was conducted in several wet markets in Kuala Terengganu,Malaysia(5.3333°N,103.1500°E).

关键词： Rattus initiated abundant

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