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Reducing the incidence of hepatocellular carcinoma due to hepatitis C virus infection by detecting resistance-associated substitutions in hepatitis C virus NS5A nonstructural protein

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Cancer Biology & Medicine 2018年第S1期15卷 7-7页

作者： RozainaneeMohd Zain nurul asshikin ruslan Sairulahkma Awang Muhammad Adib Abd Wahab Ravindran Thayan Virology Unit Infectious Disease Research CenterInstitute for Medical ResearchJalan PahangKuala LumpurMalaysia

Objective:Hepatocellular carcinoma(HCC)is one of the leading causes of liver cancer *** Malaysia,liver cancer is one of the main cancers detected in the population with an annual mortality rate of 6.1%in *** C virus(HCV)infection is one of the causes attributed to the incidence of *** infection remains a major concern in Malaysia as many people are unaware of their infection *** the accessibility and effectiveness of Direct Acting Agents(DAAs).

关键词： Reducing incidence hepatocellular

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Residual Spray for the Control of <i>Aedes</i>Vectors in Dengue Outbreak Residential Areas

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Advances in Entomology 2019年第4期7卷 105-123页

作者： nurulhusna Ab Hamid Siti Nurfadhlina Mohd Noor Mitra Saadatian-Elahi Nur Rasyidah Isa Rohaiyu Md Rodzay Balqis Md ruslan Topek Omar Mohd Iqbal Mohd Norsham Noor Hasmiza Amanzuri Nurliyana Abd Khalil Izzah Farhah Zambari Muhammad Anwar Mohd Kassim Muhammad Khairi Kamarul Zaman Ainaa Mardia Bachtiar Effendi Afiq Ahnaf Hafisool Lee Teck Peng Brian Poong Mustafakamal Ibrahim nurul Ashikin Roslan Lee Han Lim Medical Entomology Unit WHO Collaborating Centre for Vectors Institute for Medical Research Kuala Lumpur Malaysia Pôle Santé Recherche Risques et Vigilances Groupement Hospitalier Edouard Herriot Unité d’Hygiène Epidémiologie et Prévention Lyon France Vector Borne Disease Sector Disease Control Division Ministry of Health Malaysia Putrajaya Malaysia Bayer Co. (Malaysia) Sdn. Bhd. Petaling Jaya Malaysia Hulu Langat District Health Office Kajang Malaysia

The incidence of dengue in Malaysia has shown an increasing trend since the year 2000. Vector control is the primary approach for dengue control in Malaysia. There is an urgent need for new or modified approaches such as the residual spraying on the outer walls that can potentially last long enough to control the Aedes population, particularly in the outbreak-prone areas. In this field study, we conducted outdoor residual spraying (ORS) using a newly formulated polymer-enhanced suspension concentrate (SC-PE) of deltamethrin. The objectives of this study were to evaluate the efficacy of ORS using deltamethrin SC-PE and its effect on wild Aedes populations and to assess its residual bio-efficacy on painted cement walls against the pyrethroid-susceptible strains of laboratory-reared Aedes mosquitoes. Three rounds of spraying in a four-month cycle were conducted between 2014 and 2015 in four residential areas (low-rise and high-rise housing types) in Hulu Langat, Selangor. The bio-efficacy of the insecticide was evaluated by assessing its impact on vector population using ovitrap surveillance. Standard WHO wall deposit bioassay was adapted to determine bio-efficacy of deltamethrin, i.e. post 30 min knockdown and post 24 h mortality after exposure. During the treatment period, we observed significant reductions in the population of Ae. albopictus in the sprayed low-rise housing in both semi-indoor and outdoor environments, while in the high-rise housing, there was also a significant decline in Ae. aegypti population in the semi-indoor environment. The evaluation of the residual bio-efficacy of deltamethrin SC-PE against laboratory-reared Aedes mosquitoes showed that the insecticide lasted longer in the high-rise housing compared to the low-rise housing with >80% mortality achieved continuously for 16 weeks. We provide initial evidence on residual efficacy of deltamethrin SC-PE in reducing Aedes population size in the low-rise and high-rise housing. Our results showed tha

关键词： Indoor Residual Spraying Outdoor Residual Spraying Aedes Deltamethrin SC-PE Dengue Vector Control Ovitrap Index Malaysia

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