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Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration

Neural Regeneration Research 2020年第12期15卷 2207-2216页

作者： Francisco Bosch-Morell Victoria Villagrasa Teresa Ortega nuria acero Dolores Muñoz-Mingarro MEugenia González-Rosende Encarna Castillo MAmparo Sanahuja Pilar Soriano Isabel Martínez-Solís Biomedical Sciences Institute Universidad Cardenal Herrera-CEUCEU UniversitiesAlfara del PatriarcaValenciaSpain Department of Biomedical Sciences Faculty of Health SciencesUniversidad Cardenal Herrera-CEUCEU UniversitiesAlfara del PatriarcaValenciaSpain Department of Pharmacy Faculty of Health SciencesUniversidad Cardenal Herrera-CEUCEU UniversitiesAlfara del PatriarcaValenciaSpain Department of Pharmacology Pharmacognosy and BotanyUniversidad Complutense de MadridMadridSpain Department of Pharmaceutical and Health Sciences Faculty of PharmacyUniversidad San Pablo-CEUCEU UniversitiesMadridSpain Department of Chemistry and Biochemistry Faculty of PharmacyUniversidad San Pablo-CEUCEU UniversitiesMadridSpain ICBiBE-Botanical Garden University of ValenciaValenciaSpain

The retina may suffer neurodegenerative damages,as other tissues of the central nervous system do,and serious eye diseases may *** of them is age-related macular degeneration,which causes progressive loss of vision due to retina *** of age-related macular degeneration focuses on antioxidant agents and anti-vascular endothelial growth factor compounds,among others,that prevent/diminish oxidative stress and reduce neovascularisation *** phytochemicals,medicinal plants and/or plant-diet supplements might be a useful adjunct in prevention or treatment of age-related macular degeneration owing to their antioxidant and anti-vascular endothelial growth factor *** review article presents the most investigated plants and natural products in relation to age-related macular degeneration,such as saffron,ginkgo,bilberry and blueberry,curcuma or turmeric,carotenoids,polyphenols,and vitamins C and *** study provides up-to-date information on the effects,treatments,safety and efficiency of these phytotherapy products.

关键词： age-related macular degeneration bilberry blueberry curcuma carotenoids ginkgo polyphenols saffron vitamins

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Green ionic metal-organic frameworks as nanocatalysts for CO_(2)fixation

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Nano Research 2025年第1期18卷 260-269页

作者： nuria Martín Miguel Maireles-Porcar Julián Sánchez Velandia Belén Altava Francisco G.Cirujano Eduardo García-Verdugo Departamento de Química Inorgánica y Orgánica Universidad Jaume IAv.Sos Baynats/nCastellóde la PlanaCastellón 12071Spain

Co,Ni,and Zn iso-reticular coordination polymers of 2,5-dihydroxyterphthalic acid(H_(2)dot)can be rapidly obtained under room temperature and aqueous conditions using either sodium or ammonium hydroxide as the bases to deprotonate the *** use of metal bromides and tetrabutylammonium hydroxide(TBAOH)as the base allows the green synthesis of ionic metal-organic frameworks(MOFs),characterized by X-ray diffraction(XRD),Fourier transform infrared(FTIR),scanning electron microscopy(SEM),thermo gravimetric analysis(TGA),H-nuclear magnetic resonance(NMR),elemental analysis,and X-ray photoelectron spectroscopy(XPS),and employed in the pressure,solvent,and additive-free CO_(2)fixation to epoxides by its cycloaddition to epichlorohydrin,exhibiting a cooperative behavior between the MOF and the ionic liquid formed within the framework,achieving TONs of the confined tetrabutylammonium bromide(TBABr)up to 700.

关键词： metal-organic frameworks(MOFs) ionic liquids heterogeneous catalysis CO_(2)conversion

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Ionic liquids as boundary additives in water-based and PAO lubricants

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Friction 2022年第9期10卷 1405-1423页

作者： Wahyu WIJANARKO Hamid KHANMOHAMMADI nuria ESPALLARGAS Norwegian Tribology Center Department of Mechanical and Industrial EngineeringNorwegian University of Science and Technology(NTNU)Trondheim 7491Norway Department of Mechanical Engineering Sepuluh Nopember Institute of Technology(ITS)Surabaya 6011Indonesia

Ionic liquids have been widely discussed as potential lubricants,however,their properties make them also very good potential candidates as lubricant additives(e.g.,friction modifiers and anti-wear).In this work,the tribological study of two ionic liquids(tributylmethylphosphonium dimethylphosphate(PP),and 1-butyl-1-methylpyrrolidinium tris(pentafluoroethyl)trifluorophosphate(BMP))as lubricant additives has been performed on stainless steel(AISI 316L)exposed to polar(water-glycol)and non-polar(polyalphaolefin)based lubricants under boundary lubricating *** performance of these ionic liquids as lubricant additives has been compared to a classical organic friction modifier(dodecanoic acid(C12)).The water–glycol lubricant formulated with the two ionic liquids showed friction values higher than the same base lubricant formulated with dodecanoic acid,however,opposite results were observed for polyalphaolefin(PAO).A detailed surface chemical analysis using X-ray photoelectron spectroscopy(XPS)revealed differences in the passive/tribofilm thickness and chemical composition of the stainless steel surface tested in all *** the case of the polar lubricant additivated with ionic liquids,the tribochemical reaction accompanied by a tribocorrosion process led to the formation of an unstable passive/tribofilm resulting in high friction and ***,in the absence of tribocorrosion process(polyalphaolefin base lubricant),the tribochemical reaction led to the formation of a stable passive/tribofilm resulting in low friction and wear.A detailed surface and subsurface investigation of the microstructure using scanning electron microscopy equipped with a focused ion beam(SEM-FIB)showed that high wear rates resulted in thicker recrystallization region under the wear track *** all lubricant additives tested in this work,BMP in non-polar lubricant media showed the best tribological performance.

关键词： water lubricant polyalphaolefin(PAO) ionic liquids tribochemistry tribocorrosion tribofilm

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Polycaprolactone/mesoporous silica MCM-41 composites prepared by in situ polymerization

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Particuology 2017年第1期15卷 135-143页

作者： Laura Lopez-Figueras nuria Navascues Silvia Irusta Department of Chemical Engineering Nanoscience Institute of Aragon (INA) University of Zaragoza 50018 Zaragoza Spain Networking Research Center on Bioengineering Biomaterials and Nanomedicine CIBER-BBN 50018 Zaragoza Spain

Composites of polycaprolactone （PCL） with mesoporous silica MCM-41 and N-[3- （trimethoxysilyl）propyl]-ethylenediamine （EPTES）-functionalized MCM-41 （EPTES/MCM-41） were prepared by in situ polymerization. The thermal properties of the composites were characterized by thermogravimetric analysis. There was an increase in the thermal decomposition temperature of PCL by more than 55 ℃, when the EPTES/MCM-41 loading was higher than 2 wt%. Tensile test results indicated that adding MCM-41 increased the brittleness of the PCL matrix, while adding 8 wt% of EPTES/MCM-41 increased the Young＇s modulus by 26%. Incorporating MCM-41 increased the crystallinity of the resulting PCL composite, compared with that of PCL. Incorporating up to 5 wt% EPTES/MCM-41 slightly reduced the crystallinity of PCL. The different effects of MCM-41 and EPTES/MCM-41 on the composite reflected the degree of interaction and dispersion of the silica filler in the polymer matrix, as evidenced by results from transmission electron microscopy and atomic force microscopy.

关键词： Nanocomposite Mesoporous silica Polycaprolactone

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Potential relevance of pig gut content transplantation for production and research

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Journal of Animal Science and Biotechnology 2019年第3期10卷 540-558页

作者： nuria Canibe Mark O’Dea Sam Abraham Department of Animal Science Aarhus UniversityAU-FOULUMPO BOX 508830 TjeleDenmark Antimicrobial Resistance and Infectious Disease laboratory College of ScienceHealthEngineering and EducationMurdoch UniversityWestern AustraliaAustralia

It is becoming increasingly evident that the gastrointestinal microbiota has a significant impact on the overall health and production of the *** has led to intensified research on the composition of the gastrointestinal microbiota,factors affecting it,and the impact of the microbiota on health,growth performance,and more recently,behavior of the *** production research has been heavily focused on assessing the effects of feed additives and dietary modifications to alter or take advantage of select characteristics of gastrointestinal microbes to improve health and feed conversion *** on faecal microbiota transplantation(FMT) as a possible tool to improve outcomes in pigs through manipulation of the gastrointestinal microbiome is very recent and limited data is *** on FMT in humans demonstrating the transfer of phenotypic traits from donors to recipients and the high efficacy of FMT to treat Clostridium difficile infections in humans,together with data from pigs relating GI-tract microbiota composition with growth performance has likely played an important role in the interest towards this strategy in pig ***,several factors can influence the impact of FMT on the recipient,and these need to be identified and optimized before this tool can be applied to pig *** are obvious inherent biosecurity and regulatory issues in this strategy,since the donor's microbiome can never be completely screened for all possible non-desirable ***,considering the success observed in humans,it seems worth investigating this strategy for certain applications in pig ***,FMT research may lead to the identification of specific bacterial group(s) essential for a particular outcome,resulting in the development of banks of clones which can be used as targeted therapeutics,rather than the broader approach applied in *** review examines the factors associated with the use of FMT,and its pote

关键词： Clostridium difficile Faecal-microbiota-transplantation Feed conversion Gastrointestinal tract Health Microbiota Pig model Pigs

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Connecting neurodevelopment to neurodegeneration:a spotlight on the role of kinesin superfamily protein 2A(KIF2A)

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Neural Regeneration Research 2024年第2期19卷 375-379页

作者： nuria Ruiz-Reig Janne Hakanen Fadel Tissir Universitécatholique de Louvain Institute of neuroscienceBrusselsBelgium College of Health and Life Sciences Hamad Bin Khalifa University(HBKU)DohaQatar

Microtubules play a central role in cytoskeletal changes during neuronal development and *** dynamics is essential to polarity and shape transitions underlying neural cell division,differentiation,motility,and *** superfamily protein 2A is a member of human kinesin 13 gene family of proteins that depolymerize and destabilize *** dividing cells,kinesin superfamily protein 2A is involved in mitotic progression,spindle assembly,and chromosome *** postmitotic neurons,it is required for axon/dendrite specification and extension,neuronal migration,connectivity,and *** with kinesin superfamily protein 2A mutations suffer from a variety of malformations of cortical development,epilepsy,autism spectrum disorder,and *** this review,we discuss how kinesin superfamily protein 2A regulates neuronal development and function,and how its deregulation causes neurodevelopmental and neurological disorders.

关键词： brain disorders cortical malformations kinesin microtubules neurodegeneration neurodevelopment

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Minimizing carbon deposition in plasma-induced methane coupling with structured hydrogenation catalysts

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Journal of Energy Chemistry 2021年第7期30卷 271-279页

作者： nuria García-Moncada Toine Cents Gerard van Rooij Leon Lefferts Catalytic Processes and Materials(CPM) TNW FacultyUniversity of TwenteP.O.Box 2177500 AE EnschedeThe Netherlands Sasol Holding Netherlands B.V. 7544 GG EnschedeThe Netherlands Nonequilibrium Fuel Conversion DIFFER5612 AJ EindhovenThe Netherlands

The effect of temperature and hydrogen addition on undesired carbonaceous deposit formation during methane coupling was studied in DBD-plasma catalytic-wall reactors with Pd/Al2 O3, using electrical power to drive the *** with thin catalyst layers allowed comparison of the performance of empty reactors and catalytic wall reactors without significantly influencing the plasma *** product distribution varies strongly in the temperature window between 25 and 200℃Minimal formation of deposits is found at an optimal temperature around 75℃ in the catalytic-wall *** selectivity to deposits was c.a.10% with only 9 mg of catalyst loading instead of 45% in the blank reactor,while decreasing methane conversion only ***-feeding H2 to an empty reactor causes a similar decrease in selectivity to deposits,but in this case methane conversion also decreased *** of deposits formation in the catalytic-wall reactor at 75℃ is due to catalytic hydrogenation of mainly acetylene to *** the empty reactor,H2 co-feed decreases conversion but does not change the product *** catalytic-wall reactors can be regenerated with H2-plasma at room temperature,which produces more added-value hydrocarbons.

关键词： Dielectric barrier discharge(DBD)plasma-catalysis Structured reactor Methane coupling H_(2)co-feed Temperature optimization Carbon deposits

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Numerical analysis of rapid drawdown: Applications in real cases

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Water Science and Engineering 2016年第3期9卷 175-182页

作者： Eduardo E. Alonso nuria M. Pinyol Department of Civil and Environmental Engineering Universitat Politecnica de Catalunya (UPC) Barcelona 08034 Spain Centre Internacional de Metodes Numerics en Enginyeria (CIMNE) Barcelona 08034 Spain

In this study, rapid drawdown scenarios were analyzed by means of numerical examples as well as modeling of real cases with in situ measurements. The aim of the study was to evaluate different approaches available for calculating pore water pressure distributions during and after a drawdown. To do that, a single slope subjected to a drawdown was first analyzed under different calculation alternatives, and numerical results were discussed. Simple methods, such as undrained analysis and pure flow analysis, implicitly assuming a rigid soil skeleton, lead to significant errors in pore water pressure distributions when compared with coupled flow-deformation analysis. A similar analysis was performed for the upstream slope of the Glen Shira Dam, Scotland, and numerical results were compared with field measurements during a controlled drawdown. Field records indicate that classical undrained calculations are conservative but unrealistic. Then, a recent case of a major landslide triggered by a rapid drawdown in a reservoir was interpreted. A key aspect of the case was the correct characterization of permeability of a representative soil profile. This was achieved by combining laboratory test results and a back analysis of pore water pressure time records during a period of reservoir water level fluctuations. The results highlight the difficulty of predicting whether the pore water pressure is overestimated or underestimated when using simplified approaches, and it is concluded that predicting the pore water pressure distribution in a slope after a rapid drawdown requires a coupled flow-deformation analysis in saturated and unsaturated porous media.

关键词： Hydro-mechanical coupling Coupled flow-deformation analysis Numerical analysis Drawdown Landslide Pore water pressure

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Development of a PCR-based method to monitor arthropod dispersal in agroecosystems:Macrolophus pygmaeus(Hemiptera:Miridae)from banker plants to tomato crops

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Insect Science 2020年第5期27卷 1125-1134页

作者： nuria Agusti Cristina Castane Irene Fraile Oscar Alomar IRTA(Institute of Agrifood Research and Technology) CabrilsBarcelonaSpain

Development of conservation biological control programs requires the identifi-cation of sources that contribute to predator colonization of *** pygmaeus(Rambur)(Hemiptera:Miridae)is an efficient polyphagous predator used in biological con-trol programs in vegetable crops in *** have developed a marking method based on spraying with a solution of the brine shrimp Artemia spp.(Anostraca:Artemidac)cysts,followed by a PCR detection of Artemia DNA to monitor *** dispersal from banker plants to tomato *** conducted in climatic chambers show that the topical application of this marking solution on *** does not significantly reduce adult longevity and that it is detected up to 6 d after the *** this Artemia solution was applied on Calendula officinalis *** plants harboring *** and maintained outdoors,Artemia DNA was still detected on 62%of the insects after6 *** conducted field applications in commercial greenhouses have confirmed the usefulness of this method to monitor *** dispersal from banker plants to a newly planted tomato *** method can be used to assess arthropod movement,being an interesting molecular approach for further improving future pest management strategies.

关键词： Artemia arthropod dispersal Calendula officinalis Macrolophus pygmaeus PCR analysis tomato crop

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Single-cell system using monolithic PMUTs-on-CMos to monitor fluid hydrodynamic properties

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Microsystems & Nanoengineering 2022年第4期8卷 81-89页

作者： Eyglis Ledesma lvan Zamora Jesus Yanez rantxa Uranga nuria Barniol Department of Electronics Engineering Universitat Autonoma de Barcelona08193 BellaterraSpain

In this work,a single cell capable of monitoring fluid density,viscosity,sound velocity,and compressibility with a compact and small design is *** fluid measurement system is formed by a two-port AlScN piezoelectric micromachined ultrasonic transducer(PMUT)with an 80μm length monolithically fabricated with a 130 nm complementary metal-oxide semiconductor(CMOS)*** electrode configuration allows the entire system to be implemented in a single device,where one electrode is used as an input and the other as an *** verification was carried out by exploiting the features of piezoelectric devices such as resonators and acoustic transducers,where a frequency shift and amplitude variation are expected because of a change in density and viscosity.A sensitivity of 482±14 Hz/kg/m3 demonstrates the potential of the system compared to other dualelectrode *** addition,according to the acoustic measurement,the sound velocity,fluid compressibility,and viscosity coefficient can be extracted,which,to the best of our knowledge,is novel in these PMUT systems.

关键词： process. system electrode

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