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World Journal of Gastroenterology 2006年第42期12卷 6874-6878页

作者： Kenan lnar nurgül ■enol M Rü■tü zen Department of Biology Süleyman Demirel University Isparta 32260 Turkey

AIM： To detect distribution and relative frequency of endocrine cells in gastrointestinal tract of flower fish （Pseudophoxinus antalyae）. METHODS： The intestinal tract of flower fish was divided into four portions from proximal to distal; the enlarged area after oesophagus and anterior, middle and posterior intestine. Immunohistochemical method using the peroxidase anti-peroxidase complex was employed. All antisera between four portions of flower fish were compared using ANOVA. RESUlTS： Eleven types of gut endocrine cells were determined; they were immunoreactive for calcitonin gene related peptide, substance P, vasoactive intestinal peptide, bombesin, somatostatin-14, secretin, TrkA, TrkB, TrkC, neurotensin, neuropeptide Y, which were found in almost all portions of the gastrointestinal tract. CONClUSION： The regional frequency of immunoreactive distribution and relative cells in the flower fish, Pseudophoxinus antalyae, are essentially similar to those of other fish.

关键词： Flower fish Gastrointestinal tract Immunoreactive cells Pseudophoxinus antalyae

Serum vascular endothelial growth factor receptor-2 and adropin levels in age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2016年第4期9卷 556-560页

作者： nurgül rnek Kemal rnek Süleyman Aydin Musa Yilmaz Yasar lmez Department of Ophthalmology School of MedicineKirikkale University Department of Biochemistry School of Medicine Firat University

AIM： To investigate the serum levels of vascular endothelial growth factor receptor-2（VEGFR-2） and adropin in age-related macular degeneration（AMD）patients.·METHODS： Ninety-eight AMD patients were included in the study. Seventy-eight age- and sex-matched healthy volunteers were recruited as the control *** florescein angiography and optical coherence tomography were performed to assess the posterior segment details. Serum VEGFR-2 and adropin levels were measured using enzyme-linked immunosorbent assays and compared between the study groups.· RESUlTS： AMD group had significantly increased foveal retinal thickness, serum lDl and HDl levels and significantly decreased subfoveal choroidal thickness（P =0.01, 0.047, 0.025 and 〈0.001, respectively）. Serum VEGFR-2level revealed a significant decrease in AMD patients compared to controls（26.48 ±6.44 vs 30.42 ±7.92 ng/m l,P 〈0.001）. There was an insignificant increase in serum adropin level in AMD patients（6.17±3.19 vs 5.79±2.71 ng/m l,P =0.4）. Serum level of VEGFR-2 in AMD patients had a significant negative correlation with foveal retinal thickness（r =-0.226, P =0.025） and a significant positive correlation with subfoveal choroidal thickness（r=0.2, P=0.048）.·CONClUSION： The current study demonstrated that the decreased serum VEGFR-2 level may be considered in the development of AMD. Adropin does not seem to play a role in the pathogenesis of AMD.

关键词： vascular endothelial growth factor receptor-2 adropin age-related macular degeneration

The ability of biostimulants and copper-containing fungicide to protect cotton against chilling stress

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Journal of Cotton Research 2024年第3期7卷 223-230页

作者： ERGIN nurgül KUlAN Engin Gokhan HARMANCI Pinar KAYA Mehmet Demir Faculty of Agriculture and Natural Sciences Department of Field CropsBilecik Seyh Edebali UniversityBilecikTürkiye Faculty of Agriculture Department of Field CropsEskisehir Osmangazi UniversityEskisehirTürkiye

Background Cotton(Gossypium hirsutum l.),adapted to tropical and subtropical regions of the world,is highly sensitive to low temperatures throughout its life *** objective of this study was to evaluate the mitigating effects of different doses of animal-derived(0.25%,0.50%,and 1.00% Isabion■),seaweed-based(0.165%,0.330%,and 0.660% Proton■)biostimulants,as well as a copper(Cu)-containing fungicide application,on cotton cultivar lazer seedlings at the four true leaves(V4)*** plants were exposed to a low temperature of 5℃for 48 h,and the changes in morphological(seedling fresh and dry weight,plant height,and stem diameter)and physiological parameters(leaf temperature,chlorophyll content,relative water content,electrolyte leakage,and relative injury)were *** The results revealed that chilling stress reduced plant growth,while biostimulants helped protect the plants and overcome the adverse effects of *** chilling stress,there was a considerable reduction in seedling fresh weight(SFW),seedling dry weight(SDW),plant height(PH),stem diameter(SD),leaf temperature(lT),and relative water content(RWC).Cotton seedlings treated with the animal-derived biostimulants showed significantly enhanced SFW,SDW,PH,SD,lT,chlorophyll content(Chl),electrolyte leakage(El),and relative injury(RI),although there were no positive changes in *** significant differences in the morphological traits were observed among the doses of seaweed *** SDW,PH,El,and RI,the best results were obtained with the application of a fungicide containing *** These results show the efficiency of the biostimulant and fungicide treatments in mitigating low-temperature stress in cotton *** a copper-containing fungicide to cotton seedlings helped to counteract the negative effects of low-temperature stress and to protect the plants from damage by maintaining electrolyte *** the biostimulant applications,all levels of animal-derive

关键词： Gossypium hirsutum l. Cold stress Electrolyte leakage

Effect of 1%brinzolamide and 0.5%timolol fixed combination on intraocular pressure after cataract surgery with phacoemulsification

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 851-854页

作者： Kemal rnek Nesrin Byktortop nurgl rnek Reyhan Ogurel Inci Elif Erbahceci Zafer Onaran Department of Ophthalmology School of MedicineKinkkale University

AIM:To evaluate the effect of brinzolamide-timolol fixed combination on intraocular pressure(IOP)after cataract ***:The study included 92 eyes of 87 patients who underwent cataract surgery and intraocular lens *** scheduled for phacoemulsification were assigned to 1 of 2 *** treatment group received 1 drop of brinzolamide-timolol fixed combination immediately after surgery,and the control group received no *** IOP was measured preoperatively and at 2h and 24h ***:The mean IOP change was lower in the treatment group than in the control group at 2h *** difference between the mean IOP values of the two groups at 2h postoperatively was found to be statistically ***-four hours after the surgery,the mean IOP change was still higher in the control group when compared to the treatment ***:The fixed combination brinzolamidetimolol can effectively reduce IOP after cataract surgery.

关键词： brinzolamide timolol cataract surgery

Approach to Simplify the Development of IoT Systems that Interconnect Embedded Devices Using a Single Program

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Computers, Materials & Continua 2023年第11期77卷 2463-2480页

作者： enol Matilla Blanco Jordán Pascual Espada Rubén Gonzalez Crespo Department of Computer Science University of OviedoOviedo33007Spain Department of Computer Science and Technology Universidad Internacional de La RiojaLogroño26006Spain

Many Internet of Things(IoT)systems are based on the intercommunication among different devices and centralized ***,there are several commercial and research platforms available to simplify the creation of such IoT ***,developing these systems can often be a tedious *** address this challenge,a proposed solution involves the implementation of a unified program or script that encompasses the entire system,including IoT devices *** approach is based on an abstraction,integrating the control of the devices in a single program through a programmable ***,the proposal processes the unified script to generate the centralized system code and a controller for each *** adopting this approach,developers will be able to create IoT systems with significantly reduced implementation costs,surpassing current platforms by more than 10%.The results demonstrate that the single program approach can significantly accelerate the development of IoT systems relying on device communication.

关键词： IoT interconnected devices IoT platform programing devices devices coordination and communication

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

Primary sclerosing cholangitis in Turkish patients:characteristic features and prognosis

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Hepatobiliary & Pancreatic Diseases International 2009年第3期8卷 312-315页

作者： Hilmi Ataseven Erkan Parlak lhami Yüksel mer Ba■ar brahim Ertu■rul nurgül ■a■maz Burhan ■ahin Department of Gastroenterology Türkiye Yüksek htisas Hospital Department of Gastroenterology Di■kapl Yildirlm Beyazlt Education and Research Hospital

BACKGROUND:Primary sclerosing cholangitis(PSC)is a chronic cholestatic liver disease characterized by destruction and fibrosis of the bile *** study aimed to demonstrate the hepatic and extrahepatic characteristic findings and prognostic outcomes of Turkish patients with PSC. METHODS:The medical records of 35 consecutive patients with PSC from January 1988 to June 2007 were recorded *** the time of diagnosis,clinical features and laboratory data were collected. RESUlTS:The mean age of the 35 patients was 41.69 years (range 15-80 years)at the time of diagnosis;14(40%)were female,and 21(60%)were *** mean duration of follow-up was 58.86 months(1-180 months).Twenty(57.1%) of the patients with PSC were asymptomatic and 22(62.9%) had inflammatory bowel *** the time of diagnosis, 20(57.1%)of the patients had both intra-and extra-hepatic ***-one(60%)of the patients,who had undergone ERCP for stent placement,had dominant bile duct stenosis. Cholangiocarcinoma was found in 2(5.7%)of the patients and cirrhosis was detected in 7(20%);5(14.3%)underwent liver *** median follow-up time after liver transplantation was 23 months and all are still *** (17.1%)patients died. CONClUSIONS:PSC has a clinical course varied from advanced liver disease requiring liver transplantation within a short time to being asymptomatic for decades. The prognosis of Turkish patients with PSC is also disappointing as described in other studies.

关键词： primary sclerosing cholangitis cholestatic liver diseases biliary tree endoscopic retrograde cholangiopancreatography

Efficient adsorption of Th(Ⅳ) from aqueous solution by modified SBA-15 mesoporous silica

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Nuclear Science and Techniques 2018年第7期 58-66页

作者： Mutlu G?k ?enol Sert Gül?in ?zevci Meral Eral Institute of Nuclear Sciences Ege University

A very effective adsorbent for thorium has been obtained by modification of Santa Barbara Amorphous(SBA-15) using the chelating agent thenoyltrifluoroacetone(TTA).The prepared adsorbent(SBA-15-TTA) was characterized using scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FT-IR),surface area,porosity,and zeta potential *** investigated the factors affecting Th(IV) adsorption on TTA-SBA-15,such as initial p H,contact time,temperature,and initial metal *** effective initial p H for adsorption was found to be *** binding sites on TTA-SBA-15 adsorbent were saturated using an initial Th(IV) concentration of 100 mg *** Dubinin–Radushkevich isotherm suggested a strong chemical interaction between adsorbent and *** time and temperature had no significant effect on the ***,the studies show that TTA-SBA-15 is a promising adsorbent to treat Th(IV)-contaminated effluents.

关键词： Thorium SBA-15 Adsorption TTA Radionuclide

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network