检索结果-南通市图书馆

Efficacy of abatacept treatment in a patient with enteropathy carrying a variant of unsignificance in CTLA4 gene:A case report

引用

世界临床病例杂志 2023年第26期11卷 6176-6182页

作者： Ugur Musabak Tuba Erdoğan Serdar Ceylaner EmreÖzbek nuretdin suna Binnaz HandanÖzdemir Department of Immunology and Allergy Baskent University School of MedicineAnkara 06490AnkaraTurkey Department of Medical Genetics Lokman Hekim UniversityAnkara 06000Turkey Department of Medical Genetics Intergen Genetic and Rare Disease Diagnosis and Reseach CenterAnkara 06000Turkey Department of Immunology-Allergy Etlik City HospitalAnkara 06490AnkaraTurkey Division of Gastroenterology Baskent University School of MedicineAnkara 06000Turkey Department of Pathology Baskent UniversityAnkara 06000Turkey

BACKGROUND Cytotoxic T Lymphocyte Antigen-4(CTLA4)deficiency is a genetic defect that causes a common variable immunodeficiency(CVID)clinical *** studies have reported an association between CTLA mutations or variants and various autoimmune *** therapy models,which have become increasingly popular in recent years,have been successful in treating CTLA4 *** this article,we discuss the clinical outcomes of abatacept treatment in a patient with CTLA4 and lipopolysaccharide-responsive beige-like anchor(LRBA)variants that was previously diagnosed with *** SUMMARY A 25-year-old female patient,who was visibly cachectic,visited our clinic over the course of five years,complaining of *** patient was diagnosed with ulcerative colitis in the centers she had visited previously,and various treatments were administered;however,clinical improvement could not be *** hypokalemia was detected during an *** serum immunoglobulin levels,CD19+B-cell percentage,and CD4/CD8 ratio were *** endoscopic examination revealed erosive gastritis,nodular duodenitis,and *** findings supported the presence of immune mediated *** the patient was examined carefully,she was diagnosed with CVID,and intravenous immunoglobulin treatment was *** and rectal therapeutic drugs including steroid therapy episodes were administered to treat the immune mediated *** follow-ups and treatment were performed due to the *** conducting genetic analyses,the CTLA4 and LRBA variants were identified and abatacept treatment was *** targeted therapy,the patient’s clinical and laboratory findings rapidly regressed,and there was an increase in *** The heterozygous CTLA4 variant identified in the patient has been previously shown to be associated with various autoimmune *** successful clinical outcome of abatacept treatment in this patien

关键词： Common variable immunodeficiency Abatacept CTLA4 antigen Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Treatment of Crohn's disease and familial Mediterranean fever by leukopheresis:Single shot for two targets

引用

World Journal of Gastroenterology 2015年第13期21卷 4078-4081页

作者： Mahmut Yuksel Fatih Saygili Orhan Coskun nuretdin suna Mustafa Kaplan Ufuk Baris Kuzu Zeki Mesut Yalin Kilic Yasemin Ozderin Ozin Ertugrul Kayacetin Department of Gastroenterology Turkiye Yuksek Ihtisas Training and Education HospitalAnkara 06230Turkey

Coexistence of Crohn's disease(CD) and familial Mediterranean fever(FMF) is a rare condition and knowledge about this clinical situation is limited with a few case reports in the literature. The treatment of both diseases depends on their individual therapies. However, it is very hard to deal with this coexistence when CD is refractory to standard therapies. Ongoing activity of CD triggers the clinical attacks of FMF and the symptoms like abdominal pain interfere with both disease presentations which can cause problems about diagnostic and therapeutic approach. The main therapeutic agent for FMF is colchicine and diarrhea is the most common side effect of this drug. This side effect also causes problems about management of these diseases when both of them are clinically active. Here we report probably the first case in the literature with coexisting CD and FMF who was successfully treated by leukopheresis since he was refractory to conventional therapies for CD.

关键词： Crohn’s disease Familial Mediterranean fever Leuko

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：