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Magnetic mineral diagenesis in sediments of saline lake Lop nur

Journal of Mountain Science 2019年第3期16卷 548-560页

作者： LI Wen MU Gui-jin lin Yong-chong SONG hao-ze State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and GeographyChinese Academy of Sciences Cele National Station of Observation and Research for Desert-Grassland Ecosystems University of Chinese Academy of Sciences School of history and Geography Minnan Normal University

Saline lakes are useful repositories for paleo-climatic records. In recent years, magnetic properties of saline lake sediments have been widely applied to establish paleo-climatic change. However,the influence factors of magnetic properties in saline lakes have not been fully understood, which complicates the paleoenvironmental ***, we present a rock magnetic analyses result of LOP_1 profile(40°26′09″′N, 90°21′23″E) from Lop nur, a well-known saline lake, located in the eastern Tarim Basin in northwestern China. We combined the particle size, total organic content, and mineral characteristics analysis to assess the influence factors of magnetic properties in Lop nur and its environmental significance. The results indicate that early diagenesis is the major influence factor on magnetic properties of Lop nur saline *** greigite and pyrite are identified within organic-rich sediments, which produce zones with high and low magnetic susceptibilities, *** different authigenic iron sulfide contents in different layers are related to sedimentary environment changes. Sufficient supplies of organic matter and sulphate and low sedimentation rates favour the pyritization process. Moreover, if pyritization was constrained, intermediate greigite formed and was preserved. In oxidizing environments, sediment magnetic properties are consistent with those of source materials from Tarim Basin and are mainly controlled by particle size and hydrodynamic sorting of mainly detrital magnetite is largely unaffected by early diagenesis. Our study demonstrates that magnetic properties can provide a robust approach for studying depositional environment change in saline lake. In addition, the information obtained in this study would also provide insights into the geochemical processes of iron element in saline lakes.

关键词： Early diagenesis Magnetic properties Saline lake Lop nur

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Knowledge and attitudes toward corneal donation among Singaporean youth: a cross-sectional study

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Eye and Vision 2016年第1期3卷 131-140页

作者： Carisa Mariella Alvarez Paraz ha Thi Thu Truong Darren Kyauk Sai Howard Yu Cajucom-Uy Cherry Lay Li Chan Selina Md Kassim Singapore Eye Bank Singapore National Eye Centre11 Third Hospital AvenueSingapore 168751Singapore SingHealth Transplant Singapore Health Services Pte LtdTransplant Administrative and Resource OfficeSingapore General HospitalBlock 1Level 31 Hospital DriveSingapore 169608Singapore School of Applied Science Republic Polytechnic 9 Woodlands Avenue 9Singapore 738964Singapore

Background:To assess the knowledge of Singaporean youth regarding corneal donation and gauge their willingness to donate their ***:We conducted a cross-sectional study among 500 students from five tertiary institutions in *** students answered self-administered questionnaires which included seven questions that tested knowledge and three questions that determined willingness to donate ***:Among 500 Singaporean youth aged 18 to 25,most students(73.2%)answered 3 or fewer of the 7 questions about corneal donation *** regards to the willingness to donate,155(31%)were willing to donate their corneas,111(22.2%)were not willing to donate their corneas,and 234(46.8%)were *** to donate corneas was associated with an older age group(21 to 25 years old),those who are non-Muslims,and have good basic ***,students with good basic knowledge were 1.71 times more likely to willingly donate their ***:The knowledge of the Singaporean youth regarding corneal donation and transplantation is *** insufficient information was cited as the most common reason for being undecided in regards to corneal donation,specific and tailored programs to increase knowledge and awareness are needed to convince the youth to support corneal donation.

关键词： Corneal donation Donation knowledge Willingness Corneal transplant

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司美格鲁肽、德谷胰岛素联合二甲双胍治疗血糖控制不佳伴超重或肥胖2型糖尿病疗效分析

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中国基层医药 2024年第1期31卷 52-56页

作者：张雅婷张林内蒙古医科大学研究生院呼和浩特010110 巴彦淖尔市医院内分泌科

目的分析司美格鲁肽、德谷胰岛素联合二甲双胍治疗血糖控制不佳伴超重或肥胖2型糖尿病患者的疗效。方法选取巴彦淖尔市医院2022年4月至2023年3月收治的血糖控制不佳伴超重或肥胖2型糖尿病患者160例进行病例对照研究,根据治疗方案不同分... 详细信息

目的分析司美格鲁肽、德谷胰岛素联合二甲双胍治疗血糖控制不佳伴超重或肥胖2型糖尿病患者的疗效。方法选取巴彦淖尔市医院2022年4月至2023年3月收治的血糖控制不佳伴超重或肥胖2型糖尿病患者160例进行病例对照研究,根据治疗方案不同分为对照组、观察组各80例。对照组采用德谷胰岛素联合二甲双胍治疗,观察组采用司美格鲁肽、德谷胰岛素联合二甲双胍治疗,两组治疗12周。观察两组空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、餐后2 h血糖目标范围内时间(TIR)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMAIR)、身体质量指数(BMI)、内脏脂肪面积(VFA)的变化和不良反应发生情况。结果观察组总有效率为100.0%(80/80),高于对照组的97.5%(78/80)(χ^(2)=11.03,P0.05)。结论司美格鲁肽、德谷胰岛素联合二甲双胍治疗血糖控制不佳伴超重或肥胖2型糖尿病患者临床效果理想,可有效控制空腹及餐后血糖水平,明显降低身体质量指数和内脏脂肪水平,改善胰岛素抵抗且不明显增加不良反应。

关键词：糖尿病,2型超重肥胖症药物疗法,联合血糖脂肪组织司美格鲁肽德谷胰岛素二甲双胍

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Mechanical and degradation behaviour of biodegradable magnesium-zinc/hydroxyapatite composite with different powder mixing

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Journal of Magnesium and Alloys 2019年第4期7卷 566-576页

作者： Siti nur hazwani Mohamad Rodzi Hussain Zuhailawati B.K.Dhindaw Biomaterials Niche Area Group School of Materials and Mineral Resources EngineeringUniversiti Sains MalaysiaEngineering Campus14300 Nibong TebalPenangMalaysia School of Minerals Metallurgical and Materials EngineeringIndian Institute of Technology BhubaneswarBhubaneswar 751007India

Magnesium-based biomaterials have recently gained great attention as promising candidates for the new generation of biodegradable *** study investigated the mechanical performance and biodegradation behaviour of magnesium-zinc/hydroxyapatite(Mg-Zn/ha)composites fabricated by different powder mixing techniques.A single step mixing process involved mechanical alloying or mechanical milling techniques,while double step processing involved a combination of both mechanical alloying and mechanical *** mechanical properties of the composite were observed when the powders were prepared using single step processing via mechanical alloying ***,Mg-Zn/ha composite fabricated through single step processing via mechanical milling technique was found to have the most desirable low degradation rate coupled with highest *** composite achieved the lowest degradation rate of 0.039×10^−3 mm/year as measured by immersion test and 0.0230 mm/year as measured by electrochemical ***:P ratio of the composite also slightly more than enough to aid the initial bone mineralization,that is 1:1.76,as the required Ca:P ratio for initial bone mineralization is between 1:1 and 1:1.67.

关键词： Magnesium-based composite Biodegradable implant Powder metallurgy Mechanical alloying Mechanical milling

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Corneal re-innervation following refractive surgery treatments

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Neural Regeneration Research 2019年第4期14卷 557-565页

作者： Francisco Bandeira nur Zahira Yusoff Gary Hin-Fai Yam Jodhbir Singh Mehta Tissue Engineering and Stem Cell Group Singapore Eye Research Institute Federal University of S?o Paulo S?o Gon?alo Eye Hospital Eye-ACP Duke-NUS Graduate Medical School Department of Ophthalmology Yong Loo Lin School of Medicine National University of Singapore Singapore National Eye Centre School of Material Science and Engineering Nanyang Technological University

Laser refractive surgery is one of the most performed surgical procedures in the world. Although regarded safe and efficient, it has side effects. All of the laser based refractive surgical procedures invoke corneal nerve injury to some degree. The impact of this denervation can range from mild discomfort to neurotrophic corneas. Currently, three techniques are widely used for laser vision correction: small incision lenticule extraction, laser-assisted keratomileusis in situ and photorefractive keratotomy. Each of these techniques affects corneal innervation differently and has a different pattern of nerve regeneration. The purpose of this review is to summarize the different underlying mechanisms for corneal nerve injury and compare the different patterns of corneal reinnervation.

关键词： photorefractive keratotomy small incision manual lenticule extraction laser-assisted keratomileusis in situ refractive surgery in vivo confocal microscopy corneal sensation corneal nerve

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“史·著·论”视域下党史教育融入高校“原理”课的逻辑理路

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山西高等学校社会科学学报 2024年第4期36卷 39-44,61页

作者：王凡张林西南财经大学四川成都611130

中国共产党百年历史是最鲜活、最生动的教科书,是“马克思主义基本原理”课铸魂育人的最好营养剂。在“史·著·论”视域下,党史教育和高校“原理”课在教育目标、内容以及载体层面具有互通性、契合性和一致性。将百年光辉党史融入高校... 详细信息

中国共产党百年历史是最鲜活、最生动的教科书,是“马克思主义基本原理”课铸魂育人的最好营养剂。在“史·著·论”视域下,党史教育和高校“原理”课在教育目标、内容以及载体层面具有互通性、契合性和一致性。将百年光辉党史融入高校“原理”课是引导大学生树立正确党史观的迫切需要,是提升“原理”课教学成效的有效举措,是培育民族复兴时代新人的必然选择,既有利于促进大学生站稳政治立场、坚定政治信仰和强化政治担当,又有利于推动大学生自觉践行社会主义核心价值观和坚定文化自信,也有利于从思想和行动层面为民族复兴事业培育时代新人,具有重要的政治价值、文化价值和社会价值。基于此,高校要从理论性和实践性教学优化融合型育人课堂,从物质、精神和行为多层面形成融合型育人文化氛围,从学校、社会和家庭多方面发挥融合型育人主体的作用,从内容、形式和方法多维度打造融合型育人模式,推进党史教育有机融入高校“原理”课。

关键词：党史经典著作马克思主义基本原理思政课 “原理”课

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Country and My People and Sydney Opera House:The missing link

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Frontiers of Architectural Research 2019年第2期8卷 136-153页

作者： Chen-Yu Chiu Philip Goad Peter Myers nur Yildiz Ki lincer Department of Architecture Bilkent UniversityAnkaraTurkey

It is known that Jφrn Utzon(1918-2008),the principal architect for the Sydney Opera House project(1957-66),had a lifetime obsession for Chinese art and ***,previous studies did not explore the relationship between Utzon and his venerated Chinese writer lin Yutang(1895-1976).How Utzon represented the ideas and ideals he received from lin Yutang's conceptualization of Chinese art and architecture in My Country and My People(1935)has not been systematically *** this end,this article examines the role of lin Yutang's work in Utzon's architectural career generally and the architect's Sydney Opera House design in *** argues that My Country and My People nurtured young Utzon's own architectural philosophy,as reflected in his early manifestoes and design ***,lin Yutang's Chinese aesthetics encapsulated in calligraphy,painting and architecture helped Utzon to initiate,articulate and further communicate the design principles of his Sydney Opera House,as well as several other important architectural works before and *** Utzon never fully realized his Opera House due to forced resignation in 1966,the inspiration from lin Yutang vividly remains in Utzon's yet to be finished masterpiece.

关键词： lin Yutang My Country and My People Jφrn Utzon The Sydney Opera House Chinese art and architecture

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Tree assemblages and diversity patterns in Tropical Juri Forest,Bangladesh

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Journal of Forestry Research 2015年第1期26卷 159-169页

作者： Swapan Kumar Sarker Muhammad nur-Un-Nabi Md.Mohasinul haque Mahmuda Sharmin Sanjay Saha Sonet Sourav Das Niamjit Das Department of Forestry and Environmental Science Shahjalal University of Science & Technology

Juri is a biodiversity-rich primary forest in Bangladesh, which remains ecologically unexplored. We identified tree species and examined the richness, alpha（a）diversity and floristic similarity patterns within the identified communities. Vegetation and environmental data were sampled in 120（0.04 ha） study plots. Tree communities were delimited by two-way indicator species analysis（TWINSPAN）. In total, 78 tree species of 35 families and58 genera were identified. TWINSPAN identified six tree communities： A—Tricalysia singularis; B—Kydia calycina-Castanopsis tribuloides; C—Polyalthia simiarum-Duabanga grandiflora; D—Ficus roxburghii; E—Artocarpus lacucha; F—Artocarpus lacucha. Mean richness, Shannon and Gini-Simpson indices were highest for the Polyalthia simiarum-Duabanga grandiflora community, while Ficus roxburghii showed lowest diversity. Significant differences（p = 0.05） in three diversity indices were recorded between Polyalthia simiarum-Duabanga grandiflora and Ficus roxburghii. Tree compositional similarity was greatest between Kydia calycina-Castanopsis tribuloides and Polyalthia simiarum-Duabanga grandiflora（0.712）.

关键词： Two-way indicator species analysis(TWINSPAN) Richness index Shannon index Gini-Simpson index Tropical forest Conservation

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基于生物信息学分析的肝癌核心基因的筛选及验证

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基因组学与应用生物学 2021年第2期40卷 867-877页

作者：李怡敏汪洋袁琳 nur Fazleen Binti Idris 黄国旺涂增重庆医科大学基础医学院病原生物学教研室分子医学与肿瘤研究中心重庆400016 西安市第一医院西安710000

本研究基于GEO数据库,选取由慢性乙型肝炎诱导的肝细胞癌芯片数据GSE121248为研究对象,利用GEO_(2)R软件分析数据,筛选出差异表达基因,利用DAVID数据库进行GO分析和KEGG pathway富集分析。利用STrinG数据库构建PPI网络,分析筛选核心基... 详细信息

本研究基于GEO数据库,选取由慢性乙型肝炎诱导的肝细胞癌芯片数据GSE121248为研究对象,利用GEO_(2)R软件分析数据,筛选出差异表达基因,利用DAVID数据库进行GO分析和KEGG pathway富集分析。利用STrinG数据库构建PPI网络,分析筛选核心基因。利用GEPIA对核心基因的表达进行验证,Kaplan Meier Plotter在线分析工具对核心基因与患者生存情况的相关性进行验证。通过上述方法筛选出309个DEGs,其中上调基因94个,下调基因215个。差异基因功能分析显示上调的DEGs主要参与细胞周期和卵母细胞减数分裂通路等途径,下调的DEGs则在补体和凝血级联、代谢途径以及咖啡因代谢途径富集。筛选出15个具有高度关联性的核心基因(BUB1,BUB1B,BIRC5,CCNB1,CCNB2,CDC20,CDK1,KIF-20A,MAD2L1,NCAPG,ZWINT,PBK,BTL,TTK和NUSAP1),它们与肝癌患者的总体生存率具有明显相关性,并为其构建了miRNA调控网络。本研究通过生物信息学方法有效分析了肝细胞癌发生、发展相关的差异表达基因,筛选出15个核心基因,分析其生物学相关功能,以期探索肝细胞癌发病机制,并为临床诊断标志物的改进以及筛选提供一定的理论基础。

关键词：肝癌差异表达基因生物信息学

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KRAS G12C突变在消化系统恶性肿瘤中的分子特点

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肝癌电子杂志 2024年第1期11卷 4-8页

作者：赵挺祺董林应建明李卫华巴彦淖尔市医院病理科内蒙古巴彦淖尔市015000 国家癌症中心/国家肿瘤临床研究中心/中国医学科学院北京协和医学院肿瘤医院病理科北京100021

目的:探究KRAS G12C突变在不同消化系统恶性肿瘤中的发生率及分子病理特点。方法:收集2017—2022年在中国医学科学院肿瘤医院诊断为消化系统恶性肿瘤且有肿瘤组织样本的1100例患者资料。使用二代测序的方法对1100例消化系统恶性肿瘤组... 详细信息

目的:探究KRAS G12C突变在不同消化系统恶性肿瘤中的发生率及分子病理特点。方法:收集2017—2022年在中国医学科学院肿瘤医院诊断为消化系统恶性肿瘤且有肿瘤组织样本的1100例患者资料。使用二代测序的方法对1100例消化系统恶性肿瘤组织样本(包括结肠腺癌、直肠腺癌、回盲肠腺癌、十二指肠腺癌、胃腺癌、胆管腺癌和胰腺导管腺癌)的微卫星状态和肿瘤突变负荷(TMB),以及KRAS、NRAS、BRAF、PIK3CA突变进行检测。结果:微卫星高度不稳定(MSI-H)在不同消化系统肿瘤中存在差异,其中在十二指肠腺癌发生率最高(19%),其次为回盲肠腺癌(18%)和结肠腺癌(10.2%),但在100例胰腺导管腺癌中未检出MSI-H的肿瘤。不同消化系统恶性肿瘤的TMB值亦有差异,高TMB(≥10 mut/Mb)在回盲肠腺癌中最常见(24%),其次为十二指肠腺癌(22%)和胃腺癌(18.9%)。KRAS在总人群中的突变率为41.09%,其中在胰腺导管腺癌中突变率最高(85.0%),其次为十二指肠腺癌(56%)和回盲肠腺癌(53%),在胃腺癌中最低(7.3%)。KRAS G12C在总人群中的突变率为2.82%(31/1100),在所有KRAS突变的消化系统肿瘤中仅占6.9%(31/452),常见于回盲肠腺癌(2/9),其次为十二指肠腺癌(13%)和结肠腺癌(8.8%)。KRAS G12C突变和其他KRAS突变亚型患者的性别、年龄、MSI和TMB状态相近。结论:虽然近一半的消化系统恶性肿瘤患者携带有KRAS突变,但KRAS G12C突变发生率相对较低,只占KRAS突变人群的6.9%。KRAS G12C突变最常见于回盲肠腺癌、十二指肠腺癌和结肠腺癌,且与其他类型的KRAS突变相比未见明显的临床和分子病理特征差异。

关键词：消化系统肿瘤二代测序 KRAS G12C突变

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