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Psychiatric Variables in <i>Cytomegalovirus</i>or <i>Toxoplasma gondii</i>—Infected Pregnants: Prospects for Cure with a Program of “Counseling about Behavioral Change”

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Open Journal of Preventive Medicine 2015年第7期5卷 315-320页

作者： Concetta De Pasquale Maria Anna Coniglio Maria Luisa Pistorio nunzio massimo scalisi Federica Scalia Carmela Maria Costanzo Marina Marranzano Guido Scalia Department of Medical Surgical Sciences and Advanced Technologies “G.F. Ingrassia” University of Catania Catania Italy Vascular Surgery and Organ Transplant Unit Department of Surgery Transplantation and Advanced technologies University Hospital of Catania Catania Italy Clinical Virology Unit Department of Biomedical Sciences University Hospital of Catania Catania Italy

TORCH complex, one of the potential infections that may occur during pregnancy, may contribute also to prenatal pregnant women’s anxiety and depression. The aim of this study was to explore the presence of psychiatric symptoms, in relation with infection of TORCH agents, specifically the Toxoplasma gondii (T. gondii) and Cytomegalovirus (CMV). The study was conducted on 58 pregnant women recruited from the Clinical Virology Unit, A.O.U. Policlinico-Vittorio Emanuele, P.O. “Gaspare Rodolico”, from September 2012 to March 2014. Psychiatric symptoms were evaluated through the Symptom Checklist-90 Revised (SCL-90 R) in pregnant women with CMV or T. gondii infection. Moreover, pregnant women were invited to participate in a program of “Counseling about behavioral change”, an effective psychotherapeutic training for the development of new motivational strategies to the infection acceptance, the greater self-confidence and greater adherence to treatment. The age of the subjects was positively correlated with Depression (r = 0.119, p ? 0.178, p ? 0.231, r = ? 0.320, p ? 0.208, p ? 0.105, p ? 0.236, p < 0.05). Finally, we can notice an improvement of the variables Anxiety and Somatization in the whole sample after the attendance at the counseling psychotherapic program. Our study suggests the presence of anxiety and somatization in pregnant women with infection, expression of a phase of emotional fragility with the concern of transmitting a serious disease in the unborn child. The program “Counseling about behavioral change” allowed us to create an atmosphere of trust and to understand the usefulness of “empathic listening”. Giving correct and accurate information about the disease reassures the patient and prevents the realization of negative thoughts and further concern and discomfort.

关键词： Pregnancy Psychiatric Symptoms Somatization Toxoplasma gondii Cytomegalovirus

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Nano albumin bound-paclitaxel in pancreatic cancer: Current evidences and future directions

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World Journal of Gastroenterology 2017年第32期23卷 5875-5886页

作者： Guido Giordano massimo Pancione nunzio Olivieri Pietro Parcesepe Marianna Velocci Tania Di Raimo Luigi Coppola Giuseppe Toffoli Mario Rosario D’Andrea Medical Oncology Unit San Filippo Neri Hospital CRO Aviano National Cancer Institute Department of Sciences and Technologies University of Sannio Department of Biochemistry and Molecular Biology II Faculty of PharmacyComplutense University Department of Biology University of Naples Department of Pathology and Diagnostics University of Verona Strada Anatomic Pathology Unit San Filippo Neri00135 RomaItaly Experimental and Clinical Pharmacology Unit CRO-National Cancer Institute Via F

Pancreatic cancer(PDAC) is an aggressive and chemoresistant disease, representing the fourth cause of cancer related deaths in western countries. Majority of patients have unresectable, locally advanced or metastatic disease at time of diagnosis and the 5-year survival rate in these conditions is extremely low. For more than a decade gemcitabine has been the cornerstone of metastatic PDAC treatment, although survival benefit was very poor. PDAC cells are surrounded by an intense desmoplastic reaction that may create a barrier to the drugs penetration within the tumor. Recently PDAC stroma has been addressed as a potential therapeutic target. Nano albumin bound(Nab)-paclitaxel is an innovative molecule depleting tumor stroma, through interaction between albumin and secreted protein acidic and rich in cysteine. Addition of nab-paclitaxel to gemcitabine has showed activity and efficacy in metastatic PDAC first-line treatment improving survival and overall response rate vs gemcitabine alone in the MPACT phase Ⅲ study. This combination represents one of the standards of care in advanced PDAC therapy and is suitable to a broader spectrum of patients compared to other schedules. Nab-paclitaxel is under investigation as a backbone of chemotherapy in novel combinations with target agents or immunotherapy in locally advanced or metastatic PDAC. In this article, we provide an updated and critical overview about the role of nab-paclitaxel in PDAC treatment based on the latest advances in preclinical and clinical research. Furthermore, we focus on the use of nab-paclitaxel within the context of metastatic PDAC treatment landscape and we discuss about future implications in the light of current clinical ongoing trials.

关键词： Nano 白朊 bound-paclitaxel 胰腺的癌症变形疾病 Gemcitabine Folfirinox

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Dynamical evolution of Ge quantum dots on Si(111):From island formation to high temperature decay

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Aggregate 2022年第4期3卷 114-120页

作者： Navathej Preetha Genesh Fabrizio De Marchi Stefan Heun Stefano Fontana Rachid Belkhou Rahul Purandare nunzio Motta Anna Sgarlata massimo Fanfoni Jennifer MacLeod Oliver MacLean Federico Rosei CentreÉnergie Matériaux et TélécommunicationsInstitut National de la Recherche ScientifiqueQuébecCanada NEST Istituto Nanoscienze-CNR and Scuola Normale SuperiorePisaItaly Sincrotrone Trieste SCpA BasovizzaItaly LURE UniversitéParis-SudOrsay CedexFrance School of Chemistry and Physics and Centre for Materials Science Queensland University of TechnologyBrisbaneAustralia Dipartimento di Fisica Universitàdi Roma“Tor Vergata”RomeItaly Key Laboratory of Functional Materials Physics and Chemistry of the Ministry of Education Jilin Normal UniversityChangchunP.R.China

Heteroepitaxial growth is a process of profound fundamental importance as well as an avenue to realize nanostructures such as Ge/Si quantum dots(QDs),with appealing properties for applications in opto-and ***,controlling the Ge/Si QD size,shape,and composition remains a major obstacle to their practical ***,Ge nanostructures on Si(111)were investigated in situ and in real-time by low energy electron microscopy(LEEM),enabling the observation of the transition from wetting layer formation to 3D island growth and *** island size,shape,and distribution depend strongly on the growth *** the deposition temperature increases,the islands become larger and sparser,consistent with Brownian nucleation and capture *** 550◦C,two distinct Ge/Si nanostructures are formed with bright and dark appearances that correspond to flat,atoll-like and tall,faceted islands,*** annealing,the faceted islands increase in size at the expense of the flat ones,indicating that the faceted islands are thermodynamically more *** contrast,triangular islands with uniform morphology are obtained from deposition at 600◦C,suggesting that the growth more closely follows the ideal *** annealing,the islands formed at 600◦C initially show no change in morphology and size and then rupture simultaneously,signaling a homogeneous chemical potential of the *** observations reveal the role of dynamics and energetics in the evolution of Ge/Si QDs,which can serve as a step towards the precise control over the Ge nanostructure size,shape,composition,and distribution on Si(111).

关键词： epitaxial growth GeSi heterostructures low energy electron microscopy

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Sorafenib delivery nanoplatform based on superpara- magnetic iron oxide nanoparticles magnetically targets hepatocellular carcinoma

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Nano Research 2017年第7期10卷 2431-2448页

作者： Nicoletta Depalo Rosa Maria lacobazzi Gianpiero Valente Ilaria Arduino Silvia Villa Fabio Canepa Valentino Laquintana Elisabetta Fanizza Marinella Striccoli Annalisa Cutrignelli Angela Lopedota Letizia Porcelli Amalia Azzariti massimo Franco Maria Lucia Curri nunzio Denora Istituto per i Processi Chimico-Fisici-CNR UOS Bari Via Orabona 4 70125 Bari Italy Istituto Tumori IRCCS Giovanni Paolo II viale O. Flacco 65 70124 Bari Italy Dipartimento di Chimica Universita degli Studi di Bad Aldo Moro Via Orabona70125 Bari Italy Dipartimento di Farmacia-Scienze del Farmaco Universita degli Studi di Bari Aldo Moro Via Orabona 4 70125 Bari Italy Dipartimento di Chimica e Chimica Industriale Universita di Genova Via Dodecaneso 31 16146 Genova Italy

Currently, sorafenib is the only systemic therapy capable of increasing overall survival of hepatocellular carcinoma patients. Unfortunately, its side effects, particularly its overall toxicity, limit the therapeutic response that can be achieved. Superparamagnetic iron oxide nanoparticles （SPIONs） are very attractive for drug delivery because they can be targeted to specific sites in the body through application of a magnetic field, thus improving intratumoral accumulation and reducing adverse effects. Here, nanoformulations based on polyethylene glycol modified phospholipid micelles, loaded with both SPIONs and sorafenib, were successfully prepared and thoroughly investigated by complementary techniques. This nanovector system provided effective drug delivery, had an average hydrodynamic diameter of about 125 nm, had good stability in aqueous medium, and allowed controlled drug loading. Magnetic analysis allowed accurate determination of the amount of SPIONs embedded in each micelle. An in vitro system was designed to test whether the SPION micelles can be efficiently held using a magnetic field under typical flow conditions found in the human liver. Human hepatocellular carcinoma （HepG2） cells were selected as an in vitro system to evaluate tumor cell targeting efficacy of the superparamagnetic micelles loaded with sorafenib. These experiments demonstrated that this delivery platform is able to enhance sorafenib＇s antitumor effectiveness by magnetic targeting. The magnetic nanovectors described here represent promising candidates for targeting specific hepatic tumor sites, where selective release of sorafenib can improve its efficacy and safety profile.

关键词： superparamagnetic ironoxide nanoparticles poly(ethylene glycol) (PEG)-modified phospholipidmicelles drug delivery magnetic targeting hepatocellular carcinoma sorafenib

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Improving Hardenability of High Thickness Forged Steel Materials by Boron Addiction

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材料科学与工程（中英文B版） 2016年第2期6卷 105-109页

作者： Sabrina Mengaroni Paolo Emilio Di nunzio Stefano Neff massimo Calderini Andrea Di Schino Centro Sviluppo Materiali SpA Via di Castel Romano 100 00128 Roma Italy Acciai Speciali Terni Viale Benedetto Brin 118 05100 Terni Italy Universita degli Studi di Perugia Dipartimento di Ingegneria Via G. Duranti 93 06125 Perugia Italy

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