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Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling

Signal Transduction and Targeted Therapy 2023年第11期8卷 5404-5416页

作者： Catarina Macedo-Silva Vera Miranda-Gonçalves nuno tiago tavares Daniela Barros-Silva Joana Lencart João Lobo Ângelo Oliveira Margareta PCorreia Lucia Altucci Carmen Jerónimo Cancer Biology&Epigenetics Group Research Center of IPO Porto(CI-IPOP)/CI-IPOP@RISE(Health Research Network)Portuguese Oncology Institute of Porto(IPO-Porto)/Porto Comprehensive Cancer Center Raquel Seruca(Porto.CCC)R.Dr.António Bernardino de Almeida4200-072PortoPortugal Department of Precision Medicine University of Campania“Luigi Vanvitelli”80138NaplesItaly Department of Pathology and Molecular Immunology ICBAS-School of Medicine&Biomedical SciencesUniversity of PortoR.Jorge de Viterbo Ferreira 2284050-313PortoPortugal Medical Physics Radiobiology and Radiation Protection Group-Research Center of IPO Porto(CI-IPOP)/CI-IPOP@RISE(Health Research Network)Portuguese Oncology Institute of Porto(IPO-Porto)/Porto Comprehensive Cancer Center Raquel Seruca(Porto.CCC)R.Dr.António Bernardino de Almeida4200-072PortoPortugal Department of Medical Physics Portuguese Oncology Institute of Porto4200-072PortoPortugal Department of Pathology Portuguese Oncology Institute of PortoPortoPortugal Department of Radiation Oncology Portuguese Oncology Institute of PortoPortoPortugal BIOGEM Molecular Biology and Genetics Research Institute83100AvellinoItaly IEOS Institute of Endocrinology and Oncology80100NaplesItaly

External beam radiotherapy(RT)is a leading first-line therapy for prostate cancer(PCa),and,in recent years,significant advances have been ***,RT resistance can arise and result in long-term recurrence or disease progression in the worst-case ***,making crucial the discovery of new targets for PCa ***,we generated a radioresistant PCa cell line,and found p53 to be highly expressed in radioresistant PCa cells,as well as in PCa patients with recurrent/disease progression submitted to *** dissection revealed that RT could promote p53 expression via epigenetic ***,a decrease of H3K27me3 occupancy at TP53 gene promoter,due to increased KDM6B activity,was observed in radioresistant PCa ***,p53 is essential for efficient DNA damage signaling response and cell recovery upon stress induction by prolonged fractionated ***,KDM6B inhibition by GSK-J4 significantly decreased p53 expression,consequently attenuating the radioresistant phenotype of PCa cells and hampering in vivo 3D tumor ***,this work contributes to improve the understanding of p53 as a mediator of signaling transduction in DNA damage repair,as well as the impact of epigenetic targeting for PCa radiosensitization.

关键词： TP53 damage cancer

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Elastically restrained Bernoulli-Euler beams applied to rotary machinery modelling

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Acta Mechanica Sinica 2011年第1期27卷 56-62页

作者： tiago A.N.Silva nuno M.M.Maia ISEL Polytechnic Institute of LisbonDepartment of Mechanical EngineeringRua Conselheiro Emídio Navarro IDMEC-IST Technical University of LisbonDepartment of Mechanical Engineering

Facing the lateral vibration problem of a machine rotor as a beam on elastic supports in bending,the authors deal with the free vibration of elastically restrained Bernoulli-Euler beams carrying a finite number of concentrated elements along their *** on Rayleigh’s quotient,an iterative strategy is developed to find the approximated torsional stiffness coefficients,which allows the reconciliation between the theoretical model results and the experimental ones,obtained through impact *** mentioned algorithm treats the vibration of continuous beams under a determined set of boundary and continuity conditions, including different torsional stiffness coefficients and the effect of attached concentrated masses and rotational inertias, not only in the energetic terms of the Rayleigh’s quotient but also on the mode shapes,considering the shape functions defined in *** loading cases are examined and examples are given to illustrate the validity of the model and accuracy of the obtained natural frequencies.

关键词： Transverse vibration of beams · Elastic supports · Torsional stiffness coefficients

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Open Source Tool for Networks Management Communication

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Journal of Electrical Engineering 2017年第1期5卷 35-46页

作者： nuno tiago Louro Simoes Carlos Manuel da Silva Rabadao School of Technology and Management Polytechnic Institute of Leiria Leiria Portugal Research Center for Informatics and Communications Polytechnic Institute of Leiria Leiria Portugal

Considering the complexity of the networks and the need for telecommunication operators （Telco） to present innovations to their clients, the quickest possible, one of the solutions for this complexity could be to centralize its configuration. Thus the SDN （software-defmed networking） concept may be an important solution. This paper suggests the implementation of a tool to support the development and testing of networks and services before they are put into production. The use of a tool that simplifies the configuration of a network service makes the networks and services to be less susceptible to errors and failures by those who set them up, thus allowing telecom operators, among others, to be able to create new services, improve the monitorization of their human resources and, above all, improve their fmancial results. In the end, success will be achieved because with a simple interaction and basic knowledge we are able to manage network services.

关键词： SDN network services network programming NSO.

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Innovative Benthic Lander for Macroalgae Monitoring in Shallow-Water Environments

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Journal of Marine Science and Application 2020年第1期19卷 133-147页

作者： João Pedro Santana nuno Mathias Richelle Hoveling Hugo Alves tiago Morais INEGI-Institute of Science and Innovation in Mechanical and Industrial Engineering Rua Dr.Roberto Frias 400 Campus FEUP4200-465 PortoPortugal Quest Innovations BV Industrieweg 411775 PW MiddenmeerThe Netherlands

The colonization of underwater environments by exotic seaweeds is causing major ecological problems around the *** project,referred to AMALIA,aims to transform this current ocean threat into an opportunity by adding value to the macroalgae present off the northwest of the Iberian *** do so and to observe the presence of seaweeds in situ,an ocean modular submersible platform was *** platform was designed to be capable of detecting and surveying surges of invasive seaweeds while withstanding sea *** designs followed by a screening process were performed,taking into consideration criteria such as operational range and *** open-frame lander was considered and further developed using buckling *** parallel,a state-of-the-art monitoring system was created using spectral imaging,allowing for the future creation of a macroalgae identification *** addition,sensorial systems for characterizing growth conditions were *** trials were executed to assess the capability of the system,and sea trials are currently being *** simulations and laboratory trials indicate that the structure is fully capable of being deployed for shallow-water environments with a state-of-the-art invasive seaweed monitoring system while maintaining a high degree of modularity.

关键词： Benthic landers Ocean surveillance Environmental protection Ocean technology Marine instrumentation

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“小动作”改变街区面貌

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设计家 2010年第2期 86-93页

作者： tiago Mota Saraiva nuno Carvalho Andreia Salavessa Raquel Capelo with Carolina Condeo nuno Ferreira Vera Joo Joo Ribeiro Joo Ferro with Sónia Oliveira Joao Morgado Ateliermob

Sacavém是位于里斯本的市郊的一个传统小城镇,以发展陶器工业为主。传统工业的逐渐消失和快速增长的居民人数,使得它渐渐失去了原有的城市脉络,大量毫无特色的普通住宅,更使它如今看起来就像是一座"宿舍城"。上个世纪末。

关键词：里斯本传统小城镇城市规划传统工业普通住宅干预方式市政厅快速增长咖啡建筑师

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