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Finite element model with imposed slip surfaces for earth mass safety evaluation

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Journal of Central South University 2014年第9期21卷 3627-3638页

作者： nuno ArAUJO Gaspar J.MACHADO Julio B.MArTINS Hugo M.r.D.SILVA C-TAC Territory Environment and Construction Research Centre School of EngineeringUniversity of Minho Guimaraes 4800-058 Portugal Centre of Mathematics School of Sciences University of Minho Guimaraes 4800-058 Portugal

The study of earth masses requires numerical methods that provide the quantification of the safety factor without requiring detrimental assumptions. For that, equilibrium analysis can perform fast computations but require assumptions that limit its potentiality. Limit analysis does not require detrimental assumptions but are numerically demanding. This work provides a new approach that combines the advantage of both the equilibrium method and the limit analysis. The defined hybrid model allows probabilistic analysis and optimization approaches without the assumption of interslice forces. It is compared with a published case and used to perform probabilistic studies in both a homogeneous and a layered foundation. Analyses show that the shape of the density probability functions is highly relevant when computing the probability of failure, and soil elasticity hardly affects the safety of factor of the earth mass.

关键词： slope stability probabilistic methods reliability genetic algorithms safety factor

Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice

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World Journal of Gastroenterology 2018年第18期24卷 1995-2008页

作者： Maria Carolina S Mendes Daiane SM paulino Sandra r Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira Department of Internal Medicine Faculty of Medical Sciences State University of Campinas (UNICAMP) Brazilian Bioethanol Science and Technology Laboratory (CTBE) Brazilian Center for Research in Energy and Materials (CNPEM)

AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr rNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by real Time-PCr(Polymerase Chain reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P raphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. rESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(re was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P robial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines rANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC.

关键词： Intestinal microbiota Chemoprevention Lactobacillus acidophilus Lactobacillus rhamnosus Bifidobacterium bifidum

Bayesian regularized quantile regression:A robust alternative for genome-based prediction of skewed data

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The Crop Journal 2020年第5期8卷 713-722页

作者： paulino Pérez-rodríguez Osval A.Montesinos-López Abelardo Montesinos-López JoséCross Colegio de Postgraduados MontecillosEdo.de México 56230Mexico Facultad de Telemática Universidad de ColimaColima 28040Mexico Departamento de Matemáticas Centro Universitario de Ciencias Exactas e Ingenierías(CUCEI)Universidad de GuadalajaraGuadalajaraJalisco 44430Mexico International Maize and Wheat Improvement Center(CIMMYT) Km 45 Carretera México-VeracruzTexcocoEdo.de México 56237Mexico

Genomic prediction(GP)has become a valuable tool for predicting the performance of selection candidates for the next breeding cycle.A vast majority of statistical linear models on which GP is based rely on the assumption of normality of the residuals and therefore on the response variable *** this study,we propose to use Bayesian regularized quantile regression(BrQr)in the context of GP;the model has been successfully used in other research *** evaluated the prediction ability of the proposed model and compared it with the Bayesian ridge regression(Brr;equivalent to genomic best linear unbiased predictor,GBLUP).In addition,BLUP can be used with pedigree information obtained from the coefficient of coancestry(ABLUP).We have found that the prediction ability of BrQr is comparable to that of Brr and,in some cases,better;it also has the potential to efficiently deal with outliers.A program written in the r statistical package is available as Supplementary material.

关键词： Laplace distribution robust regression Bayesian quantile regression Genomic-enabled prediction

Contribution of glial cells to the neuroprotective effects triggered by repetitive magnetic stimulation:a systematic review

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Neural regeneration research 2024年第1期19卷 116-123页

作者： Susana A.Ferreira nuno Pinto Inês Serrenho Maria Vaz Pato Graça Baltazar Centro de Investigação em Ciências da Saúde(CICS-UBI) Universidade da Beira InteriorCovilhãPortugal Faculdade de Ciências da Saúde Universidade da Beira InteriorCovilhãPortugal GrUBI-Systematic reviews Group University of Beira InteriorCovilhãPortugal

repetitive transcranial magnetic stimulation has been increasingly studied in different neurological diseases,and although most studies focus on its effects on neuronal cells,the contribution of nonneuronal cells to the improvement trigge red by repetitive transcranial magnetic stimulation in these diseases has been increasingly *** systematically review the effects of repetitive magnetic stimulation on non-neuronal cells two online *** of Science and PubMed were searched fo r the effects of high-frequency-repetitive transcranial magnetic stimulation,low-frequencyrepetitive transcranial magnetic stimulation,intermittent theta-bu rst stimulation,continuous thetaburst stimulation,or repetitive magnetic stimulation on non-neuronal cells in models of disease and in unlesioned animals or cells.A total of 52 studies were *** protocol more frequently used was high-frequency-repetitive magnetic stimulation,and in models of disease,most studies report that high-frequency-repetitive magnetic stimulation led to a decrease in astrocyte and mic roglial reactivity,a decrease in the release of pro-inflammatory cyto kines,and an increase of oligodendrocyte *** trend towards decreased microglial and astrocyte reactivity as well as increased oligodendrocyte proliferation occurred with intermittent theta-burst stimulation and continuous theta-burst *** papers analyzed the low-frequency-repetitive transcranial magnetic stimulation protocol,and the parameters evaluated were restricted to the study of astrocyte reactivity and release of pro-inflammatory cytokines,repo rting the absence of effects on these paramete *** what concerns the use of magnetic stimulation in unlesioned animals or cells,most articles on all four types of stimulation reported a lack of *** is also important to point out that the studies were developed mostly in male rodents,not evaluating possible diffe rential effects of repetitive transcranial magneti

关键词： astrocyte glia high-frequency repetitive magnetic stimulation inflammation low-frequency repetitive magnetic stimulation microglia neurologic disorders oligodendrocyte repetitive magnetic stimulation theta-burst stimulation

relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells

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World Journal of Gastroenterology 2008年第9期14卷 1411-1414页

作者： Natália r Costa nuno Mendes nuno T Marcos Celso A reis Thomas Caffrey Michael A Hollingsworth Filipe Santos-Silva Institute of Molecular Pathology and Immunology University of PortoPorto 4200-465Portugal Institute of Molecular Pathology and Immunology University of Porto Porto 4200-465Portugal Medical Faculty University of Porto Porto 4200-465Portugal Eppley Institute for research in Cancer and Allied Diseases University of Nebraska Medical CenterOmaha 68198-6805United States Institute of Molecular Pathology and Immunology University of PortoPorto 4200-465Portugal

AIM:To evaluate the influence of MUC1 mucin variable number of tandem repeats (VNTr) variability on H pylori adhesion to gastric cells. METHODS: Enzyme linked immunosorbent assay (ELISA)-based adhesion assays were performed to measure the adhesion of different H pylori strains (HP26695 and HPTx30a) to gastric carcinoma cell lines (GP202 and MKN45) and GP202 clones expressing recombinant MUC1 with different VNTr lengths. rESULTS: Evaluation of adhesion results shows that H pylori pathogenic strain HP26695 has a significantly higher (P red to the non-pathogenic strain HPTx30a. Bacteria showed a significantly higher (P red to the MKN45 cell line. Furthermore, both strains showed a significantly higher (P rger MUC1 VNTr domains. CONCLUSION: This work shows that MUC1 mucin variability conditions H pylori binding to gastric cells. The extent of bacterial adhesion depends on the size of theMUC1 VNTr domain. The adhesion is further dependent on bacterial pathogenicity and the gastric cell line. MUC1 mucin variability may contribute to determine H pylori colonization of the gastric mucosa.

关键词： Hpylori MUC1 Variable number of tandem repeats Polymorphism Adhesion Mucin Gastric Infection

The Periaqueductal Gray and Its Extended Participation in Drug Addiction Phenomena

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Neuroscience Bulletin 2021年第10期37卷 1493-1509页

作者： Priscila Vazquez-Leon Abraham Miranda-Paez Jesus Chavez-reyes Gonzalo Allende paulino Barragan-Iglesias Bruno A.Marichal-Cancino Departamento de Fisiologia y Farmacologia Centro de Ciencias BasicasUniversidad Autonoma de AguascalientesCiudad Universitaria20131 AguascalientesAgs.Mexico Departamento de Fisiologia Escuela Nacional de Ciencias BiologicasInstituto Politecnico NacionalWilfrido Massieu esq.Manuel Stampa s/n Col.Nueva Industrial Vallejo07738 Gustavo A.MaderoMexico CityMexico

The periaqueductal gray(PAG)is a complex mesencephalic structure involved in the integration and execution of active and passive self-protective behaviors against imminent threats,such as immobility or flight from a *** activity is also associated with the integration of responses against physical discomfort(e.g.,anxiety,fear,pain,and disgust)which occurs prior an imminent attack,but also during withdrawal from drugs such as morphine and *** PAG sends and receives projections to and from other well-documented nuclei linked to the phenomenon of drug addiction including:(i)the ventral tegmental area;(ii)extended amygdala;(iii)medial prefrontal cortex;(iv)pontine nucleus;(v)bed nucleus of the stria terminalis;and(vi)*** models have suggested that the PAG contributes to the modulation of anxiety,fear,and nociception(all of which may produce physical discomfort)linked with chronic exposure to drugs of *** produced by the major pharmacological classes of drugs of abuse is mediated through actions that include participation of the *** support of this,there is evidence of functional,pharmacological,***/or genetic alterations in the PAG during the impulsive/compulsive intake or withdrawal from a *** to its small size,it is difficult to assess the anatomical participation of the PAG when using classical neuroimaging techniques,so its phys-iopathology in drug addiction has been underestimated and poorly *** this theoretical review,we discuss the involvement of the PAG in drug addiction mainly via its role as an integrator of responses to the physical discomfort associated with drug withdrawal.

关键词： Periaqueductal gray reward circuit Antireward circuit Alcohol Caffeine Cannabis Opioids Stimulants

Journals on legal and forensic medicine in Web of Science Core Collection:focus on Forensic Sciences research

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Forensic Sciences research 2021年第1期6卷 92-94页

作者： Hui Zhang Duarte nuno Vieira Min Shen Editorial Office of Forensic Sciences research Shanghai Key Lab of Forensic MedicineKey Lab of Forensic ScienceMinistry of JusticeShanghai Forensic Service PlatformAcademy of Forensic ScienceShanghaiChina Faculty of Medicine University of CoimbraCoimbraPortugal Shanghai Key Lab of Forensic Medicine Key Lab of Forensic ScienceMinistry of JusticeShanghai Forensic Service PlatformAcademy of Forensic ScienceShanghaiChina

Legal and Forensic Medicine is the application of medical knowledge and methodology for the resolution of legal questions and problems for individuals and society[1].In the Categories&Collections Scope Notes on Web of Science Core Collection in the Web of Science(WoS)Master Journal List,the category“Medicine,Legal”is described as“covering resources on all aspects of medical legal issues,including government regulations and policies,malpractice,toxicological and pharmacological regulations,clinical therapeutic patents and other critical legal issues at the interface of law,medicine,and healthcare”.This also“covers resources dealing with the various branches of forensic science”[2].In this study,we aimed to illustrate those journals included in the category of“Medicine,Legal”in the WoS Core Collection,and to assess the rapid development of the journal Forensic Sciences research(FSr)by comparing it with other related journals to determine whether FSr can fill a gap in the category“Medicine,Legal”of Science Citation Index Expanded(SCIE)in the WoS Core Collection.

关键词： Notes legal journal

Effects of N-acetylcysteine on growth,viability and reactive oxygen species levels in small antral follicles cultured in vitro

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Asian pacific Journal of reproduction 2023年第1期12卷 42-48页

作者： Efigênia B.Cordeiro Bianca r.Silva Laís r.F.M.paulino Pedro A.A.Barroso Laryssa G.Barrozo Miguel F.de Lima Neto Josér.V.Silva Laboratory of Biotechnology and Physiology of reproduction Federal University of CearaAv.Comandante Maurocélio Rocha Ponte 10062041-040SobralCEBrazil

Objective:To investigate the effects of different concentrations of N-acetylcysteine on follicular growth and morphology,as well as on viability,levels of reactive oxygen species(rOS)and meiotic progression of oocytes from in vitro cultured bovine early antral ***:Isolated early antral follicles(about 500μm)were cultured in TCM-199+alone or supplemented with 1.0,5.0 or 25.0 mM N-acetylcysteine at 38.5℃with 5%CO_(2) for 8 *** diameters were evaluated at day 0,4 and 8 of *** the end of culture,the levels of rOS,chromatin configuration and viability(calcein-AM and ethidium homodimer-1 staining)were investigated in the cumulus-oocyte *** of follicle diameters between treatments were *** on percentages of morphologically normal follicles,growth rates and chromatin configuration in different treatments were ***:An increase in follicular diameters after culture in all treatments was observed,except for follicles cultured with 25.0 mM *** microscopy showed that oocytes cultured in all treatments were stained positively with calcein AM,and that 5.0 mM N-acetylcysteine reduced fluorescence for ethidium *** levels of rOS in oocytes from follicles cultured with 1.0 mM N-acetylcysteine showed a significant reduction compared to other *** presence of N-acetylcysteine in culture medium did not influence the rates of oocyte at the germinal vesicle ***:N-acetylcysteine at concentrations of 1.0 and 5.0 mM reduces rOS levels and staining for ethidium homodimer-1 in in vitro cultured follicles,respectively,while 25.0 mM N-acetylcysteine decreases follicular growth and the percentages of continuously growing follicles.

关键词： Antioxidant N-acetylcysteine Antral follicles Bovine reactive oxygen species

META-r:A software to analyze data from multi-environment plant breeding trials

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The Crop Journal 2020年第5期8卷 745-756页

作者： Gregorio Alvarado Francisco M.rodríguez Angela Pacheco Juan Burgueño JoséCrossa Mateo Vargas paulino Pérez-rodríguez Marco A.Lopez-Cruz Biometrics and Statistics Unit International Maize and Wheat Improvement Center(CIMMYT)MexicoDF 6-64106600Mexico Centro de Investigación en Matemáticas(CIMAT)A.C. Jalisco S/NCol.ValencianaGuanajuatoGto 40236023Mexico Universidad Autónoma Chapingo Carretera Federal México-Texcoco km 38.5TexcocoMéxico 6356230Mexico Colegio de Postgraduados Carretera México-Texcoco Km.36.5MontecilloTexcoco 6356231Mexico Department of Plant Soil and Microbial SciencesMichigan State University1066 Bogue StEast LansingMI 48824USA

META-r(multi-environment trial analysis in r)is a suite of r scripts linked by a graphical user interface(GUI)designed in Java *** objective of META-r is to accurately analyze multi-environment plant breeding trials(METs)by fitting mixed and fixed linear models from experimental designs such as the randomized complete block design(rCBD)and the alpha-lattice/lattice ***-r simultaneously estimates the best linear and unbiased estimators(BLUEs)and the best linear and unbiased predictors(BLUPs).Additionally,it computes the variance-covariance parameters,as well as some statistical and genetic parameters such as the least significant difference(LSD)at 5%significance,the coefficient of variation in percentage(CV),the genetic variance,and the broad-sense *** parameters are very important in the selection of top performing genotypes in plant ***-r also computes the phenotypic and genetic correlations among environments and between traits,as well as their statistical *** genetic correlations between environments or traits can be visualized in a biplot graph or a tree diagram(dendrogram).Genetic correlations are very important for identifying environments with similar behavior or making indirect selection and identifying the most highly associated ***-r performs multi-environment analyses by using the residual maximum likelihood(rEML)method;these analyses can be done by environment,across environments by grouping factors(stress conditions,nitrogen content,etc.)and across environments;the analyses across environments can be done with a pre-defined degree of heritability.

关键词： environments breeding variance