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Stabilisation of estuarine sediments with an alkali-activated cement for deep soil mixing applications

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1398-1410页

作者： Claver Pinheiro Sara Rios António Viana da Fonseca nuno Cristelo Centre of Physics of Minho and Porto Universities (CF-UM-UP) Azurém CampusUniversity of MinhoGuimarães4800-058Portugal CONSTRUCT-GEO Faculty of EngineeringUniversity of PortoRua Dr.Roberto FriasPortos/n 4200-465Portugal CQ-VR School of Science and TechnologyUniversity of Trás-os-Montes e Alto DouroVila Real5000-801Portugal

In this work,an alternative alkali-activated cement(AAC)made of ladle slag precursor mixed with sodium hydroxide and sodium silicate has been developed to enhance the bearing capacity of estuarine soils in coastal conditions via deep soil mixing(DSM).The AAC was optimized to use a low reactivity precursor(ladle slag)and to deal with a contaminated high-water content natural sediment cured under *** material performance was analysed by comparison to a mixture made with Portland cement and cured in the same *** and unconfined compressive strength tests as well as seismic waves measurements after 3-,7-,14-and 28-d curing were performed to obtain a relationship between elastic stiffness and strength with curing time for both ***,the AAC mix demonstrated superior strength results,exhibiting almost double flexural and compressive strengths after 28 d compared to the Portland cement *** AAC mix also showed a higher rate of stiffness increase than the Portland cement mix,which has a higher initial stiffness at young ages but lower stiffness *** analysis confirmed that the proposed AAC could effectively immobilise any contaminants from soil or *** effect of curing under stress was analysed in triaxial compression tests and found to be insignificant,indicating that laboratory data obtained without stress curing can represent the material's behaviour in a DSM column,which will cure under the weight of the column.

关键词： Alkaline-activation Steel slag Submerged curing Seismic wave measurements Leachate analysis Curing under stress

Liquid crystal immunosensors for the selective detection of Escherichia coli with a fast analysis tool

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Photonics Research 2024年第7期12卷 1564-1573页

作者： SANDRO C.OLIVEIRA MARIA S.SOARES BÁRBARA V.GONÇALVES ANDREIA C.M.rodrigues AMADEU M.V.M.SOARES RITA G.SOBRAL nuno F.SANTOS JAN NEDOMA PEDRO L.ALMEIDA CARLOS MARQUES CICECO-Aveiro Institute of Materials Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal i3N Physics DepartmentUniversity of Aveiro3810-193 AveiroPortugal Associate Laboratory i4HB-Institute for Health and Bioeconomy School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal CESAM-Centre for Environmental and Marine Studies and Department of Biology University of Aveiro3810-193 AveiroPortugal Department of Telecommunications VSB-Technical University of OstravaOstrava 70800Czech Republic i3N-CENIMAT School of Sciences and TechnologyNOVA University of Lisbon1099-085 LisbonPortugal UnIRE ISELPolytechnic Institute of Lisbon1549-020 LisbonPortugal Department of Physics VSB-Technical University of OstravaOstrava 70800Czech Republic

The consumption of contaminated food may cause serious illnesses,and traditional methods to detect Escherichia coli are still associated with long waiting times and high costs given the necessity to transport samples to specialized *** is a need to develop new technologies that allow cheap,fast,and direct monitoring at the site of ***,in this work,we developed optical immunosensors for the selective detection of ***,based on liquid crystal technology,whose molecules can align in different manners depending on the boundary conditions (such as substrates) as well as the environment that they *** glass substrate was functionalized with *** antibody using cysteamine as an intermediate,and a vertical alignment was imposed on the liquid crystal molecules by using DMOAP during *** presence of bacteria disrupts the alignment of the liquid crystal molecules,changing the intensity of light emerging between cross polarizers,measured using a polarized optical microscope and a *** was possible to detect *** in suspensions in the concentration range from 2.8 cells/mL to 2.8×10^(9) cells∕*** was also evaluated,and the sensors were used to analyze contaminated water samples.A prototype was developed to allow faster,in-situ,and easier analysis avoiding bulky instruments.

关键词： crystal alignment analysis

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Contribution of glial cells to the neuroprotective effects triggered by repetitive magnetic stimulation:a systematic review

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Neural Regeneration Research 2024年第1期19卷 116-123页

作者： Susana A.Ferreira nuno Pinto Inês Serrenho Maria Vaz Pato Graça Baltazar Centro de Investigação em Ciências da Saúde(CICS-UBI) Universidade da Beira InteriorCovilhãPortugal Faculdade de Ciências da Saúde Universidade da Beira InteriorCovilhãPortugal GRUBI-Systematic Reviews Group University of Beira InteriorCovilhãPortugal

Repetitive transcranial magnetic stimulation has been increasingly studied in different neurological diseases,and although most studies focus on its effects on neuronal cells,the contribution of nonneuronal cells to the improvement trigge red by repetitive transcranial magnetic stimulation in these diseases has been increasingly *** systematically review the effects of repetitive magnetic stimulation on non-neuronal cells two online *** of Science and PubMed were searched fo r the effects of high-frequency-repetitive transcranial magnetic stimulation,low-frequencyrepetitive transcranial magnetic stimulation,intermittent theta-bu rst stimulation,continuous thetaburst stimulation,or repetitive magnetic stimulation on non-neuronal cells in models of disease and in unlesioned animals or cells.A total of 52 studies were *** protocol more frequently used was high-frequency-repetitive magnetic stimulation,and in models of disease,most studies report that high-frequency-repetitive magnetic stimulation led to a decrease in astrocyte and mic roglial reactivity,a decrease in the release of pro-inflammatory cyto kines,and an increase of oligodendrocyte *** trend towards decreased microglial and astrocyte reactivity as well as increased oligodendrocyte proliferation occurred with intermittent theta-burst stimulation and continuous theta-burst *** papers analyzed the low-frequency-repetitive transcranial magnetic stimulation protocol,and the parameters evaluated were restricted to the study of astrocyte reactivity and release of pro-inflammatory cytokines,repo rting the absence of effects on these paramete *** what concerns the use of magnetic stimulation in unlesioned animals or cells,most articles on all four types of stimulation reported a lack of *** is also important to point out that the studies were developed mostly in male rodents,not evaluating possible diffe rential effects of repetitive transcranial magneti

关键词： astrocyte glia high-frequency repetitive magnetic stimulation inflammation low-frequency repetitive magnetic stimulation microglia neurologic disorders oligodendrocyte repetitive magnetic stimulation theta-burst stimulation

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Blockchain-based refurbishment certification system for enhancing the circular economy

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Blockchain(Research and Applications) 2024年第1期5卷 85-96页

作者： Cristina Regueiro Aitor Gómez-Goiri nuno Pedrosa Christos Semertzidis Eider Iturbe Jason Mansell TECNALIA Research&Innovation Basque Research and Technology Alliance(BRTA)Parque Científico y Tecnológico de Bizkaia48160Derio BizkaiaSpain Projecto Desenvolvimento Manutenção Formação e Consultadoria Rua Fradesso da Silveira n.41B1300-609LisbonPortugal

As the global population continues to grow,the enormous stress on our environment and resources is becoming impossible to ignore.A focus on producing and consuming as cheaply as possible has created an economy in which objects are briefly used and then discarded as waste,featuring a linear lifecycle that creates an enormous amount of *** alternative to the linear economy“take-make-waste”is called the“circular economy”.Under this paradigm,materials are recycled to build new products or components that are designed and built to promote their reuse and *** assures the continuous(re-)exploitation of existing resources,reducing the extraction of new raw ***,customers often reject these reused or refurbished products under the suspicion that they do not meet the same usability,safety,or performance levels of new *** this sense,trustworthy records of historical details of refurbished products could increase consumers’confidence in products and components of the“circular economy”,prioritizing trustworthiness,reliability,and *** work presents a new certification tool based on blockchain technology to guarantee trusted,accurate,transparent,and traceable lifecycle information of products and their components and to generate trustworthy certificates to probe refurbished product historical *** tool aims to enhance refurbished product visibility by creating the basis for making the circular economy a reality in any domain.

关键词： Blockchain Traceability Lifecycle Product lifecycle management(PLM) Refurbishment Certification Circular economy

Environmental Impact Assessment Follow-Up of Seismic Survey Offshore Activities in Brazil

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Journal of Environmental Protection 2024年第2期15卷 141-155页

作者： Fontes nuno Eduardo Paulo Marcelo Montaño Sao Carlos School of Engineering University of Sao Paulo Sao Carlos Brazil

Follow-up of environmental impacts is an integral part of the Environmental Impact Assessment (EIA) process, closely related to the effectiveness of the instrument. EIA follow-up has been receiving a lot of interest from scientists and practitioners, though it is recognized as one of the weakest points of EIA systems globally. Also, EIA follow-up is influenced by the context, mainly in terms of the types of projects or activities and their related impacts on the environment. Therefore, the present paper is focused on the investigation of the follow-up stage applied to the activity of seismic survey coupled with offshore oil & gas exploitation in Brazil. Research was based on a qualitative approach that included document analysis and semi-structured interviews with analysts involved in EIA processes, and sought to generate evidence of effectiveness of the EIA follow-up as conducted by the Federal Environment Agency (Ibama) in order to situate the practice of follow-up in the broader context of international best practice principles. Based on the findings, it was concluded that, due to the peculiarities of offshore seismic survey, it is necessary to promote adaptations in the procedures for monitoring impacts in order to ensure proper alignment with the principles and conceptual foundations that guide EIA practice. Specifically, the timing of the execution of the activity imposes challenges for its integration into the “conventional” cycle that has guided the monitoring of the impacts in the EIA of projects.

关键词： Environmental Impact Assessment Follow-Up Follow-Up Effectiveness Oil and Gas Offshore Seismic Survey

Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia Monteiro António J.Salgado nuno A.Silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

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Percutaneous nephrostomy versus ureteral stent in hydronephrosis secondary to obstructive urolithiasis:A systematic review and meta-analysis

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Asian Journal of Urology 2024年第2期11卷 261-270页

作者： Andreia Cardoso Aparício Coutinho Gonçalo Neto Sara Anacleto Catarina Laranjo Tinoco nuno Morais Mário Cerqueira-Alves Estevão Lima Paulo Mota Department of Urology Hospital de BragaBragaPortugal School of Medicine University of MinhoBragaPortugal Association(2CA-Braga).School of Medicine University of MinhoBragaPortugal

Objective: To assess if there is a preferable intervention between retrograde ureteral stent (RUS) and percutaneous nephrostomy (PCN) tube, in cases of upper urinary tract stone obstruction with complications requiring urgent drainage, by evaluating outcomes regarding urinary symptoms, quality of life (QoL), spontaneous stone passage, and length of hospital stays, since there is no literature stating the superiority of one modality over the ***: We searched MEDLINE and other sources for relevant articles in June 2019 without any date restrictions or filters applied. The selection was done first by the title and abstract screening and then by full-text assessment for eligibility. Only randomized controlled trials or cohort studies in patients with hydronephrosis secondary to obstructive urolithiasis that presented comparative data between PCN and RUS placement concerning at least one of the defined outcome measures were included. Lastly, MEDLINE database and PubMed platform were screened again using the same terms, from June 2019 until November ***: Of 556 initial articles, seven were included in this review. Most works were considered of moderate-to-high quality. Three studies regarding QoL showed a tendency against stenting, even though only one demonstrated statistically significant negative impact on overall health state. Two works reported significantly more post-intervention urinary symptoms in stenting patients. One article found that PCN is a significant predictor of spontaneous stone passage, when adjusted for stone size and location. Findings on length of hospital stays were not consistent among ***: PCN appears to be the intervention better tolerated, with less impact on the patient’s perceived QoL and less post-operative urinary symptoms, in comparison with RUS. Nevertheless, further studies with larger samples and a randomized controlled design are suggested.

关键词： Ureteral stent Percutaneous nephrostomy Obstructive urolithiasis Urinary symptoms Quality of life

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嘉卿会所-台丰高尔夫俱乐部

现代装饰 2022年第4期 14-21页

作者： álvaro Siza Carlos Castanheira Elisabete Queirós Catarina Araújo Erika Musci Filipe Mota Joana Soeiro Jo?o Alves Jorge Pinheiro Mariana Mendes nuno Campos nuno rodrigues Pedro Afonso Rita Saturnino Sara Pinto Sofia Concei??o Carlos Castanheira 范嘉苑

在高尔夫球运动中,力量与优雅的完美平衡是衡量其水平的一个基本准则。同样的,在建筑设计与建造的表达过程中,除了回应技术问题与基本需求以外,还需要考虑其他或简单或复杂的因素。衡量一个项目不仅只是看基本要素,即使它仅需要回应基...

在高尔夫球运动中,力量与优雅的完美平衡是衡量其水平的一个基本准则。同样的,在建筑设计与建造的表达过程中,除了回应技术问题与基本需求以外,还需要考虑其他或简单或复杂的因素。衡量一个项目不仅只是看基本要素,即使它仅需要回应基础功能。好的设计应该经过谨慎的思考,由此承载巨大能量,传达优雅气息。“经验分析”能够帮助我们辨别设计的第一步,它可能源自于一种态度、概念,或者一些难以解释的想法。

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Lateral femoral neck stress fractures: A case report

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World Journal of Orthopedics 2024年第9期15卷 891-901页

作者： Christiaan AJ Oudmaijer nuno R Paulino Pereira David Visser Alexander M Wakker Wout S Veltman Robbart van Linschoten Department of Surgery Division of Hepatobiliary and Transplantation SurgeryErasmus MC Transplant InstituteRotterdam 3015 GDZuid-HollandNetherlands Princess Maxima Center for Pediatric Oncology Utrecht 3584 CSNetherlands Orthopaedics and Sports Medicine Erasmus MCErasmus University Medical Center RotterdamRotterdam 3015 GDZuid-HollandNetherlands Department of Surgery Division of Trauma SurgeryErasmus MCErasmus University Medical Center RotterdamRotterdam 3015 GDZuid-HollandNetherlands

BACKGROUND Sport-induced injuries particularly affect young,healthy,and active ***,a popular and accessible sport,can cause a wide range of injuries,including stress *** fractures can occur during high-intensity training or competitions,especially among well-trained amateurs and professional *** diagnosis can be complicated by the typically young age,unremarkable medical history,and vital condition of the *** fractures present insidiously,and this is specifically the case with stress fractures of the femoral *** intervention is crucial to prevent progressive displacement,as this can damage the blood supply to the femoral *** SUMMARY A 30-year-old male runner presented to our outpatient clinic with persistent pain 3 weeks after running a marathon.X-ray showed a complete lateral fracture of the left femoral neck,which was treated surgically with a dynamic hip *** It is essential for healthcare providers to be vigilant for the subtle symptoms of stress fractures to ensure timely *** recognition prevents com-plication and leads to a better prognosis.

关键词： Stress fractures Atypical Femoral Neck Marathon Diagnosis Case report