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Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells

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World Journal of Gastroenterology 2008年第9期14卷 1411-1414页

作者： Natália R Costa nuno mendes nuno T Marcos Celso A Reis Thomas Caffrey Michael A Hollingsworth Filipe Santos-Silva Institute of Molecular Pathology and Immunology University of PortoPorto 4200-465Portugal Institute of Molecular Pathology and Immunology University of Porto Porto 4200-465Portugal Medical Faculty University of Porto Porto 4200-465Portugal Eppley Institute for Research in Cancer and Allied Diseases University of Nebraska Medical CenterOmaha 68198-6805United States Institute of Molecular Pathology and Immunology University of PortoPorto 4200-465Portugal

AIM:To evaluate the influence of MUC1 mucin variable number of tandem repeats (VNTR) variability on H pylori adhesion to gastric cells. METHODS: Enzyme linked immunosorbent assay (ELISA)-based adhesion assays were performed to measure the adhesion of different H pylori strains (HP26695 and HPTx30a) to gastric carcinoma cell lines (GP202 and MKN45) and GP202 clones expressing recombinant MUC1 with different VNTR lengths. RESULTS: Evaluation of adhesion results shows that H pylori pathogenic strain HP26695 has a significantly higher (P < 0.05) adhesion to all the cell lines and clones tested, when compared to the non-pathogenic strain HPTx30a. Bacteria showed a significantly higher (P < 0.05) adhesion to the GP202 cell line, when compared to the MKN45 cell line. Furthermore, both strains showed a significantly higher (P < 0.05) adhesion to GP202 clones with larger MUC1 VNTR domains. CONCLUSION: This work shows that MUC1 mucin variability conditions H pylori binding to gastric cells. The extent of bacterial adhesion depends on the size of theMUC1 VNTR domain. The adhesion is further dependent on bacterial pathogenicity and the gastric cell line. MUC1 mucin variability may contribute to determine H pylori colonization of the gastric mucosa.

关键词： Hpylori MUC1 Variable number of tandem repeats Polymorphism Adhesion Mucin Gastric Infection

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Pylephlebitis—a rare complication of a fish bone migration mimicking metastatic pancreatic cancer:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6768-6774页

作者： Sofia Bezerra nuno J França Firmo Mineiro Germano Capela Cristina Duarte António Ribeiro mendes Department of Surgery Centro Hospitalar do Médio TejoTomar 2304-909Portugal

BACKGROUND Pylephlebitis is a rare condition,poorly recognized by clinicians and with few *** this case,the clinical appearance resembled the clinical course of a pancreatic cancer and was originated by the ingestion of a fish bone,making the case more interesting and *** SUMMARY A 79-year-old female presented to the emergency department with fever,loss of appetite and *** in the right upper quadrant was *** marker were high.A computed tomography(CT)scan revealed gallstones and aspects compatible with acute *** patient was admitted to surgery ward and has her condition aggravated.A magnetic resonance revealed multifocal liver ***,a cholangiopancreatography and an endoscopic ultrasound(US)were able to diagnose the *** treatment was implemented and the patient made a complete *** In conclusion,this case report demonstrates for the first time the diagnosis of an unusual case of pylephlebitis complicated by the migration of a fish bone,mimicking metastatic pancreatic *** presentation and traditional imaging studies,such as transabdominal US and CT,remain the standard for diagnosing this condition.

关键词： Pylephlebitis Portal vein thrombosis Abdominal infection Fish bone Pancreatic cancer Case report

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嘉卿会所-台丰高尔夫俱乐部

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现代装饰 2022年第4期 14-21页

作者： álvaro Siza Carlos Castanheira Elisabete Queirós Catarina Araújo Erika Musci Filipe Mota Joana Soeiro Jo?o Alves Jorge Pinheiro Mariana mendes nuno Campos nuno Rodrigues Pedro Afonso Rita Saturnino Sara Pinto Sofia Concei??o Carlos Castanheira 范嘉苑

在高尔夫球运动中,力量与优雅的完美平衡是衡量其水平的一个基本准则。同样的,在建筑设计与建造的表达过程中,除了回应技术问题与基本需求以外,还需要考虑其他或简单或复杂的因素。衡量一个项目不仅只是看基本要素,即使它仅需要回应基...

在高尔夫球运动中,力量与优雅的完美平衡是衡量其水平的一个基本准则。同样的,在建筑设计与建造的表达过程中,除了回应技术问题与基本需求以外,还需要考虑其他或简单或复杂的因素。衡量一个项目不仅只是看基本要素,即使它仅需要回应基础功能。好的设计应该经过谨慎的思考,由此承载巨大能量,传达优雅气息。“经验分析”能够帮助我们辨别设计的第一步,它可能源自于一种态度、概念,或者一些难以解释的想法。

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