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Challenges and trends in apomorphine drug delivery systems for the treatment of Parkinson's disease

Asian Journal of Pharmaceutical Sciences 2018年第6期13卷 507-517页

作者： nrupa.borka. Huiling Mu René Holm Department of Pharmacy Faculty of Health and Medical Sciences University of Copenhagen Drug Product Development Janssen Research and Development Johnson & Johnson

Parkinson's disease(PD) is a chronic debilitating disease affecting approximately 1% of the population over the age of 60. The severity of PD is correlated to the degree of dopaminergic neuronal loss. Apomorphine has a similar chemical structure as the neurotransmitter dopamine and has been used for the treatment of advanced PD patients. In PD patients,apomorphine is normally administered subcutaneously with frequent injections because of the compound's extensive hepatic first-pass metabolism. There is, hence, a large unmet need for alternative administrative routes for apomorphine to improve patient *** present review focuses on the research and development of alternative delivery of apomorphine, aiming to highlight the potential of non-invasive apomorphine therapy in PD,such as sublingual delivery and transdermal delivery.

关键词： Apomorphine Drug delivery Parkinson’s disease Alternative apomorphine therapy Non-invasive delivery Excipients

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Channeling of fast ions through the bent carbon nanotubes： The extended two-fluid hydrodynamic model

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Chinese Physics B 2016年第4期25卷 274-283页

作者： Lazar Karbunar Dusko borka Ivan Radovic Zoran L Miskovic School of Electrical Engineering University of Belgrade Bulevar Kralja Aleksandra 73 11120 Belgrade Serbia Vinca Institute of Nuclear Sciences University of Belgrade P. O. Box 522 11001 Belgrade Serbia Department of Applied Mathematics and Waterloo Institute for Nanotechnology University of Waterloo Waterloo Ontario Canada N2L 3G1

We investigate the interactions of charged particles with straight and bent single-walled carbon nanotubes （SWNTs） under channeling conditions in the presence of dynamic polarization of the valence electrons in carbon, This polarization is described by a cylindrical, two-fluid hydrodynamic model with the parameters taken from the recent modelling of several independent experiments on electron energy loss spectroscopy of carbon nano-structures. We use the hydrodynamic model to calculate the image potential for protons moving through four types of SWNTs at a speed of 3 atomic units. The image potential is then combined with the Doyle-Turner atomic potential to obtain the total potential in the bent carbon nanotubes. Using that potential, we also compute the spatial and angular distributions of protons channeled through the bent carbon nanotubes, and compare the results with the distributions obtained without taking into account the image potential.

关键词： nanotubes channeling dynamic polarization

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Air-coupled PMUTs array with residual stresses:experimental tests in the linear and non-linear dynamic regime

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International Journal of Smart and Nano Materials 2020年第4期11卷 387-399页

作者： Gianluca Massimino borka Lazarova Fabio Quaglia Alberto Corigliano Department of Civil and Environmental Engineering Politecnico Di Milano MilanItaly Analog MEMS&Sensors Group STMicroelectronicsCornaredoItaly

The mechanical characterization of a 4×4 air-coupled array of Piezoelectric Micromachined Ultrasonic Transducers(PMUTs)is *** experimental campaign consists of three set of experi-mental tests,namely:topography measurements,small signal dynamic measurements,and vibrometry in the non-linear dynamic *** behavior of three different kinds of PMUT are *** differ according to the thermo-electrical treatment that has been applied to the piezoelectric *** presence of the fabrication induced residual stresses is investigated and the treat-ment effect is evaluated in terms of the initial deflected *** results reported in this paper represent an experimental mechanical investigation useful for the design of PMUT structures with advanced functionalities in the linear and non-linear regime.

关键词： acoustic-structure interaction array experimental characterization non-linear dynamics Piezoelectric Micromachined Ultrasonic Transducers(PMUTs) ultrasound

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Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease

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World Journal of Gastroenterology 2016年第26期22卷 6027-6035页

作者： Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres Department of Pediatrics and Pediatric Health Care Center University of Szeged H-6725 Szeged Hungary 1st Department of Pediatrics Semmelweis University H-1083 Budapest Hungary 2nd Department of Pathology Semmelweis University H-1091 Budapest Hungary 1st Department of Pediatrics Semmelweis University and MTA-SE Pediatrics and Nephrology Research Group H-1083 Budapest Hungary

AIM: To evaluate the role of microRNA (miR)-146a, -155 and -122 in the duodenal mucosa of pediatric patients with Crohn’s disease (CD) and the effect of transforming growth factor-β (TGF-β) on these miRs in duodenal epithelial and fibroblast ***: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed (CD inflamed: n = 10) and intact (CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children (C: n = 10) were examined. Expression of miR-146a, -155 and -122 was determined by real-time polymerase-chain reaction (PCR). The expression of the above miRs was investigated in recombinant human TGF-β (1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells (CCL-241) and primary duodenal fibroblast cells derived from healthy children as ***: Expression of miR-146a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD (CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, P ≤ 0.01) and to the control group (CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, P ≤ 0.05). The expression of miR-155 was significantly increased in the inflamed region of the duodenum compared to the control group (CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, P ≤ 0.001). The expression of miR-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of miR-155 in small intestinal epithelial cells (TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, P ≤ 0.05) and also the expression of miR-146a (TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, P ≤ 0.01) and miR-155 (TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, P ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated control

关键词： Inflammatory bowel disease Crohn’ s disease Pediatric MicroRNAs Transforming growth factor-β

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没有架设新线路而使现有线路得到改善

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电气应用 2007年第1期26卷 4-4页

作者： borka Milosevic Robert J.Beck

美国乔治亚州电力公司在2005年6月为Laurens County投运了87Mvar的静态无功补偿装置（SVC），以解决乔治亚州Dublin的电压问题并推迟了新的230kV输电线的架设。由三菱电力产品公司（MEPPI）为Laurens County制造的SVC安装得靠近北Dubli... 详细信息

美国乔治亚州电力公司在2005年6月为Laurens County投运了87Mvar的静态无功补偿装置（SVC），以解决乔治亚州Dublin的电压问题并推迟了新的230kV输电线的架设。由三菱电力产品公司（MEPPI）为Laurens County制造的SVC安装得靠近北Dublin变电站，并且是此种产品在南方输电公司的第一台。它能在正常和故障状态下提供电压调节、快速电压恢复，提高了系统可靠性。

关键词：架设线路无功补偿装置电力产品电压调节系统可靠性电力公司故障状态

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