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Portal vein ligation accelerates tumor growth in ligated,but not contralateral lobes

World Journal of Gastroenterology 2010年第30期16卷 3816-3826页

作者： nozomu sakai Callisia N Clarke Rebecca Schuster John Blanchard Amit D Tevar Michael J Edwards Alex B Lentsch Department of Surgery University of Cincinnati231 Albert Sabin WayCincinnatiOH 45267-0558United States

AIM: To investigate the mechanisms of liver growth and atrophy after portal vein ligation (PVL) and its effects on tumor growth. METHODS: Mice were subjected to PVL, partial hepatectomy, or sham surgery. The morphological alterations, activation of transcription factors, and expression of cytokines and growth factors involved in liver regeneration were evaluated. In a separate set of experiments, murine colorectal carcinoma cells were injected via the portal vein and the effect of each operation on liver tumor growth was studied. RESULTS: Liver regeneration after PVL and partial hepatectomy were very similar. In ligated lobes, various cytokines, transcription factors and regulatory factors were signifi cantly upregulated compared to nonligated lobes after PVL. Atrophy in ligated lobes was a result of early necrosis followed by later apoptosis. Tumor growth was signifi cantly accelerated in ligated compared to non-ligated ***: Tumor growth was accelerated in ligated liver lobes and appeared to be a result of increased growth factor expression.

关键词： Portal vein ligation Tumor growth Growth factor Atrophy Apoptosis

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Percutaneous endoscopic gastrostomy with Funada-style gastropexy greatly reduces the risk of peristomal infection

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Gastroenterology Report 2015年第1期3卷 69-74页

作者： Naoki Okumura Naoko Tsuji Nobuto Ozaki nozomu Matsumoto Takehisa Takaba Masanori Kawasaki Takafumi Tomita Yasuko Umehara Satoko Taniike Masashi Kono Masatoshi Kudo Department of Gastroenterology Sakai HospitalKinki University Faculty of MedicineSakaiJapan Department of Gastroenterology and Hepatology Kinki University Faculty of MedicineOsaka-sayamaJapan

Background and aims:Peristomal wound infections are common complications of percutaneous endoscopic gastrostomy(PEG).The Funada-style gastropexy device has two parallel needles with a wire loop and suture thread,and was developed about 20 years ago in *** kit has allowed us to perform dual gastropexy very easily;PEG with gastropexy has become a very popular technique in *** present study aimed to compare the advantages and disadvantages of PEG with the gastropexy technique with the standard‘pull’***:We retrospectively reviewed 182 consecutive,non-randomized patients undergoing PEG in our hospital,and a comparative analysis was made between the gastropexy(87 patients)and non-gastropexy(95 patients)***:The rates of patients having erythema(11.6%vs.47.9%;P<0.001),exudates(2.3%vs.14.9%;P<0.01)and infection(0%vs.6.4%;P紏0.01)in the peristomal area were lower in the gastropexy than in the non-gastropexy *** rate of minor bleeding from the peristomal area was higher in the gastropexy than in the non-gastropexy group(12.8%vs.2.1%;P<0.01),but no patient required a blood *** procedure time was longer in the gastropexy group than in the non-gastropexy group(31 vs.24 min;P<0.001).The 30-day mortality rates were 4.7%and 5.3%respectively,and these deaths were not related to the gastrostomy ***:PEG with gastropexy markedly reduces peristomal *** minor bleeding and a longer procedure time were disadvantages,there were no severe *** findings suggested that PEG with Funada-style gastropexy was a safe and feasible method for reducing early complications of PEG.

关键词： percutaneous endoscopic gastrostomy gastropexy peristomal infection

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