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Surgical anatomy of the innervation of pylorus in human and Suncus murinus, in relation to surgical technique for pylorus-preserving pancreaticoduodenectomy

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World Journal of Gastroenterology 2006年第14期12卷 2209-2216页

作者： Shuang-Qin Yi Fei Ru Tetsuo Ohta Hayato Terayama Munekazu Naito Shogo Hayashi Sichen Buhe nozomi Yi Takayoshi Miyaki Shigenori Tanaka Masahiro Itoh Department of Anatomy Tokyo Medical University 6-1-1 Shinjuku Shinjuku-ku Tokyo 160-8402 Japan Department of Medicine Johns Hopkins Medical Institutions 600 North Wolfe Street Baltimore Maryland 21287 United States Department of Gastroenterologic Surgery Kanaza- wa University 13-1 Takara-Machi Kanazawa 920-8420 Japan Department of Anatomy and Neuroembryology Kanazawa University 13-1 Takara-Machi Kanazawa 920-8420 Japan

AIM： To clarify the innervation of the antro-pyloric region in humans from a clinico-anatomical perspective. METHODS： The stomach, duodenum and surrounding structures were dissected in 10 cadavers, and immersed in a 10mg/L solution of alizarin red S in ethanol to stain the peripheral nerves. The distribution details were studied to confirm innervations in the above areas using a binocular microscope. Similarly, innervations in 10 Suncus murinus were examined using the method of whole-mount imm unohistochemistry. RESULTS： The innervation of the pyloric region in humans involved three routes： One arose from the anterior hepatic plexus via the route of the suprapyloric/supraduodenal branch of the right gastric artery; the second arose from the anterior and posterior gastric divisions, and the third originated from the posterior-lower region of the pyloric region, which passed via the infrapyloric artery or retroduodenal branches and was related to the gastroduodenal artery and right gastroepiploic artery. For Suncus murinus, results similar to those in humans were observed. CONCLUSION： There are three routes of innervation of the pyloric region in humans, wherein the route of the right gastric artery is most important for preserving pyloric region innervation. Function will be preserved by more than 80% by preserving the artery in pylorus-preserving pancreaticoduodenectomy （PPPD）. However, the route of the infrapyloric artery should not be disregarded. This route is related to several arteries （the right gastroepiploic and gastroduodenal arteries）, and the preserving of these arteries is advantageous for preserving pyloric innervation in PPPD. Concurrently, the nerves of Latarjet also play an important role in maintaining innervation of the antro-pyloric region in PPPD. This is why pyloric function is not damaged in some patients when the right gastric artery is dissected or damaged in PPPD.

关键词： Innervation Quality of life Pylorus-preserving pancreaticoduodenectomy Suncus murinus Whole mount immunohistochemistry

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Calcified Nodule Formation <i>in Vitro</i>Using Rat Mandibular Incisor Pulp Cells

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Journal of Biomedical Science and Engineering 2018年第12期11卷 327-337页

作者： Hideaki Ikenaga Masataka Yoshikawa Ayano Miyamoto Hitomi Nakama Ikuo Nishikawa Satoshi Teramoto Hiroaki Aso nozomi Matsuo Hiroshi Maeda Department of Endodontics Osaka Dental University Osaka Japan

One great advantage of bone marrow is that a large number of stem cells can be obtained. However, stem cells cannot be taken from the bone marrow of a patient for the purpose of regenerating teeth. In dental practice, it may not be practical to obtain mesenchymal stem cells for the regeneration of the tooth from iliac bone marrow, as in orthopedics. Therefore, establishment of a cell source for tooth regeneration is one of the important problems in the field of regenerative medicine. Although the isolation of undifferentiated mesenchymal stem cells or odontoblasts from dental pulp may be difficult, dental pulp may be a favorable source for stem cells to regenerate a tooth via tissue engineering. As a fundamental study for tooth regeneration, this study was performed in order to clarify the culture periods for proliferation and differentiation using rat dental pulp-derived cells. The results of this study were as follows: Primary culture of the dental pulp cells does not require a long period of time. However, for sufficient proliferation of dental pulp cells to form a calcified nodule in the secondary culture, a long culture period is required. Dexamethasone was essential for the formation of calcified nodules by dental pulp-derived cells. Calcified nodule formation by dental pulp-derived cells in vitro required more than one month. The duration of the secondary culture for the dental pulp-derived cells will be much longer.

关键词： Calcified Nodule In Vitro Dental Pulp Cells Bone Marrow Cells Dexamethasone

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Assessing quality of life using the brief cancer-related worry inventory for gynecological surgery

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World Journal of Obstetrics and Gynecology 2019年第1期8卷 1-7页

作者： Ami Kikuchi Ryo Koide Masahiro Iwasaki Mizue Teramoto Seiro Satohisa Masato Tamate Masami Horiguchi nozomi Niwa Tsuyoshi Saito Toru Mizuguchi Department of Nursing and Surgical Science Sapporo Medical University Postgraduate School of Health ScienceSapporo 0608556Japan Department of Obstetrics and Gynecology Sapporo Medical University Postgraduate School of MedicineSapporo 0608556Japan

BACKGROUND The mental status of gynecologic patients has an important influence on their quality of life(QOL).Although high-quality QOL studies into breast cancer patients have been performed internationally,few QOL studies have examined patients with gynecological *** To investigate the brief cancer-related worry inventory(BCWI)could evaluate the mental status of gynecological *** Between July 2018 and December 2018,19 consecutive gynecological cancer patients were prospectively recruited for this *** BCWI is a 15-item selfreported questionnaire that assesses cancer-related worries on a numeric scale(0–100).RESULTS The high BCWI group was significantly younger than the low BCWI *** social status,the absence of a spouse and children was significantly more common in the high BCWI group than in the low BCWI *** operation time was longer in the worsening BCWI group than in the stable BCWI group(305.3±140.5 min vs 171.1±97.2 min;P=0.026).CONCLUSION Being young,having no family,and a long operation time were found to be risk factors for increased ***,gynecological cancer patients should be assessed using the BCWI,and specific perioperative mental care should be considered for highly anxious patients.

关键词： Gynecology Brief cancer-related worry inventory Quality of life Surgery

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Influence of Psychiatric Problems on Clinical Outcomes during the First 12 Months after Primary Total Knee Arthroplasty

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Open Journal of Orthopedics 2022年第5期12卷 242-252页

作者： Takehiko Sugita Naohisa Miyatake Seiya Miyamoto Akira Sasaki Ikuo Maeda Makiko Okumoto nozomi Itou Masayuki Kamimura Takashi Aki Toshimi Aizawa Department of Orthopaedic Surgery Tohoku Orthopaedic and Dental Clinic Sendai Japan Division of Rehabilitation Tohoku Orthopaedic and Dental Clinic Sendai Japan Department of Orthopaedic Surgery Tohoku University Graduate School of Medicine Sendai Japan

Background: Total knee arthroplasty (TKA) is a useful treatment option for advanced knee osteoarthritis. Excellent clinical outcomes after TKA have been widely recognized, but the influence of psychiatric problems on them has not been focused on until quite recently. This study aimed to assess the influence of psychiatric problems on clinical outcomes after TKA in Japanese patients using two assessment scales developed in Japan because the Japanese cultural lifestyle is specifically characterized by bending to the floor and standing up. Methods: Clinical outcomes and psychiatric problems were evaluated using the Japanese Knee Osteoarthritis Measure (JKOM) and Brief Scale for Psychiatric Problems in Orthopaedic Patients (BS-POP), respectively. A total of 115 TKA patients were evaluated preoperatively and at 3, 6, and 12 months after TKA. The patients were classified into four groups (groups A-D) based on the BS-POP score. The JKOM scores were then compared between the two groups (groups A and D) with the worst and least psychiatric problems. The JKOM improvement rate between pre- and postoperative status in both groups A and D was also calculated. Results: The total JKOM score was significantly poorer in group A than in group D preoperatively and at 3, 6, and 12 months after TKA. The improvement rate showed no significant difference between groups A and D. Conclusion: Psychiatric problems influence both the poorer post- and preoperative clinical outcomes. However, a similar improvement rate in both groups A and D has indicated that TKA can be an effective treatment even for patients with psychiatric problems.

关键词： Clinical Outcomes Improvement Rate Knee Osteoarthritis Psychiatric Prob-lems Total Knee Arthroplasty

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Pneumatosis intestinalis with obstructing intussusception:A case report and literature review

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World Journal of Gastrointestinal Surgery 2016年第2期8卷 173-178页

作者： Yujiro Itazaki Hironori Tsujimoto nozomi Ito Hiroyuki Horiguchi Shinsuke Nomura Kyohei Kanematsu Shuichi Hiraki Suefumi Aosasa Junji Yamamoto Kazuo Hase Department of Surgery National Defense Medical College

Pneumatosis intestinalis(PI) often represents a benign condition that should not be considered as an argument for surgery. We report a patient with PI and obstructing intussusception who underwent urgent colectomy and review the literatures regarding PI with intussusception. A 20-year-old man presented at our hospital with a 3-d intermittent lower abdominal pain history. He underwent steroid therapy for membranoproliferative glomerulonephritis for 4 years. Computed tomography revealed ascending colon intussusception with air within the wall. Intraoperative colonoscopy revealed numerous soft polypoid masses with normal overlying mucosa and right hemicolectomy was performed. Histological examination of colonic wall sections revealed large cysts in the submucosal layer. The pathological diagnosis was PI. Nine cases of intussusception associated with primary PI have been reported. Although primary PI often represents a benign condition that should not be considered as an argument for surgery,if the case involves intussusception and obstruction,emergent laparotomy should be considered.

关键词： Pneumatosis intestinalis Intussusception Urgent surgery Immunosuppressive drug Ischemia of the intestine

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Lafoensia pacari alleviates intestinal damage by modulating cyclooxygenase-2:In silico and in vivo evaluation in a colitis model

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World Journal of Gastroenterology 2023年第17期29卷 2628-2641页

作者： Gabrielle Caroline Peiter Thayene Kamyli Moesch Queiroz Edson Luiz Michalkiewicz Jr Raphael Henrique Chappuis Jennefer Sousa Luz Luiz Henrique Casagrande Piovezani Cleison Ferreira Silva Matheus nozomi Tsutumi Augusto Fernandes Chaves Rafael Messias Luiz Cinthia Façanha Wendel Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Programa Multicêntrico de Pós-graduação em Biquímica e Biologia Molecular-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Programa de Pós-graduação em Biotecnologia-Setor Palotina Universidade Federal do ParanáPalotina 85.950-000ParanáBrazil Campus Toledo Universidade Federal do ParanáToledo 85.919-899ParanáBrazil

BACKGROUND Inflammatory bowel diseases(IBD)are a worldwide health problem and mainly affect young people,consequently affecting the *** treatments are often associated with side effects,and new therapeutic options are *** centuries,plants have represented important substrates in the field of drug *** pacari(***)is a plant whose pharmaceutical potential has been described,and may have biological activity relevant to the treatment of IBD *** To investigate the activity of keto-alcoholic extracts of *** with respect to ameliorating the inflammatory and nociceptive symptoms of acute experimental colitis in *** Keto-alcoholic extracts of *** leaves and bark were administered to male andfemale Swiss mice weighing 25 g to 30 g(n=8 male mice and n=8 female mice).The effect of these extracts was observed in an acetic acid-induced acute experimental model of colitis with regard to antinociception/analgesia and inflammatory tissue *** macroscopic indices included the Wallace score and the colon weight obtained using a precision *** hyperalgesia was determined using an electronic *** related to overt pain was determined by quantifying the number of writhing instances within 20 min of administration of acetic *** docking was performed using human and murine cyclooxygenase-2(COX-2)with 3 flavonoids(ellagic acid,kaempferol,and quercetin)on the AutoDock Vina *** of variance followed by Tukey’s posttest was used with P<0.05 indicating *** In this murine model of colitis,administration of extracts from *** ameliorated acetic acidinduced writhing and colitis-associated inflammatory *** improvements may be attributable to the reduction in edema,inflammation(e.g.,ulcers,hyperemia,and bowel wall damage),and the intensity of abdominal *** keto-alcoholic extracts of *** leaves and bark administered at a

关键词： Antinociceptive activity Anti-inflammatory activity Cyclooxygenase-2 Flavonoids Inflammatory bowel disease Lafoensia pacari

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Improvement of Scalp Condition and Quality of Life through Proper Skin Care of Dry Scalp

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Journal of Cosmetics, Dermatological Sciences and Applications 2014年第4期4卷 284-292页

作者： Mika Oshima Maiko Sogawa Hiroshi Matsunaka Yumi Murakami Yumiko Saya Takashi Sugita Yoshihiro Matsudate nozomi Fukui Kazutoshi Murao Yoshiaki Kubo Department of Dermatology Institute of Health Biosciences The University of Tokushima Graduate School Tokushima Japan Tokiwa Pharmaceutical Co. Ltd. Tokyo Japan Department of Microbiology Meiji Pharmaceutical University Tokyo Japan

Introduction: Appropriate skin care for dry scalp includes treatment for dandruff and itchiness. However, little is known about the appropriate washing methods for subjects with dry scalp. Me- thods: A scalp moisturizing lotion was used for 8 weeks on 30 outpatients at the Tokushima University Hospital who had dry scalp. All subjects were given the same hair shampoo/conditioner and instructions on how to wash their hair. Scalp symptoms were observed before and after the testing period. Indigenous bacteria were collected from the scalp for quantitative assessment. A survey was conducted to assess the quality of life (QOL). Results: All scalp condition items (dryness, scales and desquamation, itchiness, excoriation, and erythema) improved significantly after the testing period;the levels of Malassezia and bacterial colonization also decreased significantly. The QOL evaluation indicated significant improvements in “symptoms”, “emotions”, and “global” measures. A correlation was found between the extent of dryness at the start of the test and the level of Malassezia colonization, as well as QOL scores. Conclusion: Using a scalp moisturizing lo- tion, washing hair with a shampoo and conditioner that cause low irritation levels, and using a hair washing method that avoids irritation led to improvement in scalp condition, QOL, and pa- tient satisfaction.

关键词： Atopic Dermatitis Seborrheic Dermatitis Moisturizer Malassezia Bacteria qPCR

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Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer

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World Journal of Gastroenterology 2008年第31期14卷 4880-4888页

作者： nozomi Togo Susumu Ohwada Shinji Sakurai Hiroyuki Toya Ichiro Sakamoto Tatsuya Yamada Tetsuhiro Nakano Ken Muroya Izumi Takeyoshi Takashi Nakajima Takashi Sekiya Yusuke Yamazumi Tsutomu Nakamura Tetsu Akiyama Departments of Surgery Graduate School of Medicine Gunma University Gunma 371-8511 Japan Departments of Tumor Pathology Graduate School of Medicine Gunma University Gunma 371-8511 Japan Laboratory of Molecular and Genetic Information Institute for Molecular and Cellular Biosciences University of Tokyo Tokyo 113-0032 Japan

AIM： To investigate the clinical significance of BMP and activin membrane-bound inhibitor （BAMBI） which is a pseudoreceptor of transforming growth factorbeta （TGF-β） type 1 receptors and acts as a negative regulator of TGF-β signaling and expression aberrantly elevated in colorectal cancers （CRCs）. We studied BAMBI expression in CRCs. METHODS： We studied BAMBI expression in 183 surgically resected CRCs by immunochemical and immunoblotting analyses using a generated monoclonal anti-BAMBI antibody. Commercially available anti-β- catenin and anti-p53 antibodies were also applied for immunochemical analyses as a comparison ***： Immunohistochemical analysis revealed that BAMBI expression was observed in 148 （80.8%）, and strong BAMBI expression was observed in 46% of the CRCs. Strong BAMBI expression was positively correlated with histological type, depth of invasion, lymph node metastases, and tumor node metastasis （TNM） stage （P 〈 0.05）. Clear associations were found between BAMBI and β-catenin （P = 0.035） and p53 （P =0.049） expression. In curatively resected CRC, 5-year recurrence-free survival was 51.9% （P = 0.037） for strong BAMBI expression compared to 79.8% for weak BAMBI expression. In the Cox＇s multivariate analysis, lymph node metastases （relative risk 6.685; P 〈 0.001） and depth of invasion （RR 14.0; P = 0.013） were significant indicators for recurrence, and strong BAMBI expression （RR 2.26; P = 0.057） tended to be significant. CONCLUSION： BAMBI was linked to a potentially aggressive tumor phenotype and predicted tumor recurrence and cancer-related death in CRC. BAMBI expression might be applicable in the routine clinical setting of CRC.

关键词： BMP and activin membrane-bound inhibitor Colorectal cancer Transforming growth factor-beta signal Prognosis Wnt signal

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可爱美女那奈休闲 Style：本月那奈休闲装 KEY WORD充满活力的色彩

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国际服装技术 2006年第6期 46-49页

作者： Sunao Ohmori（摄影） nozomi Nishimura Lin Chihiro（翻译）

“时髦、漂亮、可爱！”对片濑那奈小姐抱有好感的LUCi读者正在逐步增加。怎样才能像那奈那样漂亮？为了解答这一疑问，介绍那奈式的休闲装扮=那奈休闲装。千万不要错过哦！

关键词：休闲装 WORD 美女色彩活力时髦

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The Ability of Edible Mushrooms to Act as Biocatalysts: Preparation of Chiral Alcohols Using Basidiomycete Strains

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Advances in Microbiology 2012年第2期2卷 66-71页

作者： Kohji Ishihara Yukiko Nishikawa Mari Kaneko Anna Kinoshita nozomi Kumazawa Daichi Kobashigawa Kohei Kuroda Masashi Osawa Tatsunori Yamamoto Nobuyoshi Nakajima Hiroki Hamada Noriyoshi Masuoka Department of Life Science Okayama University of Science Okayama Japan Graduate School of Health and Welfare Science Okayama Prefectiral University Soja Japan Research Institute of Biotechnology Fujiwara Techno-Art Co. Ltd. Okayama Japan

To examine the potential ability of edible mushrooms to act as biocatalysts, 19 basidiomycete strains were screened. Modified media (PG, O, and PGO medium) for liquid cultivation of these basidiomycete strains were designed and tested. Wet cells (>10 g) of 4 basidiomycete strains (Pleurotus salmoneostramineus H7, P. salmoneostramineus H13, Ganoderma lucidum NBRC31863, Flammulina velutipes NBRC31862) were harvested from PGO medium for 7 days. The stereoselective reduction of α-keto esters using the 4 strains was tested. It was found that each of these strains had a reducing activity toward 6 aliphatic α-keto esters. In the presence of L-alanine as an additive, the reduction of ethyl 2-oxobutanoate and ethyl 2-oxopentanoete by P. salmoneostramineus H7 produced the corresponding alcohol with a high conversion ratio and with excellent enantiomeric excess (>99% e.e. (R)). Furthermore, ethyl pyruvate, ethyl 2-oxobutanoate, and ethyl 2-oxopentanoate were predominantly reduced to the corresponding (R)-hydroxy ester (>99% e.e.) by G. lucidum. Thus, we found that these edible mushrooms have great potential to be used as biocatalysts for the stereoselective reduction of carbonyl compounds.

关键词： Basidiomycete Edible Mushroom Biocatalyst Chiral Alcohol

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