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Clinical relevance of fluorodeoxyglucose positron emission tomography/computed tomography and magnifying endoscopy with narrow band imaging in decision-making regarding the treatment strategy for esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2019年第46期25卷 6767-6780页

作者： Kazuhiro Toriyama Masahiro Tajika Tsutomu Tanaka Makoto Ishihara Yutaka Hirayama Sachiyo Onishi Nobumasa Mizuno Takamichi Kuwahara nozomi okuno Shinpei Matsumoto Eiichi Sasaki Tetsuya Abe Yasushi Yatabe Kazuo Hara Keitaro Matsuo Tsuneo Tamaki Yasumasa Niwa Department of Gastroenterology Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Endoscopy Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Gastroenterology Anjo Kosei HospitalAnjo 446-8602Japan Department of Pathology and Molecular Diagnostics Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Gastroenterological Surgery Aichi Cancer Center HospitalNagoya 464-8681Japan Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research InstituteNagoya 464-8681Japan East Nagoya Imaging Diagnosis Center Nagoya 464-0044Japan

BACKGROUND Recent advances in endoscopic technology,especially magnifying endoscopy with narrow band imaging(ME-NBI)enable us to detect superficial esophageal squamous cell carcinoma(ESCC),but determining the appropriate method of resection,endoscopic resection(ER)vs surgical resection,is often ***,several studies have reported that 18F-fluorodeoxyglucose positron emission tomography(FDG-PET)is a useful indicator for decision-making regarding treatment for superficial ***,there are not enough reports on association between FDG-PET uptake and clinicopathological characteristics of superficial ***,there are not enough reports on evaluating the usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial *** study evaluated clinical relevance of FDG-PET and ME-NBI in decision-making regarding the treatment strategy for *** To investigate the association between FDG uptake and the clinicopathological characteristics of superficial ESCC and its usefulness of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial *** A database of all patients with superficial ESCC who had undergone both MENBI and FDG-PET for pre-treatment staging at Aichi Cancer Center Hospital between January 2008 and November 2018 was retrospectively *** uptake was defined positive or negative whether the primary lesion was visualized or could be distinguished from the background,or *** invasion depth of ESCC was classified according to the Japan Esophageal *** endpoint is to evaluate the association between FDG uptake and clinicopathological characteristics of superficial *** endpoint is to investigate the efficacy of combination of FDG-PET and ME-NBI for determining the treatment strategy for superficial *** A total of 82 lesions in 82 patients were ***-PET showed positive uptake in 29(35.4%)*** analysis sh

关键词： ^18F-fluorodeoxyglucose positron emission tomography Magnifying endoscopy Narrow band imaging Superficial esophageal cancer Squamous cell carcinoma Treatment strategy

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endoscopic ultrasonography-guided biliary drainage:Who,when,which,and how?

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World Journal of Gastroenterology 2016年第3期22卷 1297-1303页

作者： Kazuo Hara Kenji Yamao Nobumasa Mizuno Susumu Hijioka Hiroshi Imaoka Masahiro Tajika Tutomu Tanaka Makoto Ishihara nozomi okuno Nobuhiro Hieda Tukasa Yoshida Yasumasa Niwa Department of Gastroenterology Aichi Cancer Center HospitalNagoya 464-8681Japan Department of Endoscopy Aichi Cancer Center HospitalNagoya 464-8681Japan

Both endoscopic ultrasonography(EUS)-guided choledochoduodenostomy( EUS- CDS) and EUS-guided hepaticogastrostomy(EUS-HGS) are relatively well established as alternatives to percutaneous transhepatic biliary drainage(PTBD). Both EUSCDS and EUS-HGS have high technical and clinical success rates(more than 90%) in high-volume centers. Complications for both procedures remain high at 10%-30%. Procedures performed by endoscopists who have done fewer than 20 cases sometimes result in severe or fatal complications. When learning EUSguided biliary drainage(EUS-BD), we recommend a mentor's supervision during at least the first 20 cases. For inoperable malignant lower biliary obstruction, a skillful endoscopist should perform EUS-BD before EUS-guided rendezvous technique(EUS-RV) and PTBD. We should be select EUS-BD for patients having altered anatomy from malignant tumors before balloon-enteroscope-assisted endoscopic retrograde cholangiopancreatography, EUS-RV, and PTBD. If both EUS-CDS and EUS-HGS are available, we should select EUS-CDS, according to published data. EUSBD will potentially become a first-line biliary drainage procedure in the near future.

关键词： endoscopic ultrasonography endoscopicultrasonography-guided biliary drainage Interventionalendoscopic ultrasonography endoscopic ultrasonography-guided choledochoduodenostomy endoscopicultrasonography-guided rendezvous technique

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Exploration behavior of group-in-a-box layouts

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Visual Informatics 2019年第1期3卷 38-47页

作者： Yuki Ueno Hiroaki Natsukawa nozomi Aoyama Koji Koyamada Department of Electrical Engineering Kyoto UniversityKyotoJapan Academic Center for Computing and Media Studies Kyoto UniversityKyotoJapan

To improve visualization,it is necessary to optimize the design by analyzing the behavior of users as well as improving the evaluation index of the computational experiment and the task performance(e.g.,the correct answer rate and completion time)in the user *** various studies have investigated the influence of user behavior on the evaluation of visualization,majority of these studies focused on simple visualization tasks.A simple task does not indicate a simple visualization comprising a few visualization elements but a task in which the information obtained from visualization is the only clue for completing the ***,a few studies have targeted complicated tasks in which multiple information obtained from visualization is considered to be a clue for completing the task regardless of the number of elements that are contained in the ***,in this study,we investigated the behavior of the participants who have performed complicated *** selected two types of group-in-a-box(GIB)layouts,which can be considered to be a complicated visualization method,as the target of the user *** the user experiment,participants were asked to perform an exploration task specific to GIB layouts;which group has the maximum number of intra-edges?We also collected the eye-tracking data in addition to task *** results showed that the correct answer rate is considerably affected by the visualization factor;whether the correct answer,the box with maximum number of intra-edges,is the box with the largest ***,an analysis of the collected eye-tracking data revealed that this visualization factor affected the exploration behavior of the participants;however,it did not affect the location at which the participants were focused *** obtained results indicated that the visualization elements that were not considered by the visualization designer can influence the task of extracting information from the ***

关键词： Visual search Eye-tracking Group-in-a-box layout

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Use of central venous saturation monitoring in a patient with pediatric cardiac beriberi

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World Journal of Clinical Cases 2013年第6期1卷 205-207页

作者： nozomi Majima Osamu Umegaki Masako Soen Department of Anesthesiology Osaka Medical College Takatsuki Osaka 569-8686 Japan Department of Critical Care Medicine Osaka Medical College Osaka 569-8686 Japan

The patient was a 1-year-and-4-mo-old boy. He had drunk about 1 L of an isotonic drink for infants daily since about 10 mo after birth. He was examined by a local doctor due to anorexia and vomiting, found to have cardiomegaly, and transported to our hospital with suspected myocarditis. After admission, the patient showed polypnea, a decreased level of consciousness, and marked metabolic acidosis and lapsed into circulatory insufficiency, requiring catecholamine administration, endotracheal intubation, and extracorporeal membrane oxygenation. Initially, low-output heart failure due to acute myocarditis was suspected, but the central venous oxygen saturation was high, at 82%. Considering high-output heart failure to be more likely, we evaluated its cause and noted, by urinary organic acid analysis, increases in lactate, pyruvate, 3-OH-butyrate, acetoacetate, metabolic products of branched-chain amino acids, 2-ketoglutarate, 2-OHglutarate, 2-keto-adipate, and 2-OH-adipate. Since the vitamin B1 level was reduced to 12 ng/m L(normally 20-50 ng/m L), a diagnosis of cardiac beriberi due to vitamin B1 deficiency was made. When unexplained heart failure is observed in children, cardiac beriberi must be excluded as a differential diagnosis of myocarditis and cardiomyopathy. The measurement of the central venous oxygen saturation may be useful for the diagnosis.

关键词： Cardiac beriberi Central venous saturation Pediatric

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Efficacy of probiotics on the modulation of gut microbiota in the treatment of diabetic nephropathy

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World Journal of Diabetes 2022年第3期13卷 150-160页

作者： nozomi Nagase Yuka Ikeda Ai Tsuji Yasuko Kitagishi Satoru Matsuda Department of Food Science and Nutrition Nara Women's UniversityNara 630-8506Japan

Diabetic nephropathy(DN)is a major cause of end-stage renal disease,and therapeutic options for preventing its progression are *** number of patients with DN has been increasing in Asian countries because of westernization of dietary lifestyle,which may be associated with the following changes in gut *** in the gut microbiota composition can lead to an imbalanced gastrointestinal environment that promotes abnormal production of metabolites and/or inflammatory *** microenvironments of the gut could be changed in the different stages of *** particular,altered levels of short chain fatty acids,D-amino acids,and reactive oxygen species biosynthesis in the gut have been shown to be relevant to the pathogenesis of the *** far,evidence suggests that the gut microbiota may play a key role in determining networks in the development of *** directing the gut microbiota deserve further investigation as a new protective therapy in *** this review,we discuss the potential roles of the gut microbiota and future perspectives in the protection and/or treatment of kidneys.

关键词： Diabetic nephropathy Short chain fatty acids Superoxide dismutase Reactive oxygen species D-amino acids Gut microbiota Diabetes mellitus Renal disease

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Secretome-microRNA and anti-proliferative APRO family proteins as cancer prevention and stem cell research strategies

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BIOCELL 2022年第5期46卷 1163-1167页

作者： YUKA IKEDA nozomi NAGASE AI TSUJI KURUMI TANIGUCHI YASUKO KITAGISHI SATORU MATSUDA Department of Food Science and Nutrition Nara Women’s UniversityNara630-8506Japan

Stemness of cancer cells contains limitless self-renewal *** the purpose of proliferation,secretome might exert its effects via the paracrine *** microRNAs enclosed in the secretome of cancer stem cells could regulate the expression of anti-proliferative APRO family *** biological functions of APRO family proteins seems to be quite intricate,however,which might be a key modulator of microRNAs,then could regulate the proliferation of cancer *** addition to affecting proliferation/differentiation during cellular development,APRO family proteins might also play an imperious role on keeping homeostasis in healthy stem cells under a physiological ***,relationship between the microRNAs and the APRO family proteins has attracted much attention in the field of cancer research and regenerative ***,we have described the molecular mechanism behind this interplay that have a potential role in the future promising tools with targeting APRO family proteins for the medical applications.

关键词： Cancer Stem cell Secretome Proliferation APRO family microRNA

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Mutations of pre-core and basal core promoter before and after hepatitis B e antigen seroconversion

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World Journal of Gastroenterology 2015年第2期21卷 541-548页

作者： nozomi Kamijo Akihiro Matsumoto Takeji Umemura Soichiro Shibata Yuki Ichikawa Takefumi Kimura Michiharu Komatsu Eiji Tanaka Department of Medicine Shinshu University School of MedicineMatsumoto 390-8621Japan

AIM: To investigate the role of pre-core and basal core promoter(BCP) mutations before and after hepatitis Be antigen(HBe Ag) ***: The proportion of pre-core(G1896A) and basal core promoter(A1762T and G1764A) mutant viruses and serum levels of hepatitis B virus(HBV) DNA, hepatitis B surface antigen(HBs Ag), and HB core-related antigen were analyzed in chronic hepatitis B patients before and after HBe Ag seroconversion(n = 25), in those who were persistently HBe Ag positive(n = 18), and in those who were persistently anti-HBe positive(n = 43). All patients were infected with HBV genotype C and were followed for a median of 9 ***: Although the pre-core mutant became predominant(24% to 65%, P = 0.022) in the HBe Ag seroconversion group during follow-up, the proportion of the basal core promoter mutation did not change. Median HBV viral markers were significantly higher in patients without the mutations in an HBe Ag positive status(HBV DNA: P = 0.003; HBs Ag: P < 0.001; HB core-related antigen: P = 0.001). In contrast, HBV DNA(P = 0.012) and HBs Ag(P = 0.041) levels were significantly higher in patients with the pre-core mutation in an anti-HBe positive ***: There is an opposite association of the pre-core mutation with viral load before and after HBe Ag seroconversion in patients with HBV infection.

关键词： Seroconversion Hepatitis B core-related antigen Pr

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Aeolian Tone from a Semi-Circular Cylinder in a Stream

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Journal of Flow Control, Measurement & Visualization 2016年第1期4卷 30-37页

作者： Takayuki Yamagata nozomi Saito Nobuyuki Fujisawa Visualization Research Center Niigata University Niigata Japan Graduate School of Science and Technology Niigata University Niigata Japan

Aeolian tone from a semi-circular cylinder in a uniform flow is studied experimentally for various angles of attack. It is found that the peak sound spectrum of the Aeolian tone from the semi-circular cylinder is smaller than that from the circular cylinder and the lowest sound is observed around the zero angle of attack. This is due to the reduction in the fluctuating lift force on the semi-circular cylinder compared to that of the circular cylinder. This result suggests the validity of the analogy between the sound pressure level and the fluctuating lift force on a semi-circular cylinder in a stream. The flow visualization study also supports these results.

关键词： Aeolian Tone Semi-Circular Cylinder Fluctuating Lift Force Angle of Attack Flow Induced Sound

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Eye-Movement While Generating a Trajectory Using the Upper Limb

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Journal of Energy and Power Engineering 2012年第11期6卷 1733-1744页

作者： nozomi Toyoda Ryohei Yamamoto Tetsuro Yabuta Faculty of Engineering Yokohama National University Yokohama 2408501 Japan

This paper describes the experimental analysis of eye-movement during the generation of a trajectory by the human upper limb, carried out to elucidate the human mechanism for visual-information recognition. The results showed that the subjects adopted an eye-movement pattern called the subgoal travel method （fixating in the vicinity of the fingertip while drawing/tracing） for the complete circle. Subsequently, when the target trajectory was one of incomplete shapes, some subjects continued following the subgoal travel method by drawing the missing part of the target trajectory, while others followed two other eye-movement patterns. The first is called the center-point fixation method, in which subjects consider the center point as the most important point for generating the target-image trajectory, and therefore, fix their gaze at the center point throughout the experiment. The second is called the point-to-point travel method, in which the subjects＇ gazes shift between the center point of a displayed image and their fingertip. Further, the results confirmed that the eye-movement pattern, movement accuracy, and drawing speed are correlated. Additional experiments clarified the conditions for which different eye-movement patterns are suitable： the subgoal travel method is suitable for high-accuracy drawing; the center-point fixation method is suitable for higher-sneed drawing

关键词： Eye-movement pattern drawing strategy visual information upper-limb motion.

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Thrombomodulin in the management of acute cholangitisinduced disseminated intravascular coagulation

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World Journal of Gastroenterology 2015年第2期21卷 533-540页

作者： Keigo Suetani Chiaki Okuse Kazunari Nakahara Yosuke Michikawa Yohei Noguchi Midori Suzuki Ryo Morita nozomi Sato Masaki Kato Fumio Itoh Department of Gastroenterology and Hepatology St.Marianna UniversitySchool of MedicineKawasaki 216-8511Japan

AIM: To evaluate the need for thrombomodulin(r TM) therapy for disseminated intravascular coagulation(DIC) in patients with acute cholangitis(AC)-induced DIC. METHODS: Sixty-six patients who were diagnosedwith AC-induced DIC and who were treated at our hospital were enrolled in this study. The diagnoses of AC and DIC were made based on the 2013 Tokyo Guidelines and the DIC diagnostic criteria as defined by the Japanese Association for Acute Medicine, respectively. Thirty consecutive patients who were treated with r TM between April 2010 and September 2013(r TM group) were compared to 36 patients who were treated without r TM(before the introduction of r TM therapy at our hospital) between January 2005 and January 2010(control group). The two groups were compared in terms of patient characteristics at the time of DIC diagnosis(including age, sex, primary disease, severity of cholangitis, DIC score, biliary drainage, and anti-DIC drugs), the DIC resolution rate, DIC score, the systemic inflammatory response syndrome(SIRS) score, hematological values, and outcomes. Using logistic regression analysis based on multivariate analyses, we also examined factors that contributed to persistent DIC. RESULTS: There were no differences between the r TM group and the control group in terms of the patients' backgrounds other than administration. DIC resolution rates on day 9 were higher in the r TM group than in the control group(83.3% vs 52.8%, P < 0.01). The mean DIC scores on day 7 were lower in the r TM group than in the control group(2.1 ± 2.1 vs 3.5 ± 2.3, P = 0.02). The mean SIRS scores on day 3 were significantly lower in the r TM group than in the control group(1.1 ± 1.1 vs 1.8 ± 1.1, P = 0.03). Mortality on day 28 was 13.3% in the r TM group and 27.8% in the control group; these rates were not significantly different(P = 0.26). Multivariate analysis identified only the absence of biliary drainage as significantly associated with persistent DIC(P < 0.01, OR = 12, 95%CI: 2.

关键词： Disseminated intravascular coagulation Acute chola

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