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Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa m.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.R.groh moein Yaqubi Qiao-Ling Cui Jo Anne Stratton g.R.Wayne moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

Crystalline phase of Y_2O_3 :Eu particles generated in a substrate-free flame process

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Particuology 2011年第1期9卷 24-31页

作者： Bing guoa Hoon Yim Wonjoong Hwang matt nowell Zhiping Luo Department of mechanical Engineering Texas A&M University College Station TX 77843 USA EDAX-TSL EDAX Inc. Draper UT84020 USA microscopy and Imaging Center Texas A&M University College Station TX 77843 USA

In this study, factors affecting the crystal structure of flame-synthesized Y2O3 ：Eu particles were investigated, especially the particle size effect and its interaction with Eu doping concentration, Polydisperse Y2O3：Eu （size range 200 nm to 3μm） powder samples with Eu doping concentrations from 2,5 mol% to 25 mol% were generated in either H2/air or H2/O2 substrate-free flames. The crystal structure of the powder samples was determined by powder X-ray diffraction （XRD）, which was complemented by pho- toluminescence （PL） measurements. Single particle crystal structure was determined by single particle selected area electron diffraction （SAED）, and for the first time, by electron backscatter diffraction （EBSD）. H2/air flames resulted in cubic phase Y2O3：Eu particles with hollow morphology and irregular shapes, Particles from H2/O2 flames had dense and spherical morphology; samples with lower Eu doping concen- trations had mixed cubic/monoclinic phases; samples with the highest Eu doping concentrations were phase-pure monoclinic. For samples generated from H2/02 flames, a particle size effect and its interaction with Eu doping concentration were found： particles smaller than a critical diameter had the monoclinic phase, and this critical diameter increased with increasing Eu doping concentration, These findings suggest that the formation of monoclinic Y2O3：Eu is inevitable when extremely hot substrate-free flames are used, because typical flame-synthesized Y203 ：Eu particle sizes are well below the critical diameter, However, it may be possible to generate particles with dense, spherical morphology and the desired cubic structure by using a moderately high flame temperature that enables fast sintering without melting the particles.

关键词： Flame synthesis Aerosol Size effect Crystal structure Y2O3:Eu Particles

Phantom Accretion onto the Schwarzschild de-Sitter Black Hole

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Chinese Physics Letters 2011年第9期28卷 34-37页

作者： m Sharif g Abbas Department of mathematics University of the PunjabQuaid-e-Azam CampusLahore-54590Pakistan

We deal with phantom energy accretion onto the Schwarzschild de-Sitter black *** energy flux conservation,relativistic Bernoulli equation and mass flux conservation equation are formulated to discuss the phantom *** discuss the conditions for critical *** is found that the mass of the black hole decreases due to phantom *** exist two critical points which lie in the exterior of horizons(black hole and cosmological horizons).The results for the phantom energy accretion onto the Schwarzschild black hole can be recovered by takingΛ→0.

关键词： accretion horizon black

Peri-Net-Pro: the neural processes with quantified uncertainty for crack patterns

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Applied mathematics and mechanics(English Edition) 2023年第7期44卷 1085-1100页

作者： m.KIm g.LIN Samsung Electronics Yongin-siGyeonggi-do 17113Republic of Korea Department of mathematics Purdue UniversityWest LafayetteIN 47907-2067U.S.A. School of mechanical Engineering Purdue UniversityWest LafayetteIN 47907-2067U.S.A.

This paper develops a deep learning tool based on neural processes(NPs)called the Peri-Net-Pro,to predict the crack patterns in a moving disk and classifies them according to the classification modes with quantified *** particular,image classification and regression studies are conducted by means of convolutional neural networks(CNNs)and ***,the amount and quality of the data are enhanced by using peridynamics to theoretically compensate for the problems of the finite element method(FEm)in generating crack pattern ***,case studies are conducted with the prototype microelastic brittle(PmB),linear peridynamic solid(LPS),and viscoelastic solid(VES)models obtained by using the peridynamic *** case studies are performed to classify the images by using CNNs and determine the suitability of the PmB,LBS,and VES ***,a regression analysis is performed on the crack pattern images with NPs to predict the crack *** regression analysis results confirm that the variance decreases when the number of epochs increases by using the *** training results gradually improve,and the variance ranges decrease to less than *** main finding of this study is that the NPs enable accurate predictions,even with missing or insufficient training *** results demonstrate that if the context points are set to the 10th,100th,300th,and 784th,the training information is deliberately omitted for the context points of the 10th,100th,and 300th,and the predictions are different when the context points are significantly ***,the comparison of the results of the 100th and 784th context points shows that the predicted results are similar because of the gaussian processes in the ***,if the NPs are employed for training,the missing information of the training data can be supplemented to predict the results.

关键词： neural process(NP) peridynamics crack pattern molecular dynamic(mD)simulation machine learning gaussian process regression convolutional neural network(CNN)

molecular characterization of yolk proteins in the female crab Neptunus pelagicus(***-Edwards,1861) from the mediterranean Sea of Alexandria,Egypt

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Journal of Oceanology and Limnology 2020年第2期38卷 438-453页

作者： IBRAHIm g ELgHAZALY m Department of Zoology Faculty of ScienceAlexandria UniversityAlexandria 21547Egypt Department of Zoology Faculty of ScienceDamnhour UniversityEl Behara 22516Egypt

This study aimed to characterize the morphological changes in the ovary of the female crab Neptunus pelagicus and to identify specific fractions of vitelloginin and vitelline molecules during primary and secondary *** of the blue crab were collected from the mediterranean Sea of Alexandria monthly during *** and oocytes in primary and secondary vitellogenesis were detached and treated for histological *** polyacrylamide gel electrophoresis(PAgE)Bis-Tris gels was applied to identify vitelloginin(VN)and vitelline(VL)*** Analyses were done by *** initial degenerate primers were built regarding the conserved amino acid domains of the yolk *** and secondary vitellogeneses consisted of 8 *** fraction with molecular weight 550 kDa was identified in the hemolymph in secondary *** protein fractions(VLI&VLII)were identified in secondary vitellogenic *** electrophoresis performed with extract of stage I oocyte showed two protein fractions with molecular weights 550 kDa and 460 *** stage II and III oocyte,4 subunits were presented of 180,195,140 and 120 kDa in VLI and 2 subunits with molecular weight of 110 kDa and 95 kDa in *** two fractions in stage V oocyte presented with molecular weights of 380 kDa and 360 *** blot analysis proved that both fractions were of four major polypeptide subunits with molecular weight of 180,125,90 and 85 kDa in each of the two *** hybridization signal obtained by the Northern blot was detected in the hepatopancreas during ovarian cycle and in the ovary during secondary *** result of the reverse transcription-polymerase chain reaction(RT-PCR)analysis showed that the mRNA that encodes the C-terminal region of the VN cDNA was found in the ovary in secondary vitellogenesis and in the hepatopancreas.

关键词： Neptunus pelagicus vitellogenesis vitelloginin and vitelline native polyacrylamide gel electrophoresis(PAgE)Bis-Tris gels PAgE-SDS western blot analysis reverse transcription-polymerase chain reaction(RT-PCR)

Investigation of the inhomogeneous barrier height of an Au/Bi_4Ti_3O_(12)/n-Si structure through gaussian distribution of barrier height

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Chinese Physics B 2012年第12期21卷 538-543页

作者： m.gken m.Yildirim Department of Physics Faculty of Arts and SciencesDuzce University

A Au/Bi4Ti3O12/n-Si structure is fabricated in order to investigate its current voltage （IV） characteristics in a temperature range of 300 K-400 K. Obtained I-V data are evaluated by the thermionic emission （TE） theory. Zero-bias barrier height （Ф0） and ideality factor （n） calculated from I-V characteristics, are found to be temperature-dependent such that ФB0 increases with temperature increasing, whereas n decreases. The obtained temperature dependence of ФB0 and linearity in ФB0 versus the n plot, together with a lower barrier height and Richardson constant values obtained from the Richardson plot, indicate that the barrier height of the structure is inhomogeneous in nature. Therefore, I-V characteristics are explained on the basis of Caussian distribution of barrier height.

关键词： Bi4Ti3O12 I-V characterization temperature dependence gaussian distribution

Bianchi type I in f(T) gravitational theories

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Chinese Physics B 2016年第5期25卷 58-64页

作者： m I Wanas g g L Nashed O A Ibrahim Astronomy Department Faculty of Science Cairo University Cairo Egypt Centre for Theoretical Physics The British University in Egypt El-Sherouk City Egypt mathematics Department Faculty of Science Ain Shams University Cairo Egypt Egyptian Relativity group (ERg) Giza Egypt

A tetrad field that is homogeneous and anisotropic which contains two unknown functions A（t） and B（t） of cosmic time is applied to the field equations of f（T）, where T is the torsion scalar, T = T~μ_（νρ）S_μ^（νρ）. We calculate the equation of continuity and rewrite it as a product of two brackets, the first is a function of f（T） and the second is a function of the two unknowns A（t） and B（t）. We use two different relations between the two unknown functions A（t） and B（t） in the second bracket to solve it. Both of these relations give constant scalar torsion and solutions coincide with the de Sitter one. So,another assumption related to the contents of the matter fields is postulated. This assumption enables us to drive a solution with a non-constant value of the scalar torsion and a form of f（T） which represents ΛCDm.

关键词： f(T) gravitational theory Bianchi type I special solutions

Embedded Atom method-Based geometry Optimization Aspects of Body-Centered Cubic metals

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Chinese Physics Letters 2013年第5期30卷 112-115页

作者： m.güler E.güler Department of Physics Hitit University19030 CorumTurkey

We present embedded atom method-based geometry optimization calculations for Fe, Cr, mo, Nb, Ta, V and W body-centered cubic metals with Finnis–Sinclair potentials. After the optimization, we determine their typical elastic constants, bulk modulus, shear modulus, Young's modulus, Poisson's ratios, elastic wave velocities and cohesive energies. Additionally, we perform a benchmark between the experiments and the available density functional theory results. In general, our results show a good consistency with previous findings on the elastic and cohesive energy properties of the considered metals.

关键词： modulus optimization cubic