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人小肠上皮细胞CD23a.导的IgE-抗原复合物的转胞作用及其在食物变态反应中的作用

世界核心医学期刊文摘（胃肠病学分册） 2006年第11期2卷 21-22页

作者： nowak-wegrzyn a. Cha.lop-Powers Z. M.C. Berin 刘丽娜 Depa.tment of Pedia.rics Mount Sinai School of Medicine New York NY United States

Ba.kground &a.ms: Secreted immunoglobulins pla. a. integra. role in host defense a. mucosa. surfa.es, a.d recent evidence shows tha. IgG ca. pa.ticipa.e in a.tigen sa.pling from the intestina. lumen. We exa.ined whether IgE a.so could fa.ilita.e tra.sepithelia. a.tigen sa.pling. Methods: Stool sa.ples from food-a.lergic pa.ients undergoing ora. food cha.lenge were a.a.yzed for CD23 a.d food-specific IgE. CD23 isoform expression on prima.y huma. intestina. epithelia. cells (IEC) wa. a.a.yzed by polymera.e cha.n rea.tion. The role of CD23 isoforms in tra.scytosis of a.tigen a.d IgE-a.tigen complexes wa. a.sessed using pola.ized huma. T84 cells retrovira.ly tra.sfected with CD23a.or CD23b. Results: CD23 wa. expressed constitutively on IECs, a.d food-a.lergic pa.ients ha. increa.ed levels of soluble CD23 a.d food-specific IgE in the stool a.ter cha.lenge. CD23a. but not CD23b, wa. expressed by prima.y huma. IECs. We show in tra.scytosis a.sa.s tha. CD23a. but not CD23b, a.ts a. a.bidirectiona. tra.sporter of IgE. In a.dition, specific IgE fa.ilita.ed the upta.e of a.tigen from the a.ica. surfa.e of a. epithelia. monola.er by diverting a.tigen from delivery to lysosomes. Fina.ly, delivery of a.tigen-IgE complexes a.ross the epithelia. ba.rier could induce the degra.ula.ion of ra. ba.ophil leukemia.cells tra.sfected with the huma. high-a.finity IgE receptor. Conclusions: These studies show tha. CD23a.is expressed norma.ly on huma. IECs, a.d in the presence of IgE ca. function a. a. a.tigen-sa.pling mecha.ism ca.a.le of a.tiva.ing subepithelia. ma.t cells. IgE ma. serve a. a.secretory immunoglobulin tha. in concert with CD23 pa.ticipa.es in food-induced pa.hophysiology of the ga.trointestina. tra.t.

关键词：食物变态反应 CD23a IgE 抗原复合物转胞小肠上皮细胞食物过敏免疫球蛋白聚合酶链反应

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共济失调毛细血管扩张患儿的免疫缺陷和感染

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世界核心医学期刊文摘（儿科学分册） 2005年第8期1卷 22-23页

作者： nowak- wegrzyn a. Cra.ford T.O. Winkelstein J.a. H.M. Lederma. 贺莉 Eudowood Div. Pedia.. a.lerg. I. Johns Hopkins Hospital CMSC 1102 600 N Wolfe St. Baltimore MD 21287- 3923 United States Dr.

Objective: To cha.a.terize the immunodeficiency in a.a.ia. tela.giecta.ia.(a.- T) a.d to determine whether the immunodeficiency is progressive a.d a.socia.e d with increa.ed susceptibility to infections. Study design: Records of 100 cons ecutive pa.ients with a. T from the Johns Hopkins a.a.ia. Tela.giecta.ia.Clini ca. Center (a.CC) were reviewed. Results: Immunoglobulin (Ig) deficiencies a.e c ommon, a.fecting IgG4 in 65% of pa.ients, Iga.in 63% , IgG2 in 48% , IgE in 23% , a.d IgG in 18% . Lymphopenia.a.fected 71% of pa.ients, with reduced B - lymphocyte number in 75% , CD4 T lymphocytes in 69% , a.d CD8 T lymphocytes in 51% . There wa. no trend for increa.ed frequency or severity of immune a.no rma.ities with a.e. Recurrent upper a.d lower respira.ory tra.t infections were frequent: otitismedia.in 46% of pa.ients, sinusitis in 27% , bronchitis in 19 % , a.d pneumonia.in 15% . Sepsis occurred in 5 pa.ients, in 2 pa.ients concur rent with ca.cer chemothera.y. Wa.ts a.fected 17% of pa.ients, herpes simplex 8% , molluscum conta.iosum 5% , ca.dida. esopha.itis 3% , a.d herpes zoster 2 % . Uncomplica.ed va.icella.infection occurred in 44% of pa.ients; 2 pa.ients ha. more tha. one clinica. episode. No pa.ient ha. Pneumocystis jerovici pneumo nia.or a.complica.ion of live vira. va.cine. Conclusions: In spite of the high p reva.ence of la.ora.ory immunologic a.norma.ities, systemic ba.teria., severe vi ra., a.d opportunistic infec tions a.e uncommon in a.. Cross- sectiona. a.a.ysis suggests tha. the immune defect is ra.ely progressive.

关键词：免疫缺陷淋巴细胞减少淋巴水肿机会性感染免疫球蛋白 IgG 传染性软疣念珠菌性食管炎共济失调临床中心

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