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World Journal of Gastroenterology 2018年第19期24卷 2130-2136页

作者： Maciej nowacki Dariusz Grzanka Wojciech Zegarski Department of Surgical Oncology Ludwik Rydygier's Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun Oncology Centre-Prof. Franciszek ?ukaszczyk Memorial Hospital in Bydgoszcz Department of Clinical Pathomorphology Ludwik Rydygier's Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Torun

We report the first application of pressurized intraperitoneal aerosol chemotherapy(PIPAC) as a rescue therapy before palliative D2 gastrectomy combined with liver metastasectomy performed in a 49-yearold woman with peritoneal carcinomatosis who was primarily diagnosed with and underwent surgery for a Krukenberg tumor. The PIPAC procedure was performed with the use of cisplatin at 7.5 mg/m2 and doxorubicin at 1.5 mg/m2 for 30 min at 37 ℃. Eight weeks after the PIPAC procedure, the patient underwent open classic D2 gastrectomy with the creation of a Roux-en-Y anastomosis(RNY) combined with liver metastasectomy. The patient underwent the classic protocol for chemotherapy combined with Xeloda. The patient felt better and returned to her daily activities. Multicenter data should be gathered to confirm the usefulness of PIPAC as a rescue or neoadjuvant supportive therapy in a very select group of patients who have been recently qualified to undergo classic chemotherapy or standard oncologic surgical procedures.

关键词： Peritoneal carcinomatosis Pressurized intraperitoneal aerosol chemotherapy Neoadjuvant therapy Gastric cancer Krukenberg tumor

Assessment of stricturing Crohn's disease:Current clinicalpractice and future avenues

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World Journal of Gastroenterology 2016年第3期22卷 1008-1016页

作者： Dominik Bettenworth Tobias M nowacki Friederike Cordes Boris Buerke Frank Lenze Department of Medicine B University Hospital of Muenster48149 MuensterGermany Department of Clinical Radiology University Hospital of Muenster48149 MuensterGermany

Crohn's disease(CD) is a chronic remittent idiopathic disease. Although the early phase of the disease is commonly characterized by inflammation-driven symptoms, such as diarrhea, the frequency of fibrostenotic complications in patients with CD increases over the long-term course of the disease. This review presents the current diagnostic options for assessing CD-associated strictures. In addition to the endoscopic evaluation of CD strictures, this review summarizes the currently available imaging modalities, including ultrasound and cross-sectional imaging techniques. In addition to stricture detection, differentiating between the primarily inflammatory strictures and the predominantly fibrotic ones is essential for selecting the appropriate treatment strategy(anti-inflammatory medical treatment vs endoscopical or surgical approaches). Therefore, recent imaging advances, such as contrast-enhanced ultrasound and ultrasound elastography, contribute to the development of noninvasive non-radiating imaging of CD-associated strictures. Finally, novel magnetic resonance imaging techniques, such as diffusion-weighted, motility and magnetization transfer imaging, as well as 18F-FDG PET/CT, molecular imaging approaches and biomarkers, are critically reviewed with regard to their potential role in assessing stricturing CD.

关键词： Crohn's disease Inflammatory bowel disease Intestinal stricture Endoscopy Magnetic resonanceimaging Ultrasound Computed tomography 18F-FDGPET/CT CEUS Elastography

Crohn's disease complicated by intestinal infection with methicillin-resistant Staphylococcus aureus

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World Journal of Gastroenterology 2013年第27期19卷 4418-4421页

作者： Dominik Bettenworth Tobias M nowacki Alexander Friedrich Karsten Becker Johannes Wessling Jan Heidemann Department of Medicine B University of Münster Institute of Hygiene University of Münster Institute of Medical Microbiology University of Münster Department of Clinical Radiology University of Münster

We report on a 24-year-old male patient with history of bloody diarrhea, abdominal pain and vomiting. Endoscopy revealed massive ulcerative discontinuous proctosigmoiditis with deep, sharply demarcated epithelial denudations and enterotoxigenic methicillin-resistant Staphylococcus aureus (MRSA) was detected in mucosal biopsies. After treatment with linezolide and steroids, a significant amelioration of colitis was detected and testing for MRSA became negative. In face of the case presented here, we suggest that in patients with refractory inflammatory bowel disease (IBD), microbiological assessment should be performed to detect a possible Staphylococcus aureus infection in order to initiate an antimicrobial treatment in addition to IBDspecific treatment.

关键词： Inflammatory bowel disease Crohn’s disease Infectious colitis Staphylococcus aureus Methicillin-resistant Staphylococcus aureus

Detection and characterization of murine colitis and carcinogenesis by molecularly targeted contrast-enhanced ultrasound

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World Journal of Gastroenterology 2017年第16期23卷 2899-2911页

作者： Markus Brückner Jan Heidemann Tobias M nowacki Friederike Cordes Jorg Stypmann Philipp Lenz Faekah Gohar Andreas Lügering Dominik Bettenworth Department of Medicine B University Hospital of MünsterD-48149 MünsterGermany Department of Gastroenterology Klinikum Bielefeld MitteAcademic Teaching HospitalUniversity of MünsterD-33604 BielefeldGermany Department of Cardiology and Angiology University Hospital of MünsterD-48149 MünsterGermany Department of Palliative Care University Hospital of MünsterD-48149 MünsterGermany Department of Paediatric Rheumatology and Immunology University Hospital of MünsterD-48149 MünsterGermany Medical Care Center Portal 10 D-48155 MünsterGermany

AIM To study mucosal addressin cellular adhesion molecule-1(MAd CAM-1) and vascular endothelial growth factor(VEGF)-targeted contrast enhanced ultrasound(CEUS) for the assessment of murine colitis and carcinogenesis. METHODS C57BL/6 mice were challenged with 3% dextran sodium-sulfate(DSS) for three, six or nine days to study the development of acute colitis. Ultrasound was performed with and without the addition of unspecific contrast agents. MAd CAM-1-targeted contrast agent was used to detect and quantify MAd CAM-1 expression. Inflammatory driven colorectal azoxymethane(AOM)/DSS-induced carcinogenesis was examined on day 42 and 84 using VEGF-targeted contrast agent. Highly specific tissue echogenicity was quantified using specialized software. Sonographic findings were correlated to tissue staining, western blot analysis and immunohistochemistry to quantify the degree of inflammation and stage of carcinogenesis. RESULTS Native ultrasound detected increased general bowel wall thickening that correlated with more progressed and more severe DSS-colitis(healthy mice: 0.3 mm ± 0.03 vs six days DSS: 0.5 mm ± 0.2 vs nine days DSS: 0.6 mm ± 0.2, P < 0.05). Moreover, these sonographic findings correlated well with clinical parameters such as weight loss(r2 = 0.74) and histological damage(r2 = 0.86)(P < 0.01). In acute DSS-induced murine colitis, CEUS targeted against MAd CAM-1 detected and differentiated stages of mild, moderate and severe colitis via calculation of mean pixel contrast intensity in decibel(9.6 d B ± 1.6 vs 12.9 d B ± 1.4 vs 18 d B ± 3.33, P < 0.05). Employing the AOM/DSSinduced carcinogenesis model, tumor development was monitored by CEUS targeted against VEGF and detected a significantly increased echogenicity in tumors as compared to adjacent healthy mucosa(healthy mucosa, 1.6 d B ± 1.4 vs 42 d, 18.2 d B ± 3.3 vs 84 d, 18.6 d B ± 4.9, P < 0.01). Tissue echogenicity strongly correlated with histological analysis and immunohistochemistry findings(VEGF-posi

关键词： Colitis Dextran sodium-sulfate AOMDSS Carcinogenesis Ultrasound Contrast-enhanced ultrasound Vascular endothelial growth factor Mucosal addressin cellular adhesion molecule-1

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奥得河畔的人文记忆

人与自然 2014年第2期 78-87页

作者：南野 MIKOLAJ nowacki

早期的人类集聚地依河而建,当地人对于河流都有一种情怀。奥得河作为波兰的境内的一条航运主干道,孕育了河畔的一切。无论经历什么时代,当地人都把它视为自己最重要的依靠。驻足在河道旁,追忆自己的过往,一种对故乡淡淡的眷恋久久徘徊... 详细信息

早期的人类集聚地依河而建,当地人对于河流都有一种情怀。奥得河作为波兰的境内的一条航运主干道,孕育了河畔的一切。无论经历什么时代,当地人都把它视为自己最重要的依靠。驻足在河道旁,追忆自己的过往,一种对故乡淡淡的眷恋久久徘徊在此。奥得河是一条位于中欧的河流。它发源于捷克,流经波兰西部,并构成波兰与德国之间长达187公里的北部国界。曾被罗马人称为Viadrus,Viadua,是琥珀之路的一部分。它源源不绝地流到什切青以北的什切青泻湖,然后经三条支流济夫纳河、斯维纳河、佩内河流向波罗的海。

关键词：奥得河弗罗茨瓦夫奥德河波罗的海

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每周运动量对身体负荷能力的影响

山西体育科技 2004年第4期24卷 1-3页

作者：吴宁 nowacki PE 德国吉森大学运动医学研究所

来自德国黑森州赛克综合学校的1223名女生(年龄：11．6±1．1岁；身高：152．5±8．5厘米；体重：45．5±11．0公斤)和822名男生(年龄：11．5±1．0岁；身高：151．0±8．7厘米；体重：43．7±11．0公斤)在吉森大学运动医学研究所接受... 详细信息

来自德国黑森州赛克综合学校的1223名女生(年龄：11．6±1．1岁；身高：152．5±8．5厘米；体重：45．5±11．0公斤)和822名男生(年龄：11．5±1．0岁；身高：151．0±8．7厘米；体重：43．7±11．0公斤)在吉森大学运动医学研究所接受了运动医学检查(包括自行车功率试验)。其结果的SPSS统计显示，每周运动量(女生3．3±2．0小时，男生4．2±2．5小时)和他们在自行车功率试验中表现出的负荷能力(女生：总负荷量452．6±136.9瓦特分，最大负荷能力133．5±33.0瓦特，公斤体重负荷能力3，0±0、5公斤，最大心率192±11；男生：总负荷量608．6±1．1瓦特分，最大负荷能力151．4±40．7瓦特，公斤体重负荷能力3．6±1．5公斤，最大心率190±11)之间有弱相关性(0．12

关键词：每周运动量身体负荷能力运动医学体育教学身高体重体育锻炼

利用地震各向异性方法研究地幔底部的形变特征

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国际地震动态 2012年第5期33卷 8-15页

作者： Andy nowacki James Wookey J-Michael Kendall 吴萍萍 Department of Earth Sciences University of BristolWills Memorial BuildingQueen's RoadBristolBS8 1RJUK Department of Earth Sciences University of BristolWills Memorial BuildingQueen’s RoadBristolBS8 1RJUK 中国地震局地球物理研究所

地震波在穿过地幔底部(即D″层)时表现出很明显的各向异性特征(地震波速度随着方位角变化而变化)[1-5]。D″层各向异性的形成机制一般认为是由D″层的主要相变矿物MgSiO3-post-perovskite(ppv),由于形变导致晶体的晶格定向排列引起的。... 详细信息

地震波在穿过地幔底部(即D″层)时表现出很明显的各向异性特征(地震波速度随着方位角变化而变化)[1-5]。D″层各向异性的形成机制一般认为是由D″层的主要相变矿物MgSiO3-post-perovskite(ppv),由于形变导致晶体的晶格定向排列引起的。如果这种解释机制正确的话,那么先前从单个方向测量D″层的各向异性来推断ppv晶体的滑动机制就是不充分的,因为ppv晶体是正交晶系。我们根据美洲北部和中部地区在核-幔边界处仍残留着俯冲海洋板块的残片[6]的构造特点,挑选了穿过D″层的浅震和深震,来增加射线在D″层的方位覆盖,处理得到美洲北部和中部D″层的各向异性。我们分别处理了穿过3个研究区的D″层的700多个剪切波波形数据,每一次同时处理来自两个不同方位的震相,研究发现,先前假设的垂直对称轴的横向各向同性(波速不随方位的变化而变化)[2-3,7]机制是不可能的,需要引入更复杂的机制。我们将MgSiO3-ppv多种形变机制和观测结果进行对比,发现在(001)面上的剪切与观测到的数据和俯冲带的核-幔边界处剪切形变的预期结果相吻合。利用新的地幔流动模型及改善后的ppv滑移系的实验观测确定方法,我们可以对核-幔边界的形变特征进行成像,将D″层中的动力过程(比如,地幔柱的形成)与地幔的其他部位联系起来。

关键词：地震各向异性形变特征地幔柱底部利用地震波速度核-幔边界解释机制

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Ⅲ期结肠癌的辅助治疗药物——卡培他滨

世界核心医学期刊文摘（胃肠病学分册） 2005年第11期1卷 3-4页

作者： Twelves C. Wong A. nowacki M.P. 李明 Tom Connors Cancer Research Centre University of Bradford Richmond Road Bradford BD7 1DP United KingdomDr.

BACKGROUND: Intravenous bolus fluorouracil plus leucovorin is the standard adjuvant treatment for colon cancer. The oral fluoropyrimidine capecitabine is an established alternative to bolus fluorouracil plus leucovorin as first-line treatment for metastatic colorectal cancer. We evaluated capecitabine in the adjuvant setting. METHODS: We randomly assigned a total of 1987 patients with resected stage III colon cancer to receive either oral capecitabine (1004 patients) or bolus fluorouracil plus leucovorin (Mayo Clinic regimen; 983 patients) over a period of 24 weeks. The primary efficacy end point was at least equivalence in disease-free survival; the primary safety end point was the incidence of grade 3 or 4 toxic effects due to fluoropyrimidines. RESULTS: Disease-free survival in the capecitabine group was at least equivalent to that in the fluorouracil-plus-leucovorin group (in the intention-to-treat analysis, P < 0.001 for the comparison of the upper limit of the hazard ratio with the noninferiority margin of 1.20). Capecitabine improved relapse-free survival (hazard ratio, 0.86; 95 percent confidence interval, 0.74 to 0.99; P=0.04) and was associated with significantly fewer adverse events than fluorouracil plus leucovorin (P< 0.001). CONCLUSIONS: Oral capecitabine is an effective alternative to intravenous fluorouracil plus leucovorin in the adjuvant treatment of colon cancer.

关键词： Ⅲ期结肠癌卡培他滨辅助治疗药物甲酰四氢叶酸尿嘧啶结肠直肠癌一线治疗药物静脉推注无瘤生存率氟嘧啶

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生物碱的生物学及其在植物中的代谢作用

生物碱的生物学及其在植物中的代谢作用

血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂的使用与2019冠状病毒疾病检测阳性之间的关系

作者： G.R.·沃勒(G.R..Waller) E.K.·诺瓦茨基(E.K..nowacki)

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中华高血压杂志 2020年第5期28卷 499-499页

作者： Mehta N KalraA nowacki as Anjewierden S Han Z Bhat p Rubio AEC Jacob M Procop GW Harrington S Milinovich A Svensson LG Jehi L Young JB Chung MK 周卫(译) 叶鹏(校) 不详

血管紧张素转换酶抑制剂(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体拮抗剂(angiotensin receptor blocker,ARB)在2019新型冠状病毒疾病(coronavirus disease 2019,COVID-19)全球大流行背景下的作用备受争议。此... 详细信息

关键词：血管紧张素受体拮抗剂血管紧张素转换酶抑制剂疾病检测冠状病毒 angiotensin 慢性病

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