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Nanoskin®-ACT—The Impact of Natural Membrane & Soft with Chronic and Untreated Wounds

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Natural Nanoskin Advanced Cell Therapy (ACT) and Nanoskin ACT Soft towards the Definitive Solution for Acute and Chronic Wounds

Journal of Biomaterials and Nanobiotechnology（生物材料与纳米技术） 2024年第3期 39页

作者： Saqer Al Mualla noura salim salman Salma Saeed Ns. Nasreen Abdelatif Mohamed Kanjou Gabriel Molina de Olyveira Pierre Basmaji Antônio Carlos Guastaldi

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Journal of Biomaterials and Nanobiotechnology 2023年第2期14卷 35-45页

作者： Saqer Al Mualla noura salim salman Nasreen Abdelatif Salma Al Ketbi Pierre Basmaji Mohamed Kanjou Mirvan Ahmad Qassimi Hospital Sharjah United Arab Emirates Innovatec’s-Biotechnology Research and Development S&#227o Carlos Brazil GEM International Sharjah United Arab Emirate

Natural Nanoskin Advance cell therapy (ACT) and Nanoskin ACT Soft have been established to be remarkably versatile biomaterials and can be used in a wide variety of applied scientific endeavors, especially for medical devices. In fact, the structure of Nanoskin materials can be adapted over length scales ranging from nano to macro by controlling the bio-fabrication process. The present paper describes Natural Nanoskin Advanced cell therapy (ACT) and Nanoskin ACT Soft production for wound care applications. ACT is produced from the bio-nanotechnology process. ACT is a highly hydrated pellicle with shaped fibers less than 2 nm wide. Nanoskin ACT Soft, like a paste, is designed to fill irregularities or recesses in the wound bed, and to absorb excess exudate from lesions by prolonging the used dressing's residence time and reducing the frequency of change.

关键词： Wound Care Diabetic Ulcer Natural Fibers

Special Nanoskin-ACT-Biological Membranes from Deep Wounds

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Journal of Biomaterials and Nanobiotechnology 2018年第1期9卷 79-88页

作者： Saqer Al Mualla Mashael Al Nabooda noura salim salman Pierre Basmaji Gabriel Molina De Olyveira Ligia Maria Manzine Costa Jose Domingos Da Costa Oliveira Gino Bruno Francozo Al Qassimi Hospital/Kuwait Hospital SharjahUnited Arab Emirates Biotechnology Research and Development Sao CarlosBrazil Department of Nanomedicine and Nanotoxicology IFSC-USPSao CarlosBrazil Materials Engineering Department Sao Carlos School of EngineeringUniversity of Sao PauloSao PauloBrazil

Bacterial cellulose (BC) is established as a newest biomaterial, and it can be used for medical and odontology applications. In addition, it has called attention for uses such as membrane for wound care and tissue engineering. In this work, the bacterial cellulose fermentation process is modified by the addition of natural materials before the bacteria are inoculated. In vivo behavior using natural ECM for regenerative medicine is presented and completed wound healing process is 3 months.

关键词： Bacterial Cellulose(Nanoskin^(█))&ACT(Advanced Cell Therapy) Natural Nanocomposites Tissue Engineering

Natural Nanoskin Advanced Cell Therapy (ACT) and Nanoskin ACT Soft towards the Definitive Solution for Acute and Chronic Wounds

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Incidence and predictors of hypocalcemia in end-stage renal disease patients on denosumab therapy: A systematic review and metaanalysis

Journal of Biomaterials and Nanobiotechnology（生物材料与纳米技术） 2023年第2期

作者： Saqer Al Mualla noura salim salman Nasreen Abdelatif Salma Al Ketbi Pierre Basmaji Mohamed Kanjou Mirvan Ahmad

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World Journal of Meta-Analysis 2024年第3期12卷 68-78页

作者： Abdul Hannan Siddiqui Misbah Shaikh Afia salman Muhammad Ahmed Ali Fahim Fizzah Batool Tahreem Mari Sarah Musani Muneeb Fareed Rooma Rehan Amna Hassni Urooj Nizami Ayesha Amir Abdul Moeed salim R Surani Department of Internal Medicine Dow University of Health SciencesKarachi 74200SindhPakistan Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

BACKGROUND Denosumab inhibits the receptor activator of nuclear factor *** markedly increases bone mineral density and has been proven to reduce the risk of ***,numerous adverse effects,notably hypocalcemia,are prevalent in patients with end-stage renal disease(ESRD).AIM To analyze the incidence and predictors of hypocalcemia caused by denosumab compared to control in patients with *** We conducted this study in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses ***,Scopus,Cochrane Central,and EMBASE were systematically searched from inception through March *** original studies investigating the effects of denosumab on patients with ESRD compared to control were *** primary outcomes of our study were the incidence of mild,severe,and very severe *** outcomes included serum levels of intact parathyroid hormone,calcium,and *** results were pooled and analyzed using a random-effects *** Seven articles comprising 3240 patients were included in our *** treated with denosumab had a significantly increased incidence of mild hypocalcemia[risk ratio(RR):2.79;95%confidence interval(CI):0.99-7.91;P=0.05;I²=37%]and of very severe hypocalcemia(RR:9.58;95%CI:1.58-57.98;P=0.01;I²=49%).However,an increase in the occurrence of severe hypocalcemia was non-significant(RR:4.23;95%CI:0.47-38.34;P=0.20;I²=96%).Alternatively,denosumab showed a significant decrease in serum intact parathyroid hormone[mean difference(MD):-433.20,95%CI:-775.12 to-91.28,I2=98%,P=0.01],while there was a non-significant decrease in phosphate(MD:-0.47,95%CI:-1.35 to 0.41,I2=88%,P=0.30)and calcium levels(MD:-0.33,95%CI:-0.95 to 0.29,I2=94%,P=0.29).CONCLUSION Our study demonstrated that denosumab is significantly associated with mild and very severe hypocalcemia in patients with ESRD making it necessary to detect and prevent this side effect of treatment.

关键词： Denosumab End-stage renal disease Hypocalcemia Parathyroid hormone Dialysis

Protective effect of naringenin on acetic acid-induced ulcerative colitis in rats

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World Journal of Gastroenterology 2013年第34期19卷 5633-5644页

作者： salim S Al-Rejaie Hatem M Abuohashish Maher M Al-Enazi Abdullah H Al-Assaf Mihir Y Parmar Mohammed M Ahmed Department of Pharmacology andToxicology College of PharmacyKing Saud University Department of Medical Laboratory Sciences College of Applied Medical SciencesSalman bin Abdulaziz University Department of Science and Nutrition College of Food and Agricultural SciencesKing Saud University

AIM:To evaluate the ameliorative effect of naringenin(NG)during ulcerative colitis(UC)in ***:Rats were treated with three different doses(25,50 and 100 mg/kg per day)of NG and a single dose of mesalazine(MES,300 mg/kg per day)for seven days prior to ulcerative colitis induction by4%acetic acid(AA).Twenty four hours after AA rectal administration,animals were scarified and the colonic tissues were *** mucus content was estimated using Alcian blue dye binding *** colon tissues,levels of total glutathione sulphadryls(T-GSH),non-protein sulphadryls(NP-SH)and thiobarbituric acid reactive substances(TBARS)were *** activities of the antioxidant enzymes,catalase(CAT)and superoxide dismutase(SOD)were *** of nucleic acids(DNA and RNA)and total protein were also estimated in colon *** levels of tumor necrosis factor-(TNF-),interleukin-1(IL-1),interleukin-6(IL-6),prostaglandin E2(PGE2)and nitric oxide(NO)were *** cross section of colitis tissue the histopathological changes were ***:Colonic mucus content was decreased in AA compared to controls(587.09±65.59 mg/kg vs941.78±68.41 mg/kg,P<0.001).AA administration markedly reduced T-GSH(5.25±0.37 nmol/L vs 3.04±0.24 nmol/L,P<0.01),NP-SH(3.16±0.04 nmol/L vs 2.16±0.30 nmol/L,P<0.01),CAT(6.77±0.40 U/mg vs 3.04±0.2 U/mg,P<0.01)and SOD(3.10±0.11U/mg vs 1.77±0.18 U/mg,P<0.01)while TBARS,TNF-,IL-1,IL-6,PGE2 and NO levels(15.09±3.84nmol/L vs 59.90±16.34 nmol/L,P<0.01;113.56±1.91 pg/mg vs 134.24±4.77 pg/mg,P<0.01;209.20±36.38 pg/mg vs 422.19±31.47 pg/mg,P<0.01;250.83±25.09 pg/mg vs 638.58±115.9 pg/mg,P<0.01;248.19±36.98 pg/mg vs 541.74±58.34 pg/mg,P<0.01 and 81.26±2.98 mmol/g vs 101.90±10.73 mmol/g,P<0.001)were increased in colon of rats with UC compared controls *** supplementation,significantly and dose dependently increased the colonic mucus *** elevated TBARS levels were significantly decreased(39.35±5.86nmol/L,P<0

关键词： Naringenin Ulcerative colitis Inflammatory bowel disease Oxidative stress