检索结果-南通市图书馆

An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads:Experimental studies and molecular dynamics analysis

引用

Acta Pharmaceutica Sinica B 2024年第6期14卷 2669-2684页

作者： Jamie Anne Lugtu-Pe Xuning Zhang Sako Mirzaie Hao Han R.Chang nour al-mousawi Kuan Chen Yongqiang Li Anil Kane Daniel Bar-Shalom Xiao Yu Wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoToronto M5S 3M2Canada Candoo Pharmatech Company Inc. Mississauga L5N 5M1Canada Department of Pharmacy University of CopenhagenCopenhagen DK-2100Denmark Patheon by Thermo Fisher Scientific Toronto Region Operations(TRO)Mississauga L5N 3X4Canada

Solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution ***,most new chemical entities exhibit poor water solubility,and hence are exempt from such *** combining drug amorphization with controlled release formulation is promising to elevate drug solubility,like other supersaturating systems,the problem of drug recrystallization has yet to be resolved,particularly within the dosage ***,we explored the potential of an emerging,non-leachable terpolymer nanoparticle(TPN)pore former as an internal recrystallization inhibitor within controlled release amorphous solid dispersion(CRASD)beads comprising a poorly soluble drug(celecoxib)reservoir and insoluble polymer(ethylcellulose)*** to conventional pore former,polyvinylpyrrolidone(PVP),TPN-containing membranes exhibited superior structural integrity,less crystal formation at the CRASD bead surface,and greater extent of celecoxib ***-atom molecular dynamics analyses revealed that in the presence of TPN,intra-molecular bonding,crystal formation tendency,diffusion coefficient,and molecular flexibility of celecoxib were reduced,while intermolecular H-bonding was increased as compared to *** work suggests that selection of a pore former that promotes prolonged molecular separation within a nanoporous controlled release membrane structure may serve as an effective strategy to enhance amorphicity preservation inside CRASD.

关键词： Controlled release amorphous solid dispersion Poorly soluble drug Internal recrystallization Membrane-reservoir coated beads Molecular dynamics simulation Effect of pore formers Terpolymer nanogel Drug-polymer interactions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Feature extraction for machine learning-based intrusion detection in IoT networks

引用

Digital Communications and Networks 2024年第1期10卷 205-216页

作者： Mohanad Sarhan Siamak Layeghy nour Moustafa Marcus Gallagher Marius Portmann University of Queensland BrisbaneQLD4072Australia University of New South Wales CanberraACT2612Australia

A large number of network security breaches in IoT networks have demonstrated the unreliability of current Network Intrusion Detection Systems(NIDSs).Consequently,network interruptions and loss of sensitive data have occurred,which led to an active research area for improving NIDS *** an analysis of related works,it was observed that most researchers aim to obtain better classification results by using a set of untried combinations of Feature Reduction(FR)and Machine Learning(ML)techniques on NIDS ***,these datasets are different in feature sets,attack types,and network ***,this paper aims to discover whether these techniques can be generalised across various *** ML models are utilised:a Deep Feed Forward(DFF),Convolutional Neural Network(CNN),Recurrent Neural Network(RNN),Decision Tree(DT),Logistic Regression(LR),and Naive Bayes(NB).The accuracy of three Feature Extraction(FE)algorithms is detected;Principal Component Analysis(PCA),Auto-encoder(AE),and Linear Discriminant Analysis(LDA),are evaluated using three benchmark datasets:UNSW-NB15,ToN-IoT and *** PCA and AE algorithms have been widely used,the determination of their optimal number of extracted dimensions has been *** results indicate that no clear FE method or ML model can achieve the best scores for all *** optimal number of extracted dimensions has been identified for each dataset,and LDA degrades the performance of the ML models on two *** variance is used to analyse the extracted dimensions of LDA and ***,this paper concludes that the choice of datasets significantly alters the performance of the applied *** believe that a universal(benchmark)feature set is needed to facilitate further advancement and progress of research in this field.

关键词： Feature extraction Machine learning Network intrusion detection system IoT

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Privacy-preserved learning from non-i.i.d data in fog-assisted IoT:A federated learning approach

引用

Digital Communications and Networks 2024年第2期10卷 404-415页

作者： Mohamed Abdel-Basset Hossam Hawash nour Moustafa Imran Razzak Mohamed Abd Elfattah Faculty of Computers and Informatics Zagazig UniversityZagazigSharqiyah44519Egypt School of Engineering and Information Technology University of New South Wales@ADFACanberraACT2600Australia Deakin University Geelong Waurn Ponds CampusAustralia Computer Science Department Misr Higher Institute for Commerce and ComputersMansoura35511Egypt

With the prevalence of the Internet of Things(IoT)systems,smart cities comprise complex networks,including sensors,actuators,appliances,and cyber *** complexity and heterogeneity of smart cities have become vulnerable to sophisticated cyber-attacks,especially privacy-related attacks such as inference and data poisoning *** Learning(FL)has been regarded as a hopeful method to enable distributed learning with privacypreserved intelligence in IoT *** though the significance of developing privacy-preserving FL has drawn as a great research interest,the current research only concentrates on FL with independent identically distributed(i.i.d)data and few studies have addressed the non-i.i.d *** is known to be vulnerable to Generative Adversarial Network(GAN)attacks,where an adversary can presume to act as a contributor participating in the training process to acquire the private data of other *** paper proposes an innovative Privacy Protection-based Federated Deep Learning(PP-FDL)framework,which accomplishes data protection against privacy-related GAN attacks,along with high classification rates from non-i.i.d ***-FDL is designed to enable fog nodes to cooperate to train the FDL model in a way that ensures contributors have no access to the data of each other,where class probabilities are protected utilizing a private identifier generated for each *** PP-FDL framework is evaluated for image classification using simple convolutional networks which are trained using MNIST and CIFAR-10 *** empirical results have revealed that PF-DFL can achieve data protection and the framework outperforms the other three state-of-the-art models with 3%–8%as accuracy improvements.

关键词： Privacy preservation Federated learning Deep learning Fog computing Smart cities

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Perception of dental appearance and aesthetic analysis among patients,laypersons and dentists

引用

World Journal of Clinical Cases 2024年第23期12卷 5354-5365页

作者： alhanoof aldegheishem Hadeel Mohammed alfayadh Munirah alDossary Shahad Asaad Elzahraa Eldwakhly nour al Huda al Refaei Dana alsenan Mai Soliman Department of Clinical Dental Sciences College of DentistryPrincess Nourah Bint Abdulrahman UniversityRiyadh 11671Saudi Arabia Department of Oral Medicine and Pathology Ministry of HealthRiyadh 11176Saudi Arabia Department of Prosthodontics Ministry of HealthRiyadh 11176Saudi Arabia Department of Pediatric Ministry of HealthRiyadh 11176Saudi Arabia

BACKGROUND Current concepts of beauty are increasingly subjective,influenced by the viewpoints of *** aim of the study was to evaluate divergences in the perception of dental appearance and smile esthetics among patients,laypersons and dental *** study goals were to evaluate the influence of age,sex,education and dental specialty on the participants’judgment and to identify the values of different esthetic *** sample included 50 patients who responded to a dental appearance questionnaire(DAQ).Two frontal photographs were taken,one during a smile and one with retracted *** and dentists were asked to evaluate both photographs using a Linear Scale from(0-10),where 0 represent(absolutely unaesthetic)and 10 represent(absolutely aesthetic).One-way analysis of variance(ANOVA)and t-test analysis were measured for each *** patients in the sample expressed satisfaction with most aspects of their smiles and dental *** laypersons(including 488 participants),47 pictures“with lips”out of 50 had higher mean aesthetic scores compared to pictures“without lips”.Among the dentist sample,90 dentists’perception towards the esthetic smile and dental appearance for photos“with lips”and“without lips”were the same for 23 out of 50 *** of smile aesthetics differed between patients,laypersons and *** factors can contribute to shape the perception of smile *** To compare the perception of dental aesthetic among patients,laypersons,and professional dentists,to evaluate the impact of age,sex,educational background,and income on the judgments made by laypersons,to assess the variations in experience,specialty,age,and sex on professional dentists’judgment,and to evaluate the role of lips,skin shade and tooth shade in different participants’*** Patients sample included 50 patients who responded to *** frontal photographs were taken:one during a smile and one with retracted lip

关键词： Aesthetic perception Laypersons Dental appearance Dentists Smile analysis Dental aesthetic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemically Mediated Interactions between Grapevine, Aphid, Ladybird, and Ant in the Context of Insect Chemical Ecology

引用

Phyton-International Journal of Experimental Botany 2024年第7期93卷 1523-1542页

作者： Taghreed alsufyani noura J.alotaibi nour Houda M’sakni Mona A.almalki Eman M.alghamdi Department of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Biology College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Chemistry Department Faculty of ScienceKing AbdulAziz UniversityP.O.Box 80200Jeddah21589Saudi Arabia

This study simpliﬁes the complex relationship among grapevine plants,aphids,ladybirds,and ants,which is essential for effective pest management and ecological *** study investigated the impact of aphid attacks and the presence of ants and ladybirds on the volatile compounds proﬁle released into the chemosphere of the community consisting of the common vine Vitis vinifera,the aphid Aphis illinoisensis,the ladybird Cocci-nella undecimpunctata-and the ant Tapinoma *** study aims to analyze the volatile compounds emitted by the grapevine and surrounding insects in response to these intricate *** extraction of volatile organic compounds(VOCs)was carried out using closed-loop stripping(CLS)and then analyzed via gas chromatography-mass spectrometry(GC-MS)and principles coordinated analysis(PCA)was *** grapevine was exposed to different types and order of treatments,including non-infested,aphid-infested,aphid-infested with ant,aphid-infested with ladybird,and various combinations of ant and *** the aphid attack,the outcomes uncovered massive alterations in the volatile compound proﬁ*** grapevine displayed distinct emissions of germacrene D,an alcohol,and an alkene compared to non-infested *** characteristic VOC proﬁle was the share of infested grapes in the presence of ants,with benzene derivatives and sesquiterpenes dominating the *** coexistence of ladybirds with ants and aphids resulted in a dif-ferent volatile proﬁle characterized by elevated levels of aldehydes,ketones,α-farnesene,and its hydroxy *** was concluded that the emission of VOCs into the chemosphere of the grapevine communities varied qualitatively and quantitatively depending on the level of the relationship complexity within each community in response to the infestation of grapevines by aphids,the presence of ladybirds as natural predators,and the presence of ant as *** grapevine’s status-dependent compounds

关键词： Aphids Aphis illinoisensis volatile organic compounds chemosphere pest management gas chromatography-mass spectrometry closed-loop stripping

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dissolved Organic Matter Features of Three Adjacent Eastern Mediterranean Urbanized Watersheds

引用

Open Journal of Modern Hydrology 2024年第3期14卷 153-173页

作者： nour Abboud Elias Michel Maatouk Zeinab Matar Veronique Kazpard Research and Analysis Platform for Environmental Sciences (PRASE) Doctoral School of Sciences and Technology (EDST) The Lebanese University Rafic Hariri Campus Hadat Lebanon Laboratory of Georessources Geosciences and Environment (L2GE) Faculty of Sciences The Lebanese University Fanar Lebanon Department of Earth and Life Sciences Faculty of Sciences The Lebanese University Hadat Lebanon

Landscape urbanization broadly affects ecosystems in coastal watersheds, but, until now, the influence of nonpoint source urban inputs on dissolved organic matter (DOM) amount, composition, and source is poorly understood. To understand how DOM composition varied with urbanization, fluorescence excitation-emission matrices (EEMs) were determined for urban and non-urban waters from upstream to downstream sites along three adjacent coastal watersheds that flow into the Mediterranean Sea. Two humic DOM fluorescent components (humic-like and fulvic-like peaks) and two proteinic components (tyrosine-like and tryptophane-like peaks) were identified by EEM fluorescence. The results indicated that urbanization had an important influence on DOM concentration and composition, with urban waters having a high degree of DOM variation due to different land uses surrounding each body of water. Urban waters show a higher DOM fluorescence index (FI), the highest fluorescence intensity of protein-like manifested also by BIX values, and a lower value of the humification index (HIX) than non-urban waters which were dominated by allochthonous inputs. In addition, the EEM was compared in dry and wet season where higher DOM amounts and FI appeared in summer due to autochthonous production coming from algae growth compared to allochthonous input from rainfall dominated in wet season. The concentration of DOC increased from upstream to downstream for the three rivers, especially Beirut River. The increase in DOC values was observed in both dry and wet seasons by 39 and 19 times respectively compared to upstream (0.93 - 0.91 mgC/L).

关键词： Dissolved Organic Matter DOM EEM Fluorescence Spectroscopy Autochthonous/allochthonous DOM Urbanization Upstream/Downstream Wet/Dry Season

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surface Water Processes in Coping with Anthropogenic Impact in a Coastal Eastern Mediterranean Region

引用

Open Journal of Modern Hydrology 2024年第2期14卷 69-86页

作者： nour Abboud Zeinab Matar Elias Maatouk Véronique Kazpard Research and Analysis Platform for Environmental Sciences (PRASE) Doctoral School of Sciences and Technology (EDST) Lebanese University Hadat Lebanon Laboratory of Georessources Geosciences and Environment (L2GE) Faculty of Sciences Lebanese University Fanar Lebanon Department of Earth and Life Sciences Faculty of Sciences Lebanese University Hadat Lebanon

Rivers are progressively being exposed to increased anthropogenic pollution stresses that are undermining their designated uses and affecting sensitive coastal areas. In this study, three adjacent eastern Mediterranean coastal rivers, Ibrahim, Kaleb and Beirut, were evaluated. Water quality samples were collected in dry and wet seasons from different sampling sites along the river from the source to the outlet which represent a gradient of increased urbanization. The spatiotemporal variability of the physio-chemical properties, heavy metals (Zn, Pb, Cu, Cr, and Cd) and organic matter (DOC) were statistically analyzed to better understand the contribution of point and nonpoint pollution sources. The three rivers (Beirut, Kaleb and Ibrahim) show a similar behavior in calcium and carbonate alkalinity due to the carbonate mineral weathering effect, so they are of calcium bicarbonate type due to their calcareous geological nature. The speciation of anions was affected by temporal variation. Moreover, it is obvious that the Beirut River has a different behavioral characteristic where the water is a sulfate type water with a preferable metal-OM complexation mainly with lead, zinc and copper, whereas Kaleb and Ibrahim are considered to be of a nitrate phosphate type with a preferable metal inorganic complexation, especially copper, that has a consistent behavior in both types of waters. This difference is attributed to the urbanization effect highly impacting the Beirut River.

关键词： Anions/Cations Metals DOC Complexation Coastal Rivers Spatiotemporal Variability

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Building Custom Spreadsheet Functions with Python: End-User Software Engineering Approach

引用

Journal of Software Engineering and Applications 2024年第5期17卷 246-258页

作者： Tamer Bahgat Elserwy Atef Tayh nour El-Din Raslan Tarek ali Mervat H. Gheith Department of Software Engineering Faculty of Graduate Studies for Statistical Research (FGSSR) Cairo University Giza Egypt Department of Information Systems Higher Institute of Advanced Studies Giza Egypt

End-user computing empowers non-developers to manage data and applications, enhancing collaboration and efficiency. Spreadsheets, a prime example of end-user programming environments widely used in business for data analysis. However, Excel functionalities have limits compared to dedicated programming languages. This paper addresses this gap by proposing a prototype for integrating Python’s capabilities into Excel through on-premises desktop to build custom spreadsheet functions with Python. This approach overcomes potential latency issues associated with cloud-based solutions. This prototype utilizes Excel-DNA and IronPython. Excel-DNA allows creating custom Python functions that seamlessly integrate with Excel’s calculation engine. IronPython enables the execution of these Python (CSFs) directly within Excel. C# and VSTO add-ins form the core components, facilitating communication between Python and Excel. This approach empowers users with a potentially open-ended set of Python (CSFs) for tasks like mathematical calculations, statistical analysis, and even predictive modeling, all within the familiar Excel interface. This prototype demonstrates smooth integration, allowing users to call Python (CSFs) just like standard Excel functions. This research contributes to enhancing spreadsheet capabilities for end-user programmers by leveraging Python’s power within Excel. Future research could explore expanding data analysis capabilities by expanding the (CSFs) functions for complex calculations, statistical analysis, data manipulation, and even external library integration. The possibility of integrating machine learning models through the (CSFs) functions within the familiar Excel environment.

关键词： End-User Software Engineering Custom Spreadsheet Functions (CSFs)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enhancing Data Analysis and Automation: Integrating Python with Microsoft Excel for Non-Programmers

引用

Journal of Software Engineering and Applications 2024年第6期17卷 530-540页

作者： Osama Magdy ali Mohamed Breik Tarek aly Atef Tayh nour El-Din Raslan Mervat Gheith Software Engineering Department Faculty of Graduate Studies for Statistical Research Cairo University Giza Egypt

Microsoft Excel is essential for the End-User Approach (EUA), offering versatility in data organization, analysis, and visualization, as well as widespread accessibility. It fosters collaboration and informed decision-making across diverse domains. Conversely, Python is indispensable for professional programming due to its versatility, readability, extensive libraries, and robust community support. It enables efficient development, advanced data analysis, data mining, and automation, catering to diverse industries and applications. However, one primary issue when using Microsoft Excel with Python libraries is compatibility and interoperability. While Excel is a widely used tool for data storage and analysis, it may not seamlessly integrate with Python libraries, leading to challenges in reading and writing data, especially in complex or large datasets. Additionally, manipulating Excel files with Python may not always preserve formatting or formulas accurately, potentially affecting data integrity. Moreover, dependency on Excel’s graphical user interface (GUI) for automation can limit scalability and reproducibility compared to Python’s scripting capabilities. This paper covers the integration solution of empowering non-programmers to leverage Python’s capabilities within the familiar Excel environment. This enables users to perform advanced data analysis and automation tasks without requiring extensive programming knowledge. Based on Soliciting feedback from non-programmers who have tested the integration solution, the case study shows how the solution evaluates the ease of implementation, performance, and compatibility of Python with Excel versions.

关键词： Python End-User Approach Microsoft Excel Data Analysis Integration Spreadsheet Programming Data Visualization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Indirect Water Consumption:The Scope 3 of Water?Estimation of This Indicator in Sectors Relying on Agriculture

引用

Journal of Environmental Science and Engineering(A) 2024年第3期13卷 77-85页

作者： Grégory Schneider-Maunoury nour Emam Maria Fernanda Estrada Cabeza de Vaca Anass Fathi Ricardo Henao Martinez Kahan Korkmaz Omar Mghaieth Christianah Ramanalinjatovo Syrine Saidi Department of Economics and Management UniversitéSorbonne Paris Nord99 Av.Jean Baptiste ClémentVilletaneuse 93430France

The aim of this research project is to assess indirect water consumption,that represents the water consumed in the upstream part of the production life *** are provided for agriculture related companies,as agriculture represents 70%of water consumption on *** consumption varies greatly according to the countries where supply chain is *** estimation is attempted for 27 European listed companies in sectors relying on agriculture in its supply chain.A data is estimated for 22 companies,showing that indirect water consumption is much more important than direct *** questions raised through the estimation of indirect water consumption in various subsectors show the interest in this data,which represents the equivalent of Carbon Scope 3 for water issues.

关键词： Water consumption water footprint financial materiality impact materiality sustainability reporting

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：