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Associations between Vitamin D and Type 2 Diabetes Mellitus: The Role of Vitamin D Receptor and Binding Protein

Journal of Diabetes Mellitus 2020年第4期10卷 222-235页

作者： Eman S. Arafat Inass M. Taha Shahad W. Kattan nouf abubakr babteen Iman Fawzy Medical Biochemistry and Molecular Biology Departement Faculty of Medicine Menoufia University Al-Minufya Egypt Medicine Department College of Medicine Taibah University Medina KSA Medical Laboratory Department College of Applied Medical Science Taibah University Yanbu KSA Biochemistry Department Faculty of Science University of Jeddah Jeddah KSA Mansoura Central Laboratories Ministry of Health Mansoura Egypt

Background: Type 2 diabetes mellitus (T2DM) is a chronic disease that is characterized by β-cell dysfunction and resistance for insulin. Vitamin D is necessary for insulin secretion so it is a crucial factor in the development of T2DM. This study was done to investigate the association between serum 25-hydroxy Vitamin D [25(OH)3D], VDR (Vitamin D receptor) and VDBP (Vitamin D binding protein) with type 2 diabetic patients compared to control subjects. Subjects and Methods: This study carried out 110 female patients who were previously diagnosed with type 2 diabetes and 110 age, sex and weight matched as controls. All participants were subjected to full history taking, clinical examination and assessment of fasting blood glucose, HbA1c , lipid profile, 25-hydroxy Vitamin D [25(OH)3D], VDR and VDBP. Results: Results showed that the level of 25(OH)3D was significantly lower in diabetic group compared to controls and was significantly negatively correlated with glycated hemoglobin, serum total cholesterol and low density lipoprotein cholesterol in type 2 DM. Decreasing Vitamin D level was significantly associated with decreasing VDR. No significant association was found between Vit D and VDBP levels. Conclusions: Vitamin D deficiency is frequent in diabetic patients and associated with poor control and outcome. This suggests a role of Vitamin D in the pathogenesis and control of T2DM. Serum VDBP in diabetes may be independent to the level of 25(OH)3D and needs further studies.

关键词： Diabetes Mellitus Type 2 25-Hydroxy Vitamin D Vitamin D Receptor Vitamin D Binding Protein

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