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Activated Pro.ein C Resistance in Patients with Pre-Eclampsia in Lago., Nigeria

o.en Jo.rnal o. o.stetrics and Gyneco.o.y 2024年第4期14卷 575-590页

作者： nosimot o. da.ies Titilo.e A. Adeyemo.Sunday I. o.isakin Akaninyene A. Udo.so.o.Kabiru A. Rabiu Department o. Haemato.o.y and blo.d Transfusio. College of Medicine University of Lagos Lagos Nigeria Department o. o.stetrics and Gynaeco.o.y College of Medicine University of Lagos Lagos Nigeria Department o. o.stetrics and Gynaeco.o.y Lagos State University Teaching Hospital Lagos Nigeria Department o. o.stetrics and Gynaeco.o.y College of Medicine Lagos State University Lagos Nigeria

Backgro.nd: Preeclampsia is repo.ted to.co.plicate 2% - 8% o. pregnancies glo.ally and is an impo.tant cause o. maternal and perinatal mo.bidity and mo.tality. The aetio.o.y and patho.enesis are still po.rly understo.d and substantial impro.ement has no. been made in the predictio., preventio. and treatment o. the disease. o.jective: To.co.pare the frequency o. activated pro.ein C resistance (APC-R) in patients with pre-eclampsia to.that o. no.mo.ensive pregnant wo.en and to.determine the co.relatio. between activated pro.ein ratio.(APC-ratio. and the severity o. pre-eclampsia. Metho.o.o.y: A cro.s-sectio.al study was carried o.t in 100 pre-eclamptic patients and 100 no.mo.ensive pregnant co.tro.s. The APC-ratio.was determined using the mo.ified activated partial thro.bo.lastin time. Study participants with APC-ratio.o. less than 2.0 were defined as having APC-R. data was analyzed using SPSS versio. 22.0. Results: Mean APC-ratio.was significantly lo.er in pre-eclamptics (2.89 ± 1.70) co.pared to.no.mo.ensive pregnant wo.en (3.57 ± 1.06) (p = 0.0008) and the levels were also.higher in mild (2.95 ± 1.15) co.pared to.severe pre-eclamptics (2.62 ± 1.14). The frequency o. APC-R was 26% amo.g wo.en with pre-eclampsia co.pared to.4% amo.g no.mo.ensive co.tro.s (p = 0.000). Amo.g 100 pre-eclamptic wo.en 7 (21.2%) o.t o. 33 with mild pre–eclampsia had APC-R, while 19 (28.4%) o.t o. 67 with severe pre-eclampsia had APC-R. APC-ratio.had a significant negative co.relatio. with mean arterial blo.d pressure (r = −0.324;p = 0.000) and pro.einuria (r = −0.379;p = 0.000) amo.g study participants. Co.clusio.: The frequency o. activated pro.ein c resistance is significantly higher in pre-eclamptics co.pared to.no.mo.ensive pregnant wo.en and this is mo.e pro.o.nced in tho.e with severe pre-eclampsia co.pared with tho.e with mild disease. APC-R may therefo.e be used as a marker o. severity in the disease.

关键词： Activated Pro.ein C Resistance Activated Pro.ein C Ratio Pre-Eclampsia

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