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finDr:A web server for in silico D-peptide ligand identification

Synthetic and Systems Biotechnology 2021年第4期6卷 402-413页

作者： Helena Engel Felix Guischard Fabian Krause Janina Nandy Paulina Kaas Nico Hofflin Maja Kohn normann kilb Karsten Voigt Steffen Wolf Tahira Aslan Fabian Baezner Salom´e Hahne Carolin Ruckes Joshua Weygant Alisa Zinina Emir Bora Akmeriç Enoch B.Antwi Dennis Dombrovskij Philipp Franke Klara L.Lesch Niklas Vesper Daniel Weis Nicole Gensch Barbara Di Ventura Mehmet Ali Oztürk Signalling Research Centres BIOSS and CIBSS University of FreiburgSchanzlestr.1879104FreiburgGermany Institute of Biology III Faculty of BiologyUniversity of FreiburgSchanzlestr.179104FreiburgGermany Institute of Biology II Faculty of BiologyUniversity of FreiburgSchanzlestr.179104FreiburgGermany AG Roth-Lab for MicroarrayCopying ZBSA-Centre for Biological Systems AnalysisUniversity of FreiburgHabsburgerstrasse 4979104FreiburgGermany Biomolecular Dynamics Institute of PhysicsUniversity of FreiburgHermann-Herder-Strasse 3a79104FreiburgGermany Core Facility Signalling Factory Centre for Biological Signaling Studies(BIOSS)University of FreiburgSchanzlestr.1879104FreiburgGermany Spemann Graduate School of Biology and Medicine(SGBM) University of FreiburgAlbertstraße 19A79104FreiburgGermany Internal Medicine IV Department of MedicineMedical CenterUniversity of FreiburgHugstetter Straße 5579106FreiburgGermany Institute for Biochemistry University of FreiburgAlbertstr.2179104FreiburgGermany

In the rapidly expanding field of peptide therapeutics,the short in vivo half-life of peptides represents a considerable limitation for drug action.D-peptides,consisting entirely of the dextrorotatory enantiomers of naturally occurring levorotatory amino acids(AAs),do not suffer from these shortcomings as they are intrinsically resistant to proteolytic degradation,resulting in a favourable pharmacokinetic *** experimentally identify D-peptide binders to interesting therapeutic targets,so-called mirror-image phage display is typically performed,whereby the target is synthesized in D-form and L-peptide binders are screened as in conventional phage *** technique is extremely powerful,but it requires the synthesis of the target in D-form,which is challenging for large *** we present finDr,a novel web server for the computational identification and optimization of D-peptide ligands to any protein structure(https://***/).finDr performs molecular docking to virtually screen a library of helical 12-mer peptides extracted from the RCSB Protein Data Bank(PDB)for their ability to bind to the *** a separate,heuristic approach to search the chemical space of 12-mer peptides,finDr executes a customizable evolutionary algorithm(EA)for the de novo identification or optimization of D-peptide *** a proof of principle,we demonstrate the validity of our approach to predict optimal binders to the pharmacologically relevant target phenol soluble modulin alpha 3(PSMα3),a toxin of methicillin-resistant Staphylococcus aureus(MRSA).We validate the predictions using in vitro binding assays,supporting the success of this *** to conventional methods,finDr provides a low cost and easy-to-use alternative for the identification of D-peptide ligands against protein targets of choice without size *** believe finDr will facilitate D-peptide discovery with implications in biotechnology and biomedicine.

关键词： D-peptide Web server Evolutionary algorithm Peptide design Molecular docking Mirror-image phage display

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How forest edge-center transitions in the herb layer interact with beech dominance versus tree diversity

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Journal of Plant Ecology 2016年第5期9卷 498-507页

作者： Claudia normann Teja Tscharntke Christoph Scherber Department of Crop Sciences University of GöttingenGrisebachstraße 637077 GöttingenGermany Institute of Landscape Ecology University of MünsterHeisenbergstraße 248149 MünsterGermany

Aims Forest fragmentation and the associated augmentation of forest edge zones are increasing *** edges are characterized by altered plant species richness and community *** the tree layer and its species composition has been shown to influence herb layer composition,changes in tree species composition or richness may weaken or strengthen edge effects in forest *** studied effects of the edge-center transition,tree species composition and their potential interaction on the understory vegetation in the Hainich National Park,Germany’s largest connected deciduous forest,allowing to cover large edge-center *** We established 12 transects in an area of 75 km^(2) of continuous forest,6 beech-dominated and 6 in multispecies forest *** transect reached from the forest edge up to 500 m into the forest *** relevés were conducted in regular,logarithmic distances along each *** Findings Herb species richness was influenced by an interaction of edge effects and tree diversity *** increasing distance from the forest edge,herb species richness remained constant in multispecies forest stands but rapidly decreased in beech-dominated forest ***,herb richness was higher in the interior of multispecies forest *** forest specialists increased and percent generalists decreased with distance from the edge and this contrasting pattern was much more pronounced in beech-dominated *** using structural equation modeling,we identified litter depth mediated by tree species composition as the most important driver of herb layer plant species richness.

关键词： community composition Fagus sylvatica functional groups habitat specialists and generalists litter depth tree diversity

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Association of autoimmune hepatitis and systemic lupus erythematodes:A case series and review of the literature

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World Journal of Gastroenterology 2014年第35期20卷 12662-12667页

作者： Claudia Beisel Christina Weiler-normann Andreas Teufel Ansgar W Lohse Department of Internal Medicine University Medical Center Hamburg-Eppendorf Department of Internal Medicine Johannes Gutenberg Universit?t Mainz Department of Internal Medicine University Hospital Regensburg

Liver test abnormalities have been described in up to 60% of patients with systemic lupus erythematodes(SLE) at some point during the course of their *** treatment with potentially hepatotoxic drugs or viral hepatitis is commonly considered to be the main cause of liver disease in SLE ***,in rare cases elevated liver enzymes may be due to concurrent autoimmune hepatitis(AIH).To distinguish whether the patient has primary liver disease with associated autoimmune clinical and laboratory features resembling SLE- such as AIH- or the elevation of liver enzymes is a manifestation of SLE remains a difficult challenge for the treating ***,we present six female patients with complex autoimmune disorders and *** charts were reviewed in order to investigate the complex relationship between SLE and *** patients had coexisting autoimmune disease in their medical *** the time of diagnosis of AIH,patients presented with arthralgia,abdominal complaints,cutaneous involvement and fatigue as common *** patients fulfilled the current diagnostic criteria of both,AIH and *** of acute hepatitis was achieved in all cases after the initiation of immunosuppressive *** addition to this case study a literature review was conducted.

关键词： Systemic lupus erythematodes Elevated liver enzymes Autoimmune hepatitis

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在热稀释基础上设计的一种连续测量心输出量的计算机

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北京生物医学工程 1989年第4期8卷 241-245页

作者： R. A normann 凤琪

心输出量，即心脏每分钟泵出的血量，它是表明心脏功能的基本参数，在监护室中，一般是再常规的热稀释法对大多数病人进行这项主要参数的测定。由于常规方法工作量大，测量的准确性和重复性较差，因此作者研制了这台用于测量心输出量的... 详细信息

心输出量，即心脏每分钟泵出的血量，它是表明心脏功能的基本参数，在监护室中，一般是再常规的热稀释法对大多数病人进行这项主要参数的测定。由于常规方法工作量大，测量的准确性和重复性较差，因此作者研制了这台用于测量心输出量的仪器，控制此仪器的微机在热稀释原理的基础上可以逐分钟地测量心输出量，通过缠绕在热稀导管表面的电热元件热量传递到血液中，使肺动脉血温瞬时增高，在模拟循环管路对此仪器的进行了实验，并用于狗长达13小时，在流量测定的准确性和可重复性方面把它与常规监测系统进行了比较，这项研究表明，仅用一台心输出量计算机就可以方便地连续测定血流量而不需特殊的技术人员。

关键词：热稀释设计连续测量心输出量计算机

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Social Work in Light of Jane Addams

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Sociology Study 2017年第4期7卷 223-233页

作者： Tone Eldcen Brit Jφrgensen Sofie normann Laila Granli Aamodt Pedagogic Psychological Service Norway Center for Child and Adolescent Mental Health Norway Bodφ Family Counseling Norway Outpatient Clinic for Child and Adolescent Mental Health Norway

Classics of literature and science may characteristically be read anew outside their time and interest area, giving birth to new insights, lane Addams is one such classic author. Her writings can be read as classic texts that educate readers in the discipline of social work, among other things. Her impact on the beginnings of modern social work is foundational. She contributed to radical changes on basis of thought, understanding, and practice in the field. Many have read her texts and written about her, resulting in multiple perspectives. The authors will highlight some relevant areas ripe to be re-examined in our time.

关键词： Social work history migration democracy tacit knowledge narratives

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设计是一场恋爱

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设计 2016年第22期29卷 46-51页

作者： xiao normann Copenhagen(图)

如果你问波尔？麦德森,他会这样解释：“情况必须使这样的,我们看着产品,心想‘这东西真特别,我们之前从来没见过’.设计真正的特别之处来源于设计流程的各个部分.有时候,产品的功能很独特,有时候,产品的材质很新颖,有时候,产品的外形... 详细信息

如果你问波尔？麦德森,他会这样解释：“情况必须使这样的,我们看着产品,心想‘这东西真特别,我们之前从来没见过’.设计真正的特别之处来源于设计流程的各个部分.有时候,产品的功能很独特,有时候,产品的材质很新颖,有时候,产品的外形很吸引人.甚至可能只是两个元素的结合或者类似的小感觉.一般来说,我喜欢线条简洁、风格简约的设计.

关键词：设计流程产品

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极简温情

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现代装饰（家居） 2011年第2期 50-53页

作者： normann Copenhagen 肖俊

对北欧人来说,工作或玩乐都不足以取代家庭的重要,在他们的一天24小时里,"家"占据了最大的一部分。于是,他们不追求名牌、名车,也不沉迷于工作成就;相反的,一些充满独特巧思,与生活息息相关的用品,才是他们觉得不可或缺的。来自丹麦哥... 详细信息

对北欧人来说,工作或玩乐都不足以取代家庭的重要,在他们的一天24小时里,"家"占据了最大的一部分。于是,他们不追求名牌、名车,也不沉迷于工作成就;相反的,一些充满独特巧思,与生活息息相关的用品,才是他们觉得不可或缺的。来自丹麦哥本哈根的设计公司normann Copenhagen就非常能表达出这样的生活态度。它的品牌精神为"Less is more"。

关键词：丹麦哥本哈根北欧人品牌精神几何形状工作成就色彩缤纷开罐传统手工艺厨房用品现代感

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