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Evaluation of Unified Model Microphysics in High-resolution NWP Simulations Using Polarimetric Radar Observations

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Advances in Atmospheric Sciences 2018年第7期35卷 771-784页

作者： Marcus JOHNSON Youngsun JUNG Daniel DAWSON Timothy SUPINIE Ming XUE Jongsook PARK Yong-Hee lee center for Analysis and Prediction of Storms (cAPS) University of Oklahoma Norman OK 73072 USA School of Meteorology University of Oklahoma Norman OK 73072 USA Purdue University West Lafayette IN 47907 USA Korea Meteorological Administration Seoul 07062 Korea

The UK Met Office Unified Model（UM） is employed by many weather forecasting agencies around the globe. This model is designed to run across spatial and time scales and known to produce skillful predictions for large-scale weather systems. However, the model has only recently begun running operationally at horizontal grid spacings of ～1.5 km [e.g.,at the UK Met Office and the Korea Meteorological Administration（KMA）]. As its microphysics scheme was originally designed and tuned for large-scale precipitation systems, we investigate the performance of UM microphysics to determine potential inherent biases or weaknesses. Two rainfall cases from the KMA forecasting system are considered in this study： a changma（quasi-stationary） front, and Typhoon Sanba（2012）. The UM output is compared to polarimetric radar observations in terms of simulated polarimetric radar variables. Results show that the UM generally underpredicts median reflectivity in stratiform rain, producing high reflectivity cores and precipitation gaps between them. This is partially due to the diagnostic rain intercept parameter formulation used in the one-moment microphysics scheme. Model drop size is generally both underand overpredicted compared to observations. UM frozen hydrometeors favor generic ice（crystals and snow） rather than graupel, which is reasonable for changma and typhoon cases. The model performed best with the typhoon case in terms of simulated precipitation coverage.

关键词： Unified Model microphysics polarimetric radar radar simulator numerical weather prediction

Effect of Low Dose Radiation on Intracellular calcium and Protein Kinase c in Lymphocytes

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Biomedical and Environmental Sciences 1994年第3期7卷 284-291页

作者： LIU SHU-ZHENG SU XU HAN ZHEN-BO ZHANG YING-cHUN AND QI JIN (The MPH Radiobiology Research Unit, norman Bethune University of Medical Sciences, 6 Xinmin Street, changchun 130021, china) MPH Radiobiology Research Unit Norman Bethune University of Medical Sciences Changchun China.

It is first reported in the present paper that whole-body irradiation (WBI) with low dose X-rays could increase intracellular calcium ions ([ca2+]i) and stimulate protein kinase c (PKc) activity of mouse lymphocytes. Following WBI of male Kunming micc With 75 mGy X-rays at a dose rate of 12.5 mGy/min the mobilization of [ca2+]i with con A in cD4+ and cD8+ cells in the thymus and spleen was potentiated and the amplitude of [ca2+], mobilization in thymocytes in response to anti-cD3 monoclonal antibody increased with time from 4 to 24 h following low dose radiation. The PKc activity in the homogenate of spleen was markedly stimulated 12 h after WBl with 75 mGy, reaching its peak value at 24-48 h and coming down to lower than normal on day 7. However, the PKc activity in the separated T lymphocytes reached its peak value at 12 h and that in the B lymphocytes reached its peak value on day 4, both coming down to below control on day 7. The implications of this facilitation of signal transduction in T lymphocytes in the mechanism of immunoenhancement after low dose radiation were discussed

关键词： Zhang ca Effect of Low Dose Radiation on Intracellular calcium and Protein Kinase c in Lymphocytes

Homologous recombination mediates stable Fah gene integration and phenotypic correction in tyrosinaemia mouse-model

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World Journal of Hepatology 2018年第2期10卷 277-286页

作者： norman Junge Qinggong Yuan Thu Huong Vu Simon Krooss christien Bednarski Asha Balakrishnan Toni cathomen Michael P Manns Ulrich Baumann Amar Deep Sharma Michael Ott Department of Pediatric Gastroenterology and Hepatology Hannover Medical School Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School TWINcORE Centre for Experimental and Clinical Infection Research Medical center University of Freiburg Institute for Cell and Gene Therapy Research Group Micro RNA in Liver Regeneration Cluster of Excellence REBIRTH Hannover Medical School

AIM To stably correct tyrosinaemia in proliferating livers of fumarylacetoacetate-hydrolase knockout(Fah-/-) mice by homologous-recombination-mediated targeted addition of the Fah *** c57 BL/6 Fah?exon5 mice served as an animal model for human tyrosinaemia type 1 in our study. The vector was created by amplifying human Fah c DNA including the TTR promoter from a lentivirus plasmid as described. The Fah expression cassette was flanked by homologous arms(620 bp and 749 bp long) of the Rosa26 gene locus. Mice were injected with 2.1 × 108 VP of this vector(r ***) via the tail vein. Mice in the control group were injected with 2.1 × 108 VP of a similar vector but missing the homologous arms(r ***). Primary hepatocytes from Fah-/-recipient mice, treated with our vectors, were isolated and 1 × 106 hepatocytes were transplanted into secondary Fah-/-recipient mice by injection into the spleen. Upon either vector application or hepatocyte transplantation NTBc treatment was stopped in recipient mice. RESULTS Here, we report successful HR-mediated genome editing by integration of a Fah gene expression cassette into the "safe harbour locus" Rosa26 by recombinant AAV8. Both groups of mice showed long-term survival, weight gain and FAH positive clusters as determined by immunohistochemistry analysis of liver sections in the absence of NTBc treatment. In the group of c57 BL/6 Fah?exon5 mice, which have been transplanted with hepatocytes from a mouse injected with r *** 156 d before, 6 out of 6 mice showed long-term survival, weight gain and FAH positive clusters without need for NTBc treatment. In contrast only 1 out 5 mice, who received hepatocytes from r *** treated mice, survived and showed few and smaller FAH positive clusters. These results demonstrate that homologous recombinationmediated Fah gene transfer corrects the phenotype in a mouse model of human tyrosinaemia type 1(Fah-/-mice) and

关键词： Gene therapy AAV8 Liver based metabolic disease Targeted integration ROSA26 Paediatric liver disease

下牙槽神经移位在萎缩下颌骨后牙种植中的临床研究

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下牙槽神经移位在萎缩下颌骨后牙种植中的临床研究

Projected changes in Extreme Event Indices for Alaska

中华口腔医学会成立大会暨第六次全国口腔医学学术会议

作者：李祖兵 A. norman cranin Mark c.Mehrali 湖北医科大学口腔医学院颌面外科

在下颌后牙区放置种植体受牙槽嵴与下颌管间的骨高度的限制,本研究报道下牙槽神经移位后种植13颗骨内种植体的手术效果,手术后随访时间4～18个月,平均为10个月。随访期所有种植桥体稳固,不活动,亦无任何疼痛和感染症状。术后 X 线评价...

在下颌后牙区放置种植体受牙槽嵴与下颌管间的骨高度的限制,本研究报道下牙槽神经移位后种植13颗骨内种植体的手术效果,手术后随访时间4～18个月,平均为10个月。随访期所有种植桥体稳固,不活动,亦无任何疼痛和感染症状。术后 X 线评价种植体周无病理性骨丧失。采

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Atmospheric and climate Sciences 2024年第2期14卷 191-209页

作者： John E. Walsh Kyle Redilla norman Shippee Lukas cheung David Bigelow Ronni Wilcock International Arctic Research center University of Alaska Fairbanks Fairbanks USA Stantec Ottawa Canada Stantec Montreal Canada Stantec Calgary Canada Two Bears Environmental consulting Anchorage USA

As climate has warmed in recent decades, Alaska has experienced a variety of high-impact extreme events that include heat waves, wildfires, coastal storms and freezing rain. Because the warming is projected to continue, it is essential to consider future changes when planning adaptation actions and building resilience. In this study, we synthesize information on future changes in extreme events in Alaska from an ensemble of regional climate model simulations performed as part of Arctic-cORDEX (coordinated Regional climate Downscaling Experiment). A set of 13 extreme event indices, based on those developed by the World climate Research Programme’s Expert Team on climate change Detection and Indices (ETccDI), are evaluated from the Arctic-cORDEX output for Alaska. Of the 13 indices, six pertain to temperature, five to total precipitation, one to wind and one to snow. The results for locations in seven different climate zones of Alaska include large increases (5˚c - 10˚c) in the temperature thresholds for the five hottest and coldest days of the year, and large increases in warm spell duration and decreases in cold spell duration. changes in the cold day temperature threshold are generally larger than the changes in the hot day temperature threshold, consistent with the projections of a stronger warming in winter than in summer in Alaska yearly maximum 1-day and 5-day precipitation amounts as well as the yearly number of consecutive wet days are projected to increase at all locations. The indices for heavy snow days and high-wind days show mixed changes, although the results indicate increases in heavy snow days at the more northern locations and increases in windy days at coastal locations. The changes in the extreme event indices continue through 2100 under the higher-emission (RcP 8.5) emission scenario, while the changes generally stabilize under the lower-emission (RcP 4.5) scenario. .

关键词： Extreme Events Temperature Precipitation Alaska climate

梅县嵩溪银(锑)矿流体包裹体轻烃组成及其矿床成因意义

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地质论评 1999年第S1期45卷 817-822页

作者：孙晓明 DavidI.norman 孙凯陈炳辉陈敬德中山大学地球科学系广州510275 南京大学成矿作用国家重点实验室 210093 新墨西哥矿业技术学院地球和环境科学系

嵩溪是一个新发现的大型银(锑)矿,位于永-梅拗陷南段寨岗上火山沉积盆地的边缘。前人多认为其形成与火山活动有关,主要有海底基性火山喷流和中低温火山热液充填等成因观点。但矿物流体包裹体超高真空四极气相质谱系统测定表明其中存在... 详细信息

嵩溪是一个新发现的大型银(锑)矿,位于永-梅拗陷南段寨岗上火山沉积盆地的边缘。前人多认为其形成与火山活动有关,主要有海底基性火山喷流和中低温火山热液充填等成因观点。但矿物流体包裹体超高真空四极气相质谱系统测定表明其中存在多种轻烃气体,它们主要由c_(1～4)饱和烷烃组成,仅含微量c_(2～4)不饱和烯烃和芳烃,说明成矿过程基本未受到岩浆作用的影响。这些轻烃气为微生物作用成因和沉积岩围岩中Ⅱ类干酪根热解成因的混合气体。从有机气体组成看,嵩溪矿床的成矿背景属裂谷环境。本文的研究从一个侧面支持了作者等提出的嵩溪银(锑)矿可能属沉积热卤水改造型矿床的看法。

关键词：轻烃有机气体流体包裹体沉积热卤水嵩溪银(锑)矿

PDE5 vs PDE6 Inhibitory Activities of curcumin And Its Analogues

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PDE5 vs PDE6 Inhibitory Activities of Curcumin And Its Analo...

第十四届全国中药和天然药物学术研讨会

作者： Kanokwan changwichit Prapapan Temkitthawon Nantaka Khorana Oraya Khruangthip Krongkarn chootip Thipphawan chuprajob chatchawan changtam Apichart Suksamrarn c.norman Scholfield Kornkanok Ingkaninan Naresuan University PhitsanulokThailand

＜正＞Erectile Dysfunction（ED）is a common public health problem affecting millions of men ***（PDE5）inhibitors can be used for the treatment of ED and more recently,for Pulmonary Hypertension（PAH）.However,most of PDE5 inhibitors show some undesirable side *** aim of the study is to search for new PDE5 inhibitors from

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分析继电器触头动态性能的简易技术

电器与能效管理技术 1987年第3期 59-60页

作者： norman Yudewitz ,邓志

本文介绍一种分析多极继电器各触头瞬态状况的简单电路。它可用于: a)校准触头的连续调节; b)确定触头是否桥接; c)检查触头是否处于切换状态。在分析继电器各触头的运行状态时,常希望知道所有动触头的瞬间状态。通常完成这任务的方法... 详细信息

本文介绍一种分析多极继电器各触头瞬态状况的简单电路。它可用于: a)校准触头的连续调节; b)确定触头是否桥接; c)检查触头是否处于切换状态。在分析继电器各触头的运行状态时,常希望知道所有动触头的瞬间状态。通常完成这任务的方法是使用多线示波器。本文所介绍的简易方法,不仅采用单线示波器可以满意地完成这项工作,而且它比使用多线示波器更易于确定触头在微小时间间隔内所处的状态。该方法是将电压施加到带不同电阻元件的继电器各触头上,根据各触头状态的组合输出不同的电流,采用单线示波器显示出该线路中的输出电流波形,从电流波形就可以分析继电器各触头的运行状态。

关键词：触头继电器桥接两极电子元件多线示波器动态性能

流体包裹体轻烃有机气体组成及对矿床成因的制约──以嵩溪大型银(锑)矿为例

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矿床地质 2001年第1期20卷 15-22页

作者：孙晓明 D.I.norman 孙凯陈敬德陈炳辉中山大学地球科学系 Department of Earth and EnvironmentalScienecs New Mexico Institute of Mining and Technology Socorro

嵩溪银（锑）矿是一个新发现的大型独立银矿。矿物流体包裹体超高真空四极气相质谱系统测定显示，该矿成矿流体中存在多种轻烃有机气体，主要由Ｃ１－Ｃ４饱和烷烃组成，仅含微量Ｃ２－Ｃ４不饱和烯烃和芳烃，说明成矿过程基本未受到... 详细信息

嵩溪银（锑）矿是一个新发现的大型独立银矿。矿物流体包裹体超高真空四极气相质谱系统测定显示，该矿成矿流体中存在多种轻烃有机气体，主要由Ｃ１－Ｃ４饱和烷烃组成，仅含微量Ｃ２－Ｃ４不饱和烯烃和芳烃，说明成矿过程基本未受到高温岩浆作用的影响。化学平衡研究表明，这些轻烃气体为微生物成因和沉积岩围岩中Ⅱ类干酪根热解成因的混合气体，其中前者占２／３以上，说明成矿中微生物活动曾起到相当大的作用；后者的平衡温度为３００℃，远超过成矿深度所能达到的地热温度，因此这部分轻烃气体可能源于沉积盆地深处，经成矿流体长距离携带到达较浅的矿化部位。文章从一个侧面证实嵩溪矿可能为沉积热卤水改造型矿床，而不是前人所认为的海底基性火山喷流或中低温火山热液充填矿床。

关键词：轻烃有机气体成矿流体成因流体包裹体银矿床